Mice homozygous for the misplaced ears mutation have low set, laterally protruding ears. Fewer homozygotes than standard Mendelian genetics predicts are produced from heterozygous intercrosses. This strain is a model for oculo-auricular syndrome.
Read More +Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Spontaneous | Hmx1 | H6 homeobox 1 |
Mice homozygous for the misplaced ears mutation have low set, laterally protruding ears. Fewer homozygotes than standard Mendelian genetics predicts are produced from heterozygous intercrosses. This strain is a model for oculo-auricular syndrome.
The misplaced ears mutation arose spontaneously on the C3H/HeJ background at The Jackson Laboratory in 1998 and has been maintained on this inbred background since that time.
Allele Name | misplaced ears |
---|---|
Allele Type | Spontaneous |
Allele Synonym(s) | |
Gene Symbol and Name | Hmx1, H6 homeobox 1 |
Gene Synonym(s) | |
Strain of Origin | C3H/HeJ |
Chromosome | 5 |
Molecular Note | An 8 base pair deletion in the region of exon 2, which encodes the homeodomain, results in a frameshift beginning at amino acid 226 that is predicted to replace the C-terminal 106 amino acids with an anomalous 171 amino acids. |
When using the C3H/HeJ-Hmx1mpe/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #008676 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous for mpe |
Frozen Mouse Embryo | C3H/HeJ-Hmx1<mpe>/J | $2595.00 |
Frozen Mouse Embryo | C3H/HeJ-Hmx1<mpe>/J | $2595.00 |
Frozen Mouse Embryo | C3H/HeJ-Hmx1<mpe>/J | $3373.50 |
Frozen Mouse Embryo | C3H/HeJ-Hmx1<mpe>/J | $3373.50 |
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
What information were you hoping to find through your search?
How easy was it to find what you were looking for?
We may wish to follow up with you. Enter your email if you are happy for us to connect and reachout to you with more questions.
Please Enter a Valid Email Address
Thank you for sharing your feedback! We are working on improving the JAX Mice search. Come back soon for exciting changes.