Yellow fluorescent protein (YFP) is under the transcriptional control of the mouse integrin alpha X (<i>Itgax</i>, Cd11c) promoter which is exclusively expressed in dendritic cells of the immune system. These mice have been used to assess distribution and mobility of dendritic cells.  For example, one study using these mice showed that unilateral ureteral obstruction, renal dendritic cells exhibit inflammatory morphological and functional characteristics and are more effective antigen-presenting cells, but they do not directly contribute to tubulointerstitial damage and fibrosis.  In another study these mice were used anatomically map and phenotype a discrete population of EYFP(+) cells within the microglia.

Use of MICE by companies or for-profit entities requires a license prior to shipping.

This transgenic reporter strain expresses yellow fluorescent protein (YFP) under the transcriptional control of the mouse integrin alpha X (Cd11c) promoter which is exclusively expressed in dendritic cells of the immune system. This strain may be useful in studying the function and migration of dendritic cells in immune responses.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

<a target="_blank" href="https://www.jax.org/jax-mice-and-services/customer-support" rel="noreferrer">Contact Customer Service</a> for more information.