These mice recapitulate the phenotype of null allele mice in terms of increased macroorchidism with age, protein synthesis-dependent metabotropic glutamate receptor (mGluR)-dependent long-term depression (LTD) at CA1 hippocampal neurons, and multiple behavioral assays.  There is a significant incidence of audiogenic seizures in adulthood.  Their mRNA is of correct size and is expressed at correct levels, but protein levels are decreased to 15-30% that of wildtype, most pronounced at postnatal day 14 (P14) and normalizing somewhat in adulthood.  This strain may be useful in studies of Fragile X Mental Retardation Syndrome.

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These mice recapitulate the phenotype of null <i>Fmr1</i> (fragile X mental retardation syndrome 1 homolog) allele mice in terms of increased macroorchidism with age, protein synthesis-dependent metabotropic glutamate receptor (mGluR)-dependent long-term depression (LTD) at CA1 hippocampal neurons, and multiple behavioral assays.  There is a significant incidence of audiogenic seizures in adulthood.  Protein levels are decreased to 15-30% that of wildtype at P14, but normalize somewhat in adulthood.  This strain may be useful in studies of Fragile X Mental Retardation Syndrome.

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