JAX
Mouse Strain Datasheet - 008813
STOCK Trpa1tm2Kykw Tg(CAG-cre/Esr1*)5Amc/J
Also Known As: Trpa1 CKO/CKO deltaNeo Tg(cre/Esr1)5Amc/J
These compound mutant mice carry a floxed allele of the Trpa1 (transient receptor potential cation channel, subfamily A, member 1) gene in addition to a tamoxifen inducible cre transgene driven by the chicken beta actin promoter/enhancer coupled with the cytomegalovirus (CMV) immediate-early enhancer (see Stock No. 004682).Restricted to the cytoplasm, the cre/Esr1 protein can only gain access to the nuclear compartment after exposure to tamoxifen. Tamoxifen administration induces cre recombination within the Trpa1 allele, excising the S5/S6 transmembrane domains. Animals not treated with tamoxifen display no observable phenotype.
Donating Investigator
David P. Corey, Harvard Medical School/HHMI
Genetic overview
| Genetic Background | Generation |
|---|---|
|
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Tg(CAG-cre/Esr1*)5Amc
| Allele Type |
|---|
| Transgenic (Inducible, Recombinase-expressing) |
Trpa1tm2Kykw
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Targeted (Conditional ready (e.g. floxed), No functional change) | Trpa1 | transient receptor potential cation channel, subfamily A, member 1 |
Detailed Description
These compound mutant mice carry a floxed allele of the Trpa1 (transient receptor potential cation channel, subfamily A, member 1) gene in addition to a tamoxifen inducible cre transgene driven by the chicken beta actin promoter/enhancer coupled with the cytomegalovirus (CMV) immediate-early enhancer (see Stock No. 004682).Restricted to the cytoplasm, the cre/Esr1 protein can only gain access to the nuclear compartment after exposure to tamoxifen. Tamoxifen administration induces cre recombination within the Trpa1 allele, excising the S5/S6 transmembrane domains. Animals not treated with tamoxifen display no observable phenotype.
Development
This compound mutant strain was created by intercrossing a Trpa1 floxed strain with a tamoxifen-inducible cre mutation strain (see Stock No. 004682).
To create the Trpa1 floxed allele, loxP sites were placed on either side of the exons that encode the S5/S6 transmembrane domains. An FRT-flanked self-excising neomycin resistance cassette was initially placed within the floxed allele, and was deleted. The mutation was created with 129S6/SvEvTac-derived TC1 embryonic stem (ES) cells.
This compound mutant strain is on a mixed genetic background that involves C57BL/6, CBA, and 129.
Expression Data
| Expressed Gene | cre/Esr1, Cre recombinase and estrogen receptor 1 fusion gene, |
|---|---|
| Site of Expression | tamoxifen-inducible cre; widespread pattern of expression; tamoxifen administration will also induce Cre recombination in developing embryos of treated mothers and in cultured cells derived from transgenic mice |
| Site of Expression |
Control Suggestions
Selected References
- Corey D; Kwan KY. 2011. Generation of a conditional allele of Trpa1 MGI Direct Data Submission :. MGI: J:169738
Tg(CAG-cre/Esr1*)5Amc
Allele Symbol: Tg(CAG-cre/Esr1*)5Amc
| Allele Name | transgene insertion 5, Andrew P McMahon |
|---|---|
| Allele Type | Transgenic (Inducible, Recombinase-expressing) |
| Allele Synonym(s) | CAG-CreERT2; CAG-CreEr; CAGG-Cre; CAGG-CreERT2; CAGGCre-ER; CAGGCre-ERTM; CAGGCre-ERtm line 5.8; CAGGS-CreER; CAGGS-CreErT; CMV-creERT; CaggCreER; Cre-ER; Cre-ERTM; CreESRT; ER-cre; Tg(CAG-cre/Esr1)5Amc; Tg(cre/Esr1)5Amc; Tg:Cag-Cre/Esr1; TgCreER; TgCAGGCreER; uCreERT |
| Gene Symbol and Name | Tg(CAG-cre/Esr1*)5Amc, transgene insertion 5, Andrew P McMahon |
| Gene Synonym(s) | CAG-CreERT2; CAGG-CreERT2; CAGGCre-ER; CAGGCre-ERTM; CAGGCre-ERtm line 5.8; CAGGS-CreER; CAGGS-CreErT; CMV-creERT; Cre-ER; Cre-ERTM; ER-cre; Tg(CAG-cre/Esr1)5Amc; Tg(CAG-cre/Esr1)5Amc; Tg(cre/Esr1)5Amc; Tg(cre/Esr1)5Amc |
| Promoter | ACTB, actin, beta, chicken |
| Expressed Gene | cre/Esr1, Cre recombinase and estrogen receptor 1 fusion gene, |
| Site of Expression | tamoxifen-inducible cre; widespread pattern of expression; tamoxifen administration will also induce Cre recombination in developing embryos of treated mothers and in cultured cells derived from transgenic mice |
| Strain of Origin | (C57BL/6 x CBA)F1 |
| Chromosome | UN |
| General Note | Homozygous transgenic mice are not viable or fertile. Hemizygous transgenic mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. In transgenic mice the mutant mouse estrogen receptor does not bind natural ligand at physiological concentrations but will bind the synthetic ligand, 4-hydroxytamoxifen. Restricted to the cytoplasm, the Cre/Esr1 fusion protein can only gain access to the nuclear compartment after exposure to tamoxifen. When crossed with a strain containing loxP sites flanking a sequence of interest, tamoxifen induced, Cre-mediated targeted deletions are generated in the offspring. Tamoxifen administration will induce Cre recombination in developing embryos of treated mothers and in cultured cells derived from transgenic mice. |
| Molecular Note | This transgene expresses a fusion protein consisting of Cre recombinase joined to the ligand-binding domain of a mouse estrogen receptor modified to bind to 4-hydroxytamoxifen, but not to endogenous estrogen. The CAG promoter, containing a chicken beta actin promoter/enhancer coupled with the cytomegalovirus immediate-early (CMV-IE) enhancer, drives high levels of expression in most tissues. In the presence of tamoxifen, the fusion protein is transported into the nucleus, where cre can excise loxP-flanked segments from conditionally modified genes. |
| Mutations Made By | Shigemi Hayashi, Columbia University |
Trpa1tm2Kykw
Allele Symbol: Trpa1tm2Kykw
| Allele Name | targeted mutation 2, Kelvin Y Kwan |
|---|---|
| Allele Type | Targeted (Conditional ready (e.g. floxed), No functional change) |
| Allele Synonym(s) | Trpa1 CKO |
| Gene Symbol and Name | Trpa1, transient receptor potential cation channel, subfamily A, member 1 |
| Gene Synonym(s) | ANKTM1; Anktm1; FEPS; FEPS1 |
| Strain of Origin | 129S6/SvEvTac |
| Chromosome | 1 |
| Molecular Note | LoxP sites were placed on either side of exons 22-24 (encoding the S5/S6 transmembrane domains) and an FRT-flanked neomycin resistance cassette inserted in the opposite transcriptional orientation in intron 24. The neomycin cassette was excised by crossing these mice to a Gt(ROSA)26Sor-driven Flp strain on a 129S4/SvJaeSor. |
| Mutations Made By | Kelvin Kwan, Harvard Medical School/HHMI |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Neurobiology Research
- Behavioral and Learning Defects
- Research Tools
- Cre-lox System
- Cre Recombinase Expression
- Cre Recombinase Expression: Inducible
- Genetics Research
- Tissue/Cell Markers
- Tissue/Cell Markers: dorsal CNS marker
- Tissue/Cell Markers: neurons
- Sensorineural Research
- Cre-lox System
References
- Corey D; Kwan KY. 2011. Generation of a conditional allele of Trpa1 MGI Direct Data Submission :. MGI: J:169738
Additional - Trpa1tm2Kykw related
- De Logu F; Nassini R; Materazzi S; Carvalho Goncalves M; Nosi D; Rossi Degl'Innocenti D; Marone IM; Ferreira J; Li Puma S; Benemei S; Trevisan G; Souza Monteiro de Araujo D; Patacchini R; Bunnett NW; Geppetti P. 2017. Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice. Nat Commun 8(1):1887. PubMed: 29192190MGI: J:257664
- Sullivan MN; Gonzales AL; Pires PW; Bruhl A; Leo MD; Li W; Oulidi A; Boop FA; Feng Y; Jaggar JH; Welsh DG; Earley S. 2015. Localized TRPA1 channel Ca2+ signals stimulated by reactive oxygen species promote cerebral artery dilation. Sci Signal 8(358):ra2. PubMed: 25564678MGI: J:259447
- Zappia KJ; Garrison SR; Palygin O; Weyer AD; Barabas ME; Lawlor MW; Staruschenko A; Stucky CL. 2016. Mechanosensory and ATP Release Deficits following Keratin14-Cre-Mediated TRPA1 Deletion Despite Absence of TRPA1 in Murine Keratinocytes. PLoS One 11(3):e0151602. PubMed: 26978657MGI: J:256654
- Zappia KJ; O'Hara CL; Moehring F; Kwan KY; Stucky CL. 2017. Sensory Neuron-Specific Deletion of TRPA1 Results in Mechanical Cutaneous Sensory Deficits. eNeuro 4(1):. PubMed: 28303259MGI: J:255852
Additional - Tg(CAG-cre/Esr1*)5Amc related
- Abe M; Pelus LM; Singh P; Hirade T; Onishi C; Purevsuren J; Taketani T; Yamaguchi S; Fukuda S. 2016. Internal Tandem Duplication in FLT3 Attenuates Proliferation and Regulates Resistance to the FLT3 Inhibitor AC220 by Modulating p21Cdkn1a and Pbx1 in Hematopoietic Cells. PLoS One 11(7):e0158290. PubMed: 27387666MGI: J:248809
- Abeyrathna P; Kovacs L; Han W; Su Y. 2016. Calpain-2 activates Akt via TGF-beta1-mTORC2 pathway in pulmonary artery smooth muscle cells. Am J Physiol Cell Physiol 311(1):C24-34. PubMed: 27099352MGI: J:235680
- Aceti M; Creson TK; Vaissiere T; Rojas C; Huang WC; Wang YX; Petralia RS; Page DT; Miller CA; Rumbaugh G. 2015. Syngap1 haploinsufficiency damages a postnatal critical period of pyramidal cell structural maturation linked to cortical circuit assembly. Biol Psychiatry 77(9):805-15. PubMed: 25444158MGI: J:235121
- Achterberg KG; Buitendijk GH; Kool MJ; Goorden SM; Post L; Slump DE; Silva AJ; van Woerden GM; Kushner SA; Elgersma Y. 2014. Temporal and region-specific requirements of alphaCaMKII in spatial and contextual learning. J Neurosci 34(34):11180-7. PubMed: 25143599MGI: J:216169
- Ahmad Z; Rafeeq M; Collombat P; Mansouri A. 2015. Pax6 Inactivation in the Adult Pancreas Reveals Ghrelin as Endocrine Cell Maturation Marker. PLoS One 10(12):e0144597. PubMed: 26658466MGI: J:244508
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- Baht GS; Silkstone D; Nadesan P; Whetstone H; Alman BA. 2014. Activation of hedgehog signaling during fracture repair enhances osteoblastic-dependent matrix formation. J Orthop Res 32(4):581-6. PubMed: 24347536MGI: J:237467
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- Bale LK; Chakraborty S; Conover CA. 2014. Inducible reduction in pregnancy-associated plasma protein-A gene expression inhibits established atherosclerotic plaque progression in mice. Endocrinology 155(4):1184-7. PubMed: 24506074MGI: J:210171
- Bale LK; West SA; Conover CA. 2017. Inducible knockdown of pregnancy-associated plasma protein-A gene expression in adult female mice extends life span. Aging Cell 16(4):895-897. PubMed: 28600811MGI: J:244750
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- Chen L; Mupo A; Huynh T; Cioffi S; Woods M; Jin C; McKeehan W; Thompson-Snipes L; Baldini A; Illingworth E. 2010. Tbx1 regulates Vegfr3 and is required for lymphatic vessel development. J Cell Biol 189(3):417-24. PubMed: 20439995MGI: J:159824
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- Chen WS; Cao Z; Sugaya S; Lopez MJ; Sendra VG; Laver N; Leffler H; Nilsson UJ; Fu J; Song J; Xia L; Hamrah P; Panjwani N. 2016. Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3. Nat Commun 7:11302. PubMed: 27066737MGI: J:235778
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- Cheret C; Willem M; Fricker FR; Wende H; Wulf-Goldenberg A; Tahirovic S; Nave KA; Saftig P; Haass C; Garratt AN; Bennett DL; Birchmeier C. 2013. Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles. EMBO J 32(14):2015-28. PubMed: 23792428MGI: J:199150
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