These TCL1-tg transgenic mice express the human T-cell leukemia/lymphoma 1 (TCL1) gene under the control of the mouse CD79B antigen ( Cd79b) minimal promoter. Mice hemizygous for the transgene develop the mature B cell lymphomas: Burkitt-like lymphoma and diffuse large B cell lymphoma. This mutant mouse strain may be useful in studies of mature B and T cell leukemias and lymphomas.
Michael Teitell, UCLA
Genetic Background | Generation |
---|---|
|
Allele Type |
---|
Transgenic (Inserted expressed sequence, Humanized sequence) |
These TCL1-tg transgenic mice express the human T-cell leukemia/lymphoma 1 (TCL1) gene under the control of the mouse CD79B antigen ( Cd79b) minimal promoter. The transgene is expressed in lymphoid (B and T cell) lineage cells and precursors only. The promoter is designed to drive similar levels of expression in B and T cells. Mice hemizygous for the transgene develop mainly mature B cell lymphomas including Burkitt-like lymphoma and diffuse large B cell lymphoma. Occasional chronic B and T lymphocytic leukemias and marginal zone lymphomas also form in these mice. Most mice become clinically (visibly) ill between seven and 13 months, a few as early as four months of age. Mice that are hemizygous for the transgene are viable, normal in size and do not display any gross physical or behavioral abnormalities. Homozygotes are not viable. This mutant mouse strain may be useful in studies of mature B and T cell leukemias and lymphomas.
A transgenic construct containing 381 bp of coding sequence of the human T-cell leukemia/lymphoma 1 (TCL1) under the control of the mouse CD79B antigen ( Cd79b) minimal promoter was injected into fertilized (C57BL/6 x C3H)F1 mouse eggs. Founder animals were bred to C57BL/6 mice for 15 generations to establish founder line BK. Homozygotes are not viable.
Expressed Gene | TCL1A, T cell leukemia/lymphoma 1A, human |
---|---|
Site of Expression |
Allele Name | transgene insertion BK, Michael Teitell |
---|---|
Allele Type | Transgenic (Inserted expressed sequence, Humanized sequence) |
Allele Synonym(s) | TCL1-tg |
Gene Symbol and Name | Tg(Cd79b-TCL1A)BKTeit, transgene insertion BK, Michael Teitell |
Gene Synonym(s) | |
Promoter | Cd79b, CD79B antigen, mouse, laboratory |
Expressed Gene | TCL1A, T cell leukemia/lymphoma 1A, human |
Strain of Origin | (C57BL/6 x C3H)F1 |
Chromosome | UN |
Molecular Note | A transgenic construct containing 381 bp of coding sequence of the human T-cell leukemia/lymphoma 1 gene (TCL1A) under the control of the mouse CD79B antigen ( Cd79b) minimal promoter was injected into fertilized (C57BL/6 x C3H)F1 mouse eggs. Founder line BK was established. |
When maintaining a live colony, these mice can be bred as hemizygotes. Homozygotes are not viable.
When using the B6.Cg-Tg(Cd79b-TCL1A)BKTeit/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #010511 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Hemizygous or Non carrier for Tg(Cd79b-TCL1)BKTeit |
Frozen Mouse Embryo | B6.Cg-Tg(Cd79b-TCL1A)BKTeit/J | $2595.00 |
Frozen Mouse Embryo | B6.Cg-Tg(Cd79b-TCL1A)BKTeit/J | $2595.00 |
Frozen Mouse Embryo | B6.Cg-Tg(Cd79b-TCL1A)BKTeit/J | $3373.50 |
Frozen Mouse Embryo | B6.Cg-Tg(Cd79b-TCL1A)BKTeit/J | $3373.50 |
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
What information were you hoping to find through your search?
How easy was it to find what you were looking for?
We may wish to follow up with you. Enter your email if you are happy for us to connect and reachout to you with more questions.
Please Enter a Valid Email Address
Thank you for sharing your feedback! We are working on improving the JAX Mice search. Come back soon for exciting changes.