NOD.Cg-Tg(Itgax-Venus)1Mnz/QtngJ

Stock number: 009422
Product name: NOD.Cd11c-YFP
Research areas: Diabetes and Obesity Research, Immunology, Inflammation and Autoimmunity Research, Research Tools

Description

This transgenic strain expresses yellow fluorescent protein (YFP) under the transcriptional control of the mouse integrin alpha X (Itgax, Cd11c) promoter which is exclusively expressed in dendritic cells of the immune system.

Detailed description

This transgenic strain expresses yellow fluorescent protein (YFP) under the transcriptional control of the mouse integrin alpha X (Cd11c) promoter which is exclusively expressed in dendritic cells of the immune system. The Donating investigator indicates diabetes incidence of this stock has not been determined.

Development

Yellow fluorescent protein (YFP) was placed under the transcriptional control of the mouse integrin alpha X (Cd11c) promoter. The transgenic vector was introduced into B6CBAF1 fertilized oocytes. Founders were mated with C57BL/6 and heterozygotes were backcrossed to NOD mice for at least 13 generations prior to arrival at The Jackson Laboratory. This is the CD11c-EYFP^hi transgenic line described in the initial publication.

Allele

Symbol: Tg(Itgax-Venus)1Mnz
Name: transgene insertion 1, Michel C Nussenzweig
MGI accession ID: MGI:3835666
Generation method: Transgenic
Attributes: Reporter
Marker symbol: Tg(Itgax-Venus)1Mnz
Marker name: transgene insertion 1, Michel C Nussenzweig
Chromosome: UN
Strain of origin: (C57BL/6 x CBA)F1
Expressed genes: YFP,Yellow Fluorescent Protein,jellyfish
Site of expression: EYFP is exclusively expressed in dendritic cells of the immune system.
Molecular note: The promoter was used to drive expression of EYFP (Venus) in dendritic cells. Two founders were generated with line 1 representing the high-expressing line derived from one of the founders.