Cells from these targeted mutant mice exhibit abnormally increased immune cell adhesion and reduced motility, resulting from augmented exocytosis of &beta;2 integrin-containing granules.  Also, the cortical actin that normally co-localizes with this gene's product is reduced in homozygous targeted mice.  The animals show increased <i>in vivo</i> susceptibility to infection by <i>Listeria monocytogenes</i> and an impaired neutrophil response.  This strain may be useful in studies of immune cell motility and innate host defence against infection. Homozygous targeted mice are viable, fertile and have no obvious developmental defects. 

Cells from these Myo1f (myosin IF) targeted mutant mice exhibit abnormally increased immune cell adhesion and reduced motility, resulting from augmented exocytosis of B2 integrin-containing granules. Also, the cortical actin that normally co-localizes with this gene's product is reduced in homozygous targeted mice. The animals show increased  in vivo susceptibility to infection by Listeria monocytogenes and an impaired neutrophil response. This strain may be useful in studies of immune cell motility and innate host defence against infection.

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