In this transgenic line, a mouse Penk (preproenkephalin) promoter drives expression of the C. elegans glutamate-gated chloride channel beta subunit for recombinatorial, inducible, reversible neuronal silencing (Lerchner, et al. Neuron 54(1):35-49. 2007) and cre/ESR1. Cre recombinase is fused to a mutant form of the mouse estrogen receptor ligand binding domain. Restricted to the cytoplasm, the fusion protein can only gain access to the nuclear compartment after exposure to tamoxifen. When crossed with a strain containing a loxP site flanked sequence of interest, the flanked sequences are deleted in the offspring upon administration of tamoxifen.

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The mouse Penk (preproenkephalin) promoter drives expression of the C. elegans glutamate-gated chloride channel beta subunit and cre/ESR1. When crossed with a strain containing a loxP site-flanked sequence of interest, the flanked sequences are deleted in the offspring upon administration of tamoxifen.

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