These mice carry an ENU induced mutation that results in elevated blood pressure.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Chemically induced (ENU) | Hlb426 | heart, lung and blood, 426 |
Mice that are homozygous for the mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Screening of third generation mice (G3) on atherogenic diet for 1 week identified a female (born 3/31/2004) with a a systolic blood pressure of 142 +/- 12 mmHg, which is approximately 30% higher than controls. Retest 6 weeks later confirmed the phenotype. This mutant mouse strain may be useful in studies of hypertension.
This phenotypic deviant was identified following multidose ethylnitrosourea (ENU) treatments to induce mutations in male founder C57BL/6J mice (Stock No. 000664), in complex heart, lung, blood, and sleep disorders at the Mouse Heart, Lung, Blood, and Sleep Disorders (HLBS) Center at The Jackson Laboratory.
When using the C57BL/6J-Hlb426/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #008411 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous for Hlb426 |
Frozen Mouse Embryo | C57BL/6J-Hlb426/J Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | C57BL/6J-Hlb426/J Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | C57BL/6J-Hlb426/J Frozen Embryo | $3373.50 |
Frozen Mouse Embryo | C57BL/6J-Hlb426/J Frozen Embryo | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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