These transgenic mice express a mutant mouse Kitl (kit ligand) cDNA, TG2 or membrane SCF, under the control of the human keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner), KRT14, promoter. The mutant kit ligand carries a site directed mutation that deletes the cleavage site which produces mostly membrane bound protein. These transgenic mice have epidermal melanocytes that persist into adulthood and cause grey-black pigmented skin and increased coat pigment. Shortly after birth, transgenic pups develop visibly pigmented footpads. Transgenic mice exhibit increased sensitivity to irritants. Mice that are homozygous for the targeted mutation are viable, and do not display any gross behavioral abnormalities. Homozygotes are sometimes smaller in size than wildtype controls (as reported by the Donating Investigator). This mutant mouse strain may be useful in studies of hyperpigmentation and allergic contact dermatitis.

These transgenic mice express a mutant mouse Kitl (kit ligand) cDNA, TG2 or membrane SCF, under the control of the human keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner), KRT14, promoter. These transgenic mice have epidermal melanocytes that persist into adulthood and cause hyperpigmentation. The mice also exhibit increased sensitivity to irritants. This mutant mouse strain may be useful in studies of hyperpigmentation and allergic contact dermatitis.

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