C3H/HeJ-Varc/J

Stock number: 008697
Product name: variable circling
Research areas: Sensorineural Research

Description

This spontaneous, dominant vestibular mutation causes heterozygotes to display head tossing, mild circling phenotype, elevated ABR thresholds, and an increased propensity to develop otitis media.

Detailed description

The variable circling mutation (Varc) is dominant and causes heterozygotes to display head tossing, mild circling phenotype, elevated ABR thresholds compared with their wild-type siblings or C3H/HeJ controls, and increased propensity to develop otitis media. One mutant was assessed in a swim test and failed to orient in water. This mutation mapped to Chromosome 10, likely between D10Mit194 and D10Mit95.

Development

The Varc mutation arose spontaneously in the C3H/HeJ inbred strain at The Jackson Laboratory when that inbred was at generation F226. This dominant phenotypic deviant was maintained by continuous backcross of a heterozygote to a C3H/HeJ and sperm was cryopreserved from heterozygous males at generation N9.

Allele

Symbol: Varc
Name: variable circling
MGI accession ID: MGI:3764556
Generation method: Spontaneous
Attributes: Not Specified
Marker symbol: Varc
Marker name: variable circling
Chromosome: 10
Strain of origin: C3H/HeJ
Molecular note: This heritable phenotype arose spontaneously in C3H/HeJ at The Jackson Laboratory and was mapped to Chromosome 10.