ICR/HaJ

Stock number: 009122
Strain synonyms: ICR
Research areas: Cancer Research, Research Tools

Description

This inbred strain is derived from the outbred strain ICR. It may be useful in therapeutic drug testing and genetic analysis of carcinogen-induced colon cancer.

Detailed description

This inbred strain is derived from the outbred stock ICR. ICR/HaJ may serve as a general purpose strain and is known for susceptibility to induced colon cancer. In contrast to resistant C57BL/6HaJ (Stock No. 009123), 100% of ICR/HaJ mice develop colon tumors and adenocarcinomas by 24 weeks following subcutaneous injection of 1,2-dimethylhydrazine (DMH). ICR/HaJ carries the MHC haplotype H2^g7 and may be used as a control for NOD/ShiLtJ (Stock No. 001976). ICR/HaJ mice do not develop insulitis or diabetes. Like ICR, this inbred is highly prolific. This ICR/HaJ strain may be useful in therapeutic drug testing, genetic analysis of carcinogen-induced colon cancer and as control for NOD/ShiLtJ.

Development

This inbred strain was developed from the HA(ICR) outbred stock brought to the Roswell Park Cancer Institute by Dr. Hauschka in 1954. HA(ICR) originated from a Swiss Webster stock purchased from J. C. Landis in 1947 and was maintained by Dr. Hauschka at the Institute for Cancer Research in Philadelphia. HA(ICR) was selected for reproductive vigor (fecundity) and is one of the most prolific of the outbred strains. ICR/Ha has been maintained by sibling matings at Roswell Park for more than 30 years. Dr. Rosemary Elliott donated this strain to the Repository in 2009.

Allele

Symbol: Ccs1^ICR/Ha
Name: ICR/Ha
MGI accession ID: MGI:3618098
Generation method: QTL
Marker symbol: Ccs1
Marker name: colon cancer susceptibility 1
Chromosome: 12
Strain of origin: ICR/Ha
Molecular note: This allele confers susceptibility to colon tumors compared to C57BL/6Ha.