Mice that are homozygous for the mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Screening of third generation mice (G3) on atherogenic diet for 1 week identified a female (born 3/31/2004) with a a systolic blood pressure of 142 +/- 12 mmHg, which is approximately 30% higher than controls. Retest 6 weeks later confirmed the phenotype. This mutant mouse strain may be useful in studies of hypertension.
This phenotypic deviant was identified following multidose ethylnitrosourea (ENU) treatments to induce mutations in male founder C57BL/6J mice (Stock No. 000664), in complex heart, lung, blood, and sleep disorders at the Mouse Heart, Lung, Blood, and Sleep Disorders (HLBS) Center at The Jackson Laboratory.