This inbred strain is a substrain of C57BL/6. This strain may be useful as a general purpose strain or as a model of resistance in carcinogen-induced colon cancer.
Rosemary W. Elliott, Roswell Park Cancer Inst.
This inbred strain is a substrain of C57BL/6. C57BL/6HaJ may serve as a general purpose strain, in addition, it is known for resistance to induced colon cancer. In contrast to 100% susceptible ICR/HaJ (009122) mice, no tumors develop in C57BL/6HaJ mice following subcutaneous injection of 1,2-dimethylhydrazine (DMH) during a 44 week observation period. Other substrains, C57BL/6J (000664
) and C57BL/6N, exhibit a lesser degree of resistance, 43% and 85% respectively. This strain may be useful in genetic analysis of carcinogen-induced colon cancer.
This substrain of the inbred strain C57BL originated in the laboratory of Dr. Hauschka at Roswell Park Cancer Institute. C57BL/6Ha has been maintained by sibling matings at Roswell Park for more than 30 years. Dr. Rosemary Elliott donated this strain to the Repository in 2009.
C57BL/6HaJ mice are susceptible to malocclusion and hydrocephalus.
When using the C57BL/6HaJ mouse strain in a publication, please include JAX stock #009123 in your Materials and Methods section.