These GAS7tg transgenic mice express the human growth arrest-specific 7, GAS7, under the direction of the endogenous human gene promoter. Hemizygous male transgenic mice exhibit decreased fat/lean ratio with lower body weight; decreased gonadal fat pad weight and total fat pad weight; decreased triglycerides, unesterified cholesterol and glucose; and increased total cholesterol and HDL levels. Hemizygous female transgenic mice do not exhibit the decreased fat/lean ratio, but do have decreased mesenteric fat pad weight and reduced unesterified cholesterol. This mutant mouse strain may be useful in studies of obesity and lipid metabolism.
Aldons J. Lusis, University of California at Los Angeles
Genetic Background | Generation |
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Allele Type |
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Transgenic (Inserted expressed sequence, Humanized sequence) |
These transgenic mice express the human growth arrest-specific 7, GAS7, under the direction of the endogenous human gene promoter. Transgene expression is detected in kidney, lung, heart, brain, adipose, liver, but not spleen. The transgene inserted on the X chromosome in tandem. Hemizygous male transgenic mice exhibit decreased fat/lean ratio with lower body weight; decreased gonadal fat pad weight and total fat pad weight; decreased triglycerides, unesterified cholesterol and glucose; and increased total cholesterol and HDL levels. Hemizygous female transgenic mice do not exhibit the decreased fat/lean ratio, but do have decreased mesenteric fat pad weight and reduced unesterified cholesterol. Hemizygous male animals exhibit normal body weight at weaning. This mutant mouse strain may be useful in studies of obesity and lipid metabolism.
A transgenic construct containing the human growth arrest-specific 7, GAS7, (BAC clone RP11-952P13) was injected into fertilized FVB/N mouse eggs. Founder line 63.2 was established. The transgene inserted on the X chromosome in tandem. The strain has been maintained on the FVB/N background.
Expressed Gene | GAS7, growth arrest specific 7, human |
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Site of Expression |
Allele Name | transgene insertion 63.2, Aldons J Lusis |
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Allele Type | Transgenic (Inserted expressed sequence, Humanized sequence) |
Allele Synonym(s) | GAS7tg; GAS7tg |
Gene Symbol and Name | Tg(GAS7)63.2Lus, transgene insertion 63.2, Aldons J Lusis |
Gene Synonym(s) | |
Promoter | GAS7, growth arrest specific 7, human |
Expressed Gene | GAS7, growth arrest specific 7, human |
Strain of Origin | FVB/N |
Chromosome | X |
Molecular Note | A transgenic construct containing the human growth arrest-specific 7, GAS7, (BAC clone RP11-952P13) was injected into fertilized FVB/N mouse eggs. Founder line 63.2 was established. The transgene inserted on the X chromosome in tandem. |
Mutations Made By | Josh Deignan, UCLA |
When maintaining a live colony, these mice can be bred as hemizygotes.
When using the FVB-Tg(GAS7)63.2Lus/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #010515 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Hemizygous or Non carrier for Tg(GAS7)63.2Lus |
Frozen Mouse Embryo | FVB-Tg(GAS7)63.2Lus/J | $2595.00 |
Frozen Mouse Embryo | FVB-Tg(GAS7)63.2Lus/J | $2595.00 |
Frozen Mouse Embryo | FVB-Tg(GAS7)63.2Lus/J | $3373.50 |
Frozen Mouse Embryo | FVB-Tg(GAS7)63.2Lus/J | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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