This allele of the loss of righting induced by ethanol 5 (Lore5) gene exhibits a 50% increase in the loss righting response time as compared to ISS/TeJ (Inbred Short Sleep). This strain may be used to study the genetics of neurogenetic, neuropharmacological and behavioral phenotypes involved in alcohol-related traits.Read More +
This allele of the loss of righting induced by ethanol 5 (Lore5) gene from ILS/TejJ (Inbred Long Sleep) exhibits a 50% increase in the loss of righting response time (LORR)and a decrease in blood ethanol concentration following sedative intraperitoneal ethanol injection on the ISS/TeJ (Inbred Short Sleep) background as compared to the strain ISS/TejJ. This congenic also exhibits an increased ability to maintain body weight under dietary restriction. The congenic interval is believed to include a quantitative trait locus (QTL) for fuel efficiency in response to dietary restriction.
This strain may be used to study the genetics of neurogenetic, neuropharmacological, and behavioral phenotypes involved in alcohol-related traits and the genetics of metabolic efficiency.
This congenic strain was developed by backcrossing ILS/Tej to ISS/TeJ for minimum of 10 generations,and then intercrossing to generate a homozygotes. The Lore5 QTL is defined by D15Mit94 to D15Mit14. This strain and the set of ILSXISS recombinant inbreds were donated to The Jackson Laboratory Repository in 2009 by Dr. Thomas E. Johnson and Dr. Jerry Stitzel at the University of Colorado, Boulder.
|Gene Symbol and Name||Lore5, loss of righting induced by ethanol 5|
|Strain of Origin||LS or ILS|
|General Note||Lore5 exhibits an additive mode of inheritance.|
|Molecular Note||This allele confers increased loss of righting response (LORR) following alcohol challenge compared to SS.|
When maintaining a live colony, this mice are bred as homozygotes.
When using the ISS.ILS-Lore5ILS/TejJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #010498 in your Materials and Methods section.