These mice possess <i>loxP</i> sites on either side of exon 2 in the targeted gene. Mice that are homozygous for the floxed allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific expression of the gene. Homozygous knock out mice are embryonic lethal. Literature associated with this gene suggests the mice may be useful in studies of reproduction, development, the cardiovascular system and cancer. 

These mice possess <i>loxP</i> sites on either side of exon 2 in the Smad1, MAD homolog 1 (Drosophila) gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific expression of the gene. Literature associated with this gene suggests the mice may be useful in studies of reproduction, development, the cardiovascular system and cancer.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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