Mice that are homozygous for the mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities.  Screening of third generation mice (G3) on standard chow identified a 8 week old male (born 9/15/2002) with a n4 hour fasted plasma total cholesterol of 17 mg/dl and HDL cholesterol of 15 mg/dl,  which is approximately 85% and 79% lower than controls, respectively. This mutant mouse strain may be useful in studies of cholesterol homeostasis.

These mice carry an ENU induced mutation that results in reduced plasma total cholesterol  and HDL cholesterol levels.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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