These mice possess <i>loxP</i> sites on either side of exon 2 in the targeted gene. Mice that are homozygous for this floxed allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities.  When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific expression of the gene to elucidate the gene's function. 

<p> For example, when crossed to a strain expressing Cre recombinase in pancreatic beta cells (see Stock No. <a href="https://www.jax.org/strain/003573">003573</a>), this mutant mouse strain may be useful in studies of beta cell development and insulin secretion.

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These mice possess loxP sites on either side of exon 2 in the kinesin family member 5B gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific expression of the gene to elucidate the gene's function.

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