JAX
Mouse Strain Datasheet - 008829
B6.Cg-Tg(Itgax-Venus)1Mnz/J
Also Known As: CD11c-EYFP
This transgenic reporter strain expresses yellow fluorescent protein (YFP) under the transcriptional control of the mouse integrin alpha X (Cd11c) promoter which is exclusively expressed in dendritic cells of the immune system. This strain may be useful in studying the function and migration of dendritic cells in immune responses.
Donating Investigator
Michel C Nussenzweig, The Rockefeller University
Genetic overview
| Genetic Background | Generation |
|---|---|
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Tg(Itgax-Venus)1Mnz
| Allele Type |
|---|
| Transgenic (Reporter) |
Detailed Description
Yellow fluorescent protein (YFP) is under the transcriptional control of the mouse integrin alpha X (Itgax, Cd11c) promoter which is exclusively expressed in dendritic cells of the immune system. These mice have been used to assess distribution and mobility of dendritic cells. For example, one study using these mice showed that unilateral ureteral obstruction, renal dendritic cells exhibit inflammatory morphological and functional characteristics and are more effective antigen-presenting cells, but they do not directly contribute to tubulointerstitial damage and fibrosis. In another study these mice were used anatomically map and phenotype a discrete population of EYFP(+) cells within the microglia.
Development
EYFP-Venus was placed under the transcriptional control of the mouse integrin alpha X (Cd11c) promoter. The transgenic vector was introduced to B6CBAF1 fertilized embryos. This line was backcrossed to C57BL/6 for seven generations by the donating laboratory. This is the CD11c-EYFPhi transgenic line described in the initial publication.
Expression Data
| Expressed Gene | YFP, Yellow Fluorescent Protein, jellyfish |
|---|---|
| Site of Expression | EYFP is exclusively expressed in dendritic cells of the immune system. |
Control Suggestions
Selected References
- Lindquist RL; Shakhar G; Dudziak D; Wardemann H; Eisenreich T; Dustin ML; Nussenzweig MC. 2004. Visualizing dendritic cell networks in vivo. Nat Immunol 5(12):1243-50. PubMed: 15543150MGI: J:141750
Tg(Itgax-Venus)1Mnz
Allele Symbol: Tg(Itgax-Venus)1Mnz
| Allele Name | transgene insertion 1, Michel C Nussenzweig |
|---|---|
| Allele Type | Transgenic (Reporter) |
| Allele Synonym(s) | CD11c-EYFPhi; CD11c-YFP; CD11c-eYFP; Tg(Itgax-EYFP)1Mnz |
| Gene Symbol and Name | Tg(Itgax-Venus)1Mnz, transgene insertion 1, Michel C Nussenzweig |
| Gene Synonym(s) | CD11c-EYFPhi |
| Promoter | Itgax, integrin alpha X, mouse, laboratory |
| Expressed Gene | YFP, Yellow Fluorescent Protein, jellyfish |
| Site of Expression | EYFP is exclusively expressed in dendritic cells of the immune system. |
| Strain of Origin | (C57BL/6 x CBA)F1 |
| Chromosome | UN |
| Molecular Note | The promoter was used to drive expression of EYFP (Venus) in dendritic cells. Two founders were generated with line 1 representing the high-expressing line derived from one of the founders. |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Research Tools
- Fluorescent Proteins
- Immunology, Inflammation and Autoimmunity Research
Genotype: YFP related
- Research Tools
- Fluorescent Proteins
References
- Lindquist RL; Shakhar G; Dudziak D; Wardemann H; Eisenreich T; Dustin ML; Nussenzweig MC. 2004. Visualizing dendritic cell networks in vivo. Nat Immunol 5(12):1243-50. PubMed: 15543150MGI: J:141750
Additional - Tg(Itgax-Venus)1Mnz related
- Abtin A; Jain R; Mitchell AJ; Roediger B; Brzoska AJ; Tikoo S; Cheng Q; Ng LG; Cavanagh LL; von Andrian UH; Hickey MJ; Firth N; Weninger W. 2014. Perivascular macrophages mediate neutrophil recruitment during bacterial skin infection. Nat Immunol 15(1):45-53. PubMed: 24270515MGI: J:209087
- Angiari S; Rossi B; Piccio L; Zinselmeyer BH; Budui S; Zenaro E; Della Bianca V; Bach SD; Scarpini E; Bolomini-Vittori M; Piacentino G; Dusi S; Laudanna C; Cross AH; Miller MJ; Constantin G. 2013. Regulatory T cells suppress the late phase of the immune response in lymph nodes through P-selectin glycoprotein ligand-1. J Immunol 191(11):5489-500. PubMed: 24174617MGI: J:207010
- Benson RA; MacLeod MK; Hale BG; Patakas A; Garside P; Brewer JM. 2015. Antigen presentation kinetics control T cell/dendritic cell interactions and follicular helper T cell generation in vivo. Elife 4:. PubMed: 26258879MGI: J:226648
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- Bouma G; Mendoza-Naranjo A; Blundell MP; de Falco E; Parsley KL; Burns SO; Thrasher AJ. 2011. Cytoskeletal remodeling mediated by WASp in dendritic cells is necessary for normal immune synapse formation and T-cell priming. Blood 118(9):2492-501. PubMed: 21690559MGI: J:176916
- Braun A; Worbs T; Moschovakis GL; Halle S; Hoffmann K; Bolter J; Munk A; Forster R. 2011. Afferent lymph-derived T cells and DCs use different chemokine receptor CCR7-dependent routes for entry into the lymph node and intranodal migration. Nat Immunol 12(9):879-87. PubMed: 21841786MGI: J:176463
- Busch M; Westhofen TC; Koch M; Lutz MB; Zernecke A. 2014. Dendritic cell subset distributions in the aorta in healthy and atherosclerotic mice. PLoS One 9(2):e88452. PubMed: 24551105MGI: J:213070
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- Camirand G; Wang Y; Lu Y; Wan YY; Lin Y; Deng S; Guz G; Perkins DL; Finn PW; Farber DL; Flavell RA; Shlomchik WD; Lakkis FG; Rudd CE; Rothstein DM. 2014. CD45 ligation expands Tregs by promoting interactions with DCs. J Clin Invest 124(10):4603-13. PubMed: 25202978MGI: J:217633
- Chodaczek G; Papanna V; Zal MA; Zal T. 2012. Body-barrier surveillance by epidermal gammadelta TCRs. Nat Immunol 13(3):272-82. PubMed: 22327568MGI: J:181476
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- D'Agostino PM; Kwak C; Vecchiarelli HA; Toth JG; Miller JM; Masheeb Z; McEwen BS; Bulloch K. 2012. Viral-induced encephalitis initiates distinct and functional CD103+ CD11b+ brain dendritic cell populations within the olfactory bulb. Proc Natl Acad Sci U S A 109(16):6175-80. PubMed: 22474352MGI: J:183620
- Da Silva N; Cortez-Retamozo V; Reinecker HC; Wildgruber M; Hill E; Brown D; Swirski FK; Pittet MJ; Breton S. 2011. A dense network of dendritic cells populates the murine epididymis. Reproduction 141(5):653-63. PubMed: 21310816MGI: J:180932
- Dando SJ; Naranjo Golborne C; Chinnery HR; Ruitenberg MJ; McMenamin PG. 2016. A case of mistaken identity: CD11c-eYFP(+) cells in the normal mouse brain parenchyma and neural retina display the phenotype of microglia, not dendritic cells. Glia 64(8):1331-49. PubMed: 27189804MGI: J:232788
- Delvecchio FR; Vadrucci E; Cavalcanti E; De Santis S; Kunde D; Vacca M; Myers J; Allen F; Bianco G; Huang AY; Monsurro V; Santino A; Chieppa M. 2015. Polyphenol administration impairs T-cell proliferation by imprinting a distinct dendritic cell maturational profile. Eur J Immunol 45(9):2638-49. PubMed: 26096294MGI: J:232952
- Farache J; Koren I; Milo I; Gurevich I; Kim KW; Zigmond E; Furtado GC; Lira SA; Shakhar G. 2013. Luminal Bacteria Recruit CD103(+) Dendritic Cells into the Intestinal Epithelium to Sample Bacterial Antigens for Presentation. Immunity 38(3):581-95. PubMed: 23395676MGI: J:194474
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- Gaya M; Castello A; Montaner B; Rogers N; Reis e Sousa C; Bruckbauer A; Batista FD. 2015. Host response. Inflammation-induced disruption of SCS macrophages impairs B cell responses to secondary infection. Science 347(6222):667-72. PubMed: 25657250MGI: J:218229
- Ge S; Hertel B; Koltsova EK; Sorensen-Zender I; Kielstein JT; Ley K; Haller H; von Vietinghoff S. 2013. Increased atherosclerotic lesion formation and vascular leukocyte accumulation in renal impairment are mediated by interleukin-17A. Circ Res 113(8):965-74. PubMed: 23908345MGI: J:213467
- Gerard A; Khan O; Beemiller P; Oswald E; Hu J; Matloubian M; Krummel MF. 2013. Secondary T cell-T cell synaptic interactions drive the differentiation of protective CD8(+) T cells. Nat Immunol 14(4):356-63. PubMed: 23475183MGI: J:194908
- Gerner MY; Kastenmuller W; Ifrim I; Kabat J; Germain RN. 2012. Histo-cytometry: a method for highly multiplex quantitative tissue imaging analysis applied to dendritic cell subset microanatomy in lymph nodes. Immunity 37(2):364-76. PubMed: 22863836MGI: J:187382
- Gottfried-Blackmore A; Kaunzner UW; Idoyaga J; Felger JC; McEwen BS; Bulloch K. 2009. Acute in vivo exposure to interferon-{gamma} enables resident brain dendritic cells to become effective antigen presenting cells. Proc Natl Acad Sci U S A :. PubMed: 19906988MGI: J:155303
- Gottschalk RA; Hathorn MM; Beuneu H; Corse E; Dustin ML; Altan-Bonnet G; Allison JP. 2012. Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses. Proc Natl Acad Sci U S A :. PubMed: 22223661MGI: J:179922
- Heesters BA; Carroll MC. 2016. The Role of Dendritic Cells in S. pneumoniae Transport to Follicular Dendritic Cells. Cell Rep 16(12):3130-7. PubMed: 27653679MGI: J:239127
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- Hickman HD; Li L; Reynoso GV; Rubin EJ; Skon CN; Mays JW; Gibbs J; Schwartz O; Bennink JR; Yewdell JW. 2011. Chemokines control naive CD8+ T cell selection of optimal lymph node antigen presenting cells. J Exp Med 208(12):2511-24. PubMed: 22042976MGI: J:178641
- Hisadome K; Smith MA; Choudhury AI; Claret M; Withers DJ; Ashford ML. 2009. 5-HT inhibition of rat insulin 2 promoter Cre recombinase transgene and proopiomelanocortin neuron excitability in the mouse arcuate nucleus. Neuroscience 159(1):83-93. PubMed: 19135134MGI: J:148970
- Honda T; Egen JG; Lammermann T; Kastenmuller W; Torabi-Parizi P; Germain RN. 2014. Tuning of antigen sensitivity by T cell receptor-dependent negative feedback controls T cell effector function in inflamed tissues. Immunity 40(2):235-47. PubMed: 24440150MGI: J:209370
- Hu Z; Lancaster JN; Sasiponganan C; Ehrlich LI. 2015. CCR4 promotes medullary entry and thymocyte-dendritic cell interactions required for central tolerance. J Exp Med 212(11):1947-65. PubMed: 26417005MGI: J:229032
- Ivanov S; Scallan JP; Kim KW; Werth K; Johnson MW; Saunders BT; Wang PL; Kuan EL; Straub AC; Ouhachi M; Weinstein EG; Williams JW; Briseno C; Colonna M; Isakson BE; Gautier EL; Forster R; Davis MJ; Zinselmeyer BH; Randolph GJ. 2016. CCR7 and IRF4-dependent dendritic cells regulate lymphatic collecting vessel permeability. J Clin Invest 126(4):1581-91. PubMed: 26999610MGI: J:234708
- Kaiser P; Regoes RR; Dolowschiak T; Wotzka SY; Lengefeld J; Slack E; Grant AJ; Ackermann M; Hardt WD. 2014. Cecum lymph node dendritic cells harbor slow-growing bacteria phenotypically tolerant to antibiotic treatment. PLoS Biol 12(2):e1001793. PubMed: 24558351MGI: J:208411
- Kastenmuller W; Brandes M; Wang Z; Herz J; Egen JG; Germain RN. 2013. Peripheral Prepositioning and Local CXCL9 Chemokine-Mediated Guidance Orchestrate Rapid Memory CD8(+) T Cell Responses in the Lymph Node. Immunity 38(3):502-13. PubMed: 23352234MGI: J:194479
- Kastenmuller W; Torabi-Parizi P; Subramanian N; Lammermann T; Germain RN. 2012. A spatially-organized multicellular innate immune response in lymph nodes limits systemic pathogen spread. Cell 150(6):1235-48. PubMed: 22980983MGI: J:187962
- Katakai T; Habiro K; Kinashi T. 2013. Dendritic cells regulate high-speed interstitial T cell migration in the lymph node via LFA-1/ICAM-1. J Immunol 191(3):1188-99. PubMed: 23817428MGI: J:205712
- Kim KW; Williams JW; Wang YT; Ivanov S; Gilfillan S; Colonna M; Virgin HW; Gautier EL; Randolph GJ. 2016. MHC II+ resident peritoneal and pleural macrophages rely on IRF4 for development from circulating monocytes. J Exp Med 213(10):1951-9. PubMed: 27551152MGI: J:237036
- Koltsova EK; Garcia Z; Chodaczek G; Landau M; McArdle S; Scott SR; von Vietinghoff S; Galkina E; Miller YI; Acton ST; Ley K. 2012. Dynamic T cell-APC interactions sustain chronic inflammation in atherosclerosis. J Clin Invest 122(9):3114-26. PubMed: 22886300MGI: J:191432
- Kreisel D; Lai J; Richardson SB; Ibricevic A; Nava RG; Lin X; Li W; Kornfeld CG; Miller MJ; Brody SL; Gelman AE; Krupnick AS. 2011. Polarized alloantigen presentation by airway epithelial cells contributes to direct CD8+ T cell activation in the airway. Am J Respir Cell Mol Biol 44(6):749-54. PubMed: 21653906MGI: J:185022
- Kreisel D; Sugimoto S; Zhu J; Nava R; Li W; Okazaki M; Yamamoto S; Ibrahim M; Huang HJ; Toth KA; Ritter JH; Krupnick AS; Miller MJ; Gelman AE. 2011. Emergency granulopoiesis promotes neutrophil-dendritic cell encounters that prevent mouse lung allograft acceptance. Blood 118(23):6172-82. PubMed: 21972291MGI: J:179092
- Lee EJ; Rosenbaum JT; Planck SR. 2010. Epifluorescence intravital microscopy of murine corneal dendritic cells. Invest Ophthalmol Vis Sci 51(4):2101-8. PubMed: 20007837MGI: J:160801
- Lee KM; Danuser R; Stein JV; Graham D; Nibbs RJ; Graham GJ. 2014. The chemokine receptors ACKR2 and CCR2 reciprocally regulate lymphatic vessel density. EMBO J 33(21):2564-80. PubMed: 25271254MGI: J:216439
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- Morley SC; Wang C; Lo WL; Lio CW; Zinselmeyer BH; Miller MJ; Brown EJ; Allen PM. 2010. The actin-bundling protein L-plastin dissociates CCR7 proximal signaling from CCR7-induced motility. J Immunol 184(7):3628-38. PubMed: 20194718MGI: J:160082
- Nitschke M; Aebischer D; Abadier M; Haener S; Lucic M; Vigl B; Luche H; Fehling HJ; Biehlmaier O; Lyck R; Halin C. 2012. Differential requirement for ROCK in dendritic cell migration within lymphatic capillaries in steady-state and inflammation. Blood 120(11):2249-58. PubMed: 22855606MGI: J:191311
- Overstreet MG; Gaylo A; Angermann BR; Hughson A; Hyun YM; Lambert K; Acharya M; Billroth-Maclurg AC; Rosenberg AF; Topham DJ; Yagita H; Kim M; Lacy-Hulbert A; Meier-Schellersheim M; Fowell DJ. 2013. Inflammation-induced interstitial migration of effector CD4(+) T cells is dependent on integrin alphaV. Nat Immunol 14(9):949-58. PubMed: 23933892MGI: J:208230
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- Rattanapak T; Birchall JC; Young K; Kubo A; Fujimori S; Ishii M; Hook S. 2014. Dynamic visualization of dendritic cell-antigen interactions in the skin following transcutaneous immunization. PLoS One 9(2):e89503. PubMed: 24586830MGI: J:213821
- Riol-Blanco L; Ordovas-Montanes J; Perro M; Naval E; Thiriot A; Alvarez D; Paust S; Wood JN; von Andrian UH. 2014. Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation. Nature 510(7503):157-61. PubMed: 24759321MGI: J:212830
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- Schaeffer M; Han SJ; Chtanova T; van Dooren GG; Herzmark P; Chen Y; Roysam B; Striepen B; Robey EA. 2009. Dynamic imaging of T cell-parasite interactions in the brains of mice chronically infected with Toxoplasma gondii. J Immunol 182(10):6379-93. PubMed: 19414791MGI: J:148321
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- Shimizuhira C; Otsuka A; Honda T; Kitoh A; Egawa G; Nakajima S; Nakashima C; Watarai H; Miyachi Y; Kabashima K. 2014. Natural killer T cells are essential for the development of contact hypersensitivity in BALB/c mice. J Invest Dermatol 134(11):2709-18. PubMed: 24756110MGI: J:215941
- Shum WW; Smith TB; Cortez-Retamozo V; Grigoryeva LS; Roy JW; Hill E; Pittet MJ; Breton S; Da Silva N. 2014. Epithelial basal cells are distinct from dendritic cells and macrophages in the mouse epididymis. Biol Reprod 90(5):90. PubMed: 24648397MGI: J:210305
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- Sun T; Yang L; Kaur H; Pestel J; Looso M; Nolte H; Krasel C; Heil D; Krishnan RK; Santoni MJ; Borg JP; Bunemann M; Offermanns S; Swiercz JM; Worzfeld T. 2017. A reverse signaling pathway downstream of Sema4A controls cell migration via Scrib. J Cell Biol 216(1):199-215. PubMed: 28007914MGI: J:240630
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- Thom JT; Weber TC; Walton SM; Torti N; Oxenius A. 2015. The Salivary Gland Acts as a Sink for Tissue-Resident Memory CD8(+) T Cells, Facilitating Protection from Local Cytomegalovirus Infection. Cell Rep 13(6):1125-36. PubMed: 26526997MGI: J:228967
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- Weber C; Meiler S; Doring Y; Koch M; Drechsler M; Megens RT; Rowinska Z; Bidzhekov K; Fecher C; Ribechini E; van Zandvoort MA; Binder CJ; Jelinek I; Hristov M; Boon L; Jung S; Korn T; Lutz MB; Forster I; Zenke M; Hieronymus T; Junt T; Zernecke A. 2011. CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice. J Clin Invest 121(7):2898-910. PubMed: 21633167MGI: J:175665
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- Zangi L; Klionsky YZ; Yarimi L; Bachar-Lustig E; Eidelstein Y; Shezen E; Hagin D; Ito Y; Takai T; Reich-Zeliger S; Lask A; Milstein O; Jung S; Shinder V; Reisner Y. 2012. Deletion of cognate CD8 T cells by immature dendritic cells: a novel role for perforin, granzyme A, TREM-1, and TLR7. Blood 120(8):1647-57. PubMed: 22776817MGI: J:189175