LacZ was inserted into exon one of the Cxcl14 (chemokine (C-X-C motif) ligand 14) gene. No overt phenotype has as yet been observed. This strain may be useful in studies elucidating the role of this gene. The published literature suggests potential roles in the areas of immunology, development, and diabetes/obesity, among others.
Dr. Dan R. Littman, New York University Medical Center
Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Targeted | Cxcl14 | chemokine (C-X-C motif) ligand 14 |
LacZ (expression untested) was inserted into exon one of the gene. No overt phenotype has as yet been observed. This strain may be useful in studies elucidating the role of this gene. The published literature suggests potential roles in the areas of immunology, development, and diabetes/obesity, among others. Homozygotes are viable and fertile.
LacZ cDNA was knocked into exon 1 of the gene immediately after the endogenous start codon ATG. The construct was electroporated into 129P2/OlaHsd-derived E14 embryonic stem (ES) cells. The line was backcrossed 3 times to C57BL/6.
Expressed Gene | lacZ, beta-galactosidase, E. coli |
---|---|
Site of Expression |
Allele Name | targeted mutation 1, Dan R Littman |
---|---|
Allele Type | Targeted |
Allele Synonym(s) | |
Gene Symbol and Name | Cxcl14, chemokine (C-X-C motif) ligand 14 |
Gene Synonym(s) | |
Expressed Gene | lacZ, beta-galactosidase, E. coli |
Strain of Origin | 129P2/OlaHsd |
Chromosome | 13 |
Molecular Note | LacZ cDNA was knocked into exon 1 of the gene immediately after the endogenous start codon ATG. The construct was electroporated into 129P2/OlaHsd-derived E14 embryonic stem (ES) cells. The line was backcrossed 3 times to C57BL/6. |
Mutations Made By | Dr. Dan Littman, New York University Medical Center |
When maintained as a live colony, heterozygotes or homozygotes may be bred.
When using the B6;129P2-Cxcl14tm1Litt/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #008590 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous or wildtype for Cxcl14<tm1Litt> |
Frozen Mouse Embryo | B6;129P2-Cxcl14<tm1Litt>/J | $2595.00 |
Frozen Mouse Embryo | B6;129P2-Cxcl14<tm1Litt>/J | $2595.00 |
Frozen Mouse Embryo | B6;129P2-Cxcl14<tm1Litt>/J | $3373.50 |
Frozen Mouse Embryo | B6;129P2-Cxcl14<tm1Litt>/J | $3373.50 |
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
What information were you hoping to find through your search?
How easy was it to find what you were looking for?
We may wish to follow up with you. Enter your email if you are happy for us to connect and reachout to you with more questions.
Please Enter a Valid Email Address
Thank you for sharing your feedback! We are working on improving the JAX Mice search. Come back soon for exciting changes.