This spontaneous, dominant vestibular mutation causes heterozygotes to display head tossing, mild circling phenotype, elevated ABR thresholds, and an increased propensity to develop otitis media.Read More +
The variable circling mutation (Varc) is dominant and causes heterozygotes to display head tossing, mild circling phenotype, elevated ABR thresholds compared with their wild-type siblings or C3H/HeJ controls, and increased propensity to develop otitis media. One mutant was assessed in a swim test and failed to orient in water. This mutation mapped to Chromosome 10, likely between D10Mit194 and D10Mit95.
The Varc mutation arose spontaneously in the C3H/HeJ inbred strain at The Jackson Laboratory when that inbred was at generation F226. This dominant phenotypic deviant was maintained by continuous backcross of a heterozygote to a C3H/HeJ and sperm was cryopreserved from heterozygous males at generation N9.
|Allele Name||variable circling|
|Allele Type||Spontaneous (Not Specified)|
|Gene Symbol and Name||Varc, variable circling|
|Strain of Origin||C3H/HeJ|
|Molecular Note||This heritable phenotype arose spontaneously in C3H/HeJ at The Jackson Laboratory and was mapped to Chromosome 10.|