Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities.  No gene product (mRNA) is detected by RT-PCR analysis.  Homozygotes are indistinguishable from wildtype when maintained on <i> ad libitum </i> diet.  After fasting, male homozygotes consume less food than wildtype controls.  When fed a high fat diet homozygotes gain less weight than wildtype controls.  This mutant mouse strain may be useful in studies of energy homeostasis, nutrition and obesity.

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Mice homozygous for this <i>Galp</i> (galanin-like peptide) targeted mutation gain less weight than wildtype controls when fed a high fat diet.  This mutant mouse strain may be useful in studies of energy homeostasis, nutrition and obesity.

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