JAX Mouse Strain Datasheet - 008813

STOCK Trpa1^tm2Kykw Tg(CAG-cre/Esr1*)5Amc/J

Stock No:: 008813

Cryo Recovery

Overview

Also Known As: Trpa1 CKO/CKO deltaNeo Tg(cre/Esr1)5Amc/J

These compound mutant mice carry a floxed allele of the Trpa1 (transient receptor potential cation channel, subfamily A, member 1) gene in addition to a tamoxifen inducible cre transgene driven by the chicken beta actin promoter/enhancer coupled with the cytomegalovirus (CMV) immediate-early enhancer (see Stock No. 004682).Restricted to the cytoplasm, the cre/Esr1 protein can only gain access to the nuclear compartment after exposure to tamoxifen. Tamoxifen administration induces cre recombination within the Trpa1 allele, excising the S5/S6 transmembrane domains. Animals not treated with tamoxifen display no observable phenotype.

Donating Investigator

David P. Corey, Harvard Medical School/HHMI

Genetic overview

Genetic Background	Generation

Tg(CAG-cre/Esr1*)5Amc

Allele Type
Transgenic (Inducible, Recombinase-expressing)

Trpa1^tm2Kykw

Allele Type	Gene Symbol	Gene Name
Targeted (Conditional ready (e.g. floxed), No functional change)	Trpa1	transient receptor potential cation channel, subfamily A, member 1

View Genetics

Research Applications

Neurobiology Research
Research Tools

View All Research Applications

Base Price

Starting at:

$2,595.00 Domestic price Cryo Recovery

View Price List

Details

Detailed Description

Development

This compound mutant strain was created by intercrossing a Trpa1 floxed strain with a tamoxifen-inducible cre mutation strain (see Stock No. 004682).

To create the Trpa1 floxed allele, loxP sites were placed on either side of the exons that encode the S5/S6 transmembrane domains. An FRT-flanked self-excising neomycin resistance cassette was initially placed within the floxed allele, and was deleted. The mutation was created with 129S6/SvEvTac-derived TC1 embryonic stem (ES) cells.

This compound mutant strain is on a mixed genetic background that involves C57BL/6, CBA, and 129.

Expression Data

Expressed Gene	cre/Esr1, Cre recombinase and estrogen receptor 1 fusion gene,
Site of Expression	tamoxifen-inducible cre; widespread pattern of expression; tamoxifen administration will also induce Cre recombination in developing embryos of treated mothers and in cultured cells derived from transgenic mice
Site of Expression

Control Suggestions

None Available

Additional Information

Considerations for Choosing Controls

Selected References

Corey D; Kwan KY. 2011. Generation of a conditional allele of Trpa1 MGI Direct Data Submission :. MGI: J:169738

View All References

Genetics

Tg(CAG-cre/Esr1*)5Amc

Allele Symbol: Tg(CAG-cre/Esr1*)5Amc

Allele Name	transgene insertion 5, Andrew P McMahon
Allele Type	Transgenic (Inducible, Recombinase-expressing)
Allele Synonym(s)	CAG-CreERT2; CAG-CreEr; CAGG-Cre; CAGG-CreERT2; CAGGCre-ER; CAGGCre-ER^TM; CAGGCre-ERtm line 5.8; CAGGS-CreER; CAGGS-CreErT; CMV-creERT; CaggCreER; Cre-ER; Cre-ER^TM; CreESR^T; ER-cre; Tg(CAG-cre/Esr1)5Amc; Tg(cre/Esr1)5Amc; Tg^CreER; TgCAGGCreER; uCreER^T
Gene Symbol and Name	Tg(CAG-cre/Esr1*)5Amc, transgene insertion 5, Andrew P McMahon
Gene Synonym(s)	CAG-CreERT2; CAGG-CreERT2; CAGGCre-ER; CAGGCre-ER^TM; CAGGCre-ERtm line 5.8; CAGGS-CreER; CAGGS-CreErT; CMV-creERT; Cre-ER; Cre-ERTM; ER-cre; Tg(CAG-cre/Esr1)5Amc; Tg(CAG-cre/Esr1)5Amc; Tg(cre/Esr1)5Amc; Tg(cre/Esr1)5Amc
Promoter	ACTB, actin, beta, chicken
Expressed Gene	cre/Esr1, Cre recombinase and estrogen receptor 1 fusion gene,
Site of Expression	tamoxifen-inducible cre; widespread pattern of expression; tamoxifen administration will also induce Cre recombination in developing embryos of treated mothers and in cultured cells derived from transgenic mice
Strain of Origin	(C57BL/6 x CBA)F1
Chromosome	UN
General Note	Homozygous transgenic mice are not viable or fertile. Hemizygous transgenic mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. In transgenic mice the mutant mouse estrogen receptor does not bind natural ligand at physiological concentrations but will bind the synthetic ligand, 4-hydroxytamoxifen. Restricted to the cytoplasm, the Cre/Esr1 fusion protein can only gain access to the nuclear compartment after exposure to tamoxifen. When crossed with a strain containing loxP sites flanking a sequence of interest, tamoxifen induced, Cre-mediated targeted deletions are generated in the offspring. Tamoxifen administration will induce Cre recombination in developing embryos of treated mothers and in cultured cells derived from transgenic mice.
Molecular Note	This transgene expresses a fusion protein consisting of Cre recombinase joined to the ligand-binding domain of a mouse estrogen receptor modified to bind to 4-hydroxytamoxifen, but not to endogenous estrogen. The CAG promoter, containing a chicken beta actin promoter/enhancer coupled with the cytomegalovirus immediate-early (CMV-IE) enhancer, drives high levels of expression in most tissues. In the presence of tamoxifen, the fusion protein is transported into the nucleus, where cre can excise loxP-flanked segments from conditionally modified genes.
Mutations Made By	Shigemi Hayashi, Columbia University

Trpa1^tm2Kykw

Allele Symbol: Trpa1^tm2Kykw

Allele Name	targeted mutation 2, Kelvin Y Kwan
Allele Type	Targeted (Conditional ready (e.g. floxed), No functional change)
Allele Synonym(s)	Trpa1 CKO
Gene Symbol and Name	Trpa1, transient receptor potential cation channel, subfamily A, member 1
Gene Synonym(s)	ANKTM1; Anktm1; FEPS; FEPS1
Strain of Origin	129S6/SvEvTac
Chromosome	1
Molecular Note	LoxP sites were placed on either side of exons 22-24 (encoding the S5/S6 transmembrane domains) and an FRT-flanked neomycin resistance cassette inserted in the opposite transcriptional orientation in intron 24. The neomycin cassette was excised by crossing these mice to a Gt(ROSA)26Sor-driven Flp strain on a 129S4/SvJaeSor.
Mutations Made By	Kelvin Kwan, Harvard Medical School/HHMI

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Neurobiology Research
- Behavioral and Learning Defects
Research Tools
- Cre-lox System
  - Cre Recombinase Expression
  - Cre Recombinase Expression: Inducible
- Genetics Research
  - Tissue/Cell Markers
  - Tissue/Cell Markers: dorsal CNS marker
  - Tissue/Cell Markers: neurons
- Sensorineural Research

References

Corey D; Kwan KY. 2011. Generation of a conditional allele of Trpa1 MGI Direct Data Submission :. MGI: J:169738

Additional - Tg(CAG-cre/Esr1*)5Amc related

Abeyrathna P; Kovacs L; Han W; Su Y. 2016. Calpain-2 activates Akt via TGF-beta1-mTORC2 pathway in pulmonary artery smooth muscle cells. Am J Physiol Cell Physiol 311(1):C24-34. PubMed: 27099352 MGI: J:235680
Aceti M; Creson TK; Vaissiere T; Rojas C; Huang WC; Wang YX; Petralia RS; Page DT; Miller CA; Rumbaugh G. 2015. Syngap1 haploinsufficiency damages a postnatal critical period of pyramidal cell structural maturation linked to cortical circuit assembly. Biol Psychiatry 77(9):805-15. PubMed: 25444158 MGI: J:235121
Achterberg KG; Buitendijk GH; Kool MJ; Goorden SM; Post L; Slump DE; Silva AJ; van Woerden GM; Kushner SA; Elgersma Y. 2014. Temporal and region-specific requirements of alphaCaMKII in spatial and contextual learning. J Neurosci 34(34):11180-7. PubMed: 25143599 MGI: J:216169
Alba-Castellon L; Olivera-Salguero R; Mestre-Farrera A; Pena R; Herrera M; Bonilla F; Casal JI; Baulida J; Pena C; Garcia de Herreros A. 2016. Snail1-Dependent Activation of Cancer-Associated Fibroblast Controls Epithelial Tumor Cell Invasion and Metastasis. Cancer Res 76(21):6205-6217. PubMed: 27503928 MGI: J:236860
Bachmann C; Nguyen H; Rosenbusch J; Pham L; Rabe T; Patwa M; Sokpor G; Seong RH; Ashery-Padan R; Mansouri A; Stoykova A; Staiger JF; Tuoc T. 2016. mSWI/SNF (BAF) Complexes Are Indispensable for the Neurogenesis and Development of Embryonic Olfactory Epithelium. PLoS Genet 12(9):e1006274. PubMed: 27611684 MGI: J:235652
Baht GS; Silkstone D; Nadesan P; Whetstone H; Alman BA. 2014. Activation of hedgehog signaling during fracture repair enhances osteoblastic-dependent matrix formation. J Orthop Res 32(4):581-6. PubMed: 24347536 MGI: J:237467
Baht GS; Silkstone D; Vi L; Nadesan P; Amani Y; Whetstone H; Wei Q; Alman BA. 2015. Exposure to a youthful circulaton rejuvenates bone repair through modulation of beta-catenin. Nat Commun 6:7131. PubMed: 25988592 MGI: J:224928
Bale LK; Chakraborty S; Conover CA. 2014. Inducible reduction in pregnancy-associated plasma protein-A gene expression inhibits established atherosclerotic plaque progression in mice. Endocrinology 155(4):1184-7. PubMed: 24506074 MGI: J:210171
Basch ML; Ohyama T; Segil N; Groves AK. 2011. Canonical Notch Signaling Is Not Necessary for Prosensory Induction in the Mouse Cochlea: Insights from a Conditional Mutant of RBPj{kappa}. J Neurosci 31(22):8046-58. PubMed: 21632926 MGI: J:173382
Batlle R; Alba-Castellon L; Loubat-Casanovas J; Armenteros E; Franci C; Stanisavljevic J; Banderas R; Martin-Caballero J; Bonilla F; Baulida J; Casal JI; Gridley T; Garcia de Herreros A. 2013. Snail1 controls TGF-beta responsiveness and differentiation of mesenchymal stem cells. Oncogene 32(28):3381-9. PubMed: 22869142 MGI: J:199985
Beedle AM; Turner AJ; Saito Y; Lueck JD; Foltz SJ; Fortunato MJ; Nienaber PM; Campbell KP. 2012. Mouse fukutin deletion impairs dystroglycan processing and recapitulates muscular dystrophy. J Clin Invest 122(9):3330-42. PubMed: 22922256 MGI: J:187144
Berbari NF; Pasek RC; Malarkey EB; Yazdi SM; McNair AD; Lewis WR; Nagy TR; Kesterson RA; Yoder BK. 2013. Leptin resistance is a secondary consequence of the obesity in ciliopathy mutant mice. Proc Natl Acad Sci U S A 110(19):7796-801. PubMed: 23599282 MGI: J:197356
Berezniuk I; Sironi JJ; Wardman J; Pasek RC; Berbari NF; Yoder BK; Fricker LD. 2013. Quantitative peptidomics of Purkinje cell degeneration mice. PLoS One 8(4):e60981. PubMed: 23593366 MGI: J:200027
Bhaskara S; Chyla BJ; Amann JM; Knutson SK; Cortez D; Sun ZW; Hiebert SW. 2008. Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control. Mol Cell 30(1):61-72. PubMed: 18406327 MGI: J:134665
Bialecka M; Young T; Chuva de Sousa Lopes S; ten Berge D; Sanders A; Beck F; Deschamps J. 2012. Cdx2 contributes to the expansion of the early primordial germ cell population in the mouse. Dev Biol 371(2):227-34. PubMed: 22960234 MGI: J:190539
Boneva SK; Gross TR; Schlecht A; Schmitt SI; Sippl C; Jagle H; Volz C; Neueder A; Tamm ER; Braunger BM. 2016. Cre recombinase expression or topical tamoxifen treatment do not affect retinal structure and function, neuronal vulnerability or glial reactivity in the mouse eye. Neuroscience 325:188-201. PubMed: 27026593 MGI: J:235872
Bowen ME; Ayturk UM; Kurek KC; Yang W; Warman ML. 2014. SHP2 regulates chondrocyte terminal differentiation, growth plate architecture and skeletal cell fates. PLoS Genet 10(5):e1004364. PubMed: 24875294 MGI: J:226886
Braunger BM; Leimbeck SV; Schlecht A; Volz C; Jagle H; Tamm ER. 2015. Deletion of Ocular Transforming Growth Factor beta Signaling Mimics Essential Characteristics of Diabetic Retinopathy. Am J Pathol 185(6):1749-68. PubMed: 25857227 MGI: J:221181
Brenner-Anantharam A; Cebrian C; Guillaume R; Hurtado R; Sun TT; Herzlinger D. 2007. Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signaling. Development 134(10):1967-75. PubMed: 17442697 MGI: J:121412
Briggs LE; Takeda M; Cuadra AE; Wakimoto H; Marks MH; Walker AJ; Seki T; Oh SP; Lu JT; Sumners C; Raizada MK; Horikoshi N; Weinberg EO; Yasui K; Ikeda Y; Chien KR; Kasahara H. 2008. Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects. Circ Res 103(6):580-90. PubMed: 18689573 MGI: J:143802
Brower CS; Varshavsky A. 2009. Ablation of arginylation in the mouse N-end rule pathway: loss of fat, higher metabolic rate, damaged spermatogenesis, and neurological perturbations. PLoS One 4(11):e7757. PubMed: 19915679 MGI: J:155421
Brydges SD; Broderick L; McGeough MD; Pena CA; Mueller JL; Hoffman HM. 2013. Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies. J Clin Invest :. PubMed: 24084736 MGI: J:203992
Brydges SD; Mueller JL; McGeough MD; Pena CA; Misaghi A; Gandhi C; Putnam CD; Boyle DL; Firestein GS; Horner AA; Soroosh P; Watford WT; O'Shea JJ; Kastner DL; Hoffman HM. 2009. Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity. Immunity 30(6):875-87. PubMed: 19501000 MGI: J:150054
Bumaschny VF; Yamashita M; Casas-Cordero R; Otero-Corchon V; de Souza FS; Rubinstein M; Low MJ. 2012. Obesity-programmed mice are rescued by early genetic intervention. J Clin Invest 122(11):4203-12. PubMed: 23093774 MGI: J:194013
Bunnell TM; Burbach BJ; Shimizu Y; Ervasti JM. 2011. beta-Actin specifically controls cell growth, migration, and the G-actin pool. Mol Biol Cell 22(21):4047-58. PubMed: 21900491 MGI: J:183016
Burgess K; Xu T; Brown R; Han B; Welle S. 2011. Effect of myostatin depletion on weight gain, hyperglycemia, and hepatic steatosis during five months of high-fat feeding in mice. PLoS One 6(2):e17090. PubMed: 21390326 MGI: J:171042
Burnley P; Rahman M; Wang H; Zhang Z; Sun X; Zhuge Q; Su DM. 2013. Role of the p63-FoxN1 regulatory axis in thymic epithelial cell homeostasis during aging. Cell Death Dis 4:e932. PubMed: 24263106 MGI: J:205598
Cai J; Chen Y; Cai WH; Hurlock EC; Wu H; Kernie SG; Parada LF; Lu QR. 2007. A crucial role for Olig2 in white matter astrocyte development. Development 134(10):1887-99. PubMed: 17428828 MGI: J:121422
Callahan DG; Taylor WM; Tilearcio M; Cavanaugh T; Selkoe DJ; Young-Pearse TL. 2017. Embryonic mosaic deletion of APP results in displaced Reelin-expressing cells in the cerebral cortex. Dev Biol 424(2):138-146. PubMed: 28284905 MGI: J:241006
Cantley L; Saunders C; Guttenberg M; Candela ME; Ohta Y; Yasuhara R; Kondo N; Sgariglia F; Asai S; Zhang X; Qin L; Hecht JT; Chen D; Yamamoto M; Toyosawa S; Dormans JP; Esko JD; Yamaguchi Y; Iwamoto M; Pacifici M; Enomoto-Iwamoto M. 2013. Loss of beta-catenin induces multifocal periosteal chondroma-like masses in mice. Am J Pathol 182(3):917-27. PubMed: 23274133 MGI: J:232012
Carotta S; Dakic A; D'Amico A; Pang SH; Greig KT; Nutt SL; Wu L. 2010. The transcription factor PU.1 controls dendritic cell development and Flt3 cytokine receptor expression in a dose-dependent manner. Immunity 32(5):628-41. PubMed: 20510871 MGI: J:160816
Cerani A; Tetreault N; Menard C; Lapalme E; Patel C; Sitaras N; Beaudoin F; Leboeuf D; De Guire V; Binet F; Dejda A; Rezende FA; Miloudi K; Sapieha P. 2013. Neuron-derived semaphorin 3A is an early inducer of vascular permeability in diabetic retinopathy via neuropilin-1. Cell Metab 18(4):505-18. PubMed: 24093675 MGI: J:206005
Chan G; Kalaitzidis D; Usenko T; Kutok JL; Yang W; Mohi MG; Neel BG. 2009. Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis. Blood 113(18):4414-24. PubMed: 19179468 MGI: J:148430
Chan SY; Zhang YY; Hemann C; Mahoney CE; Zweier JL; Loscalzo J. 2009. MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2. Cell Metab 10(4):273-84. PubMed: 19808020 MGI: J:153662
Chandana EP; Maeda Y; Ueda A; Kiyonari H; Oshima N; Yamamoto M; Kondo S; Oh J; Takahashi R; Yoshida Y; Kawashima S; Alexander DB; Kitayama H; Takahashi C; Tabata Y; Matsuzaki T; Noda M. 2010. Involvement of the Reck tumor suppressor protein in maternal and embryonic vascular remodeling in mice. BMC Dev Biol 10:84. PubMed: 20691046 MGI: J:163845
Chang H; Gao F; Guillou F; Taketo MM; Huff V; Behringer RR. 2008. Wt1 negatively regulates {beta}-catenin signaling during testis development. Development 135(10):1875-85. PubMed: 18403409 MGI: J:134687
Chang I; Bramall AN; Baynash AG; Rattner A; Rakheja D; Post M; Joza S; McKerlie C; Stewart DJ; McInnes RR; Yanagisawa M. 2013. Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice. J Clin Invest 123(6):2643-53. PubMed: 23676500 MGI: J:201436
Chen JA; Huang YP; Mazzoni EO; Tan GC; Zavadil J; Wichterle H. 2011. Mir-17-3p controls spinal neural progenitor patterning by regulating Olig2/Irx3 cross-repressive loop. Neuron 69(4):721-35. PubMed: 21338882 MGI: J:174745
Chen L; Mupo A; Huynh T; Cioffi S; Woods M; Jin C; McKeehan W; Thompson-Snipes L; Baldini A; Illingworth E. 2010. Tbx1 regulates Vegfr3 and is required for lymphatic vessel development. J Cell Biol 189(3):417-24. PubMed: 20439995 MGI: J:159824
Chen M; Wang X; Wang Y; Zhang L; Xu B; Lv L; Cui X; Li W; Gao F. 2014. Wt1 is involved in leydig cell steroid hormone biosynthesis by regulating paracrine factor expression in mice. Biol Reprod 90(4):71. PubMed: 24571983 MGI: J:210334
Chen M; Zhang L; Cui X; Lin X; Li Y; Wang Y; Wang Y; Qin Y; Chen D; Han C; Zhou B; Huff V; Gao F. 2017. Wt1 directs the lineage specification of sertoli and granulosa cells by repressing Sf1 expression. Development 144(1):44-53. PubMed: 27888191 MGI: J:238424
Chen WS; Cao Z; Sugaya S; Lopez MJ; Sendra VG; Laver N; Leffler H; Nilsson UJ; Fu J; Song J; Xia L; Hamrah P; Panjwani N. 2016. Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3. Nat Commun 7:11302. PubMed: 27066737 MGI: J:235778
Cheng J; Du J. 2007. Mechanical stretch simulates proliferation of venous smooth muscle cells through activation of the insulin-like growth factor-1 receptor. Arterioscler Thromb Vasc Biol 27(8):1744-51. PubMed: 17541019 MGI: J:134907
Cheng L; Guo J; Sun L; Fu J; Barnes PF; Metzger D; Chambon P; Oshima RG; Amagai T; Su DM. 2010. Postnatal tissue-specific disruption of transcription factor FoxN1 triggers acute thymic atrophy. J Biol Chem 285(8):5836-47. PubMed: 19955175 MGI: J:159773
Cheret C; Willem M; Fricker FR; Wende H; Wulf-Goldenberg A; Tahirovic S; Nave KA; Saftig P; Haass C; Garratt AN; Bennett DL; Birchmeier C. 2013. Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles. EMBO J 32(14):2015-28. PubMed: 23792428 MGI: J:199150
Cheval H; Guy J; Merusi C; De Sousa D; Selfridge J; Bird A. 2012. Postnatal inactivation reveals enhanced requirement for MeCP2 at distinct age windows. Hum Mol Genet 21(17):3806-14. PubMed: 22653753 MGI: J:185982
Chi L; Galtseva A; Chen L; Mo R; Hui CC; Rosenblum ND. 2013. Kif3a controls murine nephron number via GLI3 repressor, cell survival, and gene expression in a lineage-specific manner. PLoS One 8(6):e65448. PubMed: 23762375 MGI: J:203312
Chiang PM; Ling J; Jeong YH; Price DL; Aja SM; Wong PC. 2010. Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism. Proc Natl Acad Sci U S A 107(37):16320-4. PubMed: 20660762 MGI: J:164406
Cho H; Zhao X; Hatori M; Yu RT; Barish GD; Lam MT; Chong LW; DiTacchio L; Atkins AR; Glass CK; Liddle C; Auwerx J; Downes M; Panda S; Evans RM. 2012. Regulation of circadian behaviour and metabolism by REV-ERB-alpha and REV-ERB-beta. Nature 485(7396):123-7. PubMed: 22460952 MGI: J:183855
Cho JH; Mao CA; Klein WH. 2012. Adult mice transplanted with embryonic retinal progenitor cells: new approach for repairing damaged optic nerves. Mol Vis 18:2658-72. PubMed: 23170059 MGI: J:192318
Cho JH; Mu X; Wang SW; Klein WH. 2009. Retinal ganglion cell death and optic nerve degeneration by genetic ablation in adult mice. Exp Eye Res 88(3):542-52. PubMed: 19109949 MGI: J:146558
Choi YJ; Li X; Hydbring P; Sanda T; Stefano J; Christie AL; Signoretti S; Look AT; Kung AL; von Boehmer H; Sicinski P. 2012. The requirement for cyclin D function in tumor maintenance. Cancer Cell 22(4):438-51. PubMed: 23079655 MGI: J:192032
Chojnowski JL; Trau HA; Masuda K; Manley NR. 2016. Temporal and spatial requirements for Hoxa3 in mouse embryonic development. Dev Biol 415(1):33-45. PubMed: 27178667 MGI: J:234117
Clegg JM; Li Z; Molinek M; Caballero IM; Manuel MN; Price DJ. 2015. Pax6 is required intrinsically by thalamic progenitors for the normal molecular patterning of thalamic neurons but not the growth and guidance of their axons. Neural Dev 10(1):26. PubMed: 26520399 MGI: J:226607
Clement JP; Aceti M; Creson TK; Ozkan ED; Shi Y; Reish NJ; Almonte AG; Miller BH; Wiltgen BJ; Miller CA; Xu X; Rumbaugh G. 2012. Pathogenic SYNGAP1 mutations impair cognitive development by disrupting maturation of dendritic spine synapses. Cell 151(4):709-23. PubMed: 23141534 MGI: J:193208
Connerney J; Andreeva V; Leshem Y; Mercado MA; Dowell K; Yang X; Lindner V; Friesel RE; Spicer DB. 2008. Twist1 homodimers enhance FGF responsiveness of the cranial sutures and promote suture closure. Dev Biol 318(2):323-34. PubMed: 18471809 MGI: J:136965
Conover CA; Bale LK; Powell DR. 2013. Inducible knock out of pregnancy-associated plasma protein-a gene expression in the adult mouse: effect on vascular injury response. Endocrinology 154(8):2734-8. PubMed: 23748359 MGI: J:201775
Crouse JA; Lopes VS; Sanagustin JT; Keady BT; Williams DS; Pazour GJ. 2014. Distinct functions for IFT140 and IFT20 in opsin transport. Cytoskeleton (Hoboken) 71(5):302-10. PubMed: 24619649 MGI: J:215152
Culbert AL; Chakkalakal SA; Theosmy EG; Brennan TA; Kaplan FS; Shore EM. 2014. Alk2 regulates early chondrogenic fate in fibrodysplasia ossificans progressiva heterotopic endochondral ossification. Stem Cells 32(5):1289-300. PubMed: 24449086 MGI: J:225253
D'Angelo A; De Angelis A; Avallone B; Piscopo I; Tammaro R; Studer M; Franco B. 2012. Ofd1 controls dorso-ventral patterning and axoneme elongation during embryonic brain development. PLoS One 7(12):e52937. PubMed: 23300826 MGI: J:195725
Diaz-Castro B; Pintado CO; Garcia-Flores P; Lopez-Barneo J; Piruat JI. 2012. Differential Impairment of Catecholaminergic Cell Maturation and Survival by Genetic Mitochondrial Complex II Dysfunction. Mol Cell Biol 32(16):3347-57. PubMed: 22711987 MGI: J:186713
Diril MK; Bisteau X; Kitagawa M; Caldez MJ; Wee S; Gunaratne J; Lee SH; Kaldis P. 2016. Loss of the Greatwall Kinase Weakens the Spindle Assembly Checkpoint. PLoS Genet 12(9):e1006310. PubMed: 27631493 MGI: J:235649
Diril MK; Ratnacaram CK; Padmakumar VC; Du T; Wasser M; Coppola V; Tessarollo L; Kaldis P. 2012. Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration. Proc Natl Acad Sci U S A 109(10):3826-31. PubMed: 22355113 MGI: J:182141
Doherty HE; Kim HS; Hiller S; Sulik KK; Maeda N. 2010. A mouse strain where basal connective tissue growth factor gene expression can be switched from low to high. PLoS One 5(9):e12909. PubMed: 20877562 MGI: J:165111
Du F; Nguyen MV; Karten A; Felice CA; Mandel G; Ballas N. 2016. Acute and crucial requirement for MeCP2 function upon transition from early to late adult stages of brain maturation. Hum Mol Genet 25(9):1690-702. PubMed: 26908602 MGI: J:233024
Dudley B; Palumbo C; Nalepka J; Molyneaux K. 2010. BMP signaling controls formation of a primordial germ cell niche within the early genital ridges. Dev Biol 343(1-2):84-93. PubMed: 20417197 MGI: J:162165
Dumitriu B; Bhattaram P; Dy P; Huang Y; Quayum N; Jensen J; Lefebvre V. 2010. Sox6 is necessary for efficient erythropoiesis in adult mice under physiological and anemia-induced stress conditions. PLoS One 5(8):e12088. PubMed: 20711497 MGI: J:163754
Eckle T; Brodsky K; Bonney M; Packard T; Han J; Borchers CH; Mariani TJ; Kominsky DJ; Mittelbronn M; Eltzschig HK. 2013. HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium. PLoS Biol 11(9):e1001665. PubMed: 24086109 MGI: J:201805
Ellis JM; Mentock SM; Depetrillo MA; Koves TR; Sen S; Watkins SM; Muoio DM; Cline GW; Taegtmeyer H; Shulman GI; Willis MS; Coleman RA. 2011. Mouse cardiac acyl coenzyme a synthetase 1 deficiency impairs Fatty Acid oxidation and induces cardiac hypertrophy. Mol Cell Biol 31(6):1252-62. PubMed: 21245374 MGI: J:241758
Fedoriw AM; Menon D; Kim Y; Mu W; Magnuson T. 2015. Key mediators of somatic ATR signaling localize to unpaired chromosomes in spermatocytes. Development 142(17):2972-80. PubMed: 26209650 MGI: J:239795
Fernandes KA; Harder JM; John SW; Shrager P; Libby RT. 2014. DLK-dependent signaling is important for somal but not axonal degeneration of retinal ganglion cells following axonal injury. Neurobiol Dis 69:108-16. PubMed: 24878510 MGI: J:214369
Fisher OS; Deng H; Liu D; Zhang Y; Wei R; Deng Y; Zhang F; Louvi A; Turk BE; Boggon TJ; Su B. 2015. Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex. Nat Commun 6:7937. PubMed: 26235885 MGI: J:224922
Foy RL; Chitalia VC; Panchenko MV; Zeng L; Lopez D; Lee JW; Rana SV; Boletta A; Qian F; Tsiokas L; Piontek KB; Germino GG; Zhou MI; Cohen HT. 2012. Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1. Hum Mol Genet 21(26):5456-71. PubMed: 23001567 MGI: J:191148
Frank DU; Carter KL; Thomas KR; Burr RM; Bakker ML; Coetzee WA; Tristani-Firouzi M; Bamshad MJ; Christoffels VM; Moon AM. 2011. Lethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasis. Proc Natl Acad Sci U S A :. PubMed: 22203979 MGI: J:179977
Fricker FR; Antunes-Martins A; Galino J; Paramsothy R; La Russa F; Perkins J; Goldberg R; Brelstaff J; Zhu N; McMahon SB; Orengo C; Garratt AN; Birchmeier C; Bennett DL. 2013. Axonal neuregulin 1 is a rate limiting but not essential factor for nerve remyelination. Brain 136(Pt 7):2279-97. PubMed: 23801741 MGI: J:199148
Fuerst PG; Bruce F; Rounds RP; Erskine L; Burgess RW. 2012. Cell autonomy of DSCAM function in retinal development. Dev Biol 361(2):326-37. PubMed: 22063212 MGI: J:179393
Fujita H; Yagishita N; Aratani S; Saito-Fujita T; Morota S; Yamano Y; Hansson MJ; Inazu M; Kokuba H; Sudo K; Sato E; Kawahara K; Nakajima F; Hasegawa D; Higuchi I; Sato T; Araya N; Usui C; Nishioka K; Nakatani Y; Maruyama I; Usui M; Hara N; Uchino H; Elmer E; Nishioka K; Nakajima T. 2015. The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC-1beta. EMBO J 34(8):1042-55. PubMed: 25698262 MGI: J:220710
Fukuda S; Hoggatt J; Singh P; Abe M; Speth JM; Hu P; Conway EM; Nucifora G; Yamaguchi S; Pelus LM. 2015. Survivin modulates genes with divergent molecular functions and regulates proliferation of hematopoietic stem cells through Evi-1. Leukemia 29(2):433-40. PubMed: 24903482 MGI: J:217841
Fukuda S; Singh P; Moh A; Abe M; Conway EM; Boswell HS; Yamaguchi S; Fu XY; Pelus LM. 2009. Survivin mediates aberrant hematopoietic progenitor cell proliferation and acute leukemia in mice induced by internal tandem duplication of Flt3. Blood 114(2):394-403. PubMed: 19411632 MGI: J:150766
Garrett AM; Weiner JA. 2009. Control of CNS synapse development by {gamma}-protocadherin-mediated astrocyte-neuron contact. J Neurosci 29(38):11723-31. PubMed: 19776259 MGI: J:153046
George RM; Biressi S; Beres BJ; Rogers E; Mulia AK; Allen RE; Rawls A; Rando TA; Wilson-Rawls J. 2013. Numb-deficient satellite cells have regeneration and proliferation defects. Proc Natl Acad Sci U S A 110(46):18549-54. PubMed: 24170859 MGI: J:202887
Gomez TS; Gorman JA; de Narvajas AA; Koenig AO; Billadeau DD. 2012. Trafficking defects in WASH-knockout fibroblasts originate from collapsed endosomal and lysosomal networks. Mol Biol Cell 23(16):3215-28. PubMed: 22718907 MGI: J:199703
Goncalves A; Zeller R. 2011. Genetic Analysis Reveals an Unexpected Role of BMP7 in Initiation of Ureteric Bud Outgrowth in Mouse Embryos. PLoS One 6(4):e19370. PubMed: 21552539 MGI: J:172359
Goorden SM; Abs E; Bruinsma CF; Riemslagh FW; van Woerden GM; Elgersma Y. 2015. Intact neuronal function in Rheb1 mutant mice: implications for TORC1-based treatments. Hum Mol Genet 24(12):3390-8. PubMed: 25759467 MGI: J:221351
Gould TW; Yonemura S; Oppenheim RW; Ohmori S; Enomoto H. 2008. The neurotrophic effects of glial cell line-derived neurotrophic factor on spinal motoneurons are restricted to fusimotor subtypes. J Neurosci 28(9):2131-46. PubMed: 18305247 MGI: J:132854
Grevengoed TJ; Cooper DE; Young PA; Ellis JM; Coleman RA. 2015. Loss of long-chain acyl-CoA synthetase isoform 1 impairs cardiac autophagy and mitochondrial structure through mechanistic target of rapamycin complex 1 activation. FASEB J 29(11):4641-53. PubMed: 26220174 MGI: J:230606
Grevengoed TJ; Martin SA; Katunga L; Cooper DE; Anderson EJ; Murphy RC; Coleman RA. 2015. Acyl-CoA synthetase 1 deficiency alters cardiolipin species and impairs mitochondrial function. J Lipid Res 56(8):1572-82. PubMed: 26136511 MGI: J:224376
Grosse AS; Pressprich MF; Curley LB; Hamilton KL; Margolis B; Hildebrand JD; Gumucio DL. 2011. Cell dynamics in fetal intestinal epithelium: implications for intestinal growth and morphogenesis. Development 138(20):4423-32. PubMed: 21880782 MGI: J:178336
Guiu J; Shimizu R; D'Altri T; Fraser ST; Hatakeyama J; Bresnick EH; Kageyama R; Dzierzak E; Yamamoto M; Espinosa L; Bigas A. 2013. Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling. J Exp Med 210(1):71-84. PubMed: 23267012 MGI: J:194596
Guy J; Gan J; Selfridge J; Cobb S; Bird A. 2007. Reversal of neurological defects in a mouse model of Rett syndrome. Science 315(5815):1143-7. PubMed: 17289941 MGI: J:118365
Hanke-Gogokhia C; Wu Z; Gerstner CD; Frederick JM; Zhang H; Baehr W. 2016. Arf-like Protein 3 (ARL3) Regulates Protein Trafficking and Ciliogenesis in Mouse Photoreceptors. J Biol Chem 291(13):7142-55. PubMed: 26814127 MGI: J:232436
Harder JM; Ding Q; Fernandes KA; Cherry JD; Gan L; Libby RT. 2012. BCL2L1 (BCL-X) promotes survival of adult and developing retinal ganglion cells. Mol Cell Neurosci 51(1-2):53-9. PubMed: 22836101 MGI: J:203586
Hathaway CK; Grant R; Hagaman JR; Hiller S; Li F; Xu L; Chang AS; Madden VJ; Bagnell CR; Rojas M; Kim HS; Wu B; Zhou B; Smithies O; Kakoki M. 2015. Endothelin-1 critically influences cardiac function via superoxide-MMP9 cascade. Proc Natl Acad Sci U S A 112(16):5141-6. PubMed: 25848038 MGI: J:220962
Hayakawa Y; Ariyama H; Stancikova J; Sakitani K; Asfaha S; Renz BW; Dubeykovskaya ZA; Shibata W; Wang H; Westphalen CB; Chen X; Takemoto Y; Kim W; Khurana SS; Tailor Y; Nagar K; Tomita H; Hara A; Sepulveda AR; Setlik W; Gershon MD; Saha S; Ding L; Shen Z; Fox JG; Friedman RA; Konieczny SF; Worthley DL; Korinek V; Wang TC. 2015. Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche. Cancer Cell 28(6):800-14. PubMed: 26585400 MGI: J:227252
Hayashi S; McMahon AP. 2002. Efficient recombination in diverse tissues by a tamoxifen-inducible form of cre: a tool for temporally regulated gene activation/inactivation in the mouse. Dev Biol 244(2):305-18. PubMed: 11944939 MGI: J:76130
He Q; Yang X; Gong Y; Kovalenko D; Canalis E; Rosen CJ; Friesel RE. 2014. Deficiency of Sef is associated with increased postnatal cortical bone mass by regulating Runx2 activity. J Bone Miner Res 29(5):1217-31. PubMed: 24127237 MGI: J:221314
Herrmann S; Stieber J; Stockl G; Hofmann F; Ludwig A. 2007. HCN4 provides a 'depolarization reserve' and is not required for heart rate acceleration in mice. EMBO J 26(21):4423-32. PubMed: 17914461 MGI: J:139560
Herzog BH; Fu J; Wilson SJ; Hess PR; Sen A; McDaniel JM; Pan Y; Sheng M; Yago T; Silasi-Mansat R; McGee S; May F; Nieswandt B; Morris AJ; Lupu F; Coughlin SR; McEver RP; Chen H; Kahn ML; Xia L. 2013. Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature 502(7469):105-9. PubMed: 23995678 MGI: J:205423
Hettmer S; Teot LA; van Hummelen P; Macconaill L; Bronson RT; Dall'osso C; Mao J; McMahon AP; Gruber PJ; Grier HE; Rodriguez-Galindo C; Fletcher CD; Wagers AJ. 2013. Mutations in Hedgehog pathway genes in fetal rhabdomyomas. J Pathol 231(1):44-52. PubMed: 23780909 MGI: J:200009
Higginbotham H; Eom TY; Mariani LE; Bachleda A; Hirt J; Gukassyan V; Cusack CL; Lai C; Caspary T; Anton ES. 2012. Arl13b in primary cilia regulates the migration and placement of interneurons in the developing cerebral cortex. Dev Cell 23(5):925-38. PubMed: 23153492 MGI: J:191083
Higginbotham H; Guo J; Yokota Y; Umberger NL; Su CY; Li J; Verma N; Hirt J; Ghukasyan V; Caspary T; Anton ES. 2013. Arl13b-regulated cilia activities are essential for polarized radial glial scaffold formation. Nat Neurosci 16(8):1000-7. PubMed: 23817546 MGI: J:203743
Higgins DF; Kimura K; Bernhardt WM; Shrimanker N; Akai Y; Hohenstein B; Saito Y; Johnson RS; Kretzler M; Cohen CD; Eckardt KU; Iwano M; Haase VH. 2007. Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition. J Clin Invest 117(12):3810-20. PubMed: 18037992 MGI: J:130751
Hirono S; Lee EY; Kuribayashi S; Fukuda T; Saeki N; Minokoshi Y; Iwanaga T; Miki T. 2016. Importance of Adult Dmbx1 in Long-Lasting Orexigenic Effect of Agouti-Related Peptide. Endocrinology 157(1):245-57. PubMed: 26505115 MGI: J:233637
Ho HY; Susman MW; Bikoff JB; Ryu YK; Jonas AM; Hu L; Kuruvilla R; Greenberg ME. 2012. Wnt5a-Ror-Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis. Proc Natl Acad Sci U S A 109(11):4044-51. PubMed: 22343533 MGI: J:182150
Hoang CQ; Hale MA; Azevedo-Pouly AC; Elsasser HP; Deering TG; Willet SG; Pan FC; Magnuson MA; Wright CV; Swift GH; MacDonald RJ. 2016. Transcriptional Maintenance of Pancreatic Acinar Identity, Differentiation, and Homeostasis by PTF1A. Mol Cell Biol 36(24):3033-3047. PubMed: 27697859 MGI: J:243000
Hoi CS; Lee SE; Lu SY; McDermitt DJ; Osorio KM; Piskun CM; Peters RM; Paus R; Tumbar T. 2010. Runx1 directly promotes proliferation of hair follicle stem cells and epithelial tumor formation in mouse skin. Mol Cell Biol 30(10):2518-36. PubMed: 20308320 MGI: J:162589
Hoopes SL; Willcockson HH; Caron KM. 2012. Characteristics of multi-organ lymphangiectasia resulting from temporal deletion of calcitonin receptor-like receptor in adult mice. PLoS One 7(9):e45261. PubMed: 23028890 MGI: J:191789
Hu Q; Gao F; Tian W; Ruteshouser EC; Wang Y; Lazar A; Stewart J; Strong LC; Behringer RR; Huff V. 2011. Wt1 ablation and Igf2 upregulation in mice result in Wilms tumors with elevated ERK1/2 phosphorylation. J Clin Invest 121(1):174-83. PubMed: 21123950 MGI: J:171852
Hu YC; Nicholls PK; Soh YQ; Daniele JR; Junker JP; van Oudenaarden A; Page DC. 2015. Licensing of primordial germ cells for gametogenesis depends on genital ridge signaling. PLoS Genet 11(3):e1005019. PubMed: 25739037 MGI: J:224163
Hu YC; Okumura LM; Page DC. 2013. Gata4 is required for formation of the genital ridge in mice. PLoS Genet 9(7):e1003629. PubMed: 23874227 MGI: J:199295
Huang J; Rajagopal R; Liu Y; Dattilo LK; Shaham O; Ashery-Padan R; Beebe DC. 2011. The mechanism of lens placode formation: a case of matrix-mediated morphogenesis. Dev Biol 355(1):32-42. PubMed: 21540023 MGI: J:173634
Huang L; Hu F; Xie X; Harder J; Fernandes K; Zeng XY; Libby R; Gan L. 2014. Pou4f1 and pou4f2 are dispensable for the long-term survival of adult retinal ganglion cells in mice. PLoS One 9(4):e94173. PubMed: 24736625 MGI: J:215207
Hunt RF; Dinday MT; Hindle-Katel W; Baraban SC. 2012. LIS1 Deficiency Promotes Dysfunctional Synaptic Integration of Granule Cells Generated in the Developing and Adult Dentate Gyrus. J Neurosci 32(37):12862-75. PubMed: 22973010 MGI: J:187663
Jacoby M; Cox JJ; Gayral S; Hampshire DJ; Ayub M; Blockmans M; Pernot E; Kisseleva MV; Compere P; Schiffmann SN; Gergely F; Riley JH; Perez-Morga D; Woods CG; Schurmans S. 2009. INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse. Nat Genet 41(9):1027-31. PubMed: 19668215 MGI: J:152712
Jae Huh W; Mysorekar IU; Mills JC. 2010. Inducible activation of Cre recombinase in adult mice causes gastric epithelial atrophy, metaplasia, and regenerative changes in the absence of 'floxed' alleles. Am J Physiol Gastrointest Liver Physiol 299(2):G368-80. PubMed: 20413717 MGI: J:163367
Ji B; Song J; Tsou L; Bi Y; Gaiser S; Mortensen R; Logsdon C. 2008. Robust acinar cell transgene expression of CreErT via BAC recombineering. Genesis 46(8):390-5. PubMed: 18693271 MGI: J:148748
Ji Y; Kim H; Yang L; Sha H; Roman CA; Long Q; Qi L. 2016. The Sel1L-Hrd1 Endoplasmic Reticulum-Associated Degradation Complex Manages a Key Checkpoint in B Cell Development. Cell Rep 16(10):2630-40. PubMed: 27568564 MGI: J:239018
Jiang L; Wei Y; Ronquillo CC; Marc RE; Yoder BK; Frederick JM; Baehr W. 2015. Heterotrimeric kinesin-2 (KIF3) mediates transition zone and axoneme formation of mouse photoreceptors. J Biol Chem 290(20):12765-78. PubMed: 25825494 MGI: J:226962
Jiang X; Khan MA; Tian W; Beilke J; Natarajan R; Kosek J; Yoder MC; Semenza GL; Nicolls MR. 2011. Adenovirus-mediated HIF-1alpha gene transfer promotes repair of mouse airway allograft microvasculature and attenuates chronic rejection. J Clin Invest 121(6):2336-49. PubMed: 21606594 MGI: J:174019
Jin J; Wu LJ; Jun J; Cheng X; Xu H; Andrews NC; Clapham DE. 2012. The channel kinase, TRPM7, is required for early embryonic development. Proc Natl Acad Sci U S A 109(5):E225-33. PubMed: 22203997 MGI: J:181963
Johnson NC; Dillard ME; Baluk P; McDonald DM; Harvey NL; Frase SL; Oliver G. 2008. Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity. Genes Dev 22(23):3282-91. PubMed: 19056883 MGI: J:142041
Joyal JS; Nim S; Zhu T; Sitaras N; Rivera JC; Shao Z; Sapieha P; Hamel D; Sanchez M; Zaniolo K; St-Louis M; Ouellette J; Montoya-Zavala M; Zabeida A; Picard E; Hardy P; Bhosle V; Varma DR; Gobeil F Jr; Beausejour C; Boileau C; Klein W; Hollenberg M; Ribeiro-da-Silva A; Andelfinger G; Chemtob S. 2014. Subcellular localization of coagulation factor II receptor-like 1 in neurons governs angiogenesis. Nat Med 20(10):1165-73. PubMed: 25216639 MGI: J:227739
Joza S; Wang J; Tseu I; Ackerley C; Post M. 2013. Fetal, but not postnatal, deletion of semaphorin-neuropilin-1 signaling affects murine alveolar development. Am J Respir Cell Mol Biol 49(4):627-36. PubMed: 23713442 MGI: J:231575
Jurberg AD; Aires R; Novoa A; Rowland JE; Mallo M. 2014. Compartment-dependent activities of Wnt3a/beta-catenin signaling during vertebrate axial extension. Dev Biol 394(2):253-63. PubMed: 25152336 MGI: J:216160
Kamal B; Russell D; Payne A; Constante D; Tanner KE; Isaksson H; Mathavan N; Cobb SR. 2015. Biomechanical properties of bone in a mouse model of Rett syndrome. Bone 71:106-14. PubMed: 25445449 MGI: J:219301
Kamata T; Jin H; Giblett S; Patel B; Patel F; Foster C; Pritchard C. 2015. The cholesterol-binding protein NPC2 restrains recruitment of stromal macrophage-lineage cells to early-stage lung tumours. EMBO Mol Med 7(9):1119-37. PubMed: 26183450 MGI: J:233537
Kaneko KJ; Depamphilis ML. 2013. TEAD4 establishes the energy homeostasis essential for blastocoel formation. Development 140(17):3680-90. PubMed: 23903192 MGI: J:199283
Kang HJ; Park JH; Chen W; Kang SI; Moroz K; Ladanyi M; Lee SB. 2014. EWS-WT1 oncoprotein activates neuronal reprogramming factor ASCL1 and promotes neural differentiation. Cancer Res 74(16):4526-35. PubMed: 24934812 MGI: J:213722
Karigane D; Kobayashi H; Morikawa T; Ootomo Y; Sakai M; Nagamatsu G; Kubota Y; Goda N; Matsumoto M; Nishimura EK; Soga T; Otsu K; Suematsu M; Okamoto S; Suda T; Takubo K. 2016. p38alpha Activates Purine Metabolism to Initiate Hematopoietic Stem/Progenitor Cell Cycling in Response to Stress. Cell Stem Cell 19(2):192-204. PubMed: 27345838 MGI: J:238357
Kariya S; Obis T; Garone C; Akay T; Sera F; Iwata S; Homma S; Monani UR. 2014. Requirement of enhanced Survival Motoneuron protein imposed during neuromuscular junction maturation. J Clin Invest 124(2):785-800. PubMed: 24463453 MGI: J:208442
Karner CM; Chirumamilla R; Aoki S; Igarashi P; Wallingford JB; Carroll TJ. 2009. Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis. Nat Genet 41(7):793-9. PubMed: 19543268 MGI: J:151498
Keady BT; Le YZ; Pazour GJ. 2011. IFT20 is required for opsin trafficking and photoreceptor outer segment development. Mol Biol Cell 22(7):921-30. PubMed: 21307337 MGI: J:183002
Kenchegowda D; Natale B; Lemus MA; Natale DR; Fisher SA. 2017. Inactivation of maternal Hif-1alpha at mid-pregnancy causes placental defects and deficits in oxygen delivery to the fetal organs under hypoxic stress. Dev Biol 422(2):171-185. PubMed: 27940158 MGI: J:239312
Kida YS; Kawamura T; Wei Z; Sogo T; Jacinto S; Shigeno A; Kushige H; Yoshihara E; Liddle C; Ecker JR; Yu RT; Atkins AR; Downes M; Evans RM. 2015. ERRs Mediate a Metabolic Switch Required for Somatic Cell Reprogramming to Pluripotency. Cell Stem Cell 16(5):547-55. PubMed: 25865501 MGI: J:224699
Kim J; Oh WJ; Gaiano N; Yoshida Y; Gu C. 2011. Semaphorin 3E-Plexin-D1 signaling regulates VEGF function in developmental angiogenesis via a feedback mechanism. Genes Dev 25(13):1399-411. PubMed: 21724832 MGI: J:174051
Kim JH; Thimmulappa RK; Kumar V; Cui W; Kumar S; Kombairaju P; Zhang H; Margolick J; Matsui W; Macvittie T; Malhotra SV; Biswal S. 2014. NRF2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation. J Clin Invest 124(2):730-41. PubMed: 24463449 MGI: J:208444
Knapp JR; Davie JK; Myer A; Meadows E; Olson EN; Klein WH. 2006. Loss of myogenin in postnatal life leads to normal skeletal muscle but reduced body size. Development 133(4):601-10. PubMed: 16407395 MGI: J:105925
Kobayashi T; Lu J; Cobb BS; Rodda SJ; McMahon AP; Schipani E; Merkenschlager M; Kronenberg HM. 2008. Dicer-dependent pathways regulate chondrocyte proliferation and differentiation. Proc Natl Acad Sci U S A 105(6):1949-54. PubMed: 18238902 MGI: J:131828
Kononenko NL; Puchkov D; Classen GA; Walter AM; Pechstein A; Sawade L; Kaempf N; Trimbuch T; Lorenz D; Rosenmund C; Maritzen T; Haucke V. 2014. Clathrin/AP-2 mediate synaptic vesicle reformation from endosome-like vacuoles but are not essential for membrane retrieval at central synapses. Neuron 82(5):981-8. PubMed: 24908483 MGI: J:214740
Konstandin MH; Toko H; Gastelum GM; Quijada P; De La Torre A; Quintana M; Collins B; Din S; Avitabile D; Volkers M; Gude N; Fassler R; Sussman MA. 2013. Fibronectin is essential for reparative cardiac progenitor cell response after myocardial infarction. Circ Res 113(2):115-25. PubMed: 23652800 MGI: J:213280
Koo Y; Barry DM; Xu K; Tanigaki K; Davis GE; Mineo C; Cleaver O. 2016. Rasip1 is essential to blood vessel stability and angiogenic blood vessel growth. Angiogenesis 19(2):173-90. PubMed: 26897025 MGI: J:241190
Kopra J; Vilenius C; Grealish S; Harma MA; Varendi K; Lindholm J; Castren E; Voikar V; Bjorklund A; Piepponen TP; Saarma M; Andressoo JO. 2015. GDNF is not required for catecholaminergic neuron survival in vivo. Nat Neurosci 18(3):319-22. PubMed: 25710828 MGI: J:222023
Kueh AJ; Dixon MP; Voss AK; Thomas T. 2011. HBO1 is required for H3K14 acetylation and normal transcriptional activity during embryonic development. Mol Cell Biol 31(4):845-60. PubMed: 21149574 MGI: J:170405
Kuhl T; Mezger M; Hausser I; Guey LT; Handgretinger R; Bruckner-Tuderman L; Nystrom A. 2016. Collagen VII Half-Life at the Dermal-Epidermal Junction Zone: Implications for Mechanisms and Therapy of Genodermatoses. J Invest Dermatol 136(6):1116-23. PubMed: 26899947 MGI: J:233455
Lee CS; Lee C; Hu T; Nguyen JM; Zhang J; Martin MV; Vawter MP; Huang EJ; Chan JY. 2011. Loss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegeneration. Proc Natl Acad Sci U S A 108(20):8408-13. PubMed: 21536885 MGI: J:171912
Lee DW; Zhao X; Yim YI; Eisenberg E; Greene LE. 2008. Essential role of cyclin-G-associated kinase (Auxilin-2) in developing and mature mice. Mol Biol Cell 19(7):2766-76. PubMed: 18434600 MGI: J:180119
Lee JK; Case LC; Chan AF; Zhu Y; Tessier-Lavigne M; Zheng B. 2009. Generation of an OMgp allelic series in mice. Genesis 47(11):751-6. PubMed: 19672953 MGI: J:154794
Lee Y; Katyal S; Downing SM; Zhao J; Russell HR; McKinnon PJ. 2012. Neurogenesis requires TopBP1 to prevent catastrophic replicative DNA damage in early progenitors. Nat Neurosci 15(6):819-26. PubMed: 22522401 MGI: J:191367
Lee Y; Shull ER; Frappart PO; Katyal S; Enriquez-Rios V; Zhao J; Russell HR; Brown EJ; McKinnon PJ. 2012. ATR maintains select progenitors during nervous system development. EMBO J 31(5):1177-89. PubMed: 22266795 MGI: J:181920
Lei L; Spradling AC. 2013. Mouse primordial germ cells produce cysts that partially fragment prior to meiosis. Development 140(10):2075-81. PubMed: 23578925 MGI: J:196666
Lepper C; Conway SJ; Fan CM. 2009. Adult satellite cells and embryonic muscle progenitors have distinct genetic requirements. Nature 460(7255):627-31. PubMed: 19554048 MGI: J:150962
Li D; Sakuma R; Vakili NA; Mo R; Puviindran V; Deimling S; Zhang X; Hopyan S; Hui CC. 2014. Formation of proximal and anterior limb skeleton requires early function of Irx3 and Irx5 and is negatively regulated by Shh signaling. Dev Cell 29(2):233-40. PubMed: 24726282 MGI: J:213418
Li FZ; Cai PC; Song LJ; Zhou LL; Zhang Q; Rao SS; Xia Y; Xiang F; Xin JB; Greer PA; Shi HZ; Su Y; Ma WL; Ye H. 2015. Crosstalk between calpain activation and TGF-beta1 augments collagen-I synthesis in pulmonary fibrosis. Biochim Biophys Acta 1852(9):1796-804. PubMed: 26071646 MGI: J:233923
Li G; Adesnik H; Li J; Long J; Nicoll RA; Rubenstein JL; Pleasure SJ. 2008. Regional distribution of cortical interneurons and development of inhibitory tone are regulated by Cxcl12/Cxcr4 signaling. J Neurosci 28(5):1085-98. PubMed: 18234887 MGI: J:131835
Li J; Chatzeli L; Panousopoulou E; Tucker AS; Green JB. 2016. Epithelial stratification and placode invagination are separable functions in early morphogenesis of the molar tooth. Development 143(4):670-81. PubMed: 26755699 MGI: J:239975
Li MM; Nilsen A; Shi Y; Fusser M; Ding YH; Fu Y; Liu B; Niu Y; Wu YS; Huang CM; Olofsson M; Jin KX; Lv Y; Xu XZ; He C; Dong MQ; Rendtlew Danielsen JM; Klungland A; Yang YG. 2013. ALKBH4-dependent demethylation of actin regulates actomyosin dynamics. Nat Commun 4:1832. PubMed: 23673617 MGI: J:205739
Li P; Pashmforoush M; Sucov HM. 2010. Retinoic acid regulates differentiation of the secondary heart field and TGFbeta-mediated outflow tract septation. Dev Cell 18(3):480-5. PubMed: 20230754 MGI: J:159110
Li P; Pashmforoush M; Sucov HM. 2012. Mesodermal retinoic acid signaling regulates endothelial cell coalescence in caudal pharyngeal arch artery vasculogenesis. Dev Biol 361(1):116-24. PubMed: 22040871 MGI: J:179213
Li Q; Wang HY; Chepelev I; Zhu Q; Wei G; Zhao K; Wang RF. 2014. Stage-dependent and locus-specific role of histone demethylase Jumonji D3 (JMJD3) in the embryonic stages of lung development. PLoS Genet 10(7):e1004524. PubMed: 25079229 MGI: J:228600
Li Q; Zhang Y; El-Naggar AK; Xiong S; Yang P; Jackson JG; Chau G; Lozano G. 2014. Therapeutic efficacy of p53 restoration in Mdm2-overexpressing tumors. Mol Cancer Res 12(6):901-11. PubMed: 24598047 MGI: J:211567
Li X; Zhu M; Penfold ME; Koenen RR; Thiemann A; Heyll K; Akhtar S; Koyadan S; Wu Z; Gremse F; Kiessling F; van Zandvoort M; Schall TJ; Weber C; Schober A. 2014. Activation of CXCR7 limits atherosclerosis and improves hyperlipidemia by increasing cholesterol uptake in adipose tissue. Circulation 129(11):1244-53. PubMed: 24374972 MGI: J:219310
Lin W; Cao J; Liu J; Beshiri ML; Fujiwara Y; Francis J; Cherniack AD; Geisen C; Blair LP; Zou MR; Shen X; Kawamori D; Liu Z; Grisanzio C; Watanabe H; Minamishima YA; Zhang Q; Kulkarni RN; Signoretti S; Rodig SJ; Bronson RT; Orkin SH; Tuck DP; Benevolenskaya EV; Meyerson M; Kaelin WG Jr; Yan Q. 2011. Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. Proc Natl Acad Sci U S A 108(33):13379-86. PubMed: 21788502 MGI: J:175625
Lin Y; Li XY; Willis AL; Liu C; Chen G; Weiss SJ. 2014. Snail1-dependent control of embryonic stem cell pluripotency and lineage commitment. Nat Commun 5:3070. PubMed: 24401905 MGI: J:223506
List K; Kosa P; Szabo R; Bey AL; Wang CB; Molinolo A; Bugge TH. 2009. Epithelial integrity is maintained by a matriptase-dependent proteolytic pathway. Am J Pathol 175(4):1453-63. PubMed: 19717635 MGI: J:153070
Liu F; Cheng G; Hamard PJ; Greenblatt S; Wang L; Man N; Perna F; Xu H; Tadi M; Luciani L; Nimer SD. 2015. Arginine methyltransferase PRMT5 is essential for sustaining normal adult hematopoiesis. J Clin Invest 125(9):3532-44. PubMed: 26258414 MGI: J:226257
Liu P; Johnson RL. 2010. Lmx1b is required for murine trabecular meshwork formation and for maintenance of corneal transparency. Dev Dyn :. PubMed: 20568247 MGI: J:161793
Liu W; Lagutin OV; Mende M; Streit A; Oliver G. 2006. Six3 activation of Pax6 expression is essential for mammalian lens induction and specification. EMBO J 25(22):5383-95. PubMed: 17066077 MGI: J:116102
Lopez-Rios J; Speziale D; Robay D; Scotti M; Osterwalder M; Nusspaumer G; Galli A; Hollander GA; Kmita M; Zeller R. 2012. GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis. Dev Cell 22(4):837-48. PubMed: 22465667 MGI: J:184012
Lou S; Adam Y; Weinstein EN; Williams E; Williams K; Parot V; Kavokine N; Liberles S; Madisen L; Zeng H; Cohen AE. 2016. Genetically Targeted All-Optical Electrophysiology with a Transgenic Cre-Dependent Optopatch Mouse. J Neurosci 36(43):11059-11073. PubMed: 27798186 MGI: J:236369
Lu L; Li Y; Kim SM; Bossuyt W; Liu P; Qiu Q; Wang Y; Halder G; Finegold MJ; Lee JS; Johnson RL. 2010. Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc Natl Acad Sci U S A :. PubMed: 20080689 MGI: J:156531
Lucitti JL; Mackey JK; Morrison JC; Haigh JJ; Adams RH; Faber JE. 2012. Formation of the collateral circulation is regulated by vascular endothelial growth factor-A and a disintegrin and metalloprotease family members 10 and 17. Circ Res 111(12):1539-50. PubMed: 22965144 MGI: J:212884
Lutz CM; Kariya S; Patruni S; Osborne MA; Liu D; Henderson CE; Li DK; Pellizzoni L; Rojas J; Valenzuela DM; Murphy AJ; Winberg ML; Monani UR. 2011. Postsymptomatic restoration of SMN rescues the disease phenotype in a mouse model of severe spinal muscular atrophy. J Clin Invest 121(8):3029-41. PubMed: 21785219 MGI: J:176007
Ma FY; Tesch GH; Ozols E; Xie M; Schneider MD; Nikolic-Paterson DJ. 2011. TGF-beta1-activated kinase-1 regulates inflammation and fibrosis in the obstructed kidney. Am J Physiol Renal Physiol 300(6):F1410-21. PubMed: 21367917 MGI: J:210583
Ma W; Han W; Greer PA; Tuder RM; Toque HA; Wang KK; Caldwell RW; Su Y. 2011. Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease. J Clin Invest 121(11):4548-66. PubMed: 22005303 MGI: J:178722
Macpherson PC; Farshi P; Goldman D. 2015. Dach2-Hdac9 signaling regulates reinnervation of muscle endplates. Development 142(23):4038-48. PubMed: 26483211 MGI: J:227705
Macpherson PC; Wang X; Goldman D. 2011. Myogenin regulates denervation-dependent muscle atrophy in mouse soleus muscle. J Cell Biochem 112(8):2149-59. PubMed: 21465538 MGI: J:200498
Maiya R; Lee S; Berger KH; Kong EC; Slawson JB; Griffith LC; Takamiya K; Huganir RL; Margolis B; Heberlein U. 2012. DlgS97/SAP97, a neuronal isoform of discs large, regulates ethanol tolerance. PLoS One 7(11):e48967. PubMed: 23145041 MGI: J:194948
Mali RS; Ma P; Zeng LF; Martin H; Ramdas B; He Y; Sims E; Nabinger S; Ghosh J; Sharma N; Munugalavadla V; Chatterjee A; Li S; Sandusky G; Craig AW; Bunting KD; Feng GS; Chan RJ; Zhang ZY; Kapur R. 2012. Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT. Blood 120(13):2669-78. PubMed: 22806893 MGI: J:189153
Mantuano E; Brifault C; Lam MS; Azmoon P; Gilder AS; Gonias SL. 2016. LDL receptor-related protein-1 regulates NFkappaB and microRNA-155 in macrophages to control the inflammatory response. Proc Natl Acad Sci U S A 113(5):1369-74. PubMed: 26787872 MGI: J:229967
Mao J; Barrow J; McMahon J; Vaughan J; McMahon AP. 2005. An ES cell system for rapid, spatial and temporal analysis of gene function in vitro and in vivo. Nucleic Acids Res 33(18):e155. PubMed: 16221970 MGI: J:165962
Mao J; Ligon KL; Rakhlin EY; Thayer SP; Bronson RT; Rowitch D; McMahon AP. 2006. A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway. Cancer Res 66(20):10171-8. PubMed: 17047082 MGI: J:114992
Maretzky T; Evers A; Zhou W; Swendeman SL; Wong PM; Rafii S; Reiss K; Blobel CP. 2011. Migration of growth factor-stimulated epithelial and endothelial cells depends on EGFR transactivation by ADAM17. Nat Commun 2:229. PubMed: 21407195 MGI: J:205661
Matsui T; Leung D; Miyashita H; Maksakova IA; Miyachi H; Kimura H; Tachibana M; Lorincz MC; Shinkai Y. 2010. Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET. Nature 464(7290):927-31. PubMed: 20164836 MGI: J:188475
Matsuki T; Pramatarova A; Howell BW. 2008. Reduction of Crk and CrkL expression blocks reelin-induced dendritogenesis. J Cell Sci 121(Pt 11):1869-75. PubMed: 18477607 MGI: J:139781
Matsuki T; Zaka M; Guerreiro R; van der Brug MP; Cooper JA; Cookson MR; Hardy JA; Howell BW. 2012. Identification of Stk25 as a genetic modifier of Tau phosphorylation in Dab1-mutant mice. PLoS One 7(2):e31152. PubMed: 22355340 MGI: J:224058
Matsumaru D; Haraguchi R; Miyagawa S; Motoyama J; Nakagata N; Meijlink F; Yamada G. 2011. Genetic analysis of Hedgehog signaling in ventral body wall development and the onset of omphalocele formation. PLoS One 6(1):e16260. PubMed: 21283718 MGI: J:169568
Matsumaru D; Haraguchi R; Moon AM; Satoh Y; Nakagata N; Yamamura K; Takahashi N; Kitazawa S; Yamada G. 2014. Genetic analysis of the role of Alx4 in the coordination of lower body and external genitalia formation. Eur J Hum Genet 22(3):350-7. PubMed: 23942202 MGI: J:234759
Matsunobu T; Torigoe K; Ishikawa M; de Vega S; Kulkarni AB; Iwamoto Y; Yamada Y. 2009. Critical roles of the TGF-beta type I receptor ALK5 in perichondrial formation and function, cartilage integrity, and osteoblast differentiation during growth plate development. Dev Biol 332(2):325-38. PubMed: 19501582 MGI: J:152864
Mazzitelli S; Xu P; Ferrer I; Davis RJ; Tournier C. 2011. The Loss of c-Jun N-Terminal Protein Kinase Activity Prevents the Amyloidogenic Cleavage of Amyloid Precursor Protein and the Formation of Amyloid Plaques In Vivo. J Neurosci 31(47):16969-76. PubMed: 22114267 MGI: J:178060
McGeough MD; Pena CA; Mueller JL; Pociask DA; Broderick L; Hoffman HM; Brydges SD. 2012. Cutting edge: IL-6 is a marker of inflammation with no direct role in inflammasome-mediated mouse models. J Immunol 189(6):2707-11. PubMed: 22904305 MGI: J:189914
McGraw CM; Samaco RC; Zoghbi HY. 2011. Adult neural function requires MeCP2. Science 333(6039):186. PubMed: 21636743 MGI: J:173307
McKillop WM; Dragan M; Schedl A; Brown A. 2013. Conditional Sox9 ablation reduces chondroitin sulfate proteoglycan levels and improves motor function following spinal cord injury. Glia 61(2):164-77. PubMed: 23027386 MGI: J:191141
McKillop WM; York EM; Rubinger L; Liu T; Ossowski NM; Xu K; Hryciw T; Brown A. 2016. Conditional Sox9 ablation improves locomotor recovery after spinal cord injury by increasing reactive sprouting. Exp Neurol 283(Pt A):1-15. PubMed: 27235933 MGI: J:236732
McPherron AC; Huynh TV; Lee SJ. 2009. Redundancy of myostatin and growth/differentiation factor 11 function. BMC Dev Biol 9:24. PubMed: 19298661 MGI: J:158173
McPherson VA; Sharma N; Everingham S; Smith J; Zhu HH; Feng GS; Craig AW. 2009. SH2 domain-containing phosphatase-2 protein-tyrosine phosphatase promotes Fc(epsilon)RI-induced activation of Fyn and Erk pathways leading to TNF(alpha) release from bone marrow-derived mast cells. J Immunol 183(8):4940-7. PubMed: 19786542 MGI: J:153823
Meadows E; Cho JH; Flynn JM; Klein WH. 2008. Myogenin regulates a distinct genetic program in adult muscle stem cells. Dev Biol 322(2):406-414. PubMed: 18721801 MGI: J:141955
Meadows E; Flynn JM; Klein WH. 2011. Myogenin regulates exercise capacity but is dispensable for skeletal muscle regeneration in adult mdx mice. PLoS One 6(1):e16184. PubMed: 21264243 MGI: J:169466
Menezes LF; Zhou F; Patterson AD; Piontek KB; Krausz KW; Gonzalez FJ; Germino GG. 2012. Network analysis of a Pkd1-mouse model of autosomal dominant polycystic kidney disease identifies HNF4alpha as a disease modifier. PLoS Genet 8(11):e1003053. PubMed: 23209428 MGI: J:194672
Meng L; Lin T; Peng G; Hsu JK; Lee S; Lin SY; Tsai RY. 2013. Nucleostemin deletion reveals an essential mechanism that maintains the genomic stability of stem and progenitor cells. Proc Natl Acad Sci U S A 110(28):11415-20. PubMed: 23798389 MGI: J:198698
Meng L; Ohman-Gault L; Ma L; Krimm RF. 2015. Taste Bud-Derived BDNF Is Required to Maintain Normal Amounts of Innervation to Adult Taste Buds. eNeuro 2(6):. PubMed: 26730405 MGI: J:239979
Merrill JC; You J; Constable C; Leeman SE; Amar S. 2011. Whole-body deletion of LPS-induced TNF-alpha factor (LITAF) markedly improves experimental endotoxic shock and inflammatory arthritis. Proc Natl Acad Sci U S A 108(52):21247-52. PubMed: 22160695 MGI: J:180147
Millan-Ucles A; Diaz-Castro B; Garcia-Flores P; Baez A; Perez-Simon JA; Lopez-Barneo J; Piruat JI. 2014. A conditional mouse mutant in the tumor suppressor SdhD gene unveils a link between p21(WAF1/Cip1) induction and mitochondrial dysfunction. PLoS One 9(1):e85528. PubMed: 24465590 MGI: J:212339
Millanes-Romero A; Herranz N; Perrera V; Iturbide A; Loubat-Casanovas J; Gil J; Jenuwein T; Garcia de Herreros A; Peiro S. 2013. Regulation of heterochromatin transcription by Snail1/LOXL2 during epithelial-to-mesenchymal transition. Mol Cell 52(5):746-57. PubMed: 24239292 MGI: J:206163
Min JN; Tian Y; Xiao Y; Wu L; Li L; Chang S. 2013. The mINO80 chromatin remodeling complex is required for efficient telomere replication and maintenance of genome stability. Cell Res 23(12):1396-413. PubMed: 23979016 MGI: J:221224
Minamishima YA; Kaelin WG Jr. 2010. Reactivation of hepatic EPO synthesis in mice after PHD loss. Science 329(5990):407. PubMed: 20651146 MGI: J:162614
Minamishima YA; Moslehi J; Bardeesy N; Cullen D; Bronson RT; Kaelin WG Jr. 2008. Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure. Blood 111(6):3236-44. PubMed: 18096761 MGI: J:132718
Minamishima YA; Moslehi J; Padera RF; Bronson RT; Liao R; Kaelin WG Jr. 2009. A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo. Mol Cell Biol 29(21):5729-41. PubMed: 19720742 MGI: J:153985
Mingote S; Masson J; Gellman C; Thomsen GM; Lin CS; Merker RJ; Gaisler-Salomon I; Wang Y; Ernst R; Hen R; Rayport S. 2015. Genetic Pharmacotherapy as an Early CNS Drug Development Strategy: Testing Glutaminase Inhibition for Schizophrenia Treatment in Adult Mice. Front Syst Neurosci 9:165. PubMed: 26778975 MGI: J:230564
Minkina A; Lindeman RE; Gearhart MD; Chassot AA; Chaboissier MC; Ghyselinck NB; Bardwell VJ; Zarkower D. 2017. Retinoic acid signaling is dispensable for somatic development and function in the mammalian ovary. Dev Biol 424(2):208-220. PubMed: 28274610 MGI: J:241008
Mirantes C; Eritja N; Dosil MA; Santacana M; Pallares J; Gatius S; Bergada L; Maiques O; Matias-Guiu X; Dolcet X. 2013. An inducible knockout mouse to model the cell-autonomous role of PTEN in initiating endometrial, prostate and thyroid neoplasias. Dis Model Mech 6(3):710-20. PubMed: 23471917 MGI: J:196368
Mirza M; Pang MF; Zaini MA; Haiko P; Tammela T; Alitalo K; Philipson L; Fuxe J; Sollerbrant K. 2012. Essential role of the coxsackie- and adenovirus receptor (CAR) in development of the lymphatic system in mice. PLoS One 7(5):e37523. PubMed: 22624044 MGI: J:225118
Mishiba T; Tanaka M; Mita N; He X; Sasamoto K; Itohara S; Ohshima T. 2014. Cdk5/p35 functions as a crucial regulator of spatial learning and memory. Mol Brain 7:82. PubMed: 25404232 MGI: J:232615
Mita N; He X; Sasamoto K; Mishiba T; Ohshima T. 2016. Cyclin-Dependent Kinase 5 Regulates Dendritic Spine Formation and Maintenance of Cortical Neuron in the Mouse Brain. Cereb Cortex 26(3):967-76. PubMed: 25404468 MGI: J:241052
Miyagawa S; Matsumaru D; Murashima A; Omori A; Satoh Y; Haraguchi R; Motoyama J; Iguchi T; Nakagata N; Hui CC; Yamada G. 2011. The role of sonic hedgehog-gli2 pathway in the masculinization of external genitalia. Endocrinology 152(7):2894-903. PubMed: 21586556 MGI: J:174885
Miyoshi H; Ajima R; Luo CT; Yamaguchi TP; Stappenbeck TS. 2012. Wnt5a potentiates TGF-beta signaling to promote colonic crypt regeneration after tissue injury. Science 338(6103):108-13. PubMed: 22956684 MGI: J:187747
Mohammad F; Pandey GK; Mondal T; Enroth S; Redrup L; Gyllensten U; Kanduri C. 2012. Long noncoding RNA-mediated maintenance of DNA methylation and transcriptional gene silencing. Development 139(15):2792-803. PubMed: 22721776 MGI: J:185569
Molero AE; Arteaga-Bracho EE; Chen CH; Gulinello M; Winchester ML; Pichamoorthy N; Gokhan S; Khodakhah K; Mehler MF. 2016. Selective expression of mutant huntingtin during development recapitulates characteristic features of Huntington's disease. Proc Natl Acad Sci U S A 113(20):5736-41. PubMed: 27140644 MGI: J:232181
Monkley SJ; Kostourou V; Spence L; Petrich B; Coleman S; Ginsberg MH; Pritchard CA; Critchley DR. 2011. Endothelial cell talin1 is essential for embryonic angiogenesis. Dev Biol 349(2):494-502. PubMed: 21081121 MGI: J:168021
Montana CL; Kolesnikov AV; Shen SQ; Myers CA; Kefalov VJ; Corbo JC. 2013. Reprogramming of adult rod photoreceptors prevents retinal degeneration. Proc Natl Acad Sci U S A 110(5):1732-7. PubMed: 23319618 MGI: J:193697
Moore BD; Khurana SS; Huh WJ; Mills JC. 2016. Hepatocyte nuclear factor 4alpha is required for cell differentiation and homeostasis in the adult mouse gastric epithelium. Am J Physiol Gastrointest Liver Physiol 311(2):G267-75. PubMed: 27340127 MGI: J:239963
Moresi V; Williams AH; Meadows E; Flynn JM; Potthoff MJ; McAnally J; Shelton JM; Backs J; Klein WH; Richardson JA; Bassel-Duby R; Olson EN. 2010. Myogenin and class II HDACs control neurogenic muscle atrophy by inducing E3 ubiquitin ligases. Cell 143(1):35-45. PubMed: 20887891 MGI: J:164645
Mudhasani R; Zhu Z; Hutvagner G; Eischen CM; Lyle S; Hall LL; Lawrence JB; Imbalzano AN; Jones SN. 2008. Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells. J Cell Biol 181(7):1055-63. PubMed: 18591425 MGI: J:139257
Mundell NA; Labosky PA. 2011. Neural crest stem cell multipotency requires Foxd3 to maintain neural potential and repress mesenchymal fates. Development 138(4):641-52. PubMed: 21228004 MGI: J:170647
Murashima A; Miyagawa S; Ogino Y; Nishida-Fukuda H; Araki K; Matsumoto T; Kaneko T; Yoshinaga K; Yamamura K; Kurita T; Kato S; Moon AM; Yamada G. 2011. Essential roles of androgen signaling in Wolffian duct stabilization and epididymal cell differentiation. Endocrinology 152(4):1640-51. PubMed: 21303954 MGI: J:173864
Narayanan P; Chatterton P; Ikeda A; Ikeda S; Corey DP; Ervasti JM; Perrin BJ. 2015. Length regulation of mechanosensitive stereocilia depends on very slow actin dynamics and filament-severing proteins. Nat Commun 6:6855. PubMed: 25897778 MGI: J:222694
Nasif S; de Souza FS; Gonzalez LE; Yamashita M; Orquera DP; Low MJ; Rubinstein M. 2015. Islet 1 specifies the identity of hypothalamic melanocortin neurons and is critical for normal food intake and adiposity in adulthood. Proc Natl Acad Sci U S A 112(15):E1861-70. PubMed: 25825735 MGI: J:220452
Nayak L; Shi H; Atkins GB; Lin Z; Schmaier AH; Jain MK. 2014. The thromboprotective effect of bortezomib is dependent on the transcription factor Kruppel-like factor 2 (KLF2). Blood 123(24):3828-31. PubMed: 24771858 MGI: J:211297
Nguyen H; Sokpor G; Pham L; Rosenbusch J; Stoykova A; Staiger JF; Tuoc T. 2016. Epigenetic regulation by BAF (mSWI/SNF) chromatin remodeling complexes is indispensable for embryonic development. Cell Cycle 15(10):1317-24. PubMed: 26986003 MGI: J:231971
Nguyen MV; Du F; Felice CA; Shan X; Nigam A; Mandel G; Robinson JK; Ballas N. 2012. MeCP2 Is Critical for Maintaining Mature Neuronal Networks and Global Brain Anatomy during Late Stages of Postnatal Brain Development and in the Mature Adult Brain. J Neurosci 32(29):10021-34. PubMed: 22815516 MGI: J:186548
Nikonova AS; Plotnikova OV; Serzhanova V; Efimov A; Bogush I; Cai KQ; Hensley HH; Egleston BL; Klein-Szanto A; Seeger-Nukpezah T; Golemis EA. 2014. Nedd9 restrains renal cystogenesis in Pkd1-/- mice. Proc Natl Acad Sci U S A 111(35):12859-64. PubMed: 25139996 MGI: J:216403
Nilsen A; Fusser M; Greggains G; Fedorcsak P; Klungland A. 2014. ALKBH4 depletion in mice leads to spermatogenic defects. PLoS One 9(8):e105113. PubMed: 25153837 MGI: J:221080
Nishide K; Nakatani Y; Kiyonari H; Kondo T. 2009. Glioblastoma formation from cell population depleted of Prominin1-expressing cells. PLoS One 4(8):e6869. PubMed: 19718438 MGI: J:152390
Nishiyama C; Uesaka T; Manabe T; Yonekura Y; Nagasawa T; Newgreen DF; Young HM; Enomoto H. 2012. Trans-mesenteric neural crest cells are the principal source of the colonic enteric nervous system. Nat Neurosci 15(9):1211-8. PubMed: 22902718 MGI: J:191577
Nystrom A; Velati D; Mittapalli VR; Fritsch A; Kern JS; Bruckner-Tuderman L. 2013. Collagen VII plays a dual role in wound healing. J Clin Invest 123(8):3498-509. PubMed: 23867500 MGI: J:201405
Oda H; Okamoto I; Murphy N; Chu J; Price SM; Shen MM; Torres-Padilla ME; Heard E; Reinberg D. 2009. Monomethylation of histone H4-lysine 20 is involved in chromosome structure and stability and is essential for mouse development. Mol Cell Biol 29(8):2278-95. PubMed: 19223465 MGI: J:147765
Olenchock BA; Moslehi J; Baik AH; Davidson SM; Williams J; Gibson WJ; Pierce KA; Miller CM; Hanse EA; Kelekar A; Sullivan LB; Wagers AJ; Clish CB; Vander Heiden MG; Kaelin WG Jr. 2016. EGLN1 Inhibition and Rerouting of alpha-Ketoglutarate Suffice for Remote Ischemic Protection. Cell 164(5):884-95. PubMed: 26919427 MGI: J:230798
Orquera DP; Nasif S; Low MJ; Rubinstein M; de Souza FS. 2016. Essential function of the transcription factor Rax in the early patterning of the mammalian hypothalamus. Dev Biol 416(1):212-24. PubMed: 27212025 MGI: J:234927
Ouseph MM; Li J; Chen HZ; Pecot T; Wenzel P; Thompson JC; Comstock G; Chokshi V; Byrne M; Forde B; Chong JL; Huang K; Machiraju R; de Bruin A; Leone G. 2012. Atypical E2F repressors and activators coordinate placental development. Dev Cell 22(4):849-62. PubMed: 22516201 MGI: J:183999
Ozkan ED; Creson TK; Kramar EA; Rojas C; Seese RR; Babyan AH; Shi Y; Lucero R; Xu X; Noebels JL; Miller CA; Lynch G; Rumbaugh G. 2014. Reduced cognition in Syngap1 mutants is caused by isolated damage within developing forebrain excitatory neurons. Neuron 82(6):1317-33. PubMed: 24945774 MGI: J:215492
Paek H; Gutin G; Hebert JM. 2009. FGF signaling is strictly required to maintain early telencephalic precursor cell survival. Development 136(14):2457-65. PubMed: 19542358 MGI: J:150347
Pallmann N; Braig M; Sievert H; Preukschas M; Hermans-Borgmeyer I; Schweizer M; Nagel CH; Neumann M; Wild P; Haralambieva E; Hagel C; Bokemeyer C; Hauber J; Balabanov S. 2015. Biological Relevance and Therapeutic Potential of the Hypusine Modification System. J Biol Chem 290(30):18343-60. PubMed: 26037925 MGI: J:236582
Pan H; Qin K; Guo Z; Ma Y; April C; Gao X; Andrews TG; Bokov A; Zhang J; Chen Y; Weintraub ST; Fan JB; Wang D; Hu Y; Aune GJ; Lindsey ML; Li R. 2014. Negative elongation factor controls energy homeostasis in cardiomyocytes. Cell Rep 7(1):79-85. PubMed: 24656816 MGI: J:211827
Pant V; Xiong S; Iwakuma T; Quintas-Cardama A; Lozano G. 2011. Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability. Proc Natl Acad Sci U S A 108(29):11995-2000. PubMed: 21730132 MGI: J:174368
Parikh VN; Jin RC; Rabello S; Gulbahce N; White K; Hale A; Cottrill KA; Shaik RS; Waxman AB; Zhang YY; Maron BA; Hartner JC; Fujiwara Y; Orkin SH; Haley KJ; Barabasi AL; Loscalzo J; Chan SY. 2012. MicroRNA-21 integrates pathogenic signaling to control pulmonary hypertension: results of a network bioinformatics approach. Circulation 125(12):1520-32. PubMed: 22371328 MGI: J:198097
Park JI; Frantz MG; Kast RJ; Chapman KS; Dorton HM; Stephany CE; Arnett MT; Herman DH; McGee AW. 2014. Nogo receptor 1 limits tactile task performance independent of basal anatomical plasticity. PLoS One 9(11):e112678. PubMed: 25386856 MGI: J:225160
Park SG; Schulze-Luehrman J; Hayden MS; Hashimoto N; Ogawa W; Kasuga M; Ghosh S. 2009. The kinase PDK1 integrates T cell antigen receptor and CD28 coreceptor signaling to induce NF-kappaB and activate T cells. Nat Immunol 10(2):158-66. PubMed: 19122654 MGI: J:144512
Pascual A; Hidalgo-Figueroa M; Piruat JI; Pintado CO; Gomez-Diaz R; Lopez-Barneo J. 2008. Absolute requirement of GDNF for adult catecholaminergic neuron survival. Nat Neurosci 11(7):755-61. PubMed: 18536709 MGI: J:139371
Paul E; Cronan R; Weston PJ; Boekelheide K; Sedivy JM; Lee SY; Wiest DL; Resnick MB; Klysik JE. 2009. Disruption of Supv3L1 damages the skin and causes sarcopenia, loss of fat, and death. Mamm Genome 20(2):92-108. PubMed: 19145458 MGI: J:144991
Pazirandeh A; Sultana T; Mirza M; Rozell B; Hultenby K; Wallis K; Vennstrom B; Davis B; Arner A; Heuchel R; Lohr M; Philipson L; Sollerbrant K. 2011. Multiple Phenotypes in Adult Mice following Inactivation of the Coxsackievirus and Adenovirus Receptor (Car) Gene. PLoS One 6(6):e20203. PubMed: 21674029 MGI: J:174138
Penzo-Mendez A; Dy P; Pallavi B; Lefebvre V. 2007. Generation of mice harboring a Sox4 conditional null allele. Genesis 45(12):776-80. PubMed: 18064674 MGI: J:130461
Perera D; Taylor SS. 2010. Sgo1 establishes the centromeric cohesion protection mechanism in G2 before subsequent Bub1-dependent recruitment in mitosis. J Cell Sci 123(Pt 5):653-9. PubMed: 20124418 MGI: J:158500
Perera D; Tilston V; Hopwood JA; Barchi M; Boot-Handford RP; Taylor SS. 2007. Bub1 maintains centromeric cohesion by activation of the spindle checkpoint. Dev Cell 13(4):566-79. PubMed: 17925231 MGI: J:128455
Perrin BJ; Strandjord DM; Narayanan P; Henderson DM; Johnson KR; Ervasti JM. 2013. beta-Actin and Fascin-2 Cooperate to Maintain Stereocilia Length. J Neurosci 33(19):8114-21. PubMed: 23658152 MGI: J:197137
Perry JM; Harandi OF; Porayette P; Hegde S; Kannan AK; Paulson RF. 2009. Maintenance of the BMP4-dependent stress erythropoiesis pathway in the murine spleen requires hedgehog signaling. Blood 113(4):911-8. PubMed: 18927434 MGI: J:144571
Personius KE; Jayaram A; Krull D; Brown R; Xu T; Han B; Burgess K; Storey C; Shah B; Tawil R; Welle S. 2010. Grip force, EDL contractile properties, and voluntary wheel running after postdevelopmental myostatin depletion in mice. J Appl Physiol 109(3):886-94. PubMed: 20595537 MGI: J:185924
Pihlajoki M; Farkkila A; Soini T; Heikinheimo M; Wilson DB. 2016. GATA factors in endocrine neoplasia. Mol Cell Endocrinol 421:2-17. PubMed: 26027919 MGI: J:236515
Piontek K; Menezes LF; Garcia-Gonzalez MA; Huso DL; Germino GG. 2007. A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1. Nat Med 13(12):1490-5. PubMed: 17965720 MGI: J:141463
Piotrowski JT; Gomez TS; Schoon RA; Mangalam AK; Billadeau DD. 2013. WASH knockout T cells demonstrate defective receptor trafficking, proliferation, and effector function. Mol Cell Biol 33(5):958-73. PubMed: 23275443 MGI: J:217269
Pozniak CD; Sengupta Ghosh A; Gogineni A; Hanson JE; Lee SH; Larson JL; Solanoy H; Bustos D; Li H; Ngu H; Jubb AM; Ayalon G; Wu J; Scearce-Levie K; Zhou Q; Weimer RM; Kirkpatrick DS; Lewcock JW. 2013. Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration. J Exp Med 210(12):2553-67. PubMed: 24166713 MGI: J:207720
Prakash A; Udager AM; Saenz DA; Gumucio DL. 2014. Roles for Nkx2-5 and Gata3 in the ontogeny of the murine smooth muscle gastric ligaments. Am J Physiol Gastrointest Liver Physiol 307(4):G430-6. PubMed: 24970776 MGI: J:221833
Qin J; Tsai MJ; Tsai SY. 2008. Essential roles of COUP-TFII in Leydig cell differentiation and male fertility. PLoS One 3(9):e3285. PubMed: 18818749 MGI: J:144248
Quignodon L; Vincent S; Winter H; Samarut J; Flamant F. 2007. A Point Mutation in the Activation Function 2 Domain of Thyroid Hormone Receptor {alpha}1 Expressed after CRE-Mediated Recombination Partially Recapitulates Hypothyroidism. Mol Endocrinol 21(10):2350-2360. PubMed: 17622582 MGI: J:125353
Rabe TI; Griesel G; Blanke S; Kispert A; Leitges M; van der Zwaag B; Burbach JP; Varoqueaux F; Mansouri A. 2012. The transcription factor Uncx4.1 acts in a short window of midbrain dopaminergic neuron differentiation. Neural Dev 7:39. PubMed: 23217170 MGI: J:192558
Rajurkar M; Huang H; Cotton JL; Brooks JK; Sicklick J; McMahon AP; Mao J. 2014. Distinct cellular origin and genetic requirement of Hedgehog-Gli in postnatal rhabdomyosarcoma genesis. Oncogene 33(46):5370-8. PubMed: 24276242 MGI: J:216560
Rantakari P; Jappinen N; Lokka E; Mokkala E; Gerke H; Peuhu E; Ivaska J; Elima K; Auvinen K; Salmi M. 2016. Fetal liver endothelium regulates the seeding of tissue-resident macrophages. Nature 538(7625):392-396. PubMed: 27732581 MGI: J:239420
Regard JB; Kataoka H; Cano DA; Camerer E; Yin L; Zheng YW; Scanlan TS; Hebrok M; Coughlin SR. 2007. Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion. J Clin Invest 117(12):4034-43. PubMed: 17992256 MGI: J:130781
Reyahi A; Nik AM; Ghiami M; Gritli-Linde A; Ponten F; Johansson BR; Carlsson P. 2015. Foxf2 Is Required for Brain Pericyte Differentiation and Development and Maintenance of the Blood-Brain Barrier. Dev Cell 34(1):19-32. PubMed: 26120030 MGI: J:239656
Robinson L; Plano A; Cobb S; Riedel G. 2013. Long-term home cage activity scans reveal lowered exploratory behaviour in symptomatic female Rett mice. Behav Brain Res 250:148-56. PubMed: 23643691 MGI: J:198941
Ruediger R; Ruiz J; Walter G. 2011. Human Cancer-Associated Mutations in the A{alpha} Subunit of Protein Phosphatase 2A Increase Lung Cancer Incidence in A{alpha} Knock-In and Knockout Mice. Mol Cell Biol 31(18):3832-44. PubMed: 21791616 MGI: J:175748
Saigusa T; Dang Y; Bunni MA; Amria MY; Steele SL; Fitzgibbon WR; Bell PD. 2015. Activation of the intrarenal renin-angiotensin-system in murine polycystic kidney disease. Physiol Rep 3(5):. PubMed: 25999403 MGI: J:229242
Saigusa T; Dang Y; Mullick AE; Yeh ST; Zile MR; Baicu CF; Bell PD. 2016. Suppressing angiotensinogen synthesis attenuates kidney cyst formation in a Pkd1 mouse model. FASEB J 30(1):370-9. PubMed: 26391272 MGI: J:237603
Sas KM; Yin H; Fitzgibbon WR; Baicu CF; Zile MR; Steele SL; Amria M; Saigusa T; Funk J; Bunni MA; Siegal GP; Siroky BJ; Bissler JJ; Bell PD. 2015. Hyperglycemia in the absence of cilia accelerates cystogenesis and induces renal damage. Am J Physiol Renal Physiol 309(1):F79-87. PubMed: 25904703 MGI: J:226958
Satyanarayana A; Gudmundsson KO; Chen X; Coppola V; Tessarollo L; Keller JR; Hou SX. 2010. RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis. Blood 116(16):2921-31. PubMed: 20595512 MGI: J:165879
Seeger-Nukpezah T; Proia DA; Egleston BL; Nikonova AS; Kent T; Cai KQ; Hensley HH; Ying W; Chimmanamada D; Serebriiskii IG; Golemis EA. 2013. Inhibiting the HSP90 chaperone slows cyst growth in a mouse model of autosomal dominant polycystic kidney disease. Proc Natl Acad Sci U S A 110(31):12786-91. PubMed: 23858461 MGI: J:198775
Sharma N; Kumar V; Everingham S; Mali RS; Kapur R; Zeng LF; Zhang ZY; Feng GS; Hartmann K; Roers A; Craig AW. 2012. SH2 domain-containing phosphatase 2 is a critical regulator of connective tissue mast cell survival and homeostasis in mice. Mol Cell Biol 32(14):2653-63. PubMed: 22566685 MGI: J:186664
Shen Q; Fuchs T; Sahir N; Luscher B. 2012. GABAergic control of critical developmental periods for anxiety- and depression-related behavior in mice. PLoS One 7(10):e47441. PubMed: 23071808 MGI: J:192225
Shi F; Hu L; Jacques BE; Mulvaney JF; Dabdoub A; Edge AS. 2014. beta-Catenin is required for hair-cell differentiation in the cochlea. J Neurosci 34(19):6470-9. PubMed: 24806673 MGI: J:211047
Shi H; Sheng B; Zhang F; Wu C; Zhang R; Zhu J; Xu K; Kuang Y; Jameson SC; Lin Z; Wang Y; Chen J; Jain MK; Atkins GB. 2013. Kruppel-like factor 2 protects against ischemic stroke by regulating endothelial blood brain barrier function. Am J Physiol Heart Circ Physiol 304(6):H796-805. PubMed: 23335794 MGI: J:195862
Shimada M; Dumitrache LC; Russell HR; McKinnon PJ. 2015. Polynucleotide kinase-phosphatase enables neurogenesis via multiple DNA repair pathways to maintain genome stability. EMBO J 34(19):2465-80. PubMed: 26290337 MGI: J:226703
Shin J; Pan H; Zhong XP. 2012. Regulation of mast cell survival and function by tuberous sclerosis complex 1. Blood 119(14):3306-14. PubMed: 22362037 MGI: J:183777
Silk AD; Holland AJ; Cleveland DW. 2009. Requirements for NuMA in maintenance and establishment of mammalian spindle poles. J Cell Biol 184(5):677-90. PubMed: 19255246 MGI: J:146214
Silva-Santos S; van Woerden GM; Bruinsma CF; Mientjes E; Jolfaei MA; Distel B; Kushner SA; Elgersma Y. 2015. Ube3a reinstatement identifies distinct developmental windows in a murine Angelman syndrome model. J Clin Invest 125(5):2069-76. PubMed: 25866966 MGI: J:222400
Smith S; Witkowski A; Moghul A; Yoshinaga Y; Nefedov M; de Jong P; Feng D; Fong L; Tu Y; Hu Y; Young SG; Pham T; Cheung C; Katzman SM; Brand MD; Quinlan CL; Fens M; Kuypers F; Misquitta S; Griffey SM; Tran S; Gharib A; Knudsen J; Hannibal-Bach HK; Wang G; Larkin S; Thweatt J; Pasta S. 2012. Compromised mitochondrial fatty acid synthesis in transgenic mice results in defective protein lipoylation and energy disequilibrium. PLoS One 7(10):e47196. PubMed: 23077570 MGI: J:192213
Smithline ZB; Nikonova AS; Hensley HH; Cai KQ; Egleston BL; Proia DA; Seeger-Nukpezah T; Golemis EA. 2014. Inhibiting heat shock protein 90 (HSP90) limits the formation of liver cysts induced by conditional deletion of Pkd1 in mice. PLoS One 9(12):e114403. PubMed: 25474361 MGI: J:225683
Sohn EJ; Li H; Reidy K; Beers LF; Christensen BL; Lee SB. 2010. EWS/FLI1 oncogene activates caspase 3 transcription and triggers apoptosis in vivo. Cancer Res 70(3):1154-63. PubMed: 20103643 MGI: J:156860
Son J; Park JW; Lambert PF; Chung SH. 2014. Requirement of estrogen receptor alpha DNA-binding domain for HPV oncogene-induced cervical carcinogenesis in mice. Carcinogenesis 35(2):489-96. PubMed: 24148821 MGI: J:206522
Song H; Mak KK; Topol L; Yun K; Hu J; Garrett L; Chen Y; Park O; Chang J; Simpson RM; Wang CY; Gao B; Jiang J; Yang Y. 2010. Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci U S A :. PubMed: 20080598 MGI: J:156541
Speed HE; Kouser M; Xuan Z; Reimers JM; Ochoa CF; Gupta N; Liu S; Powell CM. 2015. Autism-Associated Insertion Mutation (InsG) of Shank3 Exon 21 Causes Impaired Synaptic Transmission and Behavioral Deficits. J Neurosci 35(26):9648-65. PubMed: 26134648 MGI: J:224381
Stafford DA; Brunet LJ; Khokha MK; Economides AN; Harland RM. 2011. Cooperative activity of noggin and gremlin 1 in axial skeleton development. Development 138(5):1005-14. PubMed: 21303853 MGI: J:169133
Su CY; Bay SN; Mariani LE; Hillman MJ; Caspary T. 2012. Temporal deletion of Arl13b reveals that a mispatterned neural tube corrects cell fate over time. Development 139(21):4062-71. PubMed: 23014696 MGI: J:188997
Sugiyama T; Osumi N; Katsuyama Y. 2014. A novel cell migratory zone in the developing hippocampal formation. J Comp Neurol 522(15):3520-38. PubMed: 24771490 MGI: J:216104
Suhara T; Hishiki T; Kasahara M; Hayakawa N; Oyaizu T; Nakanishi T; Kubo A; Morisaki H; Kaelin WG Jr; Suematsu M; Minamishima YA. 2015. Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle. Proc Natl Acad Sci U S A 112(37):11642-7. PubMed: 26324945 MGI: J:226915
Sultana T; Hou M; Stukenborg JB; Tohonen V; Inzunza J; Chagin AS; Sollerbrant K. 2014. Mice depleted of the coxsackievirus and adenovirus receptor display normal spermatogenesis and an intact blood-testis barrier. Reproduction 147(6):875-83. PubMed: 24625359 MGI: J:212422
Sun L; Guo J; Brown R; Amagai T; Zhao Y; Su DM. 2010. Declining expression of a single epithelial cell-autonomous gene accelerates age-related thymic involution. Aging Cell 9(3):347-57. PubMed: 20156205 MGI: J:216122
Sun LT; Yamaguchi S; Hirano K; Ichisaka T; Kuroda T; Tada T. 2014. Nanog co-regulated by Nodal/Smad2 and Oct4 is required for pluripotency in developing mouse epiblast. Dev Biol 392(2):182-92. PubMed: 24929238 MGI: J:214985
Sun S; Shi G; Han X; Francisco AB; Ji Y; Mendonca N; Liu X; Locasale JW; Simpson KW; Duhamel GE; Kersten S; Yates JR 3rd; Long Q; Qi L. 2014. Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival. Proc Natl Acad Sci U S A 111(5):E582-91. PubMed: 24453213 MGI: J:206568
Surzenko N; Crowl T; Bachleda A; Langer L; Pevny L. 2013. SOX2 maintains the quiescent progenitor cell state of postnatal retinal Muller glia. Development 140(7):1445-56. PubMed: 23462474 MGI: J:194918
Sussan TE; Gajghate S; Chatterjee S; Mandke P; McCormick S; Sudini K; Kumar S; Breysse PN; Diette GB; Sidhaye VK; Biswal S. 2015. Nrf2 reduces allergic asthma in mice through enhanced airway epithelial cytoprotective function. Am J Physiol Lung Cell Mol Physiol 309(1):L27-36. PubMed: 25957295 MGI: J:232447
Suzuki H; Usui I; Kato I; Oya T; Kanatani Y; Yamazaki Y; Fujisaka S; Senda S; Ishii Y; Urakaze M; Mahmood A; Takasawa S; Okamoto H; Kobayashi M; Tobe K; Sasahara M. 2011. Deletion of platelet-derived growth factor receptor-beta improves diabetic nephropathy in Ca(2)/calmodulin-dependent protein kinase IIalpha (Thr286Asp) transgenic mice. Diabetologia 54(11):2953-62. PubMed: 21833587 MGI: J:178358
Suzuki N; Kunishima S; Ikejiri M; Maruyama S; Sone M; Takagi A; Ikawa M; Okabe M; Kojima T; Saito H; Naoe T; Matsushita T. 2013. Establishment of mouse model of MYH9 disorders: heterozygous R702C mutation provokes macrothrombocytopenia with leukocyte inclusion bodies, renal glomerulosclerosis and hearing disability. PLoS One 8(8):e71187. PubMed: 23976996 MGI: J:204923
Szabova L; Son MY; Shi J; Sramko M; Yamada SS; Swaim WD; Zerfas P; Kahan S; Holmbeck K. 2010. Membrane-type MMPs are indispensable for placental labyrinth formation and development. Blood 116(25):5752-61. PubMed: 20858856 MGI: J:167396
Takeda M; Briggs LE; Wakimoto H; Marks MH; Warren SA; Lu JT; Weinberg EO; Robertson KD; Chien KR; Kasahara H. 2009. Slow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiation. Lab Invest 89(9):983-93. PubMed: 19546853 MGI: J:151895
Tang H; Macpherson P; Marvin M; Meadows E; Klein WH; Yang XJ; Goldman D. 2009. A histone deacetylase 4/myogenin positive feedback loop coordinates denervation-dependent gene induction and suppression. Mol Biol Cell 20(4):1120-31. PubMed: 19109424 MGI: J:153383
Tang W; Yang F; Li Y; de Crombrugghe B; Jiao H; Xiao G; Zhang C. 2012. Transcriptional regulation of Vascular Endothelial Growth Factor (VEGF) by osteoblast-specific transcription factor Osterix (Osx) in osteoblasts. J Biol Chem 287(3):1671-8. PubMed: 22110141 MGI: J:180593
Terada R; Warren S; Lu JT; Chien KR; Wessels A; Kasahara H. 2011. Ablation of Nkx2-5 at mid-embryonic stage results in premature lethality and cardiac malformation. Cardiovasc Res 91(2):289-99. PubMed: 21285290 MGI: J:191637
Tilston V; Taylor SS; Perera D. 2009. Inactivating the spindle checkpoint kinase Bub1 during embryonic development results in a global shutdown of proliferation. BMC Res Notes 2:190. PubMed: 19772675 MGI: J:159053
Tober J; Yzaguirre AD; Piwarzyk E; Speck NA. 2013. Distinct temporal requirements for Runx1 in hematopoietic progenitors and stem cells. Development 140(18):3765-76. PubMed: 23924635 MGI: J:204463
Tokunaga A; Oya T; Ishii Y; Motomura H; Nakamura C; Ishizawa S; Fujimori T; Nabeshima Y; Umezawa A; Kanamori M; Kimura T; Sasahara M. 2008. PDGF receptor beta is a potent regulator of mesenchymal stromal cell function. J Bone Miner Res 23(9):1519-28. PubMed: 18410236 MGI: J:152593
Toldo S; Mezzaroma E; McGeough MD; Pena CA; Marchetti C; Sonnino C; Van Tassell BW; Salloum FN; Voelkel NF; Hoffman HM; Abbate A. 2015. Independent roles of the priming and the triggering of the NLRP3 inflammasome in the heart. Cardiovasc Res 105(2):203-12. PubMed: 25524927 MGI: J:230277
Tominaga Y; Li C; Wang RH; Deng CX. 2006. Murine Wee1 plays a critical role in cell cycle regulation and pre-implantation stages of embryonic development. Int J Biol Sci 2(4):161-70. PubMed: 16810330 MGI: J:228492
Tornqvist G; Sandberg A; Hagglund AC; Carlsson L. 2010. Cyclic expression of lhx2 regulates hair formation. PLoS Genet 6(4):e1000904. PubMed: 20386748 MGI: J:159209
Tzeng YS; Li H; Kang YL; Chen WC; Cheng WC; Lai DM. 2011. Loss of Cxcl12/Sdf-1 in adult mice decreases the quiescent state of hematopoietic stem/progenitor cells and alters the pattern of hematopoietic regeneration after myelosuppression. Blood 117(2):429-39. PubMed: 20833981 MGI: J:168434
Udager AM; Prakash A; Saenz DA; Schinke M; Moriguchi T; Jay PY; Lim KC; Engel JD; Gumucio DL. 2014. Proper development of the outer longitudinal smooth muscle of the mouse pylorus requires Nkx2-5 and Gata3. Gastroenterology 146(1):157-65.e10. PubMed: 24120474 MGI: J:228275
Uesaka T; Enomoto H. 2010. Neural precursor death is central to the pathogenesis of intestinal aganglionosis in Ret hypomorphic mice. J Neurosci 30(15):5211-8. PubMed: 20392943 MGI: J:159854
Uesaka T; Jain S; Yonemura S; Uchiyama Y; Milbrandt J; Enomoto H. 2007. Conditional ablation of GFRalpha1 in postmigratory enteric neurons triggers unconventional neuronal death in the colon and causes a Hirschsprung's disease phenotype. Development 134(11):2171-81. PubMed: 17507417 MGI: J:122607
Uesaka T; Nagashimada M; Enomoto H. 2013. GDNF signaling levels control migration and neuronal differentiation of enteric ganglion precursors. J Neurosci 33(41):16372-82. PubMed: 24107967 MGI: J:202753
Uesaka T; Nagashimada M; Yonemura S; Enomoto H. 2008. Diminished Ret expression compromises neuronal survival in the colon and causes intestinal aganglionosis in mice. J Clin Invest 118(5):1890-8. PubMed: 18414682 MGI: J:135153
Vassilopoulos A; Tominaga Y; Kim HS; Lahusen T; Li B; Yu H; Gius D; Deng CX. 2015. WEE1 murine deficiency induces hyper-activation of APC/C and results in genomic instability and carcinogenesis. Oncogene 34(23):3023-35. PubMed: 25088202 MGI: J:222532
Vidal V; Sacco S; Rocha AS; da Silva F; Panzolini C; Dumontet T; Doan TM; Shan J; Rak-Raszewska A; Bird T; Vainio S; Martinez A; Schedl A. 2016. The adrenal capsule is a signaling center controlling cell renewal and zonation through Rspo3. Genes Dev 30(12):1389-94. PubMed: 27313319 MGI: J:233303
Vitari AC; Leong KG; Newton K; Yee C; O'Rourke K; Liu J; Phu L; Vij R; Ferrando R; Couto SS; Mohan S; Pandita A; Hongo JA; Arnott D; Wertz IE; Gao WQ; French DM; Dixit VM. 2011. COP1 is a tumour suppressor that causes degradation of ETS transcription factors. Nature 474(7351):403-6. PubMed: 21572435 MGI: J:172653
Vitre B; Holland AJ; Kulukian A; Shoshani O; Hirai M; Wang Y; Maldonado M; Cho T; Boubaker J; Swing DA; Tessarollo L; Evans SM; Fuchs E; Cleveland DW. 2015. Chronic centrosome amplification without tumorigenesis. Proc Natl Acad Sci U S A 112(46):E6321-30. PubMed: 26578792 MGI: J:228145
Wagnon JL; Mahaffey CL; Sun W; Yang Y; Chao HT; Frankel WN. 2011. Etiology of a genetically complex seizure disorder in Celf4 mutant mice. Genes Brain Behav 10(7):765-77. PubMed: 21745337 MGI: J:181678
Wang G; Wang H; Singh S; Zhou P; Yang S; Wang Y; Zhu Z; Zhang J; Chen A; Billiar T; Monga SP; Wang Q. 2015. ADAR1 Prevents Liver Injury from Inflammation and Suppresses Interferon Production in Hepatocytes. Am J Pathol 185(12):3224-37. PubMed: 26453800 MGI: J:227773
Wang J; Mitsche MA; Luetjohann D; Cohen JC; Xie XS; Hobbs HH. 2014. Relative Roles of ABCG5/ABCG8 in Liver and Intestine. J Lipid Res :. PubMed: 25378657 MGI: J:215443
Wang M; Crisostomo P; Wairiuko GM; Meldrum DR. 2006. Estrogen receptor-alpha mediates acute myocardial protection in females. Am J Physiol Heart Circ Physiol 290(6):H2204-9. PubMed: 16415070 MGI: J:111852
Wang P; Bowl MR; Bender S; Peng J; Farber L; Chen J; Ali A; Zhang Z; Alberts AS; Thakker RV; Shilatifard A; Williams BO; Teh BT. 2008. Parafibromin, a component of the human PAF complex, regulates growth factors and is required for embryonic development and survival in adult mice. Mol Cell Biol 28(9):2930-40. PubMed: 18212049 MGI: J:135255
Wang W; Kissig M; Rajakumari S; Huang L; Lim HW; Won KJ; Seale P. 2014. Ebf2 is a selective marker of brown and beige adipogenic precursor cells. Proc Natl Acad Sci U S A 111(40):14466-71. PubMed: 25197048 MGI: J:216370
Wang X; Duffy P; McGee AW; Hasan O; Gould G; Tu N; Harel NY; Huang Y; Carson RE; Weinzimmer D; Ropchan J; Benowitz LI; Cafferty WB; Strittmatter SM. 2011. Recovery from chronic spinal cord contusion after Nogo receptor intervention. Ann Neurol 70(5):805-21. PubMed: 22162062 MGI: J:201118
Wang XN; Li ZS; Ren Y; Jiang T; Wang YQ; Chen M; Zhang J; Hao JX; Wang YB; Sha RN; Huang Y; Liu X; Hu JC; Sun GQ; Li HG; Xiong CL; Xie J; Jiang ZM; Cai ZM; Wang J; Wang J; Huff V; Gui YT; Gao F. 2013. The Wilms tumor gene, Wt1, is critical for mouse spermatogenesis via regulation of sertoli cell polarity and is associated with non-obstructive azoospermia in humans. PLoS Genet 9(8):e1003645. PubMed: 23935527 MGI: J:200748
Wang Y; Oxer D; Hekimi S. 2015. Mitochondrial function and lifespan of mice with controlled ubiquinone biosynthesis. Nat Commun 6:6393. PubMed: 25744659 MGI: J:221897
Wang Y; Suh YA; Fuller MY; Jackson JG; Xiong S; Terzian T; Quintas-Cardama A; Bankson JA; El-Naggar AK; Lozano G. 2011. Restoring expression of wild-type p53 suppresses tumor growth but does not cause tumor regression in mice with a p53 missense mutation. J Clin Invest 121(3):893-904. PubMed: 21285512 MGI: J:171821
Warren SA; Terada R; Briggs LE; Cole-Jeffrey CT; Chien WM; Seki T; Weinberg EO; Yang TP; Chin MT; Bungert J; Kasahara H. 2011. Differential role of Nkx2-5 in activation of the atrial natriuretic factor gene in the developing versus failing heart. Mol Cell Biol 31(22):4633-45. PubMed: 21930795 MGI: J:178775
Watanabe S; Matsushita S; Hayasaka M; Hanaoka K. 2011. Generation of a conditional null allele of Lbx1. Genesis 49(10):803-10. PubMed: 21956886 MGI: J:178868
Watkins TA; Wang B; Huntwork-Rodriguez S; Yang J; Jiang Z; Eastham-Anderson J; Modrusan Z; Kaminker JS; Tessier-Lavigne M; Lewcock JW. 2013. DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury. Proc Natl Acad Sci U S A 110(10):4039-44. PubMed: 23431164 MGI: J:196076
Welch JS; Yuan W; Ley TJ. 2011. PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice. J Clin Invest 121(4):1636-45. PubMed: 21364283 MGI: J:172024
Welle S; Bhatt K; Pinkert CA; Tawil R; Thornton CA. 2007. Muscle growth after postdevelopmental myostatin gene knockout. Am J Physiol Endocrinol Metab 292(4):E985-91. PubMed: 17148752 MGI: J:121233
Welle S; Cardillo A; Zanche M; Tawil R. 2009. Skeletal muscle gene expression after myostatin knockout in mature mice. Physiol Genomics 38(3):342-50. PubMed: 19509079 MGI: J:157964
Welle S; Mehta S; Burgess K. 2011. Effect of postdevelopmental myostatin depletion on myofibrillar protein metabolism. Am J Physiol Endocrinol Metab 300(6):E993-E1001. PubMed: 21406613 MGI: J:172300
West AP; Khoury-Hanold W; Staron M; Tal MC; Pineda CM; Lang SM; Bestwick M; Duguay BA; Raimundo N; MacDuff DA; Kaech SM; Smiley JR; Means RE; Iwasaki A; Shadel GS. 2015. Mitochondrial DNA stress primes the antiviral innate immune response. Nature 520(7548):553-7. PubMed: 25642965 MGI: J:220373
Whelan G; Kreidl E; Wutz G; Egner A; Peters JM; Eichele G. 2012. Cohesin acetyltransferase Esco2 is a cell viability factor and is required for cohesion in pericentric heterochromatin. EMBO J 31(1):71-82. PubMed: 22101327 MGI: J:180371
Wilcox CL; Terry NA; Walp ER; Lee RA; May CL. 2013. Pancreatic alpha-cell specific deletion of mouse Arx leads to alpha-cell identity loss. PLoS One 8(6):e66214. PubMed: 23785486 MGI: J:203476
Wilhelm JC; Xu M; Cucoranu D; Chmielewski S; Holmes T; Lau KS; Bassell GJ; English AW. 2012. Cooperative roles of BDNF expression in neurons and Schwann cells are modulated by exercise to facilitate nerve regeneration. J Neurosci 32(14):5002-9. PubMed: 22492055 MGI: J:184131
Willems A; De Gendt K; Deboel L; Swinnen JV; Verhoeven G. 2011. The development of an inducible androgen receptor knockout model in mouse to study the postmeiotic effects of androgens on germ cell development. Spermatogenesis 1(4):341-353. PubMed: 22332118 MGI: J:232841
Wu C; Nik-Amini S; Nadesan P; Stanford WL; Alman BA. 2010. Aggressive fibromatosis (desmoid tumor) is derived from mesenchymal progenitor cells. Cancer Res 70(19):7690-8. PubMed: 20841474 MGI: J:164675
Wu ZQ; Rowe RG; Lim KC; Lin Y; Willis A; Tang Y; Li XY; Nor JE; Maillard I; Weiss SJ. 2014. A Snail1/Notch1 signalling axis controls embryonic vascular development. Nat Commun 5:3998. PubMed: 24894949 MGI: J:214991
Xia J; Wang H; Guo J; Zhang Z; Coder B; Su DM. 2012. Age-Related Disruption of Steady-State Thymic Medulla Provokes Autoimmune Phenotype via Perturbing Negative Selection. Aging Dis 3(3):248-59. PubMed: 22724083 MGI: J:196234
Xiang J; Yan S; Li SH; Li XJ. 2015. Postnatal loss of hap1 reduces hippocampal neurogenesis and causes adult depressive-like behavior in mice. PLoS Genet 11(4):e1005175. PubMed: 25875952 MGI: J:224698
Xiang J; Yang H; Zhao T; Sun M; Xu X; Zhou XF; Li SH; Li XJ. 2014. Huntingtin-associated protein 1 regulates postnatal neurogenesis and neurotrophin receptor sorting. J Clin Invest 124(1):85-98. PubMed: 24355921 MGI: J:208015
Xiang J; Yang S; Xin N; Gaertig MA; Reeves RH; Li S; Li XJ. 2017. DYRK1A regulates Hap1-Dcaf7/WDR68 binding with implication for delayed growth in Down syndrome. Proc Natl Acad Sci U S A 114(7):E1224-E1233. PubMed: 28137862 MGI: J:240939
Xiao X; Prasadan K; Guo P; El-Gohary Y; Fischbach S; Wiersch J; Gaffar I; Shiota C; Gittes GK. 2014. Pancreatic duct cells as a source of VEGF in mice. Diabetologia 57(5):991-1000. PubMed: 24535231 MGI: J:210757
Xiao Y; Ma H; Wan P; Qin D; Wang X; Zhang X; Xiang Y; Liu W; Chen J; Yi Z; Li L. 2017. Trp-Asp (WD) Repeat Domain 1 Is Essential for Mouse Peri-implantation Development and Regulates Cofilin Phosphorylation. J Biol Chem 292(4):1438-1448. PubMed: 27994054 MGI: J:239230
Xie L; Pi X; Townley-Tilson WH; Li N; Wehrens XH; Entman ML; Taffet GE; Mishra A; Peng J; Schisler JC; Meissner G; Patterson C. 2015. PHD2/3-dependent hydroxylation tunes cardiac response to beta-adrenergic stress via phospholamban. J Clin Invest 125(7):2759-71. PubMed: 26075818 MGI: J:225429
Xu H; Cerrato F; Baldini A. 2005. Timed mutation and cell-fate mapping reveal reiterated roles of Tbx1 during embryogenesis, and a crucial function during segmentation of the pharyngeal system via regulation of endoderm expansion. Development 132(19):4387-95. PubMed: 16141220 MGI: J:127213
Xu H; Chen L; Baldini A. 2007. In vivo genetic ablation of the periotic mesoderm affects cell proliferation survival and differentiation in the cochlea. Dev Biol 310(2):329-40. PubMed: 17825816 MGI: J:128008
Xu H; Viola A; Zhang Z; Gerken CP; Lindsay-Illingworth EA; Baldini A. 2007. Tbx1 regulates population, proliferation and cell fate determination of otic epithelial cells. Dev Biol 302(2):670-82. PubMed: 17074316 MGI: J:119950
XuFeng R; Boyer MJ; Shen H; Li Y; Yu H; Gao Y; Yang Q; Wang Q; Cheng T. 2009. ADAR1 is required for hematopoietic progenitor cell survival via RNA editing. Proc Natl Acad Sci U S A 106(42):17763-8. PubMed: 19805087 MGI: J:153698
Xue Y; Lim S; Yang Y; Wang Z; Jensen LD; Hedlund EM; Andersson P; Sasahara M; Larsson O; Galter D; Cao R; Hosaka K; Cao Y. 2012. PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cells. Nat Med 18(1):100-10. PubMed: 22138754 MGI: J:180808
Yamaguchi S; Kurimoto K; Yabuta Y; Sasaki H; Nakatsuji N; Saitou M; Tada T. 2009. Conditional knockdown of Nanog induces apoptotic cell death in mouse migrating primordial germ cells. Development 136(23):4011-20. PubMed: 19906868 MGI: J:154977
Yamamoto M; Matsuzaki T; Takahashi R; Adachi E; Maeda Y; Yamaguchi S; Kitayama H; Echizenya M; Morioka Y; Alexander DB; Yagi T; Itohara S; Nakamura T; Akiyama H; Noda M. 2012. The transformation suppressor gene Reck is required for postaxial patterning in mouse forelimbs Biol Open 1(5):458-466. PubMed: 23213437 MGI: J:184585
Yang B; Zhao D; Qian L; Verkman AS. 2006. Mouse model of inducible nephrogenic diabetes insipidus produced by floxed aquaporin-2 gene deletion. Am J Physiol Renal Physiol 291(2):F465-72. PubMed: 16434568 MGI: J:110648
Yang B; Zhao D; Verkman AS. 2009. Hsp90 inhibitor partially corrects nephrogenic diabetes insipidus in a conditional knock-in mouse model of aquaporin-2 mutation. FASEB J 23(2):503-12. PubMed: 18854434 MGI: J:146024
Yang S; Huang S; Gaertig MA; Li XJ; Li S. 2014. Age-dependent decrease in chaperone activity impairs MANF expression, leading to Purkinje cell degeneration in inducible SCA17 mice. Neuron 81(2):349-65. PubMed: 24462098 MGI: J:213011
Yang X; Harkins LK; Zubanova O; Harrington A; Kovalenko D; Nadeau RJ; Chen PY; Toher JL; Lindner V; Liaw L; Friesel R. 2008. Overexpression of Spry1 in chondrocytes causes attenuated FGFR ubiquitination and sustained ERK activation resulting in chondrodysplasia. Dev Biol 321(1):64-76. PubMed: 18582454 MGI: J:138616
Yang Z; Shah K; Khodadadi-Jamayran A; Jiang H. 2016. Dpy30 is critical for maintaining the identity and function of adult hematopoietic stem cells. J Exp Med 213(11):2349-2364. PubMed: 27647347 MGI: J:237262
Yasuhara R; Ohta Y; Yuasa T; Kondo N; Hoang T; Addya S; Fortina P; Pacifici M; Iwamoto M; Enomoto-Iwamoto M. 2011. Roles of beta-catenin signaling in phenotypic expression and proliferation of articular cartilage superficial zone cells. Lab Invest 91(12):1739-52. PubMed: 21968810 MGI: J:180101
Yingling J; Youn YH; Darling D; Toyo-Oka K; Pramparo T; Hirotsune S; Wynshaw-Boris A. 2008. Neuroepithelial stem cell proliferation requires LIS1 for precise spindle orientation and symmetric division. Cell 132(3):474-86. PubMed: 18267077 MGI: J:135521
Youn YH; Pramparo T; Hirotsune S; Wynshaw-Boris A. 2009. Distinct dose-dependent cortical neuronal migration and neurite extension defects in Lis1 and Ndel1 mutant mice. J Neurosci 29(49):15520-30. PubMed: 20007476 MGI: J:156181
Young AP; Schlisio S; Minamishima YA; Zhang Q; Li L; Grisanzio C; Signoretti S; Kaelin WG Jr. 2008. VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400. Nat Cell Biol 10(3):361-9. PubMed: 18297059 MGI: J:145670
Yu L; Su B; Hollomon M; Deng Y; Facchinetti V; Kleinerman ES. 2010. Vasculogenesis Driven by Bone Marrow-Derived Cells Is Essential for Growth of Ewing's Sarcomas. Cancer Res 70(4):1334-43. PubMed: 20124484 MGI: J:157154
Yu PB; Deng DY; Lai CS; Hong CC; Cuny GD; Bouxsein ML; Hong DW; McManus PM; Katagiri T; Sachidanandan C; Kamiya N; Fukuda T; Mishina Y; Peterson RT; Bloch KD. 2008. BMP type I receptor inhibition reduces heterotopic ossification. Nat Med 14(12):1363-9. PubMed: 19029982 MGI: J:142253
Yu S; Sharma R; Nie D; Jiao H; Im HJ; Lai Y; Zhao Z; Zhu K; Fan J; Chen D; Wang Q; Xiao G. 2013. ADAR1 ablation decreases bone mass by impairing osteoblast function in mice. Gene 513(1):101-10. PubMed: 23123729 MGI: J:192270
Yu T; Lieberman AP. 2013. Npc1 acting in neurons and glia is essential for the formation and maintenance of CNS myelin. PLoS Genet 9(4):e1003462. PubMed: 23593041 MGI: J:195479
Yu T; Shakkottai VG; Chung C; Lieberman AP. 2011. Temporal and cell-specific deletion establishes that neuronal Npc1 deficiency is sufficient to mediate neurodegeneration. Hum Mol Genet 20(22):4440-51. PubMed: 21856732 MGI: J:176888
Yu Z; Crichton I; Tang SY; Hui Y; Ricciotti E; Levin MD; Lawson JA; Pure E; Fitzgerald GA. 2012. Disruption of the 5-lipoxygenase pathway attenuates atherogenesis consequent to COX-2 deletion in mice. Proc Natl Acad Sci U S A 109(17):6727-32. PubMed: 22493243 MGI: J:183843
Yuan X; Yao J; Norris D; Tran DD; Bram RJ; Chen G; Luscher B. 2008. Calcium-modulating cyclophilin ligand regulates membrane trafficking of postsynaptic GABA(A) receptors. Mol Cell Neurosci 38(2):277-89. PubMed: 18424167 MGI: J:136913
Yumimoto K; Akiyoshi S; Ueo H; Sagara Y; Onoyama I; Ueo H; Ohno S; Mori M; Mimori K; Nakayama KI. 2015. F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner. J Clin Invest 125(2):621-35. PubMed: 25555218 MGI: J:220397
Zane NA; Gundelach JH; Lindquist LD; Bram RJ. 2012. Essential role for CAML in follicular B cell survival and homeostasis. J Immunol 188(7):3009-18. PubMed: 22351938 MGI: J:183110
Zang T; Maksimova MA; Cowan CW; Bassel-Duby R; Olson EN; Huber KM. 2013. Postsynaptic FMRP bidirectionally regulates excitatory synapses as a function of developmental age and MEF2 activity. Mol Cell Neurosci 56:39-49. PubMed: 23511190 MGI: J:215299
Zhang CL; Zou Y; He W; Gage FH; Evans RM. 2008. A role for adult TLX-positive neural stem cells in learning and behaviour. Nature 451(7181):1004-7. PubMed: 18235445 MGI: J:132664
Zhang DS; Piazza V; Perrin BJ; Rzadzinska AK; Poczatek JC; Wang M; Prosser HM; Ervasti JM; Corey DP; Lechene CP. 2012. Multi-isotope imaging mass spectrometry reveals slow protein turnover in hair-cell stereocilia. Nature 481(7382):520-4. PubMed: 22246323 MGI: J:223627
Zhang L; Wang XH; Wang H; Du J; Mitch WE. 2010. Satellite cell dysfunction and impaired IGF-1 signaling cause CKD-induced muscle atrophy. J Am Soc Nephrol 21(3):419-27. PubMed: 20056750 MGI: J:185857
Zhang MZ; Ferrigno O; Wang Z; Ohnishi M; Prunier C; Levy L; Razzaque M; Horne WC; Romero D; Tzivion G; Colland F; Baron R; Atfi A. 2015. TGIF Governs a Feed-Forward Network that Empowers Wnt Signaling to Drive Mammary Tumorigenesis. Cancer Cell 27(4):547-60. PubMed: 25873176 MGI: J:220301
Zhang Y; Owens K; Hatem L; Glass CH; Karuppaiah K; Camargo F; Perkins AS. 2013. Essential role of PR-domain protein MDS1-EVI1 in MLL-AF9 leukemia. Blood 122(16):2888-92. PubMed: 24021671 MGI: J:204084
Zhang Y; Singh MK; Degenhardt KR; Lu MM; Bennett J; Yoshida Y; Epstein JA. 2009. Tie2Cre-mediated inactivation of plexinD1 results in congenital heart, vascular and skeletal defects. Dev Biol 325(1):82-93. PubMed: 18992737 MGI: J:143763
Zhang Y; Stehling-Sun S; Lezon-Geyda K; Juneja SC; Coillard L; Chatterjee G; Wuertzer CA; Camargo F; Perkins AS. 2011. PR-domain-containing Mds1-Evi1 is critical for long-term hematopoietic stem cell function. Blood 118(14):3853-61. PubMed: 21666053 MGI: J:178429
Zhang Y; Xiang Y. 2016. Molecular and cellular basis for the unique functioning of Nrf1, an indispensable transcription factor for maintaining cell homoeostasis and organ integrity. Biochem J 473(8):961-1000. PubMed: 27060105 MGI: J:239484
Zhang Y; Xiong S; Li Q; Hu S; Tashakori M; Van Pelt C; You MJ; Pageon L; Lozano G. 2014. Tissue-specific and age-dependent effects of global Mdm2 loss. J Pathol 233(4):380-91. PubMed: 24789767 MGI: J:212932
Zhao C; Ma D; Zawadzka M; Fancy SP; Elis-Williams L; Bouvier G; Stockley JH; de Castro GM; Wang B; Jacobs S; Casaccia P; Franklin RJ. 2015. Sox2 Sustains Recruitment of Oligodendrocyte Progenitor Cells following CNS Demyelination and Primes Them for Differentiation during Remyelination. J Neurosci 35(33):11482-99. PubMed: 26290228 MGI: J:226017
Zheng QS; Wang XN; Wen Q; Zhang Y; Chen SR; Zhang J; Li XX; Sha RN; Hu ZY; Gao F; Liu YX. 2014. Wt1 deficiency causes undifferentiated spermatogonia accumulation and meiotic progression disruption in neonatal mice. Reproduction 147(1):45-52. PubMed: 24129152 MGI: J:206534
Zheng Y; Zhang H; Wang Y; Li X; Lu P; Dong F; Pang Y; Ma S; Cheng H; Hao S; Tang F; Yuan W; Zhang X; Cheng T. 2016. Loss of Dnmt3b accelerates MLL-AF9 leukemia progression. Leukemia 30(12):2373-2384. PubMed: 27133822 MGI: J:237877
Zhong Z; Umemura A; Sanchez-Lopez E; Liang S; Shalapour S; Wong J; He F; Boassa D; Perkins G; Ali SR; McGeough MD; Ellisman MH; Seki E; Gustafsson AB; Hoffman HM; Diaz-Meco MT; Moscat J; Karin M. 2016. NF-kappaB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria. Cell 164(5):896-910. PubMed: 26919428 MGI: J:230797
Zhou X; Zhang Z; Feng JQ; Dusevich VM; Sinha K; Zhang H; Darnay BG; de Crombrugghe B. 2010. Multiple functions of Osterix are required for bone growth and homeostasis in postnatal mice. Proc Natl Acad Sci U S A 107(29):12919-24. PubMed: 20615976 MGI: J:162306
de Renty C; Kaneko KJ; DePamphilis ML. 2014. The dual roles of geminin during trophoblast proliferation and differentiation. Dev Biol 387(1):49-63. PubMed: 24412371 MGI: J:208821
van de Ven C; Bialecka M; Neijts R; Young T; Rowland JE; Stringer EJ; Van Rooijen C; Meijlink F; Novoa A; Freund JN; Mallo M; Beck F; Deschamps J. 2011. Concerted involvement of Cdx/Hox genes and Wnt signaling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone. Development 138(16):3451-62. PubMed: 21752936 MGI: J:180902

Also Known As: Trpa1 CKO/CKO deltaNeo Tg(cre/Esr1)5Amc/J

Donating Investigator

Genetic overview

Research Applications

Base Price

Detailed Description

Development

Expression Data

Control Suggestions

Additional Information

Selected References

Tg(CAG-cre/Esr1*)5Amc

Allele Symbol: Tg(CAG-cre/Esr1*)5Amc

Trpa1tm2Kykw

Allele Symbol: Trpa1tm2Kykw

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

References

Additional - Tg(CAG-cre/Esr1*)5Amc related

Genotyping Protocols

Breeding Considerations

Mating System

Citation

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Live Mouse

Cryorecovery - Pricing

Progeny testing is not required

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms of Use

Additional Use Restrictions Apply

Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

Trpa1^tm2Kykw

Allele Symbol: Trpa1^tm2Kykw