Mice homozygous for this targeted mutation are viable, fertile and normal in size. No gene product is detected by Western blot analysis. Mutant mice exhibit better performance during endurance training and, males in particular, exhibit increased time to fatigue, distance run and vertical work in stress tests after endurance training. Vasorelaxation and contractile responses are improved in mutant mice and the ratio of type 2a muscle fibers is increased in sedentary mice, however, this ratio does not change following exercise. This mutant mouse strain may be useful in studies of muscle and vascular adaptation to exercise.


This targeted mutation of the smoothelin-like 1 (<i>Smtnl1</i>) gene displays an abnormal response to exercise adaptation in muscle fibers and may be useful in studies of muscle and vascular adaptation to exercise.

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