Homozygotes demonstrate an approximate 10% reduction in body weight as adults and diminished fertility as they age. Mice show a significant reduction of NFAT (nuclear factor of activated T cells) transcriptional activity that is sustained in mouse embryonic fibroblasts (MEFs) for eight hours after thapsigargin stimulation to increase intracellular Ca2+. This evidence suggests a facilitator role for the gene in efficient calcineurin-NFAT coupling. Mice are also resistant to induced cardiac hypertrophy. 

CD4+ T cells of compound Rcan1/Rcan2 (Mcip1/Mcip2) targeted mutants show enhanced apoptosis. Slow/oxidative fiber-type switching is impaired in their skeletal muscle after exercise. A neurological phenotype involving increased locomotor activity and impaired working memory is also seen in the compound mutants. For more information on the Rcan2 mutation, please see Stock No. <a href="https://www.jax.org/strain/009073">009073</a>).

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Homozygous Rcan1 (regulator of calcineurin 1) targeted mice demonstrate an approximate 10% reduction in body weight as adults and diminished fertility as they age. Mice show a significant reduction of NFAT (nuclear factor of activated T cells) transcriptional activity that is sustained in mouse embryonic fibroblasts (MEFs) for eight hours after thapsigargin stimulation to increase intracellular Ca2+. This evidence suggests a facilitator role for the gene in efficient calcineurin-NFAT coupling. Mice are also resistant to induced cardiac hypertrophy.

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