These mice possess loxP sites flanking the 3 exons encoding the active-site tyrosyl residue of the targeted gene. Mice that are homozygous for this allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. When these mutant mice are bred to mice that express Cre recombinase, resulting offspring will have the 3 exons deleted in the cre-expressing tissue(s).
When bred to a strain expressing Cre recombinase during spermatogenesis (see Stock No. 003328 for example), this mutant mouse strain may be useful in studies of neural development.
When bred to a strain expressing Cre recombinase in the telencephalon and discreet head structures (see Stock No. 004337, 006084 for example), this mutant mouse strain may be useful in studies of corticogenesis.
