This spontaneous, dominant vestibular mutation causes heterozygotes to display head tossing, mild circling phenotype, elevated ABR thresholds, and an increased propensity to develop otitis media.
Read More +Genetic Background | Generation |
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000659 C3H/HeJ |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous (Not Specified) | Varc | variable circling |
The variable circling mutation (Varc) is dominant and causes heterozygotes to display head tossing, mild circling phenotype, elevated ABR thresholds compared with their wild-type siblings or C3H/HeJ controls, and increased propensity to develop otitis media. One mutant was assessed in a swim test and failed to orient in water. This mutation mapped to Chromosome 10, likely between D10Mit194 and D10Mit95.
The Varc mutation arose spontaneously in the C3H/HeJ inbred strain at The Jackson Laboratory when that inbred was at generation F226. This dominant phenotypic deviant was maintained by continuous backcross of a heterozygote to a C3H/HeJ and sperm was cryopreserved from heterozygous males at generation N9.
Allele Name | variable circling |
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Allele Type | Spontaneous (Not Specified) |
Allele Synonym(s) | |
Gene Symbol and Name | Varc, variable circling |
Gene Synonym(s) | |
Strain of Origin | C3H/HeJ |
Chromosome | 10 |
Molecular Note | This heritable phenotype arose spontaneously in C3H/HeJ at The Jackson Laboratory and was mapped to Chromosome 10. |
When using the variable circling mouse strain in a publication, please cite the originating article(s) and include JAX stock #008697 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous or wildtype for Varc |
Frozen Mouse Embryo | C3H/HeJ-Varc/J | $2595.00 |
Frozen Mouse Embryo | C3H/HeJ-Varc/J | $2595.00 |
Frozen Mouse Embryo | C3H/HeJ-Varc/J | $3373.50 |
Frozen Mouse Embryo | C3H/HeJ-Varc/J | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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