The ISS (Inbred Short Sleep) strain is the product of a selection for long duration (sleep time) of loss-of-righting response following high dose ip administration of ethanol. This strain and ISS are the progenitors used to generate the ILSXISS recombinant inbred strain set used in QTL mapping analysis.
Thomas Johnson, University of Colorado at Boulder
The ISS (Inbred Short Sleep) strain is the product of a selection for long duration (sleep time) of loss-of-righting response following high dose (3.3g/kg) intraperitoneal administration of ethanol. During the selection process, the SS mice developed insensitivity to alcohol requiring a dose increase to 4.1 g/kg. At the 18th generation of inbreeding SS (short-sleep) mice exhibited a mean sleep time of 10 minutes. This strain and ISS are the progenitors used to generate the ILSXISS recombinant inbred strain set used in QTL mapping analysis.
The ISS and SS strains were developed from a heterogenous stock derived from an 8 way cross (A, AKR, BALB/c, C3H/2, C57BL, DBA/2, IS/Bi and RIII) created at the Cancer Research Genetics Laboratory at the University of California, Berkley. ISS is the product of inbreeding SS, a line selected for short duration (sleep time) of loss-of-righting response following high dose (3.3g/kg) intraperitoneal administration of ethanol. During the selection process, the SS mice developed insensitivity to alcohol requiring a dose increase to 4.1 g/kg. At the 18th generation of inbreeding SS (short-sleep) mice exhibited a mean sleep time of 10 minutes. The name SS became ISS (inbred short-sleep) in the 20th generation of inbreeding.
This strain and ILS/IbgTej (inbred long-sleep) were used to generate the ILSXISS recombinant inbred set donated to The Jackson Laboratory Repository in 2009 by Dr. Thomas E. Johnson and Dr. Jerry Stitzel at the University of Colorado, Boulder.
An earlier RI set, LSXSS, was created using the LS and SS mice - the Repository does not maintain this set.
Currently there are no related genes or alleles for this strain.
Related Genotype: Tyrc
When using the ISS/IbgTejJ mouse strain in a publication, please include JAX stock #009325 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Inbred, 1 pair minimum will be supplied |
Frozen Mouse Embryo | ISS/IbgTejJ Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | ISS/IbgTejJ Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | ISS/IbgTejJ Frozen Embryos | $3373.50 |
Frozen Mouse Embryo | ISS/IbgTejJ Frozen Embryos | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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