Preliminary information suggests these Pstpip1 (proline-serine-threonine phosphatase-interacting protein 1) targeted mice have various defects in immune cells, predominantly T lymphocytes which appear to be hyperresponsive to antigen receptor stimulation.
Stephen P. Goff, Columbia University
Genetic Background | Generation |
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|
Allele Type | Gene Symbol | Gene Name |
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Targeted (Null/Knockout) | Pstpip1 | proline-serine-threonine phosphatase-interacting protein 1 |
Mice homozygous for this targeted mutation are viable and fertile and do not display any gross physical or behavioral abnormalities. Studies of spleen, thymus and embryonic fibroblasts indicate that expression is eliminated. Preliminary information suggests these mice have various defects in immune cells, predominantly T lymphocytes which appear to be hyperresponsive to antigen receptor stimulation.
Exon 1 was replaced by a loxP-flanked neomycin resistance cassette placed in the same transcriptional orientation as the targeted gene. A 129/SvEv-derived embryonic stem cell line was used to create the mutation. Chimeras were bred to 129/SvEv and maintained on that background by the donating laboratory.
Allele Name | targeted mutation 1, Stephen P Goff |
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Allele Type | Targeted (Null/Knockout) |
Allele Synonym(s) | |
Gene Symbol and Name | Pstpip1, proline-serine-threonine phosphatase-interacting protein 1 |
Gene Synonym(s) | |
Strain of Origin | 129S/SvEv |
Chromosome | 9 |
Molecular Note | Exon 1 was replaced by a loxP-flanked neomycin resistance cassette placed in the same transcriptional orientation as the targeted gene. |
Mutations Made By | Stephen Goff, Columbia University |
When maintained as a live colony, homozygotes or heterozygotes may be bred.
When using the 129S/SvEv-Pstpip1tm1Spg/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #009410 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous for Pstpip1<tm1Spg> |
Frozen Mouse Embryo | 129S/SvEv-Pstpip1<tm1Spg>/J | $2595.00 |
Frozen Mouse Embryo | 129S/SvEv-Pstpip1<tm1Spg>/J | $2595.00 |
Frozen Mouse Embryo | 129S/SvEv-Pstpip1<tm1Spg>/J | $3373.50 |
Frozen Mouse Embryo | 129S/SvEv-Pstpip1<tm1Spg>/J | $3373.50 |
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