These mice possess loxP sites on either side of the exon 3-6 region of the targeted gene. Mice that are homozygous for this floxed allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific expression of orphan nuclear receptor RORgamma, including the RORgammaT thymus-specific isoform. Germline deletion of RORgamma and RORgammaT induces an abnormality in lymphoid organ development, survival of CD4+ CD8+ double positive thymocytes, and differentiation of Th17 helper T cells.

These floxed mutant mice possess loxP sites flanking the exon 3-6 region of the Rorc gene. This strain is useful in eliminating tissue-specific expression of orphan nuclear receptor ROR&gamma;, which results in abnormality of lymphoid organ development, survival of CD4+ CD8+ double positive thymocytes, and differentiation of Th17 helper T cells.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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