Mice homozygous for this allele are viable and fertile and possess a <i>loxP</i> site flanked neomycin resistance cassette disrupting exon 2 of the targeted gene. Composition of the major cell populations of the immune system in spleen, bone marrow, lymph nodes and thymus is not affected by the mutation. Homozygous mice have an increased susceptibility to influenza A/B, HSV-1 and Sinbis virus, however, response to VSV and LCMV is unaltered from control mice.  These mice may be useful in studying interferon-induced antiviral responses and differing susceptibilities to viral infection.

This targeted mutation of the ISG15 ubitquitin-like modifier (<i>Isg15</i>) gene displays increased susceptibility to Influenza A/B and HSV-1, but LCMV or VSV and may be useful in studies of interferon-induced antiviral responses and differing susceptibilities to viral infection.

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