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The Diversity Outbred (DO) stock is a genetically diverse mouse resource and may be used as a tool for high resolution genetic mapping and validation of previously identified quantitative trait loci (QTLs) linked to disease susceptibility, drug resistance or behavioral phenotypes.
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The Diversity Outbred (DO) stock is designed to be the most genetically diverse mouse resource available, allowing more accurate modeling of the human population and more refined gene mapping resolution than any other mouse model. Individual DO mice have highly heterogenous genomes as a result of their diverse parental genetic contributions (see 'Development' below). DO mice may be used as a tool for high resolution genetic mapping and validation of previously identified quantitative trait loci (QTLs) linked to disease susceptibility, drug resistance or behavioral phenotypes. High density genotyping of individual mice can be achieved with genotyping arrays. DO mice may also be useful for toxicogenomic screens, compound evaluation in a genetically diverse population, and the development of opposite responder populations with high and low responses for specific phenotypes of interest.
The DO heterogeneous stock is produced in waves. It was developed by random outcross matings of 160 Collaborative Cross recombinant inbred mouse lines, and the colony is maintained by continued random matings that avoid crosses between siblings. This colony maintenance strategy retains the widest possible genetic diversity in each DO mouse. The DO parental lines, the Collaborative Cross strains, were developed by crossing eight unique and genetically diverse inbred mouse strains (A/J, C57BL/6J, 129S1/SvImJ, NOD/ShiLtJ, NZO/HlLtJ, CAST/EiJ, PWK/PhJ, and WSB/EiJ), followed by subsequent inbreeding to produce new and unique recombinant incipient inbred lines.
Currently there are no related genes or alleles for this strain.
When maintained in a live colony, these mice are randomly bred and avoid the use of sibling matings.
When using the J:DO mouse strain in a publication, please cite the originating article(s) and include JAX stock #009376 in your Materials and Methods section.