Mice that are homozygous for the mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Screening of third generation mice (G3) on standard chow identified a 7 week old female (born 4/16/2002) with a white blood cell count of 2.7 x 103 cells/ul, which is approximately 66% lower than controls. Retesting 2 weeks later confirmed the phenotype. This mutant mouse strain may be useful in studies of leukopenia.
This phenotypic deviant was identified following multidose ethylnitrosourea (ENU) treatments to induce mutations in male founder C57BL/6J mice (Stock No. 000664), in complex heart, lung, blood, and sleep disorders at the Mouse Heart, Lung, Blood, and Sleep Disorders (HLBS) Center at The Jackson Laboratory.
|Allele Name||heart, lung and blood, 145|
|Allele Type||Chemically induced (ENU)|
|Gene Symbol and Name||hlb145, heart, lung and blood, 145|
|Strain of Origin||C57BL/6J|
|Molecular Note||This mutation was discovered in an ENU mutagenesis screen for blood anomalies.|