These transgenic mice express the human growth arrest-specific 7, GAS7, under the direction of the endogenous human gene promoter. Transgene expression is detected in kidney, lung, heart, brain, adipose, liver, but not spleen. The transgene inserted on the X chromosome in tandem. Hemizygous male transgenic mice exhibit decreased fat/lean ratio with lower body weight; decreased gonadal fat pad weight and total fat pad weight; decreased triglycerides, unesterified cholesterol and glucose; and increased total cholesterol and HDL levels. Hemizygous female transgenic mice do not exhibit the decreased fat/lean ratio, but do have decreased mesenteric fat pad weight and reduced unesterified cholesterol. Hemizygous male animals exhibit normal body weight at weaning. This mutant mouse strain may be useful in studies of obesity and lipid metabolism.

These GAS7tg transgenic mice express the human growth arrest-specific 7, GAS7, under the direction of the endogenous human gene promoter. Hemizygous male transgenic mice exhibit decreased fat/lean ratio with lower body weight; decreased gonadal fat pad weight and total fat pad weight; decreased triglycerides, unesterified cholesterol and glucose; and increased total cholesterol and HDL levels. Hemizygous female transgenic mice do not exhibit the decreased fat/lean ratio, but do have decreased mesenteric fat pad weight and reduced unesterified cholesterol. This mutant mouse strain may be useful in studies of obesity and lipid metabolism.

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