JAX Mouse Strain Datasheet - 008228

C3.129S7(B6)-Ifng^tm1Ts/J

Stock No:: 008228

Cryo Recovery

Overview

Mice that are homozygous for this Ifng (interferon-gamma) targeted mutation are resistant to experimentally induced alopecia areata. Leukocytes from homozygotes do not respond to antigens or activated inflammatory cells. This mutant mouse strain may be useful in studies of immune response, inflammation and autoimmunity.

Donating Investigator

John P Sundberg, The Jackson Laboratory

Genetic overview

Genetic Background	Generation

Ifng^tm1Ts

Allele Type	Gene Symbol	Gene Name
Targeted (Null/Knockout)	Ifng	interferon gamma

View Genetics

Research Applications

Immunology, Inflammation and Autoimmunity Research
Cancer Research
Hematological Research

View All Research Applications

Base Price

Starting at:

$2,595.00 Domestic price Cryo Recovery

View Price List

Details

Detailed Description

Leukocytes do not respond to and Th1 cells are not activated by skin grafts in homozygous mice. Homozygotes are resistant to experimentally induced alopecia areata with diminished T cell infiltration in skin and reduced MHC class I and II molecule expression in the hair follicle infrainfundibular site. No gene product (protein) is detected by ELISA analysis of splenocyte supernatants from homozygous animals. Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. This mutant mouse strain may be useful in studies of immune response, inflammation and autoimmunity.

Development

A targeting vector containing a neo cassette was used to disrupt exon 2. The construct was electroporated into 129S7/SvEvBrd-Hprt1⁺ derived AB1 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient C57BL/6J blastocysts. The resulting mice were backcrossed onto the C57BL/6 background for eight generations by the donating investigator before arriving at The Jackson Laboratory. These B6.129S7-Ifng^tm1Ts/J (Stock No. 002287) mice were then backcrossed to C3H/HeJ for nine generations.

Control Suggestions

000659 C3H/HeJ

Additional Information

Considerations for Choosing Controls

Selected References

Dalton DK; Pitts-Meek S; Keshav S; Figari IS; Bradley A; Stewart TA. 1993. Multiple defects of immune cell function in mice with disrupted interferon-gamma genes [see comments] Science 259(5102):1739-42. PubMed: 8456300 MGI: J:66802

View All References

Genetics

Ifng^tm1Ts

Allele Symbol: Ifng^tm1Ts

Allele Name	targeted mutation 1, Timothy Stewart
Allele Type	Targeted (Null/Knockout)
Allele Synonym(s)	GKO; IFN-g KO; IFN-gamma KO; IFN-gamma-; IFN-gamma^tm1Ts; IFN-gammaKO; IFNgamma KO; IFNgamma-; Ifn-g^tm1Ts; Ifn^tm/Ts; Ifng^tm1Ts; Ifngtm1Ts; gko; ifg^tm1; ifn^tm1Ts; ifng^-
Gene Symbol and Name	Ifng, interferon gamma
Gene Synonym(s)	IFG; IFI; IFN-gamma; IFNG2; Ifg; Ifg
Strain of Origin	129S7/SvEvBrd-Hprt<+>
Chromosome	10
Molecular Note	Insertion of a neomycin gene into exon 2, which introduced a termination codon after the first 30 amino acids of the mature protein.
Mutations Made By	Dr. Timothy Stewart

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Immunology, Inflammation and Autoimmunity Research
- Growth Factors/Receptors/Cytokines

Genotype: Ifng^tm1Ts related

Cancer Research
- Growth Factors/Receptors/Cytokines
Hematological Research
- Immunological Defects
Immunology, Inflammation and Autoimmunity Research
- Growth Factors/Receptors/Cytokines
- Immunodeficiency
  - multiple immune defects
- Inflammation

Mammalian Phenotype Terms by Genotype

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Ifng^tm1Ts/Ifng^tm1Ts
involves: 129S7/SvEvBrd * C57BL/6

growth/size/body region phenotype

abnormal alveolar process morphology
- modest increase in alveolar bone loss at 30 weeks relative to mice at 6 and 16 weeks

immune system phenotype

abnormal MHC II cell surface expression on macrophages
- macrophages from BCG infected mice exhibit reduced class II expression

abnormal NK cell physiology
- however, the recruitment of T cells by IL12 is not impaired
- recruitment of NK cells to the liver by recombinant murine IL12 is impaired
- significantly lower resting splenic NK cell activity

abnormal macrophage physiology
- macrophages from BCG infected mice exhibit reduced production of superoxide anion in response to PMA challenge
- macrophages from BCG infected mice fail to produce nitric oxide in response to LPS challenge

abnormal type IV hypersensitivity reaction
- exposure to UVA and UVB fails to significantly reduce the UVB induced suppression of the type IV hypersensitivity reaction
- however, the type IV hypersensitivity reaction in the absence of UV exposure is similar to controls

decreased length of allograft survival
- reduced surival of cardiac grafts relative to controls

decreased susceptibility to parasitic infection
- however, IFNG-competent alpha+CD4+ T cells promote experimental cerebral malaria
- mice infected with Plasmodium berghei ANKA are protected from development of experimental cerebral malaria and survive longer than wild-type mice

decreased susceptibility to parasitic infection induced morbidity/mortality
- mice infected with Plasmodium berghei ANKA are protected from development of experimental cerebral malaria and survive longer than wild-type mice

immune system phenotype
- mice are able to clear infections of Pneumocystis carinii, similar to controls

increased splenocyte proliferation
- splenocytes from BCG infected mice exhibit increased proliferation in response to Con A

increased susceptibility to bacterial infection
- increased mortality following a sublethal dose of Mycobacterium bovis (BCG )

neoplasm

decreased tumor incidence
- tumor-bearing mice treated with Th-17-polarized cells from Tg(Tcra,Tcrb)9Rest cells show increased tumor rejection compared to controls

increased metastatic potential
- following treatment with alphaGalCer, mice fail to exhibit a reduction in the number of B16F10 tumors metastasizing to the lungs unlike similarly treated wild-type mice

craniofacial phenotype

abnormal alveolar process morphology
- modest increase in alveolar bone loss at 30 weeks relative to mice at 6 and 16 weeks

skeleton phenotype

abnormal alveolar process morphology
- modest increase in alveolar bone loss at 30 weeks relative to mice at 6 and 16 weeks

hematopoietic system phenotype

abnormal MHC II cell surface expression on macrophages
- macrophages from BCG infected mice exhibit reduced class II expression

abnormal NK cell physiology
- however, the recruitment of T cells by IL12 is not impaired
- recruitment of NK cells to the liver by recombinant murine IL12 is impaired
- significantly lower resting splenic NK cell activity

abnormal macrophage physiology
- macrophages from BCG infected mice exhibit reduced production of superoxide anion in response to PMA challenge
- macrophages from BCG infected mice fail to produce nitric oxide in response to LPS challenge

increased splenocyte proliferation
- splenocytes from BCG infected mice exhibit increased proliferation in response to Con A

integument phenotype

abnormal skin physiology
- following exposure to UVA and UVB mice fail to develop significant erythema unlike wild-type controls
- however, the increase in skin fold thickness in response to UVB or UVA and UVB exposure is not significantly different from controls

cellular phenotype

increased splenocyte proliferation
- splenocytes from BCG infected mice exhibit increased proliferation in response to Con A

mortality/aging

decreased susceptibility to parasitic infection induced morbidity/mortality
- mice infected with Plasmodium berghei ANKA are protected from development of experimental cerebral malaria and survive longer than wild-type mice

Genotype: Ifng^tm1Ts/Ifng^tm1Ts
involves: 129S7/SvEvBrd * BALB/c

immune system phenotype

altered susceptibility to infection
- mice are able to clear infectious Murine gammaherpesvirus 68 (MHV-68) from their lungs but with a slight delay relative wild-type mice
- no differences are detected in the frequency of latently infected cells, the generation of cytotoxic T cells, the infection induced cytokine profile, or the recruitment or proliferation of cells into inflammatory sites

decreased IgE level
- ovalbumin challenge fails to significantly potentiate ovalbumin specific IgE levels, unlike in wild-type controls

decreased inflammatory response
- the eosinophilic response in ovalbumin challenged mice is reduced compared to wild-type controls

immune system phenotype
- no difference in survival, tissue damage or spread of infection following infection with the opportunistic fungal pathogen Candida albicans is detected relative to wild-type controls

respiratory system phenotype

decreased airway responsiveness
- ovalbumin challenge fails to induce airway hyperresponsiveness unlike in wild-type mice

increased airway responsiveness
- in saline challenged mice relative to wild-type controls

hematopoietic system phenotype

decreased IgE level
- ovalbumin challenge fails to significantly potentiate ovalbumin specific IgE levels, unlike in wild-type controls

Genotype: Ifng^tm1Ts/Ifng^tm1Ts
involves: 129S7/SvEvBrd * A/WySn * C57BL/10SnSg * Swiss

immune system phenotype

decreased IgG level
- decrease in the induction of IgG in response to low levels of antigen ((4-hydroxy-3 nitrophenyl)acetyl)

decreased IgG2a level
- following exposure to HgCl2 for 4 weeks, relative to similarly treated wild-type and heterozygous mice

decreased susceptibility to autoimmune disorder
- resistant to mercury induced autoimmune response

increased IgG1 level
- however, mercury treatment does not result in an increase in IgG1 levels
- relative to wild-type controls

homeostasis/metabolism phenotype

decreased physiological sensitivity to xenobiotic
- resistant to mercury induced autoimmune response

hematopoietic system phenotype

decreased IgG level
- decrease in the induction of IgG in response to low levels of antigen ((4-hydroxy-3 nitrophenyl)acetyl)

decreased IgG2a level
- following exposure to HgCl2 for 4 weeks, relative to similarly treated wild-type and heterozygous mice

increased IgG1 level
- however, mercury treatment does not result in an increase in IgG1 levels
- relative to wild-type controls

Genotype: Ifng^tm1Ts/Ifng^tm1Ts
involves: 129S7/SvEvBrd * NOD

immune system phenotype

immune system phenotype
- Background Sensitivity - at generation N4 no difference is seen in the time course of diabetes development in females unlike in mice at generation N7

Genotype: Ifng^tm1Ts/Ifng^tm1Ts
B6.129S7-Ifng^tm1Ts/J

mortality/aging

increased sensitivity to xenobiotic induced morbidity/mortality
- increase in mortality following a single dose of N-methyl-N-nitrosourea (MNU) compared to similarly treated wild-type controls

increased susceptibility to bacterial infection induced morbidity/mortality
- die by 6 - 10 weeks after infection with the avirulent BCG strain of Mycobacterium bovis

increased susceptibility to parasitic infection induced morbidity/mortality
- most mice die by 9 days after infection with 1x10⁶ Cryptosporidium parvum oocysts

immune system phenotype

abnormal Langerhans cell physiology
- enhancement in hapten induced Langerhan cell migration to the draining lymph nodes

abnormal circulating cytokine level
- increase in circulating levels of CSF3 after infection with BCG especially in moribund mice

abnormal cytokine secretion

abnormal dendritic cell antigen presentation
- dendritic cells show a greater ability to stimulate T cell proliferation in vitro

abnormal dendritic cell chemotaxis
- enhancement in LPS induced dendritic cell migration to the spleen
- enhancement in the ability of dendritic cells to transmigrate across a membrane in response to RANTES in vitro

abnormal dendritic cell physiology
- increase in IL12 and decrease in IL10 secretion following LPS stimulation

abnormal humoral immune response
- however, following oral OVA exposure OVA antibody levels in response to subcutaneous OVA challenge are essentially unchanged unlike in wild-type controls where oral exposure reduces antibody levels
- the magnitude of the OVA specific antibody response to subcutaneous OVA challenge is reduced

abnormal immune tolerance
- oral exposure to antigen (OVA) fails to reduce the responsiveness of mice to subsequent subcutaneous exposure to the same antigen

abnormal immunoglobulin level
- IgG responses are restricted to IgG1 and IgG2b

abnormal macrophage chemotaxis
- 5 days after muscle injury fewer macrophages are present at the injury site compared to similarly treated wild-type mice

abnormal spleen morphology

abnormal spleen red pulp morphology
- following infection with BCG, the normal follicular structure of the red and white pulp is lost and the red pulp is replaced with extramedullary hematopoietic tissue

abnormal spleen white pulp morphology
- following infection with BCG, the normal follicular structure of the red and white pulp is lost and the lymphocytic populations of the white pulp are replaced with sheets of leukocytes

abnormal type IV hypersensitivity reaction
- in OVA fed mice only a modest decrease in the delayed type hypersensitivity response to injected OVA is seen in contrast this reaction is strongly decreased in similarly treated wild-type controls

decreased interferon-gamma secretion
- splenocytes fail to produce IFN-gamma in response to H. pylori antigen stimulation

decreased interleukin-10 secretion
- by bone marrow dendritic cells following LPS stimulation
- splenocytes from Helicobacter pylori infected mice produce 4-fold less IL-10 when cultured in the presence of H. pylori antigen

decreased length of allograft survival
- decrease in survival times of heart transplants from CBA mice after a 30 day course of anti-CD4 and anti-CD8 mAb
- only 10% of heart grafts survive more than 100 days compared to 36% of grafts in wild-type mice

enlarged mesenteric lymph nodes
- in C. parvum infected mice

enlarged spleen
- develop splenomegaly after infection with BCG

glomerulonephritis
- increased susceptibility to induced accelerated antiglomerular basement membrane nephritis as determined by increased albuminuria and more severe pathological changes

immune system phenotype
- do not exhibit defects on either IgE isotype switch or IgE production

increased NK T cell number
- unlike in wild-type mice, treatment with LPS and DGalN fails to decrease NK T cell numbers

increased circulating interleukin-6 level
- following infection with BCG

increased granulocyte number
- in the blood, bone marrow and spleen following infection with BCG

increased interleukin-12 secretion
- by bone marrow dendritic cells following LPS stimulation

increased interleukin-4 secretion
- splenocytes from Helicobacter pylori infected mice produce significantly more IL-4 than splenocytes from wild-type controls when cultured in the presence of H. pylori antigen

increased leukocyte cell number
- following infection with BCG

increased monocyte cell number
- following infection with BCG

increased susceptibility to bacterial infection
- following infection with BCG mice develop numerous granulomatous lesions in the liver and necrosis of both the liver and spleen
- following infection with BCG mice display an increased bacterial load throughout the infect in contrast to wild-type mice where bacterial numbers peak at 17 days post infection and decline thereafter

increased susceptibility to bacterial infection induced morbidity/mortality
- die by 6 - 10 weeks after infection with the avirulent BCG strain of Mycobacterium bovis

increased susceptibility to parasitic infection
- Background Sensitivity - in C. parvum infected mice on a C57BL/6 background, but not on a BALB/c background, the gastrointestinal tract is heavily colonized with parasites, the small intestines are distended and filled with gelatinous fluid, mesenteric lymph nodes are enlarged and in about 50% of mice gallbladders are enlargedd in about 50% of mice gallbladders are enlarged
- Background Sensitivity - mice on a C57BL/6 background lose weight and develop soft gelatinous stools over the course of a C. parvum infection while mice on a BALB/c background do not

increased susceptibility to parasitic infection induced morbidity/mortality
- most mice die by 9 days after infection with 1x10⁶ Cryptosporidium parvum oocysts

increased susceptibility to type IV hypersensitivity reaction
- display a more severe delayed type hypersensitivity reaction in response to sheep IgG

pale spleen
- spleens become paler as BCG infection proceeds

stomach inflammation
- 5 weeks after Helicobacter pylori infection, mice have a significantly decreased gastritis inflammation score compared to infected wild-type mice

behavior/neurological phenotype

abnormal response to new environment
- Background Sensitivity - increase in the number of defecations in a novel environment compared to wild-type controls in mice on a C57BL/6 background but not in mice on a BALB/c background
- initial locomotor activity is decreased; however, overall distance traveled is not different from controls
- the number of rearings is decreased in a novel environment

decreased vertical activity
- in a novel environment

increased fear-related response
- Background Sensitivity - increase in the number of defecations following a sound stimulus suggesting an enhancement of fear related responses in mice on a C57BL/6 background but not in mice on a BALB/c background
- make fewer entries and spend less time in the open arms of an elevated maze relative to wild-type controls
- prolonged freeze time and longer time to return to normal open field activity patterns following a startle stimulus relative to wild-type controls

cellular phenotype

abnormal dendritic cell chemotaxis
- enhancement in LPS induced dendritic cell migration to the spleen
- enhancement in the ability of dendritic cells to transmigrate across a membrane in response to RANTES in vitro

abnormal macrophage chemotaxis
- 5 days after muscle injury fewer macrophages are present at the injury site compared to similarly treated wild-type mice

abnormal redox activity
- unlike in wild-type mice, treatment with LPS and DGalN or TNF-alpha and interferon-gamma fails to increase the production of reactive oxygen species in hepatocytes

renal/urinary system phenotype

abnormal urine homeostasis
- 1 day after induction of accelerated antiglomerular basement membrane nephritis no increase in total urinary nitrate or nitrate levels is detected unlike in similarly treated wild-type controls

albuminuria
- increase in albuminuria on days 2, 3,and 4 following induction of accelerated antiglomerular basement membrane nephritis

glomerulonephritis
- increased susceptibility to induced accelerated antiglomerular basement membrane nephritis as determined by increased albuminuria and more severe pathological changes

homeostasis/metabolism phenotype

abnormal circulating cytokine level
- increase in circulating levels of CSF3 after infection with BCG especially in moribund mice

abnormal nitric oxide homeostasis
- unlike in wild-type mice, treatment with LPS and DGalN fails to increase nitric oxide levels

abnormal response to injury
- 5 days after muscle injury fewer macrophages are present at the injury site compared to similarly treated wild-type mice
- decrease in the number and area of regenerating muscle fibers 5 and 10 days after muscle injury
- fibrotic lesions are sometimes seen after injury

abnormal urine homeostasis
- 1 day after induction of accelerated antiglomerular basement membrane nephritis no increase in total urinary nitrate or nitrate levels is detected unlike in similarly treated wild-type controls

albuminuria
- increase in albuminuria on days 2, 3,and 4 following induction of accelerated antiglomerular basement membrane nephritis

decreased susceptibility to injury
- following a 48 h exposure to hyperoxia (98-99% oxygen) neutrophil migration into the lung air space and the increase in pulmonary alveolar permeability are decreased indicating a decrease susceptibility to the early phase of hyperoxia induced lung injury
- however, after 84 h of exposure to hyperoxia these measures are not different from similarly exposed to wild-type controls

increased circulating interleukin-6 level
- following infection with BCG

increased sensitivity to xenobiotic induced morbidity/mortality
- increase in mortality following a single dose of N-methyl-N-nitrosourea (MNU) compared to similarly treated wild-type controls

muscle phenotype

impaired skeletal muscle regeneration
- decrease in the number and area of regenerating fibers 5 and 10 days after injury
- fibrotic lesions are sometimes seen after injury
- however, prior to injury no difference in muscle fiber morphology are detected

skeletal muscle fibrosis
- fibrotic lesions are sometimes seen after injury

digestive/alimentary phenotype

stomach inflammation
- 5 weeks after Helicobacter pylori infection, mice have a significantly decreased gastritis inflammation score compared to infected wild-type mice

hematopoietic system phenotype

abnormal dendritic cell chemotaxis
- enhancement in LPS induced dendritic cell migration to the spleen
- enhancement in the ability of dendritic cells to transmigrate across a membrane in response to RANTES in vitro

abnormal immunoglobulin level
- IgG responses are restricted to IgG1 and IgG2b

abnormal macrophage chemotaxis
- 5 days after muscle injury fewer macrophages are present at the injury site compared to similarly treated wild-type mice

abnormal spleen morphology

abnormal spleen red pulp morphology
- following infection with BCG, the normal follicular structure of the red and white pulp is lost and the red pulp is replaced with extramedullary hematopoietic tissue

abnormal spleen white pulp morphology
- following infection with BCG, the normal follicular structure of the red and white pulp is lost and the lymphocytic populations of the white pulp are replaced with sheets of leukocytes

enlarged spleen
- develop splenomegaly after infection with BCG

extramedullary hematopoiesis
- following infection with BCG

increased NK T cell number
- unlike in wild-type mice, treatment with LPS and DGalN fails to decrease NK T cell numbers

increased granulocyte number
- in the blood, bone marrow and spleen following infection with BCG

increased leukocyte cell number
- following infection with BCG

increased monocyte cell number
- following infection with BCG

pale spleen
- spleens become paler as BCG infection proceeds

Genotype: Ifng^tm1Ts/Ifng^tm1Ts
involves: 129S7/SvEvBrd * C57BL/6J

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality
- after infection with a normally sublethal dose of the virulent Erdam strain of Mycobacterium tuberculosis mice become severely ill and need to be euthanized

immune system phenotype

increased susceptibility to bacterial infection
- by 4 weeks after aerosol infection with the virulent Erdam strain of Mycobacterium tuberculosis mice display multifocal necrotic areas contain high numbers of bacteria in the spleen, liver, lungs and kidneys
- following infection with a sublethal dose of the virulent Erdam strain of Mycobacterium tuberculosis mice develop widespread infection with high numbers of bacteria in multiple tissues and obvious bacteremia

increased susceptibility to bacterial infection induced morbidity/mortality
- after infection with a normally sublethal dose of the virulent Erdam strain of Mycobacterium tuberculosis mice become severely ill and need to be euthanized

Genotype: Ifng^tm1Ts/Ifng^tm1Ts
C.129S7(B6)-Ifng^tm1Ts/J

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality
- die by 6 - 10 weeks after infection with the avirulent BCG strain of Mycobacterium bovis

immune system phenotype

abnormal NK cell physiology
- decrease in the cytotoxicity of NK cells from mice primed with rIL12

abnormal adaptive immunity

abnormal circulating cytokine level
- increase in circulating levels of CSF3 after infection with BCG especially in moribund mice

abnormal cytokine secretion
- lymphocytes form C25/Il12 cell primed mice produce about 3 fold higher levels of CSF2

abnormal cytotoxic T cell physiology
- C26 cells induce slightly reduced CTL activity compared to the response in similarly treat wild-type mice

abnormal inflammatory response
- in C26/Il12 tumors CD4+ T cells are more numerous relative to CD8+ T cells, in tumors in wild-type mice CD8+ T cells are more numerous

abnormal macrophage physiology
- exposure to rIL12 fails to prime macrophages against subsequent LPS exposure

abnormal spleen morphology

abnormal spleen red pulp morphology
- following infection with BCG, the normal follicular structure of the red and white pulp is lost and the red pulp is replaced with extramedullary hematopoietic tissue

abnormal spleen white pulp morphology
- following infection with BCG, the normal follicular structure of the red and white pulp is lost and the lymphocytic populations of the white pulp are replaced with sheets of leukocytes

abnormal uterine NK cell morphology
- the golgi apparatus is poorly developed, the rough ER is disorganized, and numerous mitochondria are seen in uNK cell at implantation sites at gestational day 12

abnormal uterine NK cell physiology
- decrease in the number of apoptotic uNK cells in the metrial gland afte day 10 of gestation
- uNK cells at implantation sites fail to become heavily granulated and have poorly developed golgi apparati

decreased susceptibility to parasitic infection
- Background Sensitivity - unlike mice on a C57BL/6 background, mice on a BALB/c background do not lose weight, show any change in stool consistency, or display heavy parasitic loads in the gastrointestinal tract over the course of a C. parvum infection

enlarged spleen
- develop splenomegaly after infection with BCG

increased circulating interleukin-6 level
- following infection with BCG

increased granulocyte number
- in the blood, bone marrow and spleen following infection with BCG

increased leukocyte cell number
- following infection with BCG

increased monocyte cell number
- following infection with BCG

increased susceptibility to bacterial infection
- following infection with BCG mice develop numerous granulomatous lesions in the liver and necrosis of both the liver and spleen
- following infection with BCG mice display an increased bacterial load throughout the infect in contrast to wild-type mice where bacterial numbers peak at 17 days post infection and decline thereafter

increased susceptibility to bacterial infection induced morbidity/mortality
- die by 6 - 10 weeks after infection with the avirulent BCG strain of Mycobacterium bovis

increased uterine NK cell number
- after day 10 of gestation increased numbers of uNK cells are found in the metrial gland compared to wild-type controls

pale spleen
- spleens become paler as BCG infection proceeds

behavior/neurological phenotype

abnormal response to new environment
- Background Sensitivity - unlike mice on a C57BL/6 background, no increase in the number of defecations in a novel environment or following a sound stimulus is seen in mice on a BALB/c background, compared to wild-type controls
- the number of rearings is decreased in a novel environment

decreased vertical activity
- in a novel environment

increased fear-related response
- Background Sensitivity - no increase in the number of defecations following a sound stimulus is seen in mice on a BALB/c background unlike mice on a C57BL/6 background
- prolonged freeze time following a startle stimulus relative to wild-type controls

neoplasm

altered tumor pathology
- in C26/Il12 derived tumors, tumor vessels are more numerous and thinner compared to vessels in tumors in wild-type mice
- when injected with 5 x 10⁵ C26/Il12 cells only a few mice are able to reject the tumor, in contrast 80 - 100% of wild-type mice reject the tumor

decreased tumor latency
- however, no difference is detected when parental C26 cells are used
- tumor onset is accelerated in 40% of mice injected with 5 x 10⁴ C26 carcinoma cells transduced with Il12 genes (C26/Il12) compared to similarly treated wild-type mice

reproductive system phenotype

abnormal maternal decidual layer morphology
- after gestational day 10 the intercellular composition of the decidua changes suggesting accumulations of fluid and extracellular matrix, areas of necrosis are present and a lack of decidual cellularity is apparent

abnormal uterine NK cell morphology
- the golgi apparatus is poorly developed, the rough ER is disorganized, and numerous mitochondria are seen in uNK cell at implantation sites at gestational day 12

abnormal uterine NK cell physiology
- decrease in the number of apoptotic uNK cells in the metrial gland afte day 10 of gestation
- uNK cells at implantation sites fail to become heavily granulated and have poorly developed golgi apparati

decreased litter size
- decrease in litter size and increase in the number of resorbed embryos in the first litter
- no difference in litter size or number of resorbed embryos is detected in subsequent pregnancies
- phenotype is independent of the genotype of the embryos

increased uterine NK cell number
- after day 10 of gestation increased numbers of uNK cells are found in the metrial gland compared to wild-type controls

homeostasis/metabolism phenotype

abnormal circulating cytokine level
- increase in circulating levels of CSF3 after infection with BCG especially in moribund mice

increased circulating interleukin-6 level
- following infection with BCG

embryo phenotype

abnormal maternal decidual layer morphology
- after gestational day 10 the intercellular composition of the decidua changes suggesting accumulations of fluid and extracellular matrix, areas of necrosis are present and a lack of decidual cellularity is apparent

abnormal uterine NK cell morphology
- the golgi apparatus is poorly developed, the rough ER is disorganized, and numerous mitochondria are seen in uNK cell at implantation sites at gestational day 12

increased uterine NK cell number
- after day 10 of gestation increased numbers of uNK cells are found in the metrial gland compared to wild-type controls

hematopoietic system phenotype

abnormal NK cell physiology
- decrease in the cytotoxicity of NK cells from mice primed with rIL12

abnormal cytotoxic T cell physiology
- C26 cells induce slightly reduced CTL activity compared to the response in similarly treat wild-type mice

abnormal macrophage physiology
- exposure to rIL12 fails to prime macrophages against subsequent LPS exposure

abnormal spleen morphology

abnormal spleen red pulp morphology
- following infection with BCG, the normal follicular structure of the red and white pulp is lost and the red pulp is replaced with extramedullary hematopoietic tissue

abnormal spleen white pulp morphology
- following infection with BCG, the normal follicular structure of the red and white pulp is lost and the lymphocytic populations of the white pulp are replaced with sheets of leukocytes

abnormal uterine NK cell morphology
- the golgi apparatus is poorly developed, the rough ER is disorganized, and numerous mitochondria are seen in uNK cell at implantation sites at gestational day 12

abnormal uterine NK cell physiology
- decrease in the number of apoptotic uNK cells in the metrial gland afte day 10 of gestation
- uNK cells at implantation sites fail to become heavily granulated and have poorly developed golgi apparati

enlarged spleen
- develop splenomegaly after infection with BCG

extramedullary hematopoiesis
- following infection with BCG

increased granulocyte number
- in the blood, bone marrow and spleen following infection with BCG

increased leukocyte cell number
- following infection with BCG

increased monocyte cell number
- following infection with BCG

increased uterine NK cell number
- after day 10 of gestation increased numbers of uNK cells are found in the metrial gland compared to wild-type controls

pale spleen
- spleens become paler as BCG infection proceeds

endocrine/exocrine gland phenotype

abnormal uterine NK cell morphology
- the golgi apparatus is poorly developed, the rough ER is disorganized, and numerous mitochondria are seen in uNK cell at implantation sites at gestational day 12

increased uterine NK cell number
- after day 10 of gestation increased numbers of uNK cells are found in the metrial gland compared to wild-type controls

Genotype: Ifng^tm1Ts/Ifng^tm1Ts
C.129S7-Ifng^tm1Ts

respiratory system phenotype

increased lung adenocarcinoma incidence
- all are well differentiated papillary adenocarcinomas
- in a few mice, with a very late onset

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality
- following vaccination mice are able to develop resistance to L. monocytogenes infection
- however the LD50 for a mutant strain of L. monocytogenes (DP-L1942) is similar in homozygous mice and controls
- the LD50 for Listeria monocytogenes infection is 10 CFU compared to greater than 10⁴ CFU for wild-type and heterozygous controls

increased susceptibility to parasitic infection induced morbidity/mortality
- die within 9 days of inoculation with T. gondii (strain ME49) unlike controls which survive more than 30 days
- highly susceptible to the normally avirulent T. gondii isolate, ts4

immune system phenotype

abnormal cytokine secretion
- following infection with T. gondii (irradiate RH strain) splenocytes show enhanced Th2 cytokine production compared to similar cultures from wild-type mice

abnormal humoral immune response
- following oral OVA exposure OVA antibody levels are essentially unchanged unlike in wild-type controls where oral exposure reduces antibody levels
- however, following oral OVA exposure OVA antibody levels are essentially unchanged unlike in wild-type controls where oral exposure reduces antibody levels
- the magnitude of the OVA specific antibody is reduced

abnormal immune tolerance
- oral exposure to antigen (OVA) fails to reduce the responsiveness of mice to subsequent exposure to the same antigen

abnormal immunoglobulin level
- IgG responses are restricted to IgG1 and IgG2b

abnormal response to infection
- following infection with T. gondii (irradiate RH strain) splenocytes show enhanced Th2 cytokine production compared to similar cultures from wild-type mice

increased interleukin-5 secretion
- following infection with T. gondii (irradiate RH strain) splenocytes produce more IL-5 compared to similar cultures from wild-type mice

increased susceptibility to bacterial infection induced morbidity/mortality
- following vaccination mice are able to develop resistance to L. monocytogenes infection
- however the LD50 for a mutant strain of L. monocytogenes (DP-L1942) is similar in homozygous mice and controls
- the LD50 for Listeria monocytogenes infection is 10 CFU compared to greater than 10⁴ CFU for wild-type and heterozygous controls

increased susceptibility to experimental autoimmune encephalomyelitis
- immunized mice display meningeal and perivascular inflammatory infiltrates in the spinal cord and brain similar to those seen in susceptible strains like SJL/J
- incidence rate (17 of 24 compared to 1 of 16 in controls) and severity are increased compared to contols immunization results in about a 30% mortality rate

increased susceptibility to parasitic infection
- 5 days after inoculation with T. gondii (strain ME49) peritoneal exudates contain a more pronounced increase in the numbers of granulocytes, eosinophils, and mast cells compared to similarly infected wild-type controls
- IL-2 production in response to infection is similar to controls
- dramatic increase in the number of infected cells expansion of the tissues infected following inoculation with Toxoplasma gondii (strain ME49)

increased susceptibility to parasitic infection induced morbidity/mortality
- die within 9 days of inoculation with T. gondii (strain ME49) unlike controls which survive more than 30 days
- highly susceptible to the normally avirulent T. gondii isolate, ts4

neoplasm

increased lung adenocarcinoma incidence
- all are well differentiated papillary adenocarcinomas
- in a few mice, with a very late onset

increased tumor latency
- Background Sensitivity - in mice on a BALB/c background compared to mice on a C57BL/6 background

neoplasm
- Background Sensitivity - unlike mice on a congenic C57BL/6 background, mice on a BALB/c background do not develop disseminated lymphomas

hematopoietic system phenotype

abnormal immunoglobulin level
- IgG responses are restricted to IgG1 and IgG2b

Genotype: Ifng^tm1Ts/Ifng^tm1Ts
involves: 129S7/SvEvBrd

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality
- mean survival time following infecting with virulent Mycobacterium tuberculosis is 15 days compared to over 60 days for wild-type controls
- treatment with exogenous IFNG improves survival

increased susceptibility to viral infection induced morbidity/mortality
- more than 70% of mice infected on the cornea with herpes simplex virus type 1 (HSV-1) at a dose of 10⁵ TCID50 (50% tissue culture infective dose) infectious particles die

immune system phenotype

abnormal cytokine level
- T cells from mice immunized with myelin oligodendrocyte glycoprotein (MOG) peptide show more IL-17a expressing cells and greater IL-17a production after MOG restimulation than controls; IL-4 is not detectable in these cells

abnormal immunoglobulin level
- in mice with acute or chronic HSV-1 infection the ratio of IgG2a to IgG1 is dramatically reduced compared to BALB/c wild-type mice

abnormal response to infection
- 14 days after infection with virulent Mycobacterium tuberculosis serum levels of reactive nitrogen intermediates are very low, unlike in wild-type controls
- display an increased IgG1 antibody response to type A influenza infection
- the magnitude of the delayed type hypersensitive response in mice after HSV-1 infection is reduced compared to BALB/c wild-type controls

decreased susceptibility to type IV hypersensitivity reaction
- the magnitude of the delayed type hypersensitive response in mice after HSV-1 infection is reduced compared to BALB/c wild-type controls

impaired natural killer cell mediated cytotoxicity
- activated splenic and liver NK cells are less efficient in their killing of 4T1 or Renca tumor target cells

increased IgG1 level
- following infection with type A influenza

increased interleukin-17 secretion
- following culturing of IL-17 producing T cells in vitro, IL-17 production is twice as high as in similarly treated wild-type cells

increased susceptibility to bacterial infection
- at 14 days after infection with virulent Mycobacterium tuberculosis, 10- 100 fold more viable bacteria are found in the organs compared to organs of wild-type controls
- at 14 days after infection with virulent Mycobacterium tuberculosis, about 90% of the granulomas in the liver and 20% of the granulomas in the spleen are necrotic
- treatment with exogenous IFNG decreases the bacterial load

increased susceptibility to bacterial infection induced morbidity/mortality
- mean survival time following infecting with virulent Mycobacterium tuberculosis is 15 days compared to over 60 days for wild-type controls
- treatment with exogenous IFNG improves survival

increased susceptibility to viral infection
- at 5 - 8 days post infection mice develop more severe conjunctivitis, periocular skin lesions, corneal opacity, and anterior chamber exudate following infection with HSV-1 relative to wld-type BALB/c controls infected with a higher dose of virus
- infectious virus is detected up to 10 days post infection with HSV-1 in mutants compared to up to 4 or days post infection in wild-type BAL/c mice or littermate controls, respectively

increased susceptibility to viral infection induced morbidity/mortality
- more than 70% of mice infected on the cornea with herpes simplex virus type 1 (HSV-1) at a dose of 10⁵ TCID50 (50% tissue culture infective dose) infectious particles die

vision/eye phenotype

corneal vascularization
- corneal injection of a plasmid encoding short hairpin RNA targeting the C terminus of the secreted form of Flt1 (pshRNA-sflt1) induces corneal vascularization within 3 days of injection in wild-type and mutant mice

homeostasis/metabolism phenotype

abnormal cytokine level
- T cells from mice immunized with myelin oligodendrocyte glycoprotein (MOG) peptide show more IL-17a expressing cells and greater IL-17a production after MOG restimulation than controls; IL-4 is not detectable in these cells

cardiovascular system phenotype

corneal vascularization
- corneal injection of a plasmid encoding short hairpin RNA targeting the C terminus of the secreted form of Flt1 (pshRNA-sflt1) induces corneal vascularization within 3 days of injection in wild-type and mutant mice

hematopoietic system phenotype

abnormal immunoglobulin level
- in mice with acute or chronic HSV-1 infection the ratio of IgG2a to IgG1 is dramatically reduced compared to BALB/c wild-type mice

impaired natural killer cell mediated cytotoxicity
- activated splenic and liver NK cells are less efficient in their killing of 4T1 or Renca tumor target cells

increased IgG1 level
- following infection with type A influenza

Genotype: Ifng^tm1Ts/Ifng^tm1Ts
B6.129S7-Ifng^tm1Ts

endocrine/exocrine gland phenotype

increased T cell derived lymphoma incidence
- in a few mice

mortality/aging

increased susceptibility to parasitic infection induced morbidity/mortality
- die earlier after inoculation with Toxoplasma gondii (strain ME49) compared to wild-type controls
- sudden death occurs 5 to 7 weeks after infection with Leishmania major

increased susceptibility to viral infection induced morbidity/mortality
- higher mortality is seen following infection with JHMV compared to wild-type controls

premature death
- Background Sensitivity - in mice on a C57BL/6 background compared to mice on a BALB/c background

neoplasm

decreased tumor latency
- Background Sensitivity - in mice on a C57BL/6 background compared to mice on a BALB/c background

increased T cell derived lymphoma incidence
- in a few mice

increased lymphoma incidence
- Background Sensitivity - 50% of mice on a congenic C57BL/5 background develop disseminated lymphomas compared to 0% of mice on a congenic BALB/c background
- most lymphomas are diffuse large cell lymphomas

increased sarcoma incidence
- in a few mice

immune system phenotype

abnormal B cell physiology
- immature B cells fail to be excluded from the lymph nodes

abnormal cytokine secretion
- after infection with Leishmania major the number of lymphocytes producing IL4 increases unlike in control mice where the number of lymphocytes producing IFNG increases
- following infection with T. gondii (irradiate RH strain) splenocytes show enhanced Th2 cytokine production compared to similar cultures from wild-type mice

abnormal immunoglobulin level

abnormal lymph node cell ratio
- significant increase in the numbers of immature B cells in the lymph nodes

abnormal response to infection
- after infection with Leishmania major levels of IgG1 and IgE are increased while levels of IgG2a and IgG3 remain low
- after infection with Leishmania major mice display minimal Th1 type responses and increased Th2 type responses
- following infection with T. gondii (irradiate RH strain) splenocytes show enhanced Th2 cytokine production compared to similar cultures from wild-type mice

abnormal response to transplant
- after immunosuppressive treatment (anti-CD4 and anti-CD8 mAbs) allografts (BALB/c, H2-Ab1^bm12 continue to display myocardial rejection at week 12 but do not display graft arterial disease, in contrast wild-type mice at week 12 display low levels of rejection but develop coronary arteriopathys of rejection but develop coronary arteriopathy

decreased IgG2a level
- after infection with Leishmania major

decreased IgG3 level
- after infection with Leishmania major

increased CD8-positive, alpha-beta T cell number
- increase in the number of CD8+ cells in the white matter tracts of JHMV infected mice compared to similarly infected wild-type controls at 7 and 14 days post infection

increased IgE level
- after infection with Leishmania major

increased IgG1 level
- 5-fold increase in the serum levels of JHMV specific IgG1 at 14 days post infection compared to infected wild-type controls
- after infection with Leishmania major

increased interleukin-10 secretion
- cervical lymph node cells from JHMV infected mice (7 days post infection) secrete more IL10 in response to JHMV antigen compared to cells from similarly infected wild-type mice

increased interleukin-2 secretion
- cervical lymph node cells from JHMV infected mice secrete more IL2 in response to JHMV antigen compared to cells from similarly infected wild-type mice

increased interleukin-5 secretion
- cervical lymph node cells from JHMV infected mice (7 days post infection) secrete more IL5 in response to JHMV antigen compared to cells from similarly infected wild-type mice

increased susceptibility to parasitic infection
- develop progressive infection characterized by large lesions at the site of inoculation and sudden death 5 to 7 weeks after infection with Leishmania major
- numbers of parasites present in the footpads are substantially increased compared to wild-type and heterozygous controls

increased susceptibility to parasitic infection induced morbidity/mortality
- die earlier after inoculation with Toxoplasma gondii (strain ME49) compared to wild-type controls
- sudden death occurs 5 to 7 weeks after infection with Leishmania major

increased susceptibility to viral infection
- at 14 days post infection with JHMV a 10 fold increase in the number of viral antigen positive cells is detected in the brain with most of the infected cells being oligodendrocytes
- following infection with the JHM strain of mouse hepatitis virus (JHMV) mice display a slower clinical recovery and higher viral titers in the central nervous system compared to wild-type controls
- however, no differences are found in JHMV specific cytotoxic T lymphocyte activity

increased susceptibility to viral infection induced morbidity/mortality
- higher mortality is seen following infection with JHMV compared to wild-type controls

hematopoietic system phenotype

abnormal B cell physiology
- immature B cells fail to be excluded from the lymph nodes

abnormal immunoglobulin level

decreased IgG2a level
- after infection with Leishmania major

decreased IgG3 level
- after infection with Leishmania major

increased CD8-positive, alpha-beta T cell number
- increase in the number of CD8+ cells in the white matter tracts of JHMV infected mice compared to similarly infected wild-type controls at 7 and 14 days post infection

increased IgE level
- after infection with Leishmania major

increased IgG1 level
- 5-fold increase in the serum levels of JHMV specific IgG1 at 14 days post infection compared to infected wild-type controls
- after infection with Leishmania major

References

Dalton DK; Pitts-Meek S; Keshav S; Figari IS; Bradley A; Stewart TA. 1993. Multiple defects of immune cell function in mice with disrupted interferon-gamma genes [see comments] Science 259(5102):1739-42. PubMed: 8456300 MGI: J:66802

Additional - Ifng^tm1Ts related

Aachoui Y; Kajiwara Y; Leaf IA; Mao D; Ting JP; Coers J; Aderem A; Buxbaum JD; Miao EA. 2015. Canonical Inflammasomes Drive IFN-gamma to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium. Cell Host Microbe 18(3):320-32. PubMed: 26320999 MGI: J:243015
Aachoui Y; Leaf IA; Hagar JA; Fontana MF; Campos CG; Zak DE; Tan MH; Cotter PA; Vance RE; Aderem A; Miao EA. 2013. Caspase-11 protects against bacteria that escape the vacuole. Science 339(6122):975-8. PubMed: 23348507 MGI: J:193387
Abdullah Z; Geiger S; Nino-Castro A; Bottcher JP; Muraliv E; Gaidt M; Schildberg FA; Riethausen K; Flossdorf J; Krebs W; Chakraborty T; Kurts C; Schultze JL; Knolle PA; Klotz L. 2012. Lack of PPARgamma in myeloid cells confers resistance to Listeria monocytogenes infection. PLoS One 7(5):e37349. PubMed: 22629382 MGI: J:196535
Abromson-Leeman S; Bronson R; Luo Y; Berman M; Leeman R; Leeman J; Dorf M. 2004. T-cell properties determine disease site, clinical presentation, and cellular pathology of experimental autoimmune encephalomyelitis. Am J Pathol 165(5):1519-33. PubMed: 15509523 MGI: J:109724
Abromson-Leeman S; Ladell DS; Bronson RT; Dorf ME. 2007. Heterogeneity of EAE mediated by multiple distinct T-effector subsets. J Neuroimmunol 192(1-2):3-12. PubMed: 17976744 MGI: J:128953
Adams B; Nagy N; Paulart F; Vanderhaeghen ML; Goldman M; Flamand V. 2003. CD8+ T lymphocytes regulating Th2 pathology escape neonatal tolerization. J Immunol 171(10):5071-6. PubMed: 14607904 MGI: J:117990
Afanasyeva M; Georgakopoulos D; Belardi DF; Bedja D; Fairweather D; Wang Y; Kaya Z; Gabrielson KL; Rodriguez ER; Caturegli P; Kass DA; Rose NR. 2005. Impaired up-regulation of CD25 on CD4+ T cells in IFN-gamma knockout mice is associated with progression of myocarditis to heart failure. Proc Natl Acad Sci U S A 102(1):180-5. PubMed: 15611472 MGI: J:95757
Afshar-Sterle S; Zotos D; Bernard NJ; Scherger AK; Rodling L; Alsop AE; Walker J; Masson F; Belz GT; Corcoran LM; O'Reilly LA; Strasser A; Smyth MJ; Johnstone R; Tarlinton DM; Nutt SL; Kallies A. 2014. Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas. Nat Med 20(3):283-90. PubMed: 24487434 MGI: J:208773
Aguilar PV; Paessler S; Carrara AS; Baron S; Poast J; Wang E; Moncayo AC; Anishchenko M; Watts D; Tesh RB; Weaver SC. 2005. Variation in interferon sensitivity and induction among strains of eastern equine encephalitis virus. J Virol 79(17):11300-10. PubMed: 16103182 MGI: J:101624
Akhiani AA; Pappo J; Kabok Z; Schon K; Gao W; Franzen LE; Lycke N. 2002. Protection against Helicobacter pylori infection following immunization is IL-12-dependent and mediated by Th1 cells. J Immunol 169(12):6977-84. PubMed: 12471132 MGI: J:118009
Al Shamsi M; Shahin A; Iwakura Y; Lukic ML; Mensah-Brown EP. 2013. Pam3CSK(4) enhanced beta cell loss and diabetogenesis: the roles of IFN-gamma and IL-17. Clin Immunol 149(1):86-96. PubMed: 23899994 MGI: J:202102
Alayan J; Ivanovski S; Farah CS. 2007. Alveolar bone loss in T helper 1/T helper 2 cytokine-deficient mice. J Periodontal Res 42(2):97-103. PubMed: 17305866 MGI: J:147935
Alexander WS; Starr R; Fenner JE; Scott CL; Handman E; Sprigg NS; Corbin JE; Cornish AL; Darwiche R; Owczarek CM; Kay TW; Nicola NA; Hertzog PJ; Metcalf D; Hilton DJ. 1999. SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine. Cell 98(5):597-608. PubMed: 10490099 MGI: J:57474
Aliberti JC; Souto JT; Marino AP; Lannes-Vieira J; Teixeira MM; Farber J; Gazzinelli RT; Silva JS. 2001. Modulation of chemokine production and inflammatory responses in interferon-gamma- and tumor necrosis factor-R1-deficient mice during Trypanosoma cruzi infection. Am J Pathol 158(4):1433-40. PubMed: 11290561 MGI: J:68668
Aly S; Laskay T; Mages J; Malzan A; Lang R; Ehlers S. 2007. Interferon-gamma-dependent mechanisms of mycobacteria-induced pulmonary immunopathology: the role of angiostasis and CXCR3-targeted chemokines for granuloma necrosis. J Pathol 212(3):295-305. PubMed: 17534845 MGI: J:122272
Amante FH; Haque A; Stanley AC; Rivera Fde L; Randall LM; Wilson YA; Yeo G; Pieper C; Crabb BS; de Koning-Ward TF; Lundie RJ; Good MF; Pinzon-Charry A; Pearson MS; Duke MG; McManus DP; Loukas A; Hill GR; Engwerda CR. 2010. Immune-Mediated Mechanisms of Parasite Tissue Sequestration during Experimental Cerebral Malaria. J Immunol 185(6):3632-42. PubMed: 20720206 MGI: J:163540
Ambati BK; Nozaki M; Singh N; Takeda A; Jani PD; Suthar T; Albuquerque RJ; Richter E; Sakurai E; Newcomb MT; Kleinman ME; Caldwell RB; Lin Q; Ogura Y; Orecchia A; Samuelson DA; Agnew DW; St Leger J; Green WR; Mahasreshti PJ; Curiel DT; Kwan D; Marsh H; Ikeda S; Leiper LJ; Collinson JM; Bogdanovich S; Khurana TS; Shibuya M; Baldwin ME; Ferrara N; Gerber HP; De Falco S; Witta J; Baffi JZ; Raisler BJ; Ambati J. 2006. Corneal avascularity is due to soluble VEGF receptor-1. Nature 443(7114):993-7. PubMed: 17051153 MGI: J:114973
Amiri P; Haak-Frendscho M; Robbins K; McKerrow JH; Stewart T; Jardieu P. 1994. Anti-immunoglobulin E treatment decreases worm burden and egg production in Schistosoma mansoni-infected normal and interferon gamma knockout mice. J Exp Med 180(1):43-51. PubMed: 8006599 MGI: J:18740
Andersen C; Jensen T; Nansen A; Marker O; Thomsen AR. 1999. CD4(+) T cell-mediated protection against a lethal outcome of systemic infection with vesicular stomatitis virus requires CD40 ligand expression, but not IFN-gamma or IL-4. Int Immunol 11(12):2035-42. PubMed: 10590269 MGI: J:110491
Andoh A; Masuda A; Kumazawa Y; Kasajima T. 2002. Serum antibody response and nasal lymphoid tissue (NALT) structure in the absence of IL-4 or IFN-gamma. Cytokine 20(3):107-12. PubMed: 12453468 MGI: J:102594
Andoh A; Masuda A; Yamakawa M; Kumazawa Y; Kasajima T. 2000. Absence of interleukin-4 enhances germinal center reaction in secondary immune response. Immunol Lett 73(1):35-41. PubMed: 10963809 MGI: J:110473
Andoh M; Zhang G; Russell-Lodrigue KE; Shive HR; Weeks BR; Samuel JE. 2007. T Cells Are Essential for Bacterial Clearance, and Gamma Interferon, Tumor Necrosis Factor Alpha, and B Cells Are Crucial for Disease Development in Coxiella burnetii Infection in Mice. Infect Immun 75(7):3245-55. PubMed: 17438029 MGI: J:122426
Andrade RM; Portillo JA; Wessendarp M; Subauste CS. 2005. CD40 signaling in macrophages induces activity against an intracellular pathogen independently of gamma interferon and reactive nitrogen intermediates. Infect Immun 73(5):3115-23. PubMed: 15845519 MGI: J:97614
Andreasen SO; Christensen JE; Marker O; Thomsen AR. 2000. Role of CD40 ligand and CD28 in induction and maintenance of antiviral CD8+ effector T cell responses. J Immunol 164(7):3689-97. PubMed: 10725727 MGI: J:123023
Anthony DA; Andrews DM; Chow M; Watt SV; House C; Akira S; Bird PI; Trapani JA; Smyth MJ. 2010. A role for granzyme M in TLR4-driven inflammation and endotoxicosis. J Immunol 185(3):1794-803. PubMed: 20585036 MGI: J:162467
Apte SH; Groves P; Olver S; Baz A; Doolan DL; Kelso A; Kienzle N. 2010. IFN-gamma inhibits IL-4-induced type 2 cytokine expression by CD8 T cells in vivo and modulates the anti-tumor response. J Immunol 185(2):998-1004. PubMed: 20562261 MGI: J:161926
Arantes RM; Marche HH; Bahia MT; Cunha FQ; Rossi MA; Silva JS. 2004. Interferon-gamma-induced nitric oxide causes intrinsic intestinal denervation in Trypanosoma cruzi-infected mice. Am J Pathol 164(4):1361-8. PubMed: 15039223 MGI: J:89108
Arens R; Baars PA; Jak M; Tesselaar K; van der Valk M; van Oers MH; van Lier RA. 2005. Cutting edge: CD95 maintains effector T cell homeostasis in chronic immune activation. J Immunol 174(10):5915-20. PubMed: 15879081 MGI: J:98994
Arens R; Nolte MA; Tesselaar K; Heemskerk B; Reedquist KA; van Lier RA; van Oers MH. 2004. Signaling through CD70 regulates B cell activation and IgG production. J Immunol 173(6):3901-8. PubMed: 15356138 MGI: J:92744
Arora S; Hernandez Y; Erb-Downward JR; McDonald RA; Toews GB; Huffnagle GB. 2005. Role of IFN-gamma in regulating T2 immunity and the development of alternatively activated macrophages during allergic bronchopulmonary mycosis. J Immunol 174(10):6346-56. PubMed: 15879135 MGI: J:99045
Arora S; Olszewski MA; Tsang TM; McDonald RA; Toews GB; Huffnagle GB. 2011. Effect of Cytokine Interplay on Macrophage Polarization during Chronic Pulmonary Infection with Cryptococcus neoformans. Infect Immun 79(5):1915-26. PubMed: 21383052 MGI: J:171937
Arsenijevic D; Clavel S; Sanchis D; Plamondon J; Huang Q; Ricquier D; Rouger L; Richard D. 2007. Induction of Ucp2 expression in brain phagocytes and neurons following murine toxoplasmosis: an essential role of IFN-gamma and an association with negative energy balance. J Neuroimmunol 186(1-2):121-32. PubMed: 17467814 MGI: J:124552
Artis D; Villarino A; Silverman M; He W; Thornton EM; Mu S; Summer S; Covey TM; Huang E; Yoshida H; Koretzky G; Goldschmidt M; Wu GD; de Sauvage F; Miller HR; Saris CJ; Scott P; Hunter CA. 2004. The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity. J Immunol 173(9):5626-34. PubMed: 15494513 MGI: J:93739
Ashkar AA; Croy BA. 1999. Interferon-gamma contributes to the normalcy of murine pregnancy. Biol Reprod 61(2):493-502. PubMed: 10411532 MGI: J:56503
Ashkar AA; Di Santo JP; Croy BA. 2000. Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy [see comments] J Exp Med 192(2):259-70. PubMed: 10899912 MGI: J:63645
Awoniyi M; Miller SI; Wilson CB; Hajjar AM; Smith KD. 2012. Homeostatic regulation of Salmonella-induced mucosal inflammation and injury by IL-23. PLoS One 7(5):e37311. PubMed: 22624013 MGI: J:187224
Badovinac VP; Harty JT. 2000. Adaptive immunity and enhanced CD8+ T cell response to Listeria monocytogenes in the absence of perforin and IFN-gamma. J Immunol 164(12):6444-52. PubMed: 10843700 MGI: J:83175
Badovinac VP; Tvinnereim AR; Harty JT. 2000. Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-gamma. Science 290(5495):1354-8. PubMed: 11082062 MGI: J:83176
Bai Y; Liu R; Huang D; La Cava A; Tang YY; Iwakura Y; Campagnolo DI; Vollmer TL; Ransohoff RM; Shi FD. 2008. CCL2 recruitment of IL-6-producing CD11b(+) monocytes to the draining lymph nodes during the initiation of Th17-dependent B cell-mediated autoimmunity. Eur J Immunol 38(7):1877-88. PubMed: 18581322 MGI: J:137386
Baird JR; Byrne KT; Lizotte PH; Toraya-Brown S; Scarlett UK; Alexander MP; Sheen MR; Fox BA; Bzik DJ; Bosenberg M; Mullins DW; Turk MJ; Fiering S. 2013. Immune-Mediated Regression of Established B16F10 Melanoma by Intratumoral Injection of Attenuated Toxoplasma gondii Protects against Rechallenge. J Immunol 190(1):469-78. PubMed: 23225891 MGI: J:190812
Baldeviano GC; Barin JG; Talor MV; Srinivasan S; Bedja D; Zheng D; Gabrielson K; Iwakura Y; Rose NR; Cihakova D. 2010. Interleukin-17A is dispensable for myocarditis but essential for the progression to dilated cardiomyopathy. Circ Res 106(10):1646-55. PubMed: 20378858 MGI: J:172627
Baldridge MT; King KY; Boles NC; Weksberg DC; Goodell MA. 2010. Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection. Nature 465(7299):793-7. PubMed: 20535209 MGI: J:161947
Balish E; Wagner RD; Vazquez-Torres A; Pierson C; Warner T. 1998. Candidiasis in interferon-gamma knockout (IFN-gamma-/-) mice. J Infect Dis 178(2):478-87. PubMed: 9697730 MGI: J:120514
Ballas ZK; Buchta CM; Rosean TR; Heusel JW; Shey MR. 2013. Role of NK cell subsets in organ-specific murine melanoma metastasis. PLoS One 8(6):e65599. PubMed: 23776508 MGI: J:204234
Balomenos D; Rumold R; Theofilopoulos AN. 1998. Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice. J Clin Invest 101(2):364-71. PubMed: 9435308 MGI: J:45391
Bao S; Beagley KW; France MP; Shen J; Husband AJ. 2000. Interferon-gamma plays a critical role in intestinal immunity against Salmonella typhimurium infection. Immunology 99(3):464-72. PubMed: 10712678 MGI: J:61050
Baratono SR; Chu N; Richman LP; Behrens EM. 2015. Toll-like receptor 9 and interferon-gamma receptor signaling suppress the B-cell fate of uncommitted progenitors in mice. Eur J Immunol 45(5):1313-25. PubMed: 25639361 MGI: J:229269
Barber EM; Fazzari M; Pollard JW. 2005. Th1 cytokines are essential for placental immunity to Listeria monocytogenes. Infect Immun 73(10):6322-31. PubMed: 16177303 MGI: J:104232
Barkhouse DA; Garcia SA; Bongiorno EK; Lebrun A; Faber M; Hooper DC. 2015. Expression of interferon gamma by a recombinant rabies virus strongly attenuates the pathogenicity of the virus via induction of type I interferon. J Virol 89(1):312-22. PubMed: 25320312 MGI: J:221392
Barr TA; Brown S; Mastroeni P; Gray D. 2010. TLR and B cell receptor signals to B cells differentially program primary and memory Th1 responses to Salmonella enterica. J Immunol 185(5):2783-9. PubMed: 20675594 MGI: J:163256
Barr TA; Brown S; Mastroeni P; Gray D. 2009. B cell intrinsic MyD88 signals drive IFN-gamma production from T cells and control switching to IgG2c. J Immunol 183(2):1005-12. PubMed: 19542370 MGI: J:151505
Bartholdy C; Nansen A; Christensen JE; Marker O; Thomsen AR. 1999. Inducible nitric-oxide synthase plays a minimal role in lymphocytic choriomeningitis virus-induced, T cell-mediated protective immunity and immunopathology. J Gen Virol 80(Pt 11):2997-3005. PubMed: 10580062 MGI: J:103345
Baschant U; Frappart L; Rauchhaus U; Bruns L; Reichardt HM; Kamradt T; Brauer R; Tuckermann JP. 2011. Glucocorticoid therapy of antigen-induced arthritis depends on the dimerized glucocorticoid receptor in T cells. Proc Natl Acad Sci U S A 108(48):19317-22. PubMed: 22084093 MGI: J:180395
Bastos KR; de Deus Vieira de Moraes L; Zago CA; Marinho CR; Russo M; Alvarez JM; D'Imperio Lima MR. 2005. Analysis of the activation profile of dendritic cells derived from the bone marrow of interleukin-12/interleukin-23-deficient mice. Immunology 114(4):499-506. PubMed: 15804287 MGI: J:97435
Basu R; O'Quinn DB; Silberger DJ; Schoeb TR; Fouser L; Ouyang W; Hatton RD; Weaver CT. 2012. Th22 Cells Are an Important Source of IL-22 for Host Protection against Enteropathogenic Bacteria. Immunity 37(6):1061-75. PubMed: 23200827 MGI: J:191059
Batchelder JM; Burns JM Jr; Cigel FK; Lieberg H; Manning DD; Pepper BJ; Yanez DM; van der Heyde H; Weidanz WP. 2003. Plasmodium chabaudi adami: interferon-gamma but not IL-2 is essential for the expression of cell-mediated immunity against blood-stage parasites in mice. Exp Parasitol 105(2):159-66. PubMed: 14969693 MGI: J:102606
Beattie L; Svensson M; Bune A; Brown N; Maroof A; Zubairi S; Smith KR; Kaye PM. 2010. Leishmania donovani-induced expression of signal regulatory protein alpha on Kupffer cells enhances hepatic invariant NKT-cell activation. Eur J Immunol 40(1):117-23. PubMed: 19877019 MGI: J:155693
Behrens EM; Canna SW; Slade K; Rao S; Kreiger PA; Paessler M; Kambayashi T; Koretzky GA. 2011. Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice. J Clin Invest 121(6):2264-77. PubMed: 21576823 MGI: J:173903
Bendle GM; Linnemann C; Hooijkaas AI; Bies L; de Witte MA; Jorritsma A; Kaiser AD; Pouw N; Debets R; Kieback E; Uckert W; Song JY; Haanen JB; Schumacher TN. 2010. Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy. Nat Med 16(5):565-70, 1p following 570. PubMed: 20400962 MGI: J:160623
Bergmann CC; Parra B; Hinton DR; Chandran R; Morrison M; Stohlman SA. 2003. Perforin-mediated effector function within the central nervous system requires IFN-gamma-mediated MHC up-regulation. J Immunol 170(6):3204-13. PubMed: 12626579 MGI: J:126219
Berner V; Liu H; Zhou Q; Alderson KL; Sun K; Weiss JM; Back TC; Longo DL; Blazar BR; Wiltrout RH; Welniak LA; Redelman D; Murphy WJ. 2007. IFN-gamma mediates CD4+ T-cell loss and impairs secondary antitumor responses after successful initial immunotherapy. Nat Med 13(3):354-60. PubMed: 17334371 MGI: J:121706
Betts G; Twohig J; Van den Broek M; Sierro S; Godkin A; Gallimore A. 2007. The impact of regulatory T cells on carcinogen-induced sarcogenesis. Br J Cancer 96(12):1849-54. PubMed: 17565340 MGI: J:122744
Bi Y; Zhou J; Yang H; Wang X; Zhang X; Wang Q; Wu X; Han Y; Song Y; Tan Y; Du Z; Yang H; Zhou D; Cui Y; Zhou L; Yan Y; Zhang P; Guo Z; Wang X; Liu G; Yang R. 2014. IL-17A produced by neutrophils protects against pneumonic plague through orchestrating IFN-gamma-activated macrophage programming. J Immunol 192(2):704-13. PubMed: 24337746 MGI: J:207323
Birkner K; Steiner B; Rinkler C; Kern Y; Aichele P; Bogdan C; von Loewenich FD. 2008. The elimination of Anaplasma phagocytophilum requires CD4(+) T cells, but is independent of Th1 cytokines and a wide spectrum of effector mechanisms. Eur J Immunol 38(12):3395-3410. PubMed: 19039769 MGI: J:141369
Bishop DK; Chan Wood S; Eichwald EJ; Orosz CG. 2001. Immunobiology of allograft rejection in the absence of IFN-gamma: CD8+ effector cells develop independently of CD4+ cells and CD40-CD40 ligand interactions. J Immunol 166(5):3248-55. PubMed: 11207279 MGI: J:126479
Bitsaktsis C; Huntington J; Winslow G. 2004. Production of IFN-gamma by CD4 T cells is essential for resolving ehrlichia infection. J Immunol 172(11):6894-901. PubMed: 15153508 MGI: J:90518
Bitsaktsis C; Nandi B; Racine R; MacNamara KC; Winslow G. 2007. T-Cell-independent humoral immunity is sufficient for protection against fatal intracellular ehrlichia infection. Infect Immun 75(10):4933-41. PubMed: 17664264 MGI: J:125283
Bitsaktsis C; Rawool DB; Li Y; Kurkure NV; Iglesias B; Gosselin EJ. 2009. Differential requirements for protection against mucosal challenge with Francisella tularensis in the presence versus absence of cholera toxin B and inactivated F. tularensis. J Immunol 182(8):4899-909. PubMed: 19342669 MGI: J:147502
Blais ME; Brochu S; Giroux M; Belanger MP; Dulude G; Sekaly RP; Perreault C. 2008. Why T cells of thymic versus extrathymic origin are functionally different. J Immunol 180(4):2299-312. PubMed: 18250439 MGI: J:131997
Blazar BR; Carreno BM; Panoskaltsis-Mortari A; Carter L; Iwai Y; Yagita H; Nishimura H; Taylor PA. 2003. Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism. J Immunol 171(3):1272-7. PubMed: 12874215 MGI: J:120213
Blazar BR; Lees CJ; Martin PJ; Noelle RJ; Kwon B; Murphy W; Taylor PA. 2000. Host T cells resist graft-versus-host disease mediated by donor leukocyte infusions. J Immunol 165(9):4901-9. PubMed: 11046015 MGI: J:118027
Blohm U; Potthoff D; van der Kogel AJ; Pircher H. 2006. Solid tumors 'melt' from the inside after successful CD8 T cell attack. Eur J Immunol 36(2):468-77. PubMed: 16385625 MGI: J:113858
Bokhari SM; Kim KJ; Pinson DM; Slusser J; Yeh HW; Parmely MJ. 2008. NK cells and gamma interferon coordinate the formation and function of hepatic granulomas in mice infected with the Francisella tularensis live vaccine strain. Infect Immun 76(4):1379-89. PubMed: 18227174 MGI: J:133531
Borjesson DL; Simon SI; Hodzic E; Ballantyne CM; Barthold SW. 2002. Kinetics of CD11b/CD18 up-regulation during infection with the agent of human granulocytic ehrlichiosis in mice. Lab Invest 82(3):303-11. PubMed: 11896209 MGI: J:75433
Bouley DM; Kanangat S; Wire W; Rouse BT. 1995. Characterization of herpes simplex virus type-1 infection and herpetic stromal keratitis development in IFN-gamma knockout mice. J Immunol 155(8):3964-71. PubMed: 7561104 MGI: J:29170
Bour-Jordan H; Thompson HL; Bluestone JA. 2005. Distinct effector mechanisms in the development of autoimmune neuropathy versus diabetes in nonobese diabetic mice. J Immunol 175(9):5649-55. PubMed: 16237054 MGI: J:119359
Brandl K; Plitas G; Schnabl B; DeMatteo RP; Pamer EG. 2007. MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection. J Exp Med 204(8):1891-900. PubMed: 17635956 MGI: J:125955
Bregenholt S; Berche P; Brombacher F; Di Santo JP. 2001. Conventional alpha beta T cells are sufficient for innate and adaptive immunity against enteric Listeria monocytogenes. J Immunol 166(3):1871-6. PubMed: 11160234 MGI: J:127008
Breser ML; Motrich RD; Sanchez LR; Mackern-Oberti JP; Rivero VE. 2013. Expression of CXCR3 on Specific T Cells Is Essential for Homing to the Prostate Gland in an Experimental Model of Chronic Prostatitis/Chronic Pelvic Pain Syndrome. J Immunol 190(7):3121-33. PubMed: 23455510 MGI: J:194822
Brien JD; Uhrlaub JL; Hirsch A; Wiley CA; Nikolich-Zugich J. 2009. Key role of T cell defects in age-related vulnerability to West Nile virus. J Exp Med 206(12):2735-45. PubMed: 19901080 MGI: J:155455
Briesemeister D; Friese C; Isern CC; Dietz E; Blankenstein T; Thoene-Reineke C; Kammertoens T. 2012. Differences in serum cytokine levels between wild type mice and mice with a targeted mutation suggests necessity of using control littermates. Cytokine 60(3):626-33. PubMed: 22902947 MGI: J:192770
Brochard V; Combadiere B; Prigent A; Laouar Y; Perrin A; Beray-Berthat V; Bonduelle O; Alvarez-Fischer D; Callebert J; Launay JM; Duyckaerts C; Flavell RA; Hirsch EC; Hunot S. 2009. Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease. J Clin Invest 119(1):182-92. PubMed: 19104149 MGI: J:144702
Brown DM; Dilzer AM; Meents DL; Swain SL. 2006. CD4 T cell-mediated protection from lethal influenza: perforin and antibody-mediated mechanisms give a one-two punch. J Immunol 177(5):2888-98. PubMed: 16920924 MGI: J:139502
Bry L; Brigl M; Brenner MB. 2006. CD4+-T-cell effector functions and costimulatory requirements essential for surviving mucosal infection with Citrobacter rodentium. Infect Immun 74(1):673-81. PubMed: 16369024 MGI: J:104251
Buchanan RM; Arulanandam BP; Metzger DW. 1998. IL-12 enhances antibody responses to T-independent polysaccharide vaccines in the absence of T and NK cells. J Immunol 161(10):5525-33. PubMed: 9820529 MGI: J:115023
Buhtoiarov IN; Lum HD; Berke G; Sondel PM; Rakhmilevich AL. 2006. Synergistic activation of macrophages via CD40 and TLR9 results in T cell independent antitumor effects. J Immunol 176(1):309-18. PubMed: 16365423 MGI: J:126263
Buhtoiarov IN; Sondel PM; Eickhoff JC; Rakhmilevich AL. 2007. Macrophages are essential for antitumour effects against weakly immunogenic murine tumours induced by class B CpG-oligodeoxynucleotides. Immunology 120(3):412-23. PubMed: 17163960 MGI: J:122619
Bullen DV; Baldwin TM; Curtis JM; Alexander WS; Handman E. 2003. Persistence of lesions in suppressor of cytokine signaling-1-deficient mice infected with Leishmania major. J Immunol 170(8):4267-72. PubMed: 12682261 MGI: J:125437
Bullen DV; Darwiche R; Metcalf D; Handman E; Alexander WS. 2001. Neutralization of interferon-gamma in neonatal SOCS1-/- mice prevents fatty degeneration of the liver but not subsequent fatal inflammatory disease. Immunology 104(1):92-8. PubMed: 11576226 MGI: J:71691
Buono C; Come CE; Stavrakis G; Maguire GF; Connelly PW; Lichtman AH. 2003. Influence of interferon-gamma on the extent and phenotype of diet-induced atherosclerosis in the LDLR-deficient mouse. Arterioscler Thromb Vasc Biol 23(3):454-60. PubMed: 12615659 MGI: J:103072
Burch LH; Yang IV; Whitehead GS; Chao FG; Berman KG; Schwartz DA. 2006. The transcriptional response to lipopolysaccharide reveals a role for interferon-gamma in lung neutrophil recruitment. Am J Physiol Lung Cell Mol Physiol 291(4):L677-82. PubMed: 16766576 MGI: J:144404
Burdeinick-Kerr R; Wind J; Griffin DE. 2007. Synergistic roles of antibody and interferon in noncytolytic clearance of Sindbis virus from different regions of the central nervous system. J Virol 81(11):5628-36. PubMed: 17376910 MGI: J:153321
Burman AC; Banovic T; Kuns RD; Clouston AD; Stanley AC; Morris ES; Rowe V; Bofinger H; Skoczylas R; Raffelt N; Fahy O; McColl SR; Engwerda CR; McDonald KP; Hill GR. 2007. IFNgamma differentially controls the development of idiopathic pneumonia syndrome and GVHD of the gastrointestinal tract. Blood 110(3):1064-72. PubMed: 17449800 MGI: J:145394
Burne MJ; Daniels F; El Ghandour A; Mauiyyedi S; Colvin RB; O'Donnell MP; Rabb H. 2001. Identification of the CD4(+) T cell as a major pathogenic factor in ischemic acute renal failure. J Clin Invest 108(9):1283-90. PubMed: 11696572 MGI: J:118005
Burrell BE; Csencsits K; Lu G; Grabauskiene S; Bishop DK. 2008. CD8+ Th17 mediate costimulation blockade-resistant allograft rejection in T-bet-deficient mice. J Immunol 181(6):3906-14. PubMed: 18768845 MGI: J:139106
Buxbaum LU; Uzonna JE; Goldschmidt MH; Scott P. 2002. Control of New World cutaneous leishmaniasis is IL-12 independent but STAT4 dependent. Eur J Immunol 32(11):3206-15. PubMed: 12555666 MGI: J:115538
Byrne KT; Vonderheide RH. 2016. CD40 Stimulation Obviates Innate Sensors and Drives T Cell Immunity in Cancer. Cell Rep 15(12):2719-32. PubMed: 27292635 MGI: J:238302
Caccamo N; Sireci G; Meraviglia S; Dieli F; Ivanyi J; Salerno A. 2006. gammadelta T cells condition dendritic cells in vivo for priming pulmonary CD8 T cell responses against Mycobacterium tuberculosis. Eur J Immunol 36(10):2681-90. PubMed: 16981183 MGI: J:118094
Cafruny WA; Bradley SE; Rowland RR. 1999. Regulation of immune complexes during infection of mice with lactate dehydrogenase-elevating virus: studies with interferon-gamma gene knockout and tolerant mice. Viral Immunol 12(2):163-73. PubMed: 10413362 MGI: J:58076
Cain JA; Smith JA; Ondr JK; Wang B; Katz JD. 2006. NKT cells and IFN-gamma establish the regulatory environment for the control of diabetogenic T cells in the nonobese diabetic mouse. J Immunol 176(3):1645-54. PubMed: 16424194 MGI: J:126603
Calabrese V; Mallette FA; Deschenes-Simard X; Ramanathan S; Gagnon J; Moores A; Ilangumaran S; Ferbeyre G. 2009. SOCS1 links cytokine signaling to p53 and senescence. Mol Cell 36(5):754-67. PubMed: 20005840 MGI: J:155447
Campos MA; Closel M; Valente EP; Cardoso JE; Akira S; Alvarez-Leite JI; Ropert C; Gazzinelli RT. 2004. Impaired production of proinflammatory cytokines and host resistance to acute infection with Trypanosoma cruzi in mice lacking functional myeloid differentiation factor 88. J Immunol 172(3):1711-8. PubMed: 14734753 MGI: J:87693
Campos RA; Szczepanik M; Itakura A; Akahira-Azuma M; Sidobre S; Kronenberg M; Askenase PW. 2003. Cutaneous immunization rapidly activates liver invariant Valpha14 NKT cells stimulating B-1 B cells to initiate T cell recruitment for elicitation of contact sensitivity. J Exp Med 198(12):1785-96. PubMed: 14676294 MGI: J:132827
Cannons JL; Yu LJ; Hill B; Mijares LA; Dombroski D; Nichols KE; Antonellis A; Koretzky GA; Gardner K; Schwartzberg PL. 2004. SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1. Immunity 21(5):693-706. PubMed: 15539155 MGI: J:93887
Cantin E; Tanamachi B; Openshaw H; Mann J; Clarke K. 1999. Gamma interferon (IFN-gamma) receptor null-mutant mice are more susceptible to herpes simplex virus type 1 infection than IFN-gamma ligand null-mutant mice. J Virol 73(6):5196-200. PubMed: 10233988 MGI: J:54949
Cao W; Yang Y; Wang Z; Liu A; Fang L; Wu F; Hong J; Shi Y; Leung S; Dong C; Zhang JZ. 2011. Leukemia inhibitory factor inhibits T helper 17 cell differentiation and confers treatment effects of neural progenitor cell therapy in autoimmune disease. Immunity 35(2):273-84. PubMed: 21835648 MGI: J:176067
Cao X; Leonard K; Collins LI; Cai SF; Mayer JC; Payton JE; Walter MJ; Piwnica-Worms D; Schreiber RD; Ley TJ. 2009. Interleukin 12 stimulates IFN-gamma-mediated inhibition of tumor-induced regulatory T-cell proliferation and enhances tumor clearance. Cancer Res 69(22):8700-9. PubMed: 19843867 MGI: J:154453
Caretto D; Katzman SD; Villarino AV; Gallo E; Abbas AK. 2010. Cutting edge: the Th1 response inhibits the generation of peripheral regulatory T cells. J Immunol 184(1):30-4. PubMed: 19949064 MGI: J:159046
Carow B; Ye X; Gavier-Widen D; Bhuju S; Oehlmann W; Singh M; Skold M; Ignatowicz L; Yoshimura A; Wigzell H; Rottenberg ME. 2011. Silencing suppressor of cytokine signaling-1 (SOCS1) in macrophages improves Mycobacterium tuberculosis control in an interferon-gamma (IFN-gamma)-dependent manner. J Biol Chem 286(30):26873-87. PubMed: 21622562 MGI: J:175389
Carvalho-Pinto CE; Garcia MI; Mellado M; Rodriguez-Frade JM; Martin-Caballero J; Flores J; Martinez-A C; Balomenos D. 2002. Autocrine production of IFN-gamma by macrophages controls their recruitment to kidney and the development of glomerulonephritis in MRL/lpr mice. J Immunol 169(2):1058-67. PubMed: 12097414 MGI: J:123834
Case LK; Petell L; Yurkovetskiy L; Purdy A; Savage KJ; Golovkina TV. 2008. Replication of beta- and gammaretroviruses is restricted in I/LnJ mice via the same genetic mechanism. J Virol 82(3):1438-47. PubMed: 18057254 MGI: J:163153
Castilow EM; Legge KL; Varga SM. 2008. Cutting edge: Eosinophils do not contribute to respiratory syncytial virus vaccine-enhanced disease. J Immunol 181(10):6692-6. PubMed: 18981084 MGI: J:140954
Cathcart HM; Zheng M; Covar JJ; Liu Y; Podolsky R; Atherton SS. 2011. Interferon-gamma, macrophages, and virus spread after HSV-1 injection. Invest Ophthalmol Vis Sci 52(7):3984-93. PubMed: 21345992 MGI: J:181441
Cenci E; Mencacci A; Del Sero G; Bacci A; Montagnoli C; d'Ostiani CF; Mosci P; Bachmann M; Bistoni F; Kopf M; Romani L. 1999. Interleukin-4 causes susceptibility to invasive pulmonary aspergillosis through suppression of protective type I responses. J Infect Dis 180(6):1957-68. PubMed: 10558953 MGI: J:119841
Cernetich A; Garver LS; Jedlicka AE; Klein PW; Kumar N; Scott AL; Klein SL. 2006. Involvement of gonadal steroids and gamma interferon in sex differences in response to blood-stage malaria infection. Infect Immun 74(6):3190-203. PubMed: 16714546 MGI: J:109239
Chan CJ; Andrews DM; McLaughlin NM; Yagita H; Gilfillan S; Colonna M; Smyth MJ. 2010. DNAM-1/CD155 interactions promote cytokine and NK cell-mediated suppression of poorly immunogenic melanoma metastases. J Immunol 184(2):902-11. PubMed: 20008292 MGI: J:159408
Chan WC; Duong TT; Yeung RS. 2004. Presence of IFN-gamma does not indicate its necessity for induction of coronary arteritis in an animal model of Kawasaki disease. J Immunol 173(5):3492-503. PubMed: 15322214 MGI: J:92708
Chang CP; Yang MC; Lei HY. 2011. Concanavalin A/IFN-gamma triggers autophagy-related necrotic hepatocyte death through IRGM1-mediated lysosomal membrane disruption. PLoS One 6(12):e28323. PubMed: 22163006 MGI: J:182269
Chang JH; Cha HR; Chang SY; Ko HJ; Seo SU; Kweon MN. 2011. IFN-gamma secreted by CD103+ dendritic cells leads to IgG generation in the mesenteric lymph node in the absence of vitamin A. J Immunol 186(12):6999-7005. PubMed: 21572021 MGI: J:175489
Chang JT; Shevach EM; Segal BM. 1999. Regulation of interleukin (IL)-12 receptor beta2 subunit expression by endogenous IL-12: a critical step in the differentiation of pathogenic autoreactive T cells. J Exp Med 189(6):969-78. PubMed: 10075980 MGI: J:53619
Chang YJ; Kim HY; Albacker LA; Baumgarth N; McKenzie AN; Smith DE; Dekruyff RH; Umetsu DT. 2011. Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity. Nat Immunol 12(7):631-8. PubMed: 21623379 MGI: J:174316
Charlebois R; Allard B; Allard D; Buisseret L; Turcotte M; Pommey S; Chrobak P; Stagg J. 2017. PolyI:C and CpG Synergize with Anti-ErbB2 mAb for Treatment of Breast Tumors Resistant to Immune Checkpoint Inhibitors. Cancer Res 77(2):312-319. PubMed: 27872096 MGI: J:238428
Charles E; Joshi S; Ash JD; Fox BA; Farris AD; Bzik DJ; Lang ML; Blader IJ. 2010. CD4 T-cell suppression by cells from Toxoplasma gondii-infected retinas is mediated by surface protein PD-L1. Infect Immun 78(8):3484-92. PubMed: 20498261 MGI: J:161696
Chatterjee S; Eby JM; Al-Khami AA; Soloshchenko M; Kang HK; Kaur N; Naga OS; Murali A; Nishimura MI; Le Poole IC; Mehrotra S. 2014. A quantitative increase in regulatory T cells controls development of vitiligo. J Invest Dermatol 134(5):1285-94. PubMed: 24366614 MGI: J:208054
Chen ES; Greenlee BM; Wills-Karp M; Moller DR. 2001. Attenuation of lung inflammation and fibrosis in interferon-gamma-deficient mice after intratracheal bleomycin. Am J Respir Cell Mol Biol 24(5):545-55. PubMed: 11350823 MGI: J:114439
Chen J; Feng X; Desierto MJ; Keyvanfar K; Young NS. 2015. IFN-gamma-mediated hematopoietic cell destruction in murine models of immune-mediated bone marrow failure. Blood 126(24):2621-31. PubMed: 26491068 MGI: J:230069
Chen K; McAleer JP; Lin Y; Paterson DL; Zheng M; Alcorn JF; Weaver CT; Kolls JK. 2011. Th17 cells mediate clade-specific, serotype-independent mucosal immunity. Immunity 35(6):997-1009. PubMed: 22195749 MGI: J:179276
Chen K; Wei Y; Sharp GC; Braley-Mullen H. 2003. Mechanisms of spontaneous resolution versus fibrosis in granulomatous experimental autoimmune thyroiditis. J Immunol 171(11):6236-43. PubMed: 14634140 MGI: J:117995
Chen ML; Yan BS; Kozoriz D; Weiner HL. 2009. Novel CD8+ Treg suppress EAE by TGF-beta- and IFN-gamma-dependent mechanisms. Eur J Immunol 39(12):3423-35. PubMed: 19768696 MGI: J:155492
Chen Y; Chong MM; Darwiche R; Thomas HE; Kay TW. 2004. Severe pancreatitis with exocrine destruction and increased islet neogenesis in mice with suppressor of cytokine signaling-1 deficiency. Am J Pathol 165(3):913-21. PubMed: 15331415 MGI: J:92419
Cheng M; Nguyen MH; Fantuzzi G; Koh TJ. 2008. Endogenous interferon-gamma is required for efficient skeletal muscle regeneration. Am J Physiol Cell Physiol 294(5):C1183-91. PubMed: 18353892 MGI: J:136628
Chensue SW; Warmington K; Ruth JH; Lukacs N; Kunkel SL. 1997. Mycobacterial and schistosomal antigen-elicited granuloma formation in IFN-gamma and IL-4 knockout mice: analysis of local and regional cytokine and chemokine networks. J Immunol 159(7):3565-73. PubMed: 9317156 MGI: J:43085
Chessler AD; Unnikrishnan M; Bei AK; Daily JP; Burleigh BA. 2009. Trypanosoma cruzi triggers an early type I IFN response in vivo at the site of intradermal infection. J Immunol 182(4):2288-96. PubMed: 19201883 MGI: J:144788
Chiaramonte MG; Hesse M; Cheever AW; Wynn TA. 2000. CpG oligonucleotides can prophylactically immunize against Th2-mediated schistosome egg-induced pathology by an IL-12-independent mechanism. J Immunol 164(2):973-85. PubMed: 10623847 MGI: J:127058
Chiarle R; Martinengo C; Mastini C; Ambrogio C; D'Escamard V; Forni G; Inghirami G. 2008. The anaplastic lymphoma kinase is an effective oncoantigen for lymphoma vaccination. Nat Med 14(6):676-80. PubMed: 18469826 MGI: J:136968
Chinen T; Kobayashi T; Ogata H; Takaesu G; Takaki H; Hashimoto M; Yagita H; Nawata H; Yoshimura A. 2006. Suppressor of cytokine signaling-1 regulates inflammatory bowel disease in which both IFNgamma and IL-4 are involved. Gastroenterology 130(2):373-88. PubMed: 16472593 MGI: J:124924
Chinen T; Komai K; Muto G; Morita R; Inoue N; Yoshida H; Sekiya T; Yoshida R; Nakamura K; Takayanagi R; Yoshimura A. 2011. Prostaglandin E2 and SOCS1 have a role in intestinal immune tolerance. Nat Commun 2:190. PubMed: 21304519 MGI: J:220939
Chiodoni C; Stoppacciaro A; Sangaletti S; Gri G; Cappetti B; Koezuka Y; Colombo MP. 2001. Different requirements for alpha-galactosylceramide and recombinant IL-12 antitumor activity in the treatment of C-26 colon carcinoma hepatic metastases. Eur J Immunol 31(10):3101-10. PubMed: 11592087 MGI: J:115631
Cho HI; Celis E. 2009. Optimized peptide vaccines eliciting extensive CD8 T-cell responses with therapeutic antitumor effects. Cancer Res 69(23):9012-9. PubMed: 19903852 MGI: J:155054
Cho HI; Lee YR; Celis E. 2011. Interferon gamma limits the effectiveness of melanoma peptide vaccines. Blood 117(1):135-44. PubMed: 20889921 MGI: J:168428
Choi BK; Kim YH; Kim CH; Kim MS; Kim KH; Oh HS; Lee MJ; Lee DK; Vinay DS; Kwon BS. 2010. Peripheral 4-1BB signaling negatively regulates NK cell development through IFN-gamma. J Immunol 185(3):1404-11. PubMed: 20610645 MGI: J:162245
Choi KS; Song EK; Yim CY. 2008. Cytokines secreted by IL-2-activated lymphocytes induce endogenous nitric oxide synthesis and apoptosis in macrophages. J Leukoc Biol 83(6):1440-50. PubMed: 18339892 MGI: J:136847
Chong SZ; Tan KW; Wong FH; Chua YL; Tang Y; Ng LG; Angeli V; Kemeny DM. 2014. CD8 T Cells Regulate Allergic Contact Dermatitis by Modulating CCR2-Dependent TNF/iNOS-Expressing Ly6C(+)CD11b(+) Monocytic Cells. J Invest Dermatol 134(3):666-76. PubMed: 24061165 MGI: J:206039
Chopra M; Langenhorst D; Beilhack A; Serfling E; Patra AK. 2015. Interleukin-2 critically regulates bone marrow erythropoiesis and prevents anemia development. Eur J Immunol 45(12):3362-74. PubMed: 26404745 MGI: J:233778
Choudhury A; Cohen PL; Eisenberg RA. 2010. B cells require 'nurturing' by CD4 T cells during development in order to respond in chronic graft-versus-host model of systemic lupus erythematosus. Clin Immunol :. PubMed: 20381429 MGI: J:160847
Christensen JE; Simonsen S; Fenger C; Sorensen MR; Moos T; Christensen JP; Finsen B; Thomsen AR. 2009. Fulminant lymphocytic choriomeningitis virus-induced inflammation of the CNS involves a cytokine-chemokine-cytokine-chemokine cascade. J Immunol 182(2):1079-87. PubMed: 19124751 MGI: J:143550
Christensen JE; Wodarz D; Christensen JP; Thomsen AR. 2004. Perforin and IFN-gamma do not significantly regulate the virus-specific CD8+ T cell response in the absence of antiviral effector activity. Eur J Immunol 34(5):1389-94. PubMed: 15114672 MGI: J:89390
Christensen JP; Bartholdy C; Wodarz D; Thomsen AR. 2001. Depletion of CD4+ T cells precipitates immunopathology in immunodeficient mice infected with a noncytocidal virus. J Immunol 166(5):3384-91. PubMed: 11207295 MGI: J:126477
Chu CQ; Song Z; Mayton L; Wu B; Wooley PH. 2003. IFNgamma deficient C57BL/6 (H-2b) mice develop collagen induced arthritis with predominant usage of T cell receptor Vbeta6 and Vbeta8 in arthritic joints. Ann Rheum Dis 62(10):983-90. PubMed: 12972478 MGI: J:106216
Chu CQ; Wittmer S; Dalton DK. 2000. Failure to suppress the expansion of the activated CD4 T cell population in interferon gamma-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis J Exp Med 192(1):123-8. PubMed: 10880533 MGI: J:63143
Ciric B; El-behi M; Cabrera R; Zhang GX; Rostami A. 2009. IL-23 drives pathogenic IL-17-producing CD8+ T cells. J Immunol 182(9):5296-305. PubMed: 19380776 MGI: J:150310
Cobb D; Hambright D; Smeltz RB. 2010. T-bet-independent effects of IL-12 family cytokines on regulation of Th17 responses to experimental T. cruzi infection. J Leukoc Biol 88(5):965-71. PubMed: 20807701 MGI: J:166092
Codarri L; Gyulveszi G; Tosevski V; Hesske L; Fontana A; Magnenat L; Suter T; Becher B. 2011. RORgammat drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation. Nat Immunol 12(6):560-7. PubMed: 21516112 MGI: J:172802
Coers J; Gondek DC; Olive AJ; Rohlfing A; Taylor GA; Starnbach MN. 2011. Compensatory T cell responses in IRG-deficient mice prevent sustained Chlamydia trachomatis infections. PLoS Pathog 7(6):e1001346. PubMed: 21731484 MGI: J:182190
Cohen M; Elkabets M; Perlmutter M; Porgador A; Voronov E; Apte RN; Lichtenstein RG. 2010. Sialylation of 3-methylcholanthrene-induced fibrosarcoma determines antitumor immune responses during immunoediting. J Immunol 185(10):5869-78. PubMed: 20956342 MGI: J:165779
Cohn L; Herrick C; Niu N; Homer R; Bottomly K. 2001. IL-4 promotes airway eosinophilia by suppressing IFN-gamma production: defining a novel role for IFN-gamma in the regulation of allergic airway inflammation. J Immunol 166(4):2760-7. PubMed: 11160342 MGI: J:126916
Collazo CM; Meierovics AI; De Pascalis R; Wu TH; Lyons CR; Elkins KL. 2009. T cells from lungs and livers of Francisella tularensis-immune mice control the growth of intracellular bacteria. Infect Immun 77(5):2010-21. PubMed: 19237526 MGI: J:148524
Collins JT; Shi J; Burrell BE; Bishop DK; Dunnick WA. 2006. Induced expression of murine gamma2a by CD40 ligation independently of IFN-gamma. J Immunol 177(8):5414-9. PubMed: 17015727 MGI: J:139436
Combe CL; Moretto MM; Schwartzman JD; Gigley JP; Bzik DJ; Khan IA. 2006. Lack of IL-15 results in the suboptimal priming of CD4+ T cell response against an intracellular parasite. Proc Natl Acad Sci U S A 103(17):6635-40. PubMed: 16614074 MGI: J:109105
Cone RE; Li X; Sharafieh R; O'Rourke J; Vella AT. 2007. The suppression of delayed-type hypersensitivity by CD8+ regulatory T cells requires interferon-gamma. Immunology 120(1):112-9. PubMed: 17052246 MGI: J:122316
Cooper AM; Dalton DK; Stewart TA; Griffin JP; Russell DG; Orme IM. 1993. Disseminated tuberculosis in interferon gamma gene-disrupted mice. J Exp Med 178(6):2243-7. PubMed: 8245795 MGI: J:15723
Copin R; Vitry MA; Hanot Mambres D; Machelart A; De Trez C; Vanderwinden JM; Magez S; Akira S; Ryffel B; Carlier Y; Letesson JJ; Muraille E. 2012. In situ microscopy analysis reveals local innate immune response developed around Brucella infected cells in resistant and susceptible mice. PLoS Pathog 8(3):e1002575. PubMed: 22479178 MGI: J:195395
Cornish AL; Chong MM; Davey GM; Darwiche R; Nicola NA; Hilton DJ; Kay TW; Starr R; Alexander WS. 2003. Suppressor of cytokine signaling-1 regulates signaling in response to interleukin-2 and other gamma c-dependent cytokines in peripheral T cells. J Biol Chem 278(25):22755-61. PubMed: 12665516 MGI: J:124411
Cornish AL; Davey GM; Metcalf D; Purton JF; Corbin JE; Greenhalgh CJ; Darwiche R; Wu L; Nicola NA; Godfrey DI; Heath WR; Hilton DJ; Alexander WS; Starr R. 2003. Suppressor of cytokine signaling-1 has IFN-gamma-independent actions in T cell homeostasis. J Immunol 170(2):878-86. PubMed: 12517953 MGI: J:127134
Costigan M; Moss A; Latremoliere A; Johnston C; Verma-Gandhu M; Herbert TA; Barrett L; Brenner GJ; Vardeh D; Woolf CJ; Fitzgerald M. 2009. T-cell infiltration and signaling in the adult dorsal spinal cord is a major contributor to neuropathic pain-like hypersensitivity. J Neurosci 29(46):14415-22. PubMed: 19923276 MGI: J:158280
Coursey TG; Chen PW; Niederkorn JY. 2011. Abrogating TNF-{alpha} Expression Prevents Bystander Destruction of Normal Tissues during iNOS-Mediated Elimination of Intraocular Tumors. Cancer Res 71(7):2445-54. PubMed: 21307132 MGI: J:170908
Coursey TG; Chen PW; Niederkorn JY. 2011. IL-17-dependent, IFN-gamma-independent tumor rejection is mediated by cytotoxic T lymphocytes and occurs at extraocular sites, but is excluded from the eye. J Immunol 187(8):4219-28. PubMed: 21918192 MGI: J:179307
Coursey TG; Tukler Henriksson J; Barbosa FL; de Paiva CS; Pflugfelder SC. 2016. Interferon-gamma-Induced Unfolded Protein Response in Conjunctival Goblet Cells as a Cause of Mucin Deficiency in Sjogren Syndrome. Am J Pathol 186(6):1547-58. PubMed: 27085137 MGI: J:233696
Cretney E; Takeda K; Yagita H; Glaccum M; Peschon JJ; Smyth MJ. 2002. Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice. J Immunol 168(3):1356-61. PubMed: 11801676 MGI: J:73948
Croker B; Crozat K; Berger M; Xia Y; Sovath S; Schaffer L; Eleftherianos I; Imler JL; Beutler B. 2007. ATP-sensitive potassium channels mediate survival during infection in mammals and insects. Nat Genet 39(12):1453-60. PubMed: 18026101 MGI: J:126658
Croom HA; Izon DJ; Chong MM; Curtis DJ; Roberts AW; Kay TW; Hilton DJ; Alexander WS; Starr R. 2008. Perturbed thymopoiesis in vitro in the absence of suppressor of cytokine signalling 1 and 3. Mol Immunol 45(10):2888-96. PubMed: 18321577 MGI: J:134472
Cruz A; Khader SA; Torrado E; Fraga A; Pearl JE; Pedrosa J; Cooper AM; Castro AG. 2006. Cutting edge: IFN-gamma regulates the induction and expansion of IL-17-producing CD4 T cells during mycobacterial infection. J Immunol 177(3):1416-20. PubMed: 16849446 MGI: J:137981
Cuff S; Dolton G; Matthews RJ; Gallimore A. 2010. Antigen specificity determines the pro- or antitumoral nature of CD8+ T cells. J Immunol 184(2):607-14. PubMed: 20007540 MGI: J:159412
Curtsinger JM; Agarwal P; Lins DC; Mescher MF. 2012. Autocrine IFN-gamma promotes naive CD8 T cell differentiation and synergizes with IFN-alpha to stimulate strong function. J Immunol 189(2):659-68. PubMed: 22706089 MGI: J:189538
D'Aveni M; Rossignol J; Coman T; Sivakumaran S; Henderson S; Manzo T; Santos e Sousa P; Bruneau J; Fouquet G; Zavala F; Alegria-Prevot O; Garfa-Traore M; Suarez F; Trebeden-Negre H; Mohty M; Bennett CL; Chakraverty R; Hermine O; Rubio MT. 2015. G-CSF mobilizes CD34+ regulatory monocytes that inhibit graft-versus-host disease. Sci Transl Med 7(281):281ra42. PubMed: 25834108 MGI: J:234081
Dai JH; Iwatani Y; Ishida T; Terunuma H; Kasai H; Iwakula Y; Fujiwara H; Ito M. 2001. Glycyrrhizin enhances interleukin-12 production in peritoneal macrophages. Immunology 103(2):235-43. PubMed: 11412311 MGI: J:69773
Dalton DK; Haynes L; Chu CQ; Swain SL; Wittmer S. 2000. Interferon gamma eliminates responding CD4 T cells during mycobacterial infection by inducing apoptosis of activated CD4 T cells. J Exp Med 192(1):117-22. PubMed: 10880532 MGI: J:115328
Dandekar AA; Anghelina D; Perlman S. 2004. Bystander CD8 T-cell-mediated demyelination is interferon-gamma-dependent in a coronavirus model of multiple sclerosis. Am J Pathol 164(2):363-9. PubMed: 14742242 MGI: J:88552
Davey GM; Starr R; Cornish AL; Burghardt JT; Alexander WS; Carbone FR; Surh CD; Heath WR. 2005. SOCS-1 regulates IL-15-driven homeostatic proliferation of antigen-naive CD8 T cells, limiting their autoimmune potential. J Exp Med 202(8):1099-108. PubMed: 16216888 MGI: J:116818
De Colvenaer V; Taveirne S; Hamann J; de Bruin AM; De Smedt M; Taghon T; Vandekerckhove B; Plum J; van Lier R; Leclercq G. 2010. Continuous CD27 triggering in vivo strongly reduces NK cell numbers. Eur J Immunol 40(4):1107-17. PubMed: 20140903 MGI: J:159189
De Paiva CS; Chotikavanich S; Pangelinan SB; Pitcher JD 3rd; Fang B; Zheng X; Ma P; Farley WJ; Siemasko KF; Niederkorn JY; Stern ME; Li DQ; Pflugfelder SC. 2009. IL-17 disrupts corneal barrier following desiccating stress. Mucosal Immunol 2(3):243-53. PubMed: 19242409 MGI: J:191918
De Paiva CS; Villarreal AL; Corrales RM; Rahman HT; Chang VY; Farley WJ; Stern ME; Niederkorn JY; Li DQ; Pflugfelder SC. 2007. Dry eye-induced conjunctival epithelial squamous metaplasia is modulated by interferon-gamma. Invest Ophthalmol Vis Sci 48(6):2553-60. PubMed: 17525184 MGI: J:123281
Deepe GS Jr; Gibbons RS. 2008. TNF-alpha antagonism generates a population of antigen-specific CD4+CD25+ T cells that inhibit protective immunity in murine histoplasmosis. J Immunol 180(2):1088-97. PubMed: 18178849 MGI: J:130944
Demaude J; Salvador-Cartier C; Fioramonti J; Ferrier L; Bueno L. 2006. Phenotypic changes in colonocytes following acute stress or activation of mast cells in mice: implications for delayed epithelial barrier dysfunction. Gut 55(5):655-61. PubMed: 16299034 MGI: J:195107
Deng J; Yuan S; Pennati A; Murphy J; Wu JH; Lawson D; Galipeau J. 2014. Engineered fusokine GIFT4 licenses the ability of B cells to trigger a tumoricidal T-cell response. Cancer Res 74(15):4133-44. PubMed: 24938765 MGI: J:213719
Deng Y; Guo X; Ferguson DO; Chang S. 2009. Multiple roles for MRE11 at uncapped telomeres. Nature 460(7257):914-8. PubMed: 19633651 MGI: J:151777
Desvignes L; Weidinger C; Shaw P; Vaeth M; Ribierre T; Liu M; Fergus T; Kozhaya L; McVoy L; Unutmaz D; Ernst JD; Feske S. 2015. STIM1 controls T cell-mediated immune regulation and inflammation in chronic infection. J Clin Invest 125(6):2347-62. PubMed: 25938788 MGI: J:222964
Ding Q; Lu L; Wang B; Zhou Y; Jiang Y; Zhou X; Xin L; Jiao Z; Chou KY. 2006. B7H1-Ig fusion protein activates the CD4+ IFN-gamma receptor+ type 1 T regulatory subset through IFN-gamma-secreting Th1 cells. J Immunol 177(6):3606-14. PubMed: 16951320 MGI: J:138053
Do JS; Visperas A; Oh K; Stohlman SA; Min B. 2012. Memory CD4 T cells induce selective expression of IL-27 in CD8+ dendritic cells and regulate homeostatic naive T cell proliferation. J Immunol 188(1):230-7. PubMed: 22116827 MGI: J:180589
Dogan RN; Vasu C; Holterman MJ; Prabhakar BS. 2003. Absence of IL-4, and not suppression of the Th2 response, prevents development of experimental autoimmune Graves' disease. J Immunol 170(4):2195-204. PubMed: 12574393 MGI: J:126279
Doherty TM; Sher A. 1997. Defects in cell-mediated immunity affect chronic, but not innate, resistance of mice to Mycobacterium avium infection. J Immunol 158(10):4822-31. PubMed: 9144497 MGI: J:40202
Dohi T; Fujihashi K; Kiyono H; Elson CO; McGhee JR. 2000. Mice deficient in Th1- and Th2-type cytokines develop distinct forms of hapten-induced colitis. Gastroenterology 119(3):724-33. PubMed: 10982767 MGI: J:64230
Dohi T; Fujihashi K; Koga T; Etani Y; Yoshino N; Kawamura YI; McGhee JR. 2004. CD4+CD45RBHi interleukin-4 defective T cells elicit antral gastritis and duodenitis. Am J Pathol 165(4):1257-68. PubMed: 15466391 MGI: J:93676
Dohi T; Fujihashi K; Koga T; Shirai Y; Kawamura YI; Ejima C; Kato R; Saitoh K; McGhee JR. 2003. T helper type-2 cells induce ileal villus atrophy, goblet cell metaplasia, and wasting disease in T cell-deficient mice. Gastroenterology 124(3):672-82. PubMed: 12612906 MGI: J:82106
Dohi T; Fujihashi K; Rennert PD; Iwatani K; Kiyono H; McGhee JR. 1999. Hapten-induced colitis is associated with colonic patch hypertrophy and T helper cell 2-type responses. J Exp Med 189(8):1169-80. PubMed: 10209035 MGI: J:119172
Dokun AO; Chu DT; Yang L; Bendelac AS; Yokoyama WM. 2001. Analysis of in situ NK cell responses during viral infection. J Immunol 167(9):5286-93. PubMed: 11673544 MGI: J:72673
Domeier PP; Chodisetti SB; Soni C; Schell SL; Elias MJ; Wong EB; Cooper TK; Kitamura D; Rahman ZS. 2016. IFN-gamma receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity. J Exp Med 213(5):715-32. PubMed: 27069112 MGI: J:233319
Doodes PD; Cao Y; Hamel KM; Wang Y; Farkas B; Iwakura Y; Finnegan A. 2008. Development of proteoglycan-induced arthritis is independent of IL-17. J Immunol 181(1):329-37. PubMed: 18566398 MGI: J:137406
Doodes PD; Cao Y; Hamel KM; Wang Y; Rodeghero RL; Mikecz K; Glant TT; Iwakura Y; Finnegan A. 2010. IFN-gamma regulates the requirement for IL-17 in proteoglycan-induced arthritis. J Immunol 184(3):1552-9. PubMed: 20028652 MGI: J:159538
Doolan DL; Hoffman SL. 1999. IL-12 and NK cells are required for antigen-specific adaptive immunity against malaria initiated by CD8+ T cells in the Plasmodium yoelii model. J Immunol 163(2):884-92. PubMed: 10395683 MGI: J:119784
Dougan M; Li D; Neuberg D; Mihm M; Googe P; Wong KK; Dranoff G. 2011. A dual role for the immune response in a mouse model of inflammation-associated lung cancer. J Clin Invest 121(6):2436-46. PubMed: 21537082 MGI: J:173919
Downs I; Liu J; Aw TY; Adegboyega PA; Ajuebor MN. 2012. The ROS scavenger, NAC, regulates hepatic Valpha14iNKT cells signaling during Fas mAb-dependent fulminant liver failure. PLoS One 7(6):e38051. PubMed: 22701598 MGI: J:187842
Drevets DA; Schawang JE; Dillon MJ; Lerner MR; Bronze MS; Brackett DJ. 2008. Innate responses to systemic infection by intracellular bacteria trigger recruitment of Ly-6Chigh monocytes to the brain. J Immunol 181(1):529-36. PubMed: 18566419 MGI: J:137399
Dubey JP; Liddell S; Mattson D; Speert CA; Howe DK; Jenkins MC. 2001. Characterization of the Oregon isolate of Neospora hughesi from a horse. J Parasitol 87(2):345-53. PubMed: 11318565 MGI: J:109880
Dubois A; Deruytter N; Adams B; Kanda A; Delbauve S; Fleury S; Torres D; Francois A; Petein M; Goldman M; Dombrowicz D; Flamand V. 2010. Regulation of Th2 responses and allergic inflammation through bystander activation of CD8+ T lymphocytes in early life. J Immunol 185(2):884-91. PubMed: 20562264 MGI: J:161925
Dugan CM; Fullerton AM; Roth RA; Ganey PE. 2011. Natural killer cells mediate severe liver injury in a murine model of halothane hepatitis. Toxicol Sci 120(2):507-18. PubMed: 21245496 MGI: J:171014
Dunussi-Joannopoulos K; Hancock GE; Kunz A; Hegen M; Zhou XX; Sheppard BJ; Lamothe J; Li E; Ma HL; Hamann PR; Damle NK; Collins M. 2005. B-cell depletion inhibits arthritis in a collagen-induced arthritis (CIA) model, but does not adversely affect humoral responses in a respiratory syncytial virus (RSV) vaccination model. Blood 106(7):2235-43. PubMed: 15947095 MGI: J:119369
Durbin JE; Fernandez-Sesma A; Lee CK; Rao TD; Frey AB; Moran TM; Vukmanovic S; Garcia-Sastre A; Levy DE. 2000. Type I IFN modulates innate and specific antiviral immunity. J Immunol 164(8):4220-8. PubMed: 10754318 MGI: J:123432
Durbin JE; Johnson TR; Durbin RK; Mertz SE; Morotti RA; Peebles RS; Graham BS. 2002. The role of IFN in respiratory syncytial virus pathogenesis. J Immunol 168(6):2944-52. PubMed: 11884466 MGI: J:126678
Eaton KA; Mefford M; Thevenot T. 2001. The role of T cell subsets and cytokines in the pathogenesis of Helicobacter pylori gastritis in mice. J Immunol 166(12):7456-61. PubMed: 11390498 MGI: J:124425
Eberle ME; Dalpke AH. 2012. Dectin-1 stimulation induces suppressor of cytokine signaling 1, thereby modulating TLR signaling and T cell responses. J Immunol 188(11):5644-54. PubMed: 22547696 MGI: J:188728
Echeverry A; Saijo S; Schesser K; Adkins B. 2010. Yersinia enterocolitica promotes robust mucosal inflammatory T-cell immunity in murine neonates. Infect Immun 78(8):3595-608. PubMed: 20515925 MGI: J:161817
Egan CE; Craven MD; Leng J; Mack M; Simpson KW; Denkers EY. 2009. CCR2-dependent intraepithelial lymphocytes mediate inflammatory gut pathology during Toxoplasma gondii infection. Mucosal Immunol 2(6):527-35. PubMed: 19741601 MGI: J:193378
Egan PJ; Lawlor KE; Alexander WS; Wicks IP. 2003. Suppressor of cytokine signaling-1 regulates acute inflammatory arthritis and T cell activation. J Clin Invest 111(6):915-24. PubMed: 12639998 MGI: J:82519
Eigenbrod T; Bode KA; Dalpke AH. 2013. Early inhibition of IL-1beta expression by IFN-gamma is mediated by impaired binding of NF-kappaB to the IL-1beta promoter but is independent of nitric oxide. J Immunol 190(12):6533-41. PubMed: 23667107 MGI: J:204860
Eisenring M; vom Berg J; Kristiansen G; Saller E; Becher B. 2010. IL-12 initiates tumor rejection via lymphoid tissue-inducer cells bearing the natural cytotoxicity receptor NKp46. Nat Immunol 11(11):1030-8. PubMed: 20935648 MGI: J:166535
El-Assaad F; Hempel C; Combes V; Mitchell AJ; Ball HJ; Kurtzhals JA; Hunt NH; Mathys JM; Grau GE. 2011. Differential MicroRNA Expression in Experimental Cerebral and Noncerebral Malaria. Infect Immun 79(6):2379-84. PubMed: 21422175 MGI: J:171928
Elboim M; Gazit R; Gur C; Ghadially H; Betser-Cohen G; Mandelboim O. 2010. Tumor immunoediting by NKp46. J Immunol 184(10):5637-44. PubMed: 20404273 MGI: J:160984
Ellison CA; Fischer JM; HayGlass KT; Gartner JG. 1998. Murine graft-versus-host disease in an F1-hybrid model using IFN-gamma gene knockout donors. J Immunol 161(2):631-40. PubMed: 9670937 MGI: J:48545
Ely KH; Kasper LH; Khan IA. 1999. Augmentation of the CD8+ T cell response by IFN-gamma in IL-12-deficient mice during Toxoplasma gondii infection. J Immunol 162(9):5449-54. PubMed: 10228024 MGI: J:111011
Enzler T; Gillessen S; Dougan M; Allison JP; Neuberg D; Oble DA; Mihm M; Dranoff G. 2007. Functional deficiencies of granulocyte-macrophage colony stimulating factor and interleukin-3 contribute to insulitis and destruction of beta cells. Blood 110(3):954-61. PubMed: 17483299 MGI: J:145518
Enzler T; Gillessen S; Manis JP; Ferguson D; Fleming J; Alt FW; Mihm M; Dranoff G. 2003. Deficiencies of GM-CSF and interferon gamma link inflammation and cancer. J Exp Med 197(9):1213-9. PubMed: 12732663 MGI: J:83086
Erie AJ; Samsel L; Takaku T; Desierto MJ; Keyvanfar K; McCoy JP; Young NS; Chen J. 2011. MHC class II upregulation and colocalization with Fas in experimental models of immune-mediated bone marrow failure. Exp Hematol 39(8):837-49. PubMed: 21635935 MGI: J:186746
Eriksson U; Kurrer MO; Sebald W; Brombacher F; Kopf M. 2001. Dual role of the IL-12/IFN-gamma axis in the development of autoimmune myocarditis: induction by IL-12 and protection by IFN-gamma. J Immunol 167(9):5464-9. PubMed: 11673566 MGI: J:72665
Eschke M; Piehler D; Schulze B; Richter T; Grahnert A; Protschka M; Muller U; Kohler G; Hofling C; Rossner S; Alber G. 2015. A novel experimental model of Cryptococcus neoformans-related immune reconstitution inflammatory syndrome (IRIS) provides insights into pathogenesis. Eur J Immunol 45(12):3339-50. PubMed: 26381487 MGI: J:233787
Evel-Kabler K; Song XT; Aldrich M; Huang XF; Chen SY. 2006. SOCS1 restricts dendritic cells' ability to break self tolerance and induce antitumor immunity by regulating IL-12 production and signaling. J Clin Invest 116(1):90-100. PubMed: 16357940 MGI: J:105256
Eyles JL; Metcalf D; Grusby MJ; Hilton DJ; Starr R. 2002. Negative regulation of interleukin-12 signaling by suppressor of cytokine signaling-1. J Biol Chem 277(46):43735-40. PubMed: 12221108 MGI: J:119132
Fairweather D; Frisancho-Kiss S; Yusung SA; Barrett MA; Davis SE; Gatewood SJ; Njoku DB; Rose NR. 2004. Interferon-gamma protects against chronic viral myocarditis by reducing mast cell degranulation, fibrosis, and the profibrotic cytokines transforming growth factor-beta 1, interleukin-1 beta, and interleukin-4 in the heart. Am J Pathol 165(6):1883-94. PubMed: 15579433 MGI: J:94973
Fairweather D; Frisancho-Kiss S; Yusung SA; Barrett MA; Davis SE; Steele RA; Gatewood SJ; Rose NR. 2005. IL-12 protects against coxsackievirus B3-induced myocarditis by increasing IFN-gamma and macrophage and neutrophil populations in the heart. J Immunol 174(1):261-9. PubMed: 15611248 MGI: J:95857
Fairweather D; Yusung S; Frisancho S; Barrett M; Gatewood S; Steele R; Rose NR. 2003. IL-12 Receptor beta1 and Toll-Like Receptor 4 Increase IL-1beta- and IL-18-Associated Myocarditis and Coxsackievirus Replication. J Immunol 170(9):4731-7. PubMed: 12707353 MGI: J:83020
Fallarino F; Bianchi R; Orabona C; Vacca C; Belladonna ML; Fioretti MC; Serreze DV; Grohmann U; Puccetti P. 2004. CTLA-4-Ig activates forkhead transcription factors and protects dendritic cells from oxidative stress in nonobese diabetic mice. J Exp Med 200(8):1051-62. PubMed: 15492127 MGI: J:93957
Fang M; Xie H; Dougan SK; Ploegh H; van Oudenaarden A. 2013. Stochastic cytokine expression induces mixed T helper cell States. PLoS Biol 11(7):e1001618. PubMed: 23935453 MGI: J:201603
Fang Y; Chen K; Jackson DA; Sharp GC; Braley-Mullen H. 2010. Eosinophils infiltrate thyroids, but have no apparent role in induction or resolution of experimental autoimmune thyroiditis in interferon-gamma(-/-) mice. Immunology 129(3):329-37. PubMed: 19845793 MGI: J:166199
Fang Y; Yu S; Braley-Mullen H. 2012. TGF-beta Promotes Proliferation of Thyroid Epithelial Cells in IFN-gamma(-/-) Mice by Down-Regulation of p21 and p27 via AKT Pathway. Am J Pathol 180(2):650-60. PubMed: 22119715 MGI: J:180437
Feng CG; Kaviratne M; Rothfuchs AG; Cheever A; Hieny S; Young HA; Wynn TA; Sher A. 2006. NK cell-derived IFN-gamma differentially regulates innate resistance and neutrophil response in T cell-deficient hosts infected with Mycobacterium tuberculosis. J Immunol 177(10):7086-93. PubMed: 17082625 MGI: J:140483
Feng CG; Scanga CA; Collazo-Custodio CM; Cheever AW; Hieny S; Caspar P; Sher A. 2003. Mice lacking myeloid differentiation factor 88 display profound defects in host resistance and immune responses to Mycobacterium avium infection not exhibited by Toll-like receptor 2 (TLR2)- and TLR4-deficient animals. J Immunol 171(9):4758-64. PubMed: 14568952 MGI: J:118915
Feng CG; Zheng L; Jankovic D; Bafica A; Cannons JL; Watford WT; Chaussabel D; Hieny S; Caspar P; Schwartzberg PL; Lenardo MJ; Sher A. 2008. The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell death. Nat Immunol 9(11):1279-87. PubMed: 18806793 MGI: J:142840
Feng HM; Walker DH. 2004. Mechanisms of immunity to Ehrlichia muris: a model of monocytotropic ehrlichiosis. Infect Immun 72(2):966-71. PubMed: 14742542 MGI: J:87862
Fenner JE; Starr R; Cornish AL; Zhang JG; Metcalf D; Schreiber RD; Sheehan K; Hilton DJ; Alexander WS; Hertzog PJ. 2006. Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity. Nat Immunol 7(1):33-9. PubMed: 16311601 MGI: J:112593
Ferber IA; Brocke S; Taylor-Edwards C; Ridgway W; Dinisco C; Steinman L; Dalton D; Fathman CG. 1996. Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J Immunol 156(1):5-7. PubMed: 8598493 MGI: J:30237
Ferrari de Andrade L; Ngiow SF; Stannard K; Rusakiewicz S; Kalimutho M; Khanna KK; Tey SK; Takeda K; Zitvogel L; Martinet L; Smyth MJ. 2014. Natural killer cells are essential for the ability of BRAF inhibitors to control BRAFV600E-mutant metastatic melanoma. Cancer Res 74(24):7298-308. PubMed: 25351955 MGI: J:218275
Feuerer M; Eulenburg K; Loddenkemper C; Hamann A; Huehn J. 2006. Self-limitation of Th1-mediated inflammation by IFN-gamma. J Immunol 176(5):2857-63. PubMed: 16493042 MGI: J:129422
Finnegan A; Grusby MJ; Kaplan CD; O'Neill SK; Eibel H; Koreny T; Czipri M; Mikecz K; Zhang J. 2002. IL-4 and IL-12 regulate proteoglycan-induced arthritis through Stat-dependent mechanisms. J Immunol 169(6):3345-52. PubMed: 12218156 MGI: J:120443
Fischer R; Tome D; McGhee JR; Boyaka PN. 2007. Th1 and Th2 cells are required for both eosinophil- and neutrophil-associated airway inflammatory responses in mice. Biochem Biophys Res Commun 357(1):44-9. PubMed: 17412309 MGI: J:121793
Flaishon L; Hershkoviz R; Lantner F; Lider O; Alon R; Levo Y; Flavell RA; Shachar I. 2000. Autocrine secretion of interferon gamma negatively regulates homing of immature B cells. J Exp Med 192(9):1381-8. PubMed: 11067886 MGI: J:112084
Flano E; Woodland DL; Blackman MA. 1999. Requirement for CD4+ T cells in V beta 4+CD8+ T cell activation associated with latent murine gammaherpesvirus infection. J Immunol 163(6):3403-8. PubMed: 10477611 MGI: J:119171
Florido M; Borges M; Rodrigues P; Vale-Costa S; Salome Gomes M; Appelberg R. 2009. Constitutive expression of Bcl-2 in the haematopoietic compartment alters the metabolism of iron and increases resistance to mycobacterial infection. Clin Exp Immunol 156(1):61-8. PubMed: 19210523 MGI: J:146435
Florido M; Pearl JE; Solache A; Borges M; Haynes L; Cooper AM; Appelberg R. 2005. Gamma interferon-induced T-cell loss in virulent Mycobacterium avium infection. Infect Immun 73(6):3577-86. PubMed: 15908387 MGI: J:99143
Flynn JL; Chan J; Triebold KJ; Dalton DK; Stewart TA; Bloom BR. 1993. An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection. J Exp Med 178(6):2249-54. PubMed: 7504064 MGI: J:110856
Flynn JL; Goldstein MM; Triebold KJ; Sypek J; Wolf S; Bloom BR. 1995. IL-12 increases resistance of BALB/c mice to Mycobacterium tuberculosis infection. J Immunol 155(5):2515-24. PubMed: 7650381 MGI: J:28196
Fogler WE; Volker K; Watanabe M; Wigginton JM; Roessler P; Brunda MJ; Ortaldo JR; Wiltrout RH. 1998. Recruitment of hepatic NK cells by IL-12 is dependent on IFN-gamma and VCAM-1 and is rapidly down-regulated by a mechanism involving T cells and expression of Fas. J Immunol 161(11):6014-21. PubMed: 9834083 MGI: J:115033
Fox BA; Bzik DJ. 2010. Avirulent uracil auxotrophs based on disruption of orotidine-5'-monophosphate decarboxylase elicit protective immunity to Toxoplasma gondii. Infect Immun 78(9):3744-52. PubMed: 20605980 MGI: J:163001
France MP; Smith AL; Stevenson R; Barthold SW. 1999. Granulomatous peritonitis and pleuritis in interferon-gamma gene knockout mice naturally infected with mouse hepatitis virus. Aust Vet J 77(9):600-4. PubMed: 10561796 MGI: J:59661
Franklin BS; Parroche P; Ataide MA; Lauw F; Ropert C; de Oliveira RB; Pereira D; Tada MS; Nogueira P; da Silva LH; Bjorkbacka H; Golenbock DT; Gazzinelli RT. 2009. Malaria primes the innate immune response due to interferon-gamma induced enhancement of toll-like receptor expression and function. Proc Natl Acad Sci U S A 106(14):5789-94. PubMed: 19297619 MGI: J:147570
Frazer LC; Sullivan JE; Zurenski MA; Mintus M; Tomasak TE; Prantner D; Nagarajan UM; Darville T. 2013. CD4+ T cell expression of MyD88 is essential for normal resolution of Chlamydia muridarum genital tract infection. J Immunol 191(8):4269-79. PubMed: 24038087 MGI: J:206277
Freyschmidt-Paul P; McElwee KJ; Hoffmann R; Sundberg JP; Vitacolonna M; Kissling S; Zoller M. 2006. Interferon-gamma-deficient mice are resistant to the development of alopecia areata. Br J Dermatol 155(3):515-21. PubMed: 16911275 MGI: J:135859
Frisancho-Kiss S; Davis SE; Nyland JF; Frisancho JA; Cihakova D; Barrett MA; Rose NR; Fairweather D. 2007. Cutting edge: cross-regulation by TLR4 and T cell Ig mucin-3 determines sex differences in inflammatory heart disease. J Immunol 178(11):6710-4. PubMed: 17513715 MGI: J:147853
Fritz RB; Zhao ML. 2001. Regulation of experimental autoimmune encephalomyelitis in the C57BL/6J mouse by NK1.1+, DX5+, alpha beta+ T cells. J Immunol 166(6):4209-15. PubMed: 11238673 MGI: J:126134
Fujigaki S; Saito K; Sekikawa K; Tone S; Takikawa O; Fujii H; Wada H; Noma A; Seishima M. 2001. Lipopolysaccharide induction of indoleamine 2,3-dioxygenase is mediated dominantly by an IFN-gamma-independent mechanism. Eur J Immunol 31(8):2313-8. PubMed: 11477543 MGI: J:71158
Fukushima A; Yamaguchi T; Ishida W; Fukata K; Mittler RS; Yagita H; Ueno H. 2005. Engagement of 4-1BB inhibits the development of experimental allergic conjunctivitis in mice. J Immunol 175(8):4897-903. PubMed: 16210591 MGI: J:119054
Fukushima A; Yamaguchi T; Ishida W; Fukata K; Taniguchi T; Liu FT; Ueno H. 2006. Genetic background determines susceptibility to experimental immune-mediated blepharoconjunctivitis: comparison of Balb/c and C57BL/6 mice. Exp Eye Res 82(2):210-8. PubMed: 16102751 MGI: J:106441
Fukuyama S; Nakano T; Matsumoto T; Oliver BG; Burgess JK; Moriwaki A; Tanaka K; Kubo M; Hoshino T; Tanaka H; McKenzie AN; Matsumoto K; Aizawa H; Nakanishi Y; Yoshimura A; Black JL; Inoue H. 2009. Pulmonary suppressor of cytokine signaling-1 induced by IL-13 regulates allergic asthma phenotype. Am J Respir Crit Care Med 179(11):992-8. PubMed: 19299500 MGI: J:164975
Fullerton AM; Roth RA; Ganey PE. 2013. 2,3,7,8-TCDD enhances the sensitivity of mice to concanavalin A immune-mediated liver injury. Toxicol Appl Pharmacol 266(2):317-27. PubMed: 23164664 MGI: J:193201
Furman D; Jojic V; Sharma S; Shen-Orr SS; Angel CJ; Onengut-Gumuscu S; Kidd BA; Maecker HT; Concannon P; Dekker CL; Thomas PG; Davis MM. 2015. Cytomegalovirus infection enhances the immune response to influenza. Sci Transl Med 7(281):281ra43. PubMed: 25834109 MGI: J:234080
Gajendran N; Mittrucker HW; Bordasch K; Heinemann E; Koch M; Kaufmann SH. 2007. Regional IFN{gamma} expression is insufficient for efficacious control of food-borne bacterial pathogens at the gut epithelial barrier. Int Immunol 19(9):1075-81. PubMed: 17698562 MGI: J:124869
Gallina G; Dolcetti L; Serafini P; De Santo C; Marigo I; Colombo MP; Basso G; Brombacher F; Borrello I; Zanovello P; Bicciato S; Bronte V. 2006. Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells. J Clin Invest 116(10):2777-90. PubMed: 17016559 MGI: J:114986
Gao D; Kasten-Jolly J; Lawrence DA. 2006. The paradoxical effects of lead in interferon-gamma knockout BALB/c mice. Toxicol Sci 89(2):444-53. PubMed: 16280381 MGI: J:113282
Gao JJ; Filla MB; Fultz MJ; Vogel SN; Russell SW; Murphy WJ. 1998. Autocrine/paracrine IFN-alphabeta mediates the lipopolysaccharide-induced activation of transcription factor Stat1alpha in mouse macrophages: pivotal role of Stat1alpha in induction of the inducible nitric oxide synthase gene. J Immunol 161(9):4803-10. PubMed: 9794412 MGI: J:115235
Gao N; Dang T; Dunnick WA; Collins JT; Blazar BR; Yuan D. 2005. Receptors and counterreceptors involved in NK-B cell interactions. J Immunol 174(7):4113-9. PubMed: 15778370 MGI: J:97960
Gao N; Jennings P; Yuan D. 2008. Requirements for the natural killer cell-mediated induction of IgG1 and IgG2a expression in B lymphocytes. Int Immunol 20(5):645-57. PubMed: 18339657 MGI: J:134466
Gao X; Gillig TA; Ye P; D'Ercole AJ; Matsushima GK; Popko B. 2000. Interferon-gamma protects against cuprizone-induced demyelination Mol Cell Neurosci 16(4):338-49. PubMed: 11085872 MGI: J:65508
Gao Y; Grassi F; Ryan MR; Terauchi M; Page K; Yang X; Weitzmann MN; Pacifici R. 2007. IFN-gamma stimulates osteoclast formation and bone loss in vivo via antigen-driven T cell activation. J Clin Invest 117(1):122-32. PubMed: 17173138 MGI: J:117462
Gao Y; Li Z; Hassan N; Mehta P; Burns AR; Tang X; Smith CW. 2013. NK cells are necessary for recovery of corneal CD11c+ dendritic cells after epithelial abrasion injury. J Leukoc Biol 94(2):343-51. PubMed: 23695308 MGI: J:203224
Gao Y; Tao J; Li MO; Zhang D; Chi H; Henegariu O; Kaech SM; Davis RJ; Flavell RA; Yin Z. 2005. JNK1 is essential for CD8+ T cell-mediated tumor immune surveillance. J Immunol 175(9):5783-9. PubMed: 16237070 MGI: J:119340
Garcia AG; Wilson RM; Heo J; Murthy NR; Baid S; Ouchi N; Sam F. 2012. Interferon-gamma ablation exacerbates myocardial hypertrophy in diastolic heart failure. Am J Physiol Heart Circ Physiol 303(5):H587-96. PubMed: 22730392 MGI: J:189195
Ge MQ; Ho AW; Tang Y; Wong KH; Chua BY; Gasser S; Kemeny DM. 2012. NK cells regulate CD8+ T cell priming and dendritic cell migration during influenza A infection by IFN-gamma and perforin-dependent mechanisms. J Immunol 189(5):2099-109. PubMed: 22869906 MGI: J:189840
Gentil K; Pearlman E. 2009. Gamma interferon and interleukin-1 receptor 1 regulate neutrophil recruitment to the corneal stroma in a murine model of Onchocerca volvulus keratitis. Infect Immun 77(4):1606-12. PubMed: 19168746 MGI: J:147171
Gerber SA; Sedlacek AL; Cron KR; Murphy SP; Frelinger JG; Lord EM. 2013. IFN-gamma mediates the antitumor effects of radiation therapy in a murine colon tumor. Am J Pathol 182(6):2345-54. PubMed: 23583648 MGI: J:198468
Gerber SA; Sorensen EW; Sedlacek AL; Lim JY; Skrombolas D; Frelinger JG; Lord EM. 2013. Local expression of interleukin-2 by B16 melanoma cells results in decreased tumour growth and long-term tumour dormancy. Immunology 138(3):280-92. PubMed: 23198850 MGI: J:198085
Gerbitz A; Sukumar M; Helm F; Wilke A; Friese C; Fahrenwaldt C; Lehmann FM; Loddenkemper C; Kammertoens T; Mautner J; Schmitt CA; Blankenstein T; Bornkamm GW. 2012. Stromal interferon-gamma signaling and cross-presentation are required to eliminate antigen-loss variants of B cell lymphomas in mice. PLoS One 7(3):e34552. PubMed: 22479645 MGI: J:187120
Getahun A; Smith MJ; Kogut I; van Dyk LF; Cambier JC. 2012. Retention of anergy and inhibition of antibody responses during acute gamma herpesvirus 68 infection. J Immunol 189(6):2965-74. PubMed: 22904300 MGI: J:189918
Gewies A; Gorka O; Bergmann H; Pechloff K; Petermann F; Jeltsch KM; Rudelius M; Kriegsmann M; Weichert W; Horsch M; Beckers J; Wurst W; Heikenwalder M; Korn T; Heissmeyer V; Ruland J. 2014. Uncoupling Malt1 threshold function from paracaspase activity results in destructive autoimmune inflammation. Cell Rep 9(4):1292-305. PubMed: 25456129 MGI: J:225698
Gibbons DL; Haque SF; Copestake SL; Wells JW; Noble A; Smith AL; Hayday AC. 2009. Suppression of airway inflammation by a natural acute infection of the intestinal epithelium. Mucosal Immunol 2(2):144-55. PubMed: 19129755 MGI: J:191921
Gigley JP; Fox BA; Bzik DJ. 2009. Cell-mediated immunity to Toxoplasma gondii develops primarily by local Th1 host immune responses in the absence of parasite replication. J Immunol 182(2):1069-78. PubMed: 19124750 MGI: J:143485
Gill N; Deacon PM; Lichty B; Mossman KL; Ashkar AA. 2006. Induction of innate immunity against herpes simplex virus type 2 infection via local delivery of Toll-like receptor ligands correlates with beta interferon production. J Virol 80(20):9943-50. PubMed: 17005672 MGI: J:153329
Gingras S; Parganas E; de Pauw A; Ihle JN; Murray PJ. 2004. Re-examination of the role of suppressor of cytokine signaling 1 (SOCS1) in the regulation of toll-like receptor signaling. J Biol Chem 279(52):54702-7. PubMed: 15491990 MGI: J:95152
Glabinski AR; Krakowski M; Han Y; Owens T; Ransohoff RM. 1999. Chemokine expression in GKO mice (lacking interferon-gamma) with experimental autoimmune encephalomyelitis. J Neurovirol 5(1):95-101. PubMed: 10190695 MGI: J:53694
Goes N; Sims T; Urmson J; Vincent D; Ramassar V; Halloran PF. 1995. Disturbed MHC regulation in the IFN-gamma knockout mouse. Evidence for three states of MHC expression with distinct roles for IFN-gamma. J Immunol 155(10):4559-66. PubMed: 7594453 MGI: J:29680
Goes N; Urmson J; Hobart M; Halloran PF. 1996. The unique role of interferon-gamma in the regulation of MHC expression on arterial endothelium. Transplantation 62(12):1889-94. PubMed: 8990382 MGI: J:37405
Goes N; Urmson J; Vincent D; Halloran PF. 1995. Acute renal injury in the interferon-gamma gene knockout mouse: effect on cytokine gene expression. Transplantation 60(12):1560-4. PubMed: 8545890 MGI: J:31381
Gokmen MR; Dong R; Kanhere A; Powell N; Perucha E; Jackson I; Howard JK; Hernandez-Fuentes M; Jenner RG; Lord GM. 2013. Genome-wide regulatory analysis reveals that T-bet controls Th17 lineage differentiation through direct suppression of IRF4. J Immunol 191(12):5925-32. PubMed: 24249732 MGI: J:207104
Goktuna SI; Canli O; Bollrath J; Fingerle AA; Horst D; Diamanti MA; Pallangyo C; Bennecke M; Nebelsiek T; Mankan AK; Lang R; Artis D; Hu Y; Patzelt T; Ruland J; Kirchner T; Taketo MM; Chariot A; Arkan MC; Greten FR. 2014. IKKalpha Promotes Intestinal Tumorigenesis by Limiting Recruitment of M1-like Polarized Myeloid Cells. Cell Rep 7(6):1914-25. PubMed: 24882009 MGI: J:211784
Goldman KP; Park CS; Kim M; Matzinger P; Anderson CC. 2005. Thymic cortical epithelium induces self tolerance. Eur J Immunol 35(3):709-17. PubMed: 15719367 MGI: J:96619
Goldszmid RS; Bafica A; Jankovic D; Feng CG; Caspar P; Winkler-Pickett R; Trinchieri G; Sher A. 2007. TAP-1 indirectly regulates CD4+ T cell priming in Toxoplasma gondii infection by controlling NK cell IFN-{gamma} production. J Exp Med 204(11):2591-602. PubMed: 17923502 MGI: J:126112
Gomes MS; Sousa Fernandes S; Cordeiro JV; Silva Gomes S; Vieira A; Appelberg R. 2008. Engagement of Toll-like receptor 2 in mouse macrophages infected with Mycobacterium avium induces non-oxidative and TNF-independent anti-mycobacterial activity. Eur J Immunol 38(8):2180-9. PubMed: 18624355 MGI: J:138559
Gondek DC; Roan NR; Starnbach MN. 2009. T cell responses in the absence of IFN-gamma exacerbate uterine infection with Chlamydia trachomatis. J Immunol 183(2):1313-9. PubMed: 19561106 MGI: J:151656
Gorham JD; Lin JT; Sung JL; Rudner LA; French MA. 2001. Genetic regulation of autoimmune disease: balb/c background tgf-beta1-deficient mice develop necroinflammatory ifn-gamma-dependent hepatitis. J Immunol 166(10):6413-22. PubMed: 11342667 MGI: J:69346
Gourzi P; Leonova T; Papavasiliou FN. 2007. Viral induction of AID is independent of the interferon and the Toll-like receptor signaling pathways but requires NF-kappaB. J Exp Med 204(2):259-65. PubMed: 17242162 MGI: J:125375
Grabie N; Gotsman I; DaCosta R; Pang H; Stavrakis G; Butte MJ; Keir ME; Freeman GJ; Sharpe AH; Lichtman AH. 2007. Endothelial programmed death-1 ligand 1 (PD-L1) regulates CD8+ T-cell mediated injury in the heart. Circulation 116(18):2062-71. PubMed: 17938288 MGI: J:142996
Graham MB; Dalton DK; Giltinan D; Braciale VL; Stewart TA; Braciale TJ. 1993. Response to influenza infection in mice with a targeted disruption in the interferon gamma gene. J Exp Med 178(5):1725-32. PubMed: 8228818 MGI: J:110721
Gramaglia I; Sahlin H; Nolan JP; Frangos JA; Intaglietta M; van der Heyde HC. 2005. Cell- rather than antibody-mediated immunity leads to the development of profound thrombocytopenia during experimental Plasmodium berghei malaria. J Immunol 175(11):7699-707. PubMed: 16301680 MGI: J:122163
Gray BM; Fontaine CA; Poe SA; Eaton KA. 2013. Complex T Cell Interactions Contribute to Helicobacter pylori Gastritis in Mice. Infect Immun 81(3):740-52. PubMed: 23264048 MGI: J:193044
Gregg RK; Nichols L; Chen Y; Lu B; Engelhard VH. 2010. Mechanisms of spatial and temporal development of autoimmune vitiligo in tyrosinase-specific TCR transgenic mice. J Immunol 184(4):1909-17. PubMed: 20083666 MGI: J:159480
Gu T; Rowswell-Turner RB; Kilinc MO; Egilmez NK. 2010. Central role of IFNgamma-indoleamine 2,3-dioxygenase axis in regulation of interleukin-12-mediated antitumor immunity. Cancer Res 70(1):129-38. PubMed: 20028855 MGI: J:155738
Guarda G; Braun M; Staehli F; Tardivel A; Mattmann C; Forster I; Farlik M; Decker T; Du Pasquier RA; Romero P; Tschopp J. 2011. Type I interferon inhibits interleukin-1 production and inflammasome activation. Immunity 34(2):213-23. PubMed: 21349431 MGI: J:168972
Gunther C; He GW; Kremer AE; Murphy JM; Petrie EJ; Amann K; Vandenabeele P; Linkermann A; Poremba C; Schleicher U; Dewitz C; Krautwald S; Neurath MF; Becker C; Wirtz S. 2016. The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis. J Clin Invest 126(11):4346-4360. PubMed: 27756058 MGI: J:239618
Guo J; McQuillan JA; Yau B; Tullo GS; Long CA; Bertolino P; Roediger B; Weninger W; Taylor GA; Hunt NH; Ball HJ; Mitchell AJ. 2015. IRGM3 contributes to immunopathology and is required for differentiation of antigen-specific effector CD8+ T cells in experimental cerebral malaria. Infect Immun 83(4):1406-17. PubMed: 25644000 MGI: J:229266
Gupta M; Greer P; Mahanty S; Shieh WJ; Zaki SR; Ahmed R; Rollin PE. 2005. CD8-mediated protection against Ebola virus infection is perforin dependent. J Immunol 174(7):4198-202. PubMed: 15778381 MGI: J:97965
Halloran PF; Afrouzian M; Ramassar V; Urmson J; Zhu LF; Helms LM; Solez K; Kneteman NM. 2001. Interferon-gamma acts directly on rejecting renal allografts to prevent graft necrosis. Am J Pathol 158(1):215-26. PubMed: 11141495 MGI: J:68439
Halloran PF; Miller LW; Urmson J; Ramassar V; Zhu LF; Kneteman NM; Solez K; Afrouzian M. 2001. IFN-gamma alters the pathology of graft rejection: protection from early necrosis. J Immunol 166(12):7072-81. PubMed: 11390451 MGI: J:123807
Hamadien M; Lycke N; Bakhiet M. 1999. Induction of the trypanosome lymphocyte-triggering factor (TLTF) and neutralizing antibodies to the TLTF in experimental african trypanosomiasis. Immunology 96(4):606-11. PubMed: 10233748 MGI: J:110523
Han YL; Li YL; Jia LX; Cheng JZ; Qi YF; Zhang HJ; Du J. 2012. Reciprocal interaction between macrophages and T cells stimulates IFN-gamma and MCP-1 production in Ang II-induced cardiac inflammation and fibrosis. PLoS One 7(5):e35506. PubMed: 22567105 MGI: J:187265
Hanada T; Kobayashi T; Chinen T; Saeki K; Takaki H; Koga K; Minoda Y; Sanada T; Yoshioka T; Mimata H; Kato S; Yoshimura A. 2006. IFNgamma-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice. J Exp Med 203(6):1391-7. PubMed: 16717119 MGI: J:115075
Hancock WW; Szaba FM; Berggren KN; Parent MA; Mullarky IK; Pearl J; Cooper AM; Ely KH; Woodland DL; Kim IJ; Blackman MA; Johnson LL; Smiley ST. 2004. Intact type 1 immunity and immune-associated coagulative responses in mice lacking IFN gamma-inducible fibrinogen-like protein 2. Proc Natl Acad Sci U S A 101(9):3005-10. PubMed: 14976252 MGI: J:88648
Hao S; Yuan J; Xu S; Munegowda MA; Deng Y; Gordon J; Xing Z; Xiang J. 2008. Antigen specificity acquisition of adoptive CD4+ regulatory T cells via acquired peptide-MHC class I complexes. J Immunol 181(4):2428-37. PubMed: 18684933 MGI: J:140189
Harbour SN; Maynard CL; Zindl CL; Schoeb TR; Weaver CT. 2015. Th17 cells give rise to Th1 cells that are required for the pathogenesis of colitis. Proc Natl Acad Sci U S A 112(22):7061-6. PubMed: 26038559 MGI: J:223378
Hardison SE; Wozniak KL; Kolls JK; Wormley FL Jr. 2010. Interleukin-17 Is Not Required for Classical Macrophage Activation in a Pulmonary Mouse Model of Cryptococcus neoformans Infection. Infect Immun 78(12):5341-51. PubMed: 20921149 MGI: J:166071
Haring JS; Badovinac VP; Olson MR; Varga SM; Harty JT. 2005. In vivo generation of pathogen-specific Th1 cells in the absence of the IFN-gamma receptor. J Immunol 175(5):3117-22. PubMed: 16116201 MGI: J:113254
Haring JS; Harty JT. 2006. Aberrant contraction of antigen-specific CD4 T cells after infection in the absence of gamma interferon or its receptor. Infect Immun 74(11):6252-63. PubMed: 16966404 MGI: J:113551
Harrington LE; Hatton RD; Mangan PR; Turner H; Murphy TL; Murphy KM; Weaver CT. 2005. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6(11):1123-32. PubMed: 16200070 MGI: J:112601
Harris DP; Goodrich S; Gerth AJ; Peng SL; Lund FE. 2005. Regulation of IFN-gamma production by B effector 1 cells: essential roles for T-bet and the IFN-gamma receptor. J Immunol 174(11):6781-90. PubMed: 15905519 MGI: J:99038
Harris TH; Mansfield JM; Paulnock DM. 2007. CpG oligodeoxynucleotide treatment enhances innate resistance and acquired immunity to African trypanosomes. Infect Immun 75(5):2366-73. PubMed: 17339353 MGI: J:121887
Hart G; Avin-Wittenberg T; Shachar I. 2008. IL-15 regulates immature B-cell homing in an Ly49D-, IL-12 , and IL-18 dependent manner. Blood 111(1):50-9. PubMed: 17901247 MGI: J:130042
Hart G; Flaishon L; Becker-Herman S; Shachar I. 2003. Ly49D receptor expressed on immature B cells regulates their IFN-gamma secretion, actin polymerization, and homing. J Immunol 171(9):4630-8. PubMed: 14568937 MGI: J:119214
Hart G; Flaishon L; Shachar I. 2007. IL-12 and IL-18 down-regulate B cell migration in an Ly49D-dependent manner. Eur J Immunol 37(7):1996-2007. PubMed: 17557376 MGI: J:123474
Harty JT; Bevan MJ. 1995. Specific immunity to Listeria monocytogenes in the absence of IFN gamma. Immunity 3(1):109-17. PubMed: 7621071 MGI: J:83180
Hashimoto M; Ayada T; Kinjyo I; Hiwatashi K; Yoshida H; Okada Y; Kobayashi T; Yoshimura A. 2009. Silencing of SOCS1 in macrophages suppresses tumor development by enhancing antitumor inflammation. Cancer Sci 100(4):730-6. PubMed: 19469017 MGI: J:150670
Hashimoto M; Hiwatashi K; Ichiyama K; Morita R; Sekiya T; Kimura A; Sugiyama Y; Sibata T; Kuroda K; Takahashi R; Yoshimura A. 2011. SOCS1 regulates type I/type II NKT cell balance by regulating IFN{gamma} signaling. Int Immunol 23(3):165-76. PubMed: 21393632 MGI: J:169668
Hata H; Sakaguchi N; Yoshitomi H; Iwakura Y; Sekikawa K; Azuma Y; Kanai C; Moriizumi E; Nomura T; Nakamura T; Sakaguchi S. 2004. Distinct contribution of IL-6, TNF-alpha, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice. J Clin Invest 114(4):582-8. PubMed: 15314695 MGI: J:92002
Hausmann J; Pagenstecher A; Baur K; Richter K; Rziha HJ; Staeheli P. 2005. CD8 T cells require gamma interferon to clear borna disease virus from the brain and prevent immune system-mediated neuronal damage. J Virol 79(21):13509-18. PubMed: 16227271 MGI: J:102183
Havarinasab S; Haggqvist B; Bjorn E; Pollard KM; Hultman P. 2005. Immunosuppressive and autoimmune effects of thimerosal in mice. Toxicol Appl Pharmacol 204(2):109-21. PubMed: 15808517 MGI: J:97345
Havarinasab S; Pollard KM; Hultman P. 2009. Gold- and silver-induced murine autoimmunity--requirement for cytokines and CD28 in murine heavy metal-induced autoimmunity. Clin Exp Immunol 155(3):567-76. PubMed: 19077085 MGI: J:146057
Hayward AR; Chmura K; Cosyns M. 2000. Interferon-gamma is required for innate immunity to Cryptosporidium parvum in mice. J Infect Dis 182(3):1001-4. PubMed: 10950807 MGI: J:125986
He W; Hao J; Dong S; Gao Y; Tao J; Chi H; Flavell R; O'Brien RL; Born WK; Craft J; Han J; Wang P; Zhao L; Wu J; Yin Z. 2010. Naturally activated Vgamma4 gammadelta T cells play a protective role in tumor immunity through expression of eomesodermin. J Immunol 185(1):126-33. PubMed: 20525896 MGI: J:161612
Heath L; Chrisp C; Huffnagle G; LeGendre M; Osawa Y; Hurley M; Engleberg C; Fantone J; Brieland J. 1996. Effector mechanisms responsible for gamma interferon-mediated host resistance to Legionella pneumophila lung infection: the role of endogenous nitric oxide differs in susceptible and resistant murine hosts. Infect Immun 64(12):5151-60. PubMed: 8945559 MGI: J:36862
Hegazy AN; Peine M; Helmstetter C; Panse I; Frohlich A; Bergthaler A; Flatz L; Pinschewer DD; Radbruch A; Lohning M. 2010. Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions. Immunity 32(1):116-28. PubMed: 20079668 MGI: J:157702
Helmby H. 2009. Gastrointestinal nematode infection exacerbates malaria-induced liver pathology. J Immunol 182(9):5663-71. PubMed: 19380813 MGI: J:147710
Helmby H; Grencis RK. 2002. IL-18 regulates intestinal mastocytosis and Th2 cytokine production independently of IFN-gamma during Trichinella spiralis infection. J Immunol 169(5):2553-60. PubMed: 12193725 MGI: J:120688
Henke PK; Pearce CG; Moaveni DM; Moore AJ; Lynch EM; Longo C; Varma M; Dewyer NA; Deatrick KB; Upchurch GR Jr; Wakefield TW; Hogaboam C; Kunkel SL. 2006. Targeted deletion of CCR2 impairs deep vein thombosis resolution in a mouse model. J Immunol 177(5):3388-97. PubMed: 16920980 MGI: J:139537
Hepworth MR; Fung TC; Masur SH; Kelsen JR; McConnell FM; Dubrot J; Withers DR; Hugues S; Farrar MA; Reith W; Eberl G; Baldassano RN; Laufer TM; Elson CO; Sonnenberg GF. 2015. Immune tolerance. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4(+) T cells. Science 348(6238):1031-5. PubMed: 25908663 MGI: J:223811
Hertz CJ; Filutowicz H; Mansfield JM. 1998. Resistance to the African trypanosomes is IFN-gamma dependent. J Immunol 161(12):6775-83. PubMed: 9862708 MGI: J:115095
Hertz CJ; Mansfield JM. 1999. IFN-gamma-dependent nitric oxide production is not linked to resistance in experimental African trypanosomiasis. Cell Immunol 192(1):24-32. PubMed: 10066343 MGI: J:114251
Herz J; Johnson KR; McGavern DB. 2015. Therapeutic antiviral T cells noncytopathically clear persistently infected microglia after conversion into antigen-presenting cells. J Exp Med 212(8):1153-69. PubMed: 26122661 MGI: J:226451
Hinrichs CS; Borman ZA; Cassard L; Gattinoni L; Spolski R; Yu Z; Sanchez-Perez L; Muranski P; Kern SJ; Logun C; Palmer DC; Ji Y; Reger RN; Leonard WJ; Danner RL; Rosenberg SA; Restifo NP. 2009. Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity. Proc Natl Acad Sci U S A 106(41):17469-74. PubMed: 19805141 MGI: J:153682
Hitchcock JR; Cook CN; Bobat S; Ross EA; Flores-Langarica A; Lowe KL; Khan M; Dominguez-Medina CC; Lax S; Carvalho-Gaspar M; Hubscher S; Rainger GE; Cobbold M; Buckley CD; Mitchell TJ; Mitchell A; Jones ND; Van Rooijen N; Kirchhofer D; Henderson IR; Adams DH; Watson SP; Cunningham AF. 2015. Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets. J Clin Invest 125(12):4429-46. PubMed: 26571395 MGI: J:229832
Hofer M; Hausmann J; Staeheli P; Pagenstecher A. 2004. Cerebral expression of interleukin-12 induces neurological disease via differential pathways and recruits antigen-specific T cells in virus-infected mice. Am J Pathol 165(3):949-58. PubMed: 15331418 MGI: J:92418
Hoff DR; Ryan GJ; Driver ER; Ssemakulu CC; De Groote MA; Basaraba RJ; Lenaerts AJ. 2011. Location of intra- and extracellular M. tuberculosis populations in lungs of mice and guinea pigs during disease progression and after drug treatment. PLoS One 6(3):e17550. PubMed: 21445321 MGI: J:171674
Hofstetter HH; Sewell DL; Liu F; Sandor M; Forsthuber T; Lehmann PV; Fabry Z. 2003. Autoreactive T cells promote post-traumatic healing in the central nervous system. J Neuroimmunol 134(1-2):25-34. PubMed: 12507769 MGI: J:119263
Hofstra CL; Van Ark I; Hofman G; Nijkamp FP; Jardieu PM; Van Oosterhout AJ. 1998. Differential effects of endogenous and exogenous interferon-gamma on immunoglobulin E, cellular infiltration, and airway responsiveness in a murine model of allergic asthma. Am J Respir Cell Mol Biol 19(5):826-35. PubMed: 9806748 MGI: J:114213
Hollenbaugh JA; Reome J; Dobrzanski M; Dutton RW. 2004. The rate of the CD8-dependent initial reduction in tumor volume is not limited by contact-dependent perforin, Fas ligand, or TNF-mediated cytolysis. J Immunol 173(3):1738-43. PubMed: 15265903 MGI: J:92134
Hong F; Jaruga B; Kim WH; Radaeva S; El-Assal ON; Tian Z; Nguyen VA; Gao B. 2002. Opposing roles of STAT1 and STAT3 in T cell-mediated hepatitis: regulation by SOCS. J Clin Invest 110(10):1503-13. PubMed: 12438448 MGI: J:80183
Hong Y; Peng Y; Xiao H; Mi M; Munn D; He Y. 2012. Immunoglobulin Fc fragment tagging allows strong activation of endogenous CD4 T cells to reshape the tumor milieu and enhance the antitumor effect of lentivector immunization. J Immunol 188(10):4819-27. PubMed: 22504640 MGI: J:188675
Horino J; Fujimoto M; Terabe F; Serada S; Takahashi T; Soma Y; Tanaka K; Chinen T; Yoshimura A; Nomura S; Kawase I; Hayashi N; Kishimoto T; Naka T. 2008. Suppressor of cytokine signaling-1 ameliorates dextran sulfate sodium-induced colitis in mice. Int Immunol 20(6):753-62. PubMed: 18381351 MGI: J:136172
Horwitz MS; Krahl T; Fine C; Lee J; Sarvetnick N. 1999. Protection from lethal coxsackievirus-induced pancreatitis by expression of gamma interferon. J Virol 73(3):1756-66. PubMed: 9971752 MGI: J:120473
Hoshino T; Kato S; Oka N; Imaoka H; Kinoshita T; Takei S; Kitasato Y; Kawayama T; Imaizumi T; Yamada K; Young HA; Aizawa H. 2007. Pulmonary inflammation and emphysema: role of the cytokines IL-18 and IL-13. Am J Respir Crit Care Med 176(1):49-62. PubMed: 17400729 MGI: J:147547
Hoshino T; Winkler-Pickett RT; Mason AT; Ortaldo JR; Young HA. 1999. IL-13 production by NK cells: IL-13-producing NK and T cells are present in vivo in the absence of IFN-gamma. J Immunol 162(1):51-9. PubMed: 9886369 MGI: J:112424
Houpt ER; Glembocki DJ; Obrig TG; Moskaluk CA; Lockhart LA; Wright RL; Seaner RM; Keepers TR; Wilkins TD; Petri WA Jr. 2002. The mouse model of amebic colitis reveals mouse strain susceptibility to infection and exacerbation of disease by CD4+ T cells. J Immunol 169(8):4496-503. PubMed: 12370386 MGI: J:120012
Houri-Haddad Y; Soskolne WA; Shai E; Palmon A; Shapira L. 2002. Interferon-gamma deficiency attenuates local P. gingivalis-induced inflammation. J Dent Res 81(6):395-8. PubMed: 12097431 MGI: J:105950
Hu J; Sahu N; Walsh E; August A. 2007. Memory phenotype CD8(+) T cells with innate function selectively develop in the absence of active Itk. Eur J Immunol 37(10):2892-9. PubMed: 17724684 MGI: J:125268
Huang G; Wang Y; Vogel P; Kanneganti TD; Otsu K; Chi H. 2012. Signaling via the kinase p38alpha programs dendritic cells to drive TH17 differentiation and autoimmune inflammation. Nat Immunol 13(2):152-61. PubMed: 22231518 MGI: J:181211
Huang J; Xiao L; Gong X; Shao W; Yin Y; Liao Q; Meng Y; Zhang Y; Ma D; Qiu X. 2014. Cytokine-like molecule CCDC134 contributes to CD8(+) T-cell effector functions in cancer immunotherapy. Cancer Res 74(20):5734-45. PubMed: 25125657 MGI: J:216176
Huang X; McClellan SA; Barrett RP; Hazlett LD. 2002. IL-18 contributes to host resistance against infection with Pseudomonas aeruginosa through induction of IFN-gamma production. J Immunol 168(11):5756-63. PubMed: 12023376 MGI: J:123799
Hultgren B; Huang X; Dybdal N; Stewart TA. 1996. Genetic absence of gamma-interferon delays but does not prevent diabetes in NOD mice. Diabetes 45(6):812-7. PubMed: 8635658 MGI: J:33427
Hung K; Hayashi R; Lafond-Walker A; Lowenstein C; Pardoll D; Levitsky H. 1998. The central role of CD4(+) T cells in the antitumor immune response. J Exp Med 188(12):2357-68. PubMed: 9858522 MGI: J:51677
Husain S; Abdul Y; Webster C; Chatterjee S; Kesarwani P; Mehrotra S. 2014. Interferon-gamma (IFN-gamma)-mediated retinal ganglion cell death in human tyrosinase T cell receptor transgenic mouse. PLoS One 9(2):e89392. PubMed: 24586745 MGI: J:213830
Hwang SJ; Kim S; Park WS; Chung DH. 2006. IL-4-secreting NKT cells prevent hypersensitivity pneumonitis by suppressing IFN-gamma-producing neutrophils. J Immunol 177(8):5258-68. PubMed: 17015711 MGI: J:139446
Hyland NP; Sjoberg F; Tough IR; Herzog H; Cox HM. 2003. Functional consequences of neuropeptide Y Y 2 receptor knockout and Y2 antagonism in mouse and human colonic tissues. Br J Pharmacol 139(4):863-71. PubMed: 12813010 MGI: J:103044
Iijima H; Neurath MF; Nagaishi T; Glickman JN; Nieuwenhuis EE; Nakajima A; Chen D; Fuss IJ; Utku N; Lewicki DN; Becker C; Gallagher TM; Holmes KV; Blumberg RS. 2004. Specific regulation of T helper cell 1-mediated murine colitis by CEACAM1. J Exp Med 199(4):471-82. PubMed: 14970176 MGI: J:90476
Ilangumaran S; Ramanathan S; La Rose J; Poussier P; Rottapel R. 2003. Suppressor of cytokine signaling 1 regulates IL-15 receptor signaling in CD8+CD44(high) memory T lymphocytes. J Immunol 171(5):2435-45. PubMed: 12928391 MGI: J:85085
Ilangumaran S; Ramanathan S; Ning T; La Rose J; Reinhart B; Poussier P; Rottapel R. 2003. Suppressor of cytokine signaling 1 attenuates IL-15 receptor signaling in CD8+ thymocytes. Blood 102(12):4115-22. PubMed: 12907450 MGI: J:86680
Imai T; Shen J; Chou B; Duan X; Tu L; Tetsutani K; Moriya C; Ishida H; Hamano S; Shimokawa C; Hisaeda H; Himeno K. 2010. Involvement of CD8+ T cells in protective immunity against murine blood-stage infection with Plasmodium yoelii 17XL strain. Eur J Immunol 40(4):1053-61. PubMed: 20101613 MGI: J:159116
Irmler IM; Gajda M; Brauer R. 2007. Exacerbation of antigen-induced arthritis in IFN-gamma-deficient mice as a result of unrestricted IL-17 response. J Immunol 179(9):6228-36. PubMed: 17947698 MGI: J:152989
Ishigame H; Zenewicz LA; Sanjabi S; Licona-Limon P; Nakayama M; Leonard WJ; Flavell RA. 2013. Excessive Th1 responses due to the absence of TGF-beta signaling cause autoimmune diabetes and dysregulated Treg cell homeostasis. Proc Natl Acad Sci U S A 110(17):6961-6. PubMed: 23569233 MGI: J:196160
Ishii KJ; Ito S; Tamura T; Hemmi H; Conover J; Ozato K; Akira S; Klinman DM. 2005. CpG-activated Thy1.2+ dendritic cells protect against lethal Listeria monocytogenes infection. Eur J Immunol 35(8):2397-405. PubMed: 16047338 MGI: J:100431
Ishiwata K; Watanabe N; Guo M; Tomihara K; Brumlik MJ; Yagita H; Pardoll D; Chen L; Shin T. 2010. Costimulator B7-DC attenuates strong Th2 responses induced by Nippostrongylus brasiliensis. J Immunol 184(4):2086-94. PubMed: 20065112 MGI: J:159489
Ito T; Nishiyama C; Nakano N; Nishiyama M; Usui Y; Takeda K; Kanada S; Fukuyama K; Akiba H; Tokura T; Hara M; Tsuboi R; Ogawa H; Okumura K. 2009. Roles of PU.1 in monocyte- and mast cell-specific gene regulation: PU.1 transactivates CIITA pIV in cooperation with IFN-gamma. Int Immunol 21(7):803-16. PubMed: 19502584 MGI: J:150283
Jacobs JP; Wu HJ; Benoist C; Mathis D. 2009. IL-17-producing T cells can augment autoantibody-induced arthritis. Proc Natl Acad Sci U S A :. PubMed: 19955422 MGI: J:155519
Jamieson E; Chong MM; Steinberg GR; Jovanovska V; Fam BC; Bullen DV; Chen Y; Kemp BE; Proietto J; Kay TW; Andrikopoulos S. 2005. Socs1 deficiency enhances hepatic insulin signaling. J Biol Chem 280(36):31516-21. PubMed: 15983045 MGI: J:101166
Jankovic D; Kullberg MC; Hieny S; Caspar P; Collazo CM; Sher A. 2002. In the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) setting. Immunity 16(3):429-39. PubMed: 11911827 MGI: J:113516
Jaruga B; Hong F; Kim WH; Gao B. 2004. IFN-gamma/STAT1 acts as a proinflammatory signal in T cell-mediated hepatitis via induction of multiple chemokines and adhesion molecules: a critical role of IRF-1. Am J Physiol Gastrointest Liver Physiol 287(5):G1044-52. PubMed: 15246962 MGI: J:96187
Jasperson LK; Bucher C; Panoskaltsis-Mortari A; Mellor AL; Munn DH; Blazar BR. 2009. Inducing the tryptophan catabolic pathway, indoleamine 2,3-dioxygenase (IDO), for suppression of graft-versus-host disease (GVHD) lethality. Blood 114(24):5062-70. PubMed: 19828695 MGI: J:155467
Jegerlehner A; Maurer P; Bessa J; Hinton HJ; Kopf M; Bachmann MF. 2007. TLR9 signaling in B cells determines class switch recombination to IgG2a. J Immunol 178(4):2415-20. PubMed: 17277148 MGI: J:143978
Jelinsky SA; Miyashiro JS; Saraf KA; Tunkey C; Reddy P; Newcombe J; Oestreicher JL; Brown E; Trepicchio WL; Leonard JP; Marusic S. 2005. Exploiting genotypic differences to identify genes important for EAE development. J Neurol Sci 239(1):81-93. PubMed: 16214174 MGI: J:106390
Jenner RG; Townsend MJ; Jackson I; Sun K; Bouwman RD; Young RA; Glimcher LH; Lord GM. 2009. The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes. Proc Natl Acad Sci U S A 106(42):17876-81. PubMed: 19805038 MGI: J:153703
Jeon SB; Yoon HJ; Chang CY; Koh HS; Jeon SH; Park EJ. 2010. Galectin-3 Exerts Cytokine-Like Regulatory Actions through the JAK-STAT Pathway. J Immunol 185(11):7037-46. PubMed: 20980634 MGI: J:166149
Jiang Q; Weiss JM; Back T; Chan T; Ortaldo JR; Guichard S; Wiltrout RH. 2011. mTOR Kinase Inhibitor AZD8055 Enhances the Immunotherapeutic Activity of an Agonist CD40 Antibody in Cancer Treatment. Cancer Res 71(12):4074-84. PubMed: 21540234 MGI: J:173408
Jiang X; Clark RA; Liu L; Wagers AJ; Fuhlbrigge RC; Kupper TS. 2012. Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity. Nature 483(7388):227-31. PubMed: 22388819 MGI: J:181682
Jin JO; Yu Q. 2013. Systemic administration of TLR3 agonist induces IL-7 expression and IL-7-dependent CXCR3 ligand production in the lung. J Leukoc Biol 93(3):413-25. PubMed: 23271706 MGI: J:198081
Jinushi M; Nakazaki Y; Dougan M; Carrasco DR; Mihm M; Dranoff G. 2007. MFG-E8-mediated uptake of apoptotic cells by APCs links the pro- and antiinflammatory activities of GM-CSF. J Clin Invest 117(7):1902-13. PubMed: 17557120 MGI: J:124038
Johnson LL; Sayles PC. 1995. Strong cytolytic activity of natural killer cells is neither necessary nor sufficient for preimmune resistance to Toxoplasma gondii infection. Nat Immunol 14(4):209-15. PubMed: 8696010 MGI: J:113057
Jones TG; Finkelman FD; Austen KF; Gurish MF. 2010. T regulatory cells control antigen-induced recruitment of mast cell progenitors to the lungs of C57BL/6 mice. J Immunol 185(3):1804-11. PubMed: 20601599 MGI: J:162451
Jones TG; Hallgren J; Humbles A; Burwell T; Finkelman FD; Alcaide P; Austen KF; Gurish MF. 2009. Antigen-induced increases in pulmonary mast cell progenitor numbers depend on IL-9 and CD1d-restricted NKT cells. J Immunol 183(8):5251-60. PubMed: 19783672 MGI: J:153832
Joosten LA; van De Loo FA; Lubberts E; Helsen MM; Netea MG; van Der Meer JW; Dinarello CA; van Den Berg WB. 2000. An IFN-gamma-independent proinflammatory role of IL-18 in murine streptococcal cell wall arthritis. J Immunol 165(11):6553-8. PubMed: 11086098 MGI: J:127165
Joshi N; Kopec AK; Ray JL; Cline-Fedewa H; Nawabi A; Schmitt T; Nault R; Zacharewski TR; Rockwell CE; Flick MJ; Luyendyk JP. 2016. Fibrin deposition following bile duct injury limits fibrosis through an alphaMbeta2-dependent mechanism. Blood 127(22):2751-62. PubMed: 26921287 MGI: J:234730
Jouanguy E; Doffinger R; Dupuis S; Pallier A; Altare F; Casanova JL. 1999. IL-12 and IFN-gamma in host defense against mycobacteria and salmonella in mice and men. Curr Opin Immunol 11(3):346-51. PubMed: 10375558 MGI: J:55697
Junqueira-Kipnis AP; Basaraba RJ; Gruppo V; Palanisamy G; Turner OC; Hsu T; Jacobs WR Jr; Fulton SA; Reba SM; Boom WH; Orme IM. 2006. Mycobacteria lacking the RD1 region do not induce necrosis in the lungs of mice lacking interferon-gamma. Immunology 119(2):224-31. PubMed: 17005003 MGI: J:118520
Jupelli M; Guentzel MN; Meier PA; Zhong G; Murthy AK; Arulanandam BP. 2008. Endogenous IFN-{gamma} Production Is Induced and Required for Protective Immunity against Pulmonary Chlamydial Infection in Neonatal Mice. J Immunol 180(6):4148-55. PubMed: 18322226 MGI: J:132958
Kamanaka M; Huber S; Zenewicz LA; Gagliani N; Rathinam C; O'Connor W Jr; Wan YY; Nakae S; Iwakura Y; Hao L; Flavell RA. 2011. Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology. J Exp Med 208(5):1027-40. PubMed: 21518800 MGI: J:177300
Kammertoens T; Willebrand R; Erdmann B; Li L; Li Y; Engels B; Uckert W; Blankenstein T. 2005. CY15, a malignant histiocytic tumor that is phenotypically similar to immature dendritic cells. Cancer Res 65(7):2560-4. PubMed: 15805249 MGI: J:97347
Kane M; Case LK; Wang C; Yurkovetskiy L; Dikiy S; Golovkina TV. 2011. Innate Immune Sensing of Retroviral Infection via Toll-like Receptor 7 Occurs upon Viral Entry. Immunity 35(1):135-45. PubMed: 21723157 MGI: J:174379
Kang MJ; Lee CG; Lee JY; Dela Cruz CS; Chen ZJ; Enelow R; Elias JA. 2008. Cigarette smoke selectively enhances viral PAMP- and virus-induced pulmonary innate immune and remodeling responses in mice. J Clin Invest 118(8):2771-84. PubMed: 18654661 MGI: J:140864
Kanhere A; Hertweck A; Bhatia U; Gokmen MR; Perucha E; Jackson I; Lord GM; Jenner RG. 2012. T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements. Nat Commun 3:1268. PubMed: 23232398 MGI: J:205611
Kania G; Siegert S; Behnke S; Prados-Rosales R; Casadevall A; Luscher TF; Luther SA; Kopf M; Eriksson U; Blyszczuk P. 2013. Innate signaling promotes formation of regulatory nitric oxide-producing dendritic cells limiting T-cell expansion in experimental autoimmune myocarditis. Circulation 127(23):2285-94. PubMed: 23671208 MGI: J:211390
Kanistanon D; Powell DA; Hajjar AM; Pelletier MR; Cohen IE; Way SS; Skerrett SJ; Wang X; Raetz CR; Ernst RK. 2012. Role of Francisella lipid A phosphate modification in virulence and long-term protective immune responses. Infect Immun 80(3):943-51. PubMed: 22215738 MGI: J:182434
Karachunski PI; Ostlie NS; Monfardini C; Conti-Fine BM. 2000. Absence of IFN-gamma or IL-12 has different effects on experimental myasthenia gravis in C57BL/6 mice. J Immunol 164(10):5236-44. PubMed: 10799884 MGI: J:62120
Karpuzoglu E; Fenaux JB; Phillips RA; Lengi AJ; Elvinger F; Ansar Ahmed S. 2006. Estrogen up-regulates inducible nitric oxide synthase, nitric oxide, and cyclooxygenase-2 in splenocytes activated with T cell stimulants: role of interferon-gamma. Endocrinology 147(2):662-71. PubMed: 16293660 MGI: J:129444
Kastenmuller W; Brandes M; Wang Z; Herz J; Egen JG; Germain RN. 2013. Peripheral Prepositioning and Local CXCL9 Chemokine-Mediated Guidance Orchestrate Rapid Memory CD8(+) T Cell Responses in the Lymph Node. Immunity 38(3):502-13. PubMed: 23352234 MGI: J:194479
Kataru RP; Kim H; Jang C; Choi DK; Koh BI; Kim M; Gollamudi S; Kim YK; Lee SH; Koh GY. 2011. T lymphocytes negatively regulate lymph node lymphatic vessel formation. Immunity 34(1):96-107. PubMed: 21256057 MGI: J:168062
Kawamura T; Takeda K; Kaneda H; Matsumoto H; Hayakawa Y; Raulet DH; Ikarashi Y; Kronenberg M; Yagita H; Kinoshita K; Abo T; Okumura K; Smyth MJ. 2009. NKG2A inhibits invariant NKT cell activation in hepatic injury. J Immunol 182(1):250-8. PubMed: 19109156 MGI: J:143037
Kawano M; Nakayama M; Aoshima Y; Nakamura K; Ono M; Nishiya T; Nakamura S; Takeda Y; Dobashi A; Takahashi A; Endo M; Ito A; Ueda K; Sato N; Higuchi S; Kondo T; Hashimoto S; Watanabe M; Watanabe M; Takahashi T; Sasaki K; Nakamura M; Sasazuki T; Narushima T; Suzuki R; Ogasawara K. 2014. NKG2D(+) IFN-gamma(+) CD8(+) T cells are responsible for palladium allergy. PLoS One 9(2):e86810. PubMed: 24533050 MGI: J:212941
Kawata K; Tsuda M; Yang GX; Zhang W; Tanaka H; Tsuneyama K; Leung P; He XS; Knechtle S; Ansari AA; Coppel RL; Gershwin ME. 2013. Identification of potential cytokine pathways for therapeutic intervention in murine primary biliary cirrhosis. PLoS One 8(9):e74225. PubMed: 24040208 MGI: J:206046
Kayes TD; Braley-Mullen H. 2013. Culture promotes transfer of thyroid epithelial cell hyperplasia and proliferation by reducing regulatory T cell numbers. Cell Immunol 285(1-2):84-91. PubMed: 24135055 MGI: J:206056
Kellermann SA; McEvoy LM. 2001. The Peyer's patch microenvironment suppresses T cell responses to chemokines and other stimuli. J Immunol 167(2):682-90. PubMed: 11441071 MGI: J:120507
Kerkar SP; Goldszmid RS; Muranski P; Chinnasamy D; Yu Z; Reger RN; Leonardi AJ; Morgan RA; Wang E; Marincola FM; Trinchieri G; Rosenberg SA; Restifo NP. 2011. IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors. J Clin Invest 121(12):4746-57. PubMed: 22056381 MGI: J:184027
Khader SA; Bell GK; Pearl JE; Fountain JJ; Rangel-Moreno J; Cilley GE; Shen F; Eaton SM; Gaffen SL; Swain SL; Locksley RM; Haynes L; Randall TD; Cooper AM. 2007. IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Nat Immunol 8(4):369-77. PubMed: 17351619 MGI: J:120806
Khan AA; Priya S; Saha B. 2009. IL-2 regulates SEB induced toxic shock syndrome in BALB/c mice. PLoS One 4(12):e8473. PubMed: 20041187 MGI: J:155944
Khan S; van den Broek M; Schwarz K; de Giuli R; Diener PA; Groettrup M. 2001. Immunoproteasomes largely replace constitutive proteasomes during an antiviral and antibacterial immune response in the liver. J Immunol 167(12):6859-68. PubMed: 11739503 MGI: J:73089
Kim G; Turovskaya O; Levin M; Byrne FR; Whoriskey JS; McCabe JG; Kronenberg M. 2008. Spontaneous colitis occurrence in transgenic mice with altered B7-mediated costimulation. J Immunol 181(8):5278-88. PubMed: 18832683 MGI: J:140772
Kim HY; Kim HJ; Min HS; Kim S; Park WS; Park SH; Chung DH. 2005. NKT cells promote antibody-induced joint inflammation by suppressing transforming growth factor beta1 production. J Exp Med 201(1):41-7. PubMed: 15630137 MGI: J:95287
Kim JH; Chung DH. 2011. CD1d-restricted IFN-gamma-secreting NKT cells promote immune complex-induced acute lung injury by regulating macrophage-inflammatory protein-1alpha production and activation of macrophages and dendritic cells. J Immunol 186(3):1432-41. PubMed: 21191075 MGI: J:168903
Kim JH; Kim HY; Kim S; Chung JH; Park WS; Chung DH. 2005. Natural Killer T (NKT) Cells Attenuate Bleomycin-Induced Pulmonary Fibrosis by Producing Interferon-{gamma}. Am J Pathol 167(5):1231-41. PubMed: 16251408 MGI: J:102402
Kim ML; Chae JJ; Park YH; De Nardo D; Stirzaker RA; Ko HJ; Tye H; Cengia L; DiRago L; Metcalf D; Roberts AW; Kastner DL; Lew AM; Lyras D; Kile BT; Croker BA; Masters SL. 2015. Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1beta. J Exp Med 212(6):927-38. PubMed: 26008898 MGI: J:224778
Kim YK; Oh SY; Jeon SG; Park HW; Lee SY; Chun EY; Bang B; Lee HS; Oh MH; Kim YS; Kim JH; Gho YS; Cho SH; Min KU; Kim YY; Zhu Z. 2007. Airway exposure levels of lipopolysaccharide determine type 1 versus type 2 experimental asthma. J Immunol 178(8):5375-82. PubMed: 17404323 MGI: J:145264
Kimura K; Kimura D; Matsushima Y; Miyakoda M; Honma K; Yuda M; Yui K. 2013. CD8+ T Cells Specific for a Malaria Cytoplasmic Antigen Form Clusters around Infected Hepatocytes and Are Protective at the Liver Stage of Infection. Infect Immun 81(10):3825-34. PubMed: 23897612 MGI: J:200595
Kimura MY; Pobezinsky LA; Guinter TI; Thomas J; Adams A; Park JH; Tai X; Singer A. 2013. IL-7 signaling must be intermittent, not continuous, during CD8(+) T cell homeostasis to promote cell survival instead of cell death. Nat Immunol 14(2):143-51. PubMed: 23242416 MGI: J:192537
King VL; Lin AY; Kristo F; Anderson TJ; Ahluwalia N; Hardy GJ; Owens AP 3rd; Howatt DA; Shen D; Tager AM; Luster AD; Daugherty A; Gerszten RE. 2009. Interferon-gamma and the interferon-inducible chemokine CXCL10 protect against aneurysm formation and rupture. Circulation 119(3):426-35. PubMed: 19139386 MGI: J:166204
Kinjyo I; Hanada T; Inagaki-Ohara K; Mori H; Aki D; Ohishi M; Yoshida H; Kubo M; Yoshimura A. 2002. SOCS1/JAB is a negative regulator of LPS-induced macrophage activation. Immunity 17(5):583-91. PubMed: 12433365 MGI: J:125159
Kirimanjeswara GS; Golden JM; Bakshi CS; Metzger DW. 2007. Prophylactic and therapeutic use of antibodies for protection against respiratory infection with Francisella tularensis. J Immunol 179(1):532-9. PubMed: 17579074 MGI: J:149409
Kirksey MA; Tischler AD; Simeone R; Hisert KB; Uplekar S; Guilhot C; McKinney JD. 2011. Spontaneous Phthiocerol Dimycocerosate-Deficient Variants of Mycobacterium tuberculosis Are Susceptible to Gamma Interferon-Mediated Immunity. Infect Immun 79(7):2829-38. PubMed: 21576344 MGI: J:173476
Kish DD; Li X; Fairchild RL. 2009. CD8 T cells producing IL-17 and IFN-gamma initiate the innate immune response required for responses to antigen skin challenge. J Immunol 182(10):5949-59. PubMed: 19414746 MGI: J:148247
Kitching AR; Turner AL; Semple T; Li M; Edgtton KL; Wilson GR; Timoshanko JR; Hudson BG; Holdsworth SR. 2004. Experimental autoimmune anti-glomerular basement membrane glomerulonephritis: a protective role for IFN-gamma. J Am Soc Nephrol 15(7):1764-74. PubMed: 15213264 MGI: J:132564
Klebanoff CA; Yu Z; Hwang LN; Palmer DC; Gattinoni L; Restifo NP. 2009. Programming tumor-reactive effector memory CD8+ T cells in vitro obviates the requirement for in vivo vaccination. Blood 114(9):1776-83. PubMed: 19561320 MGI: J:152256
Kleinman ME; Yamada K; Takeda A; Chandrasekaran V; Nozaki M; Baffi JZ; Albuquerque RJ; Yamasaki S; Itaya M; Pan Y; Appukuttan B; Gibbs D; Yang Z; Kariko K; Ambati BK; Wilgus TA; DiPietro LA; Sakurai E; Zhang K; Smith JR; Taylor EW; Ambati J. 2008. Sequence- and target-independent angiogenesis suppression by siRNA via TLR3. Nature 452(7187):591-7. PubMed: 18368052 MGI: J:133772
Kleinschek MA; Owyang AM; Joyce-Shaikh B; Langrish CL; Chen Y; Gorman DM; Blumenschein WM; McClanahan T; Brombacher F; Hurst SD; Kastelein RA; Cua DJ. 2007. IL-25 regulates Th17 function in autoimmune inflammation. J Exp Med 204(1):161-70. PubMed: 17200411 MGI: J:125296
Kleinschnitz C; Kraft P; Dreykluft A; Hagedorn I; Gobel K; Schuhmann MK; Langhauser F; Helluy X; Schwarz T; Bittner S; Mayer CT; Brede M; Varallyay C; Pham M; Bendszus M; Jakob P; Magnus T; Meuth SG; Iwakura Y; Zernecke A; Sparwasser T; Nieswandt B; Stoll G; Wiendl H. 2013. Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature. Blood 121(4):679-91. PubMed: 23160472 MGI: J:194093
Kline J; Zhang L; Battaglia L; Cohen KS; Gajewski TF. 2012. Cellular and molecular requirements for rejection of b16 melanoma in the setting of regulatory T cell depletion and homeostatic proliferation. J Immunol 188(6):2630-42. PubMed: 22312128 MGI: J:181862
Knight DA; Ngiow SF; Li M; Parmenter T; Mok S; Cass A; Haynes NM; Kinross K; Yagita H; Koya RC; Graeber TG; Ribas A; McArthur GA; Smyth MJ. 2013. Host immunity contributes to the anti-melanoma activity of BRAF inhibitors. J Clin Invest 123(3):1371-81. PubMed: 23454771 MGI: J:196375
Kobayashi T; Kawamura H; Kanda Y; Matsumoto H; Saito S; Takeda K; Kawamura T; Abo T. 2012. Natural killer T cells suppress zymosan A-mediated granuloma formation in the liver by modulating interferon-gamma and interleukin-10. Immunology 136(1):86-95. PubMed: 22268994 MGI: J:184091
Koch M; Witzenrath M; Reuter C; Herma M; Schutte H; Suttorp N; Collins H; Kaufmann SH. 2006. Role of local pulmonary IFN-gamma expression in murine allergic airway inflammation. Am J Respir Cell Mol Biol 35(2):211-9. PubMed: 16543606 MGI: J:123674
Koch MA; Thomas KR; Perdue NR; Smigiel KS; Srivastava S; Campbell DJ. 2012. T-bet(+) Treg Cells Undergo Abortive Th1 Cell Differentiation due to Impaired Expression of IL-12 Receptor beta2. Immunity 37(3):501-10. PubMed: 22960221 MGI: J:187671
Koenecke C; Lee CW; Thamm K; Fohse L; Schafferus M; Mittrucker HW; Floess S; Huehn J; Ganser A; Forster R; Prinz I. 2012. IFN-gamma production by allogeneic Foxp3+ regulatory T cells is essential for preventing experimental graft-versus-host disease. J Immunol 189(6):2890-6. PubMed: 22869903 MGI: J:189843
Kohlhapp FJ; Zloza A; O'Sullivan JA; Moore TV; Lacek AT; Jagoda MC; McCracken J; Cole DJ; Guevara-Patino JA. 2012. CD8(+) T cells sabotage their own memory potential through IFN-gamma-dependent modification of the IL-12/IL-15 receptor alpha axis on dendritic cells. J Immunol 188(8):3639-47. PubMed: 22430740 MGI: J:184140
Komiyama Y; Nakae S; Matsuki T; Nambu A; Ishigame H; Kakuta S; Sudo K; Iwakura Y. 2006. IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. J Immunol 177(1):566-73. PubMed: 16785554 MGI: J:134438
Kono DH; Balomenos D; Pearson DL; Park MS; Hildebrandt B; Hultman P; Pollard KM. 1998. The prototypic Th2 autoimmunity induced by mercury is dependent on IFN-gamma and not Th1/Th2 imbalance. J Immunol 161(1):234-40. PubMed: 9647229 MGI: J:119207
Kontoyiannis D; Boulougouris G; Manoloukos M; Armaka M; Apostolaki M; Pizarro T; Kotlyarov A; Forster I; Flavell R; Gaestel M; Tsichlis P; Cominelli F; Kollias G. 2002. Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease. J Exp Med 196(12):1563-74. PubMed: 12486099 MGI: J:108572
Koschella M; Voehringer D; Pircher H. 2004. CD40 ligation in vivo induces bystander proliferation of memory phenotype CD8 T cells. J Immunol 172(8):4804-11. PubMed: 15067057 MGI: J:89113
Kossmann S; Schwenk M; Hausding M; Karbach SH; Schmidgen MI; Brandt M; Knorr M; Hu H; Kroller-Schon S; Schonfelder T; Grabbe S; Oelze M; Daiber A; Munzel T; Becker C; Wenzel P. 2013. Angiotensin II-induced vascular dysfunction depends on interferon-gamma-driven immune cell recruitment and mutual activation of monocytes and NK-cells. Arterioscler Thromb Vasc Biol 33(6):1313-9. PubMed: 23520167 MGI: J:218876
Koustova E; Sei Y; McCarty T; Espey MG; Ming R; Morse HC 3rd; Basile AS. 2000. Accelerated development of neurochemical and behavioral deficits in LP-BM5 infected mice with targeted deletions of the IFN-gamma gene. J Neuroimmunol 108(1-2):112-21. PubMed: 10900344 MGI: J:102969
Kovacic B; Stoiber D; Moriggl R; Weisz E; Ott RG; Kreibich R; Levy DE; Beug H; Freissmuth M; Sexl V. 2006. STAT1 acts as a tumor promoter for leukemia development. Cancer Cell 10(1):77-87. PubMed: 16843267 MGI: J:110949
Krakowski M; Owens T. 1996. Interferon-gamma confers resistance to experimental allergic encephalomyelitis. Eur J Immunol 26(7):1641-6. PubMed: 8766573 MGI: J:34161
Kuhl AA; Pawlowski NN; Grollich K; Loddenkemper C; Zeitz M; Hoffmann JC. 2007. Aggravation of intestinal inflammation by depletion/deficiency of gammadelta T cells in different types of IBD animal models. J Leukoc Biol 81(1):168-75. PubMed: 17041003 MGI: J:117270
KuoLee R; Zhao X; Austin J; Harris G; Conlan JW; Chen W. 2007. Mouse model of oral infection with virulent type A Francisella tularensis. Infect Immun 75(4):1651-60. PubMed: 17242058 MGI: J:119508
Kupz A; Scott TA; Belz GT; Andrews DM; Greyer M; Lew AM; Brooks AG; Smyth MJ; Curtiss R 3rd; Bedoui S; Strugnell RA. 2013. Contribution of Thy1+ NK cells to protective IFN-gamma production during Salmonella Typhimurium infections. Proc Natl Acad Sci U S A 110(6):2252-7. PubMed: 23345426 MGI: J:194337
Kustova Y; Sei Y; Morse HC Jr; Basile AS. 1998. The influence of a targeted deletion of the IFNgamma gene on emotional behaviors. Brain Behav Immun 12(4):308-24. PubMed: 10080860 MGI: J:54250
Kweon MN; Fujihashi K; VanCott JL; Higuchi K; Yamamoto M; McGhee JR; Kiyono H. 1998. Lack of orally induced systemic unresponsiveness in IFN-gamma knockout mice. J Immunol 160(4):1687-93. PubMed: 9469425 MGI: J:45665
Larena M; Regner M; Lobigs M. 2013. Cytolytic effector pathways and IFN-gamma help protect against Japanese encephalitis. Eur J Immunol 43(7):1789-98. PubMed: 23568450 MGI: J:201027
Lavigne LM; Schopf LR; Chung CL; Maylor R; Sypek JP. 1998. The role of recombinant murine IL-12 and IFN-gamma in the pathogenesis of a murine systemic Candida albicans infection. J Immunol 160(1):284-92. PubMed: 9551982 MGI: J:44920
Lazar-Molnar E; Gacser A; Freeman GJ; Almo SC; Nathenson SG; Nosanchuk JD. 2008. The PD-1/PD-L costimulatory pathway critically affects host resistance to the pathogenic fungus Histoplasma capsulatum. Proc Natl Acad Sci U S A 105(7):2658-63. PubMed: 18268348 MGI: J:132166
Leadbetter EA; Brigl M; Illarionov P; Cohen N; Luteran MC; Pillai S; Besra GS; Brenner MB. 2008. NK T cells provide lipid antigen-specific cognate help for B cells. Proc Natl Acad Sci U S A 105(24):8339-44. PubMed: 18550809 MGI: J:137193
Lean IS; Lacroix-Lamande S; Laurent F; McDonald V. 2006. Role of tumor necrosis factor alpha in development of immunity against Cryptosporidium parvum infection Infect Immun 74(7):4379-4382. PubMed: 16790816 MGI: J:110124
Lee CC; Kung JT. 2012. Marginal zone B cell is a major source of Il-10 in Listeria monocytogenes susceptibility. J Immunol 189(7):3319-27. PubMed: 22933629 MGI: J:190348
Lee CK; Smith E; Gimeno R; Gertner R; Levy DE. 2000. STAT1 affects lymphocyte survival and proliferation partially independent of its role downstream of IFN-gamma J Immunol 164(3):1286-92. PubMed: 10640742 MGI: J:59955
Lee EY; Schultz KL; Griffin DE. 2013. Mice deficient in interferon-gamma or interferon-gamma receptor 1 have distinct inflammatory responses to acute viral encephalomyelitis. PLoS One 8(10):e76412. PubMed: 24204622 MGI: J:209188
Lee HH; Meyer EH; Goya S; Pichavant M; Kim HY; Bu X; Umetsu SE; Jones JC; Savage PB; Iwakura Y; Casasnovas JM; Kaplan G; Freeman GJ; DeKruyff RH; Umetsu DT. 2010. Apoptotic cells activate NKT cells through T cell Ig-like mucin-like-1 resulting in airway hyperreactivity. J Immunol 185(9):5225-35. PubMed: 20889552 MGI: J:165181
Lee HJ; Oh YK; Rhee M; Lim JY; Hwang JY; Park YS; Kwon Y; Choi KH; Jo I; Park SI; Gao B; Kim WH. 2007. The role of STAT1/IRF-1 on synergistic ROS production and loss of mitochondrial transmembrane potential during hepatic cell death induced by LPS/d-GalN. J Mol Biol 369(4):967-84. PubMed: 17475277 MGI: J:122801
Lee J; Lee J; Park MK; Lim MA; Park EM; Kim EK; Yang EJ; Lee SY; Jhun JY; Park SH; Kim HY; Cho ML. 2013. Interferon gamma suppresses collagen-induced arthritis by regulation of Th17 through the induction of indoleamine-2,3-deoxygenase. PLoS One 8(4):e60900. PubMed: 23613752 MGI: J:200571
Lee J; Reinke EK; Zozulya AL; Sandor M; Fabry Z. 2008. Mycobacterium bovis bacille Calmette-Guerin infection in the CNS suppresses experimental autoimmune encephalomyelitis and Th17 responses in an IFN-gamma-independent manner. J Immunol 181(9):6201-12. PubMed: 18941210 MGI: J:140733
Lee PY; Li Y; Kumagai Y; Xu Y; Weinstein JS; Kellner ES; Nacionales DC; Butfiloski EJ; van Rooijen N; Akira S; Sobel ES; Satoh M; Reeves WH. 2009. Type I interferon modulates monocyte recruitment and maturation in chronic inflammation. Am J Pathol 175(5):2023-33. PubMed: 19808647 MGI: J:154704
Lee SH; Prince JE; Rais M; Kheradmand F; Shardonofsky F; Lu H; Beaudet AL; Smith CW; Soong L; Corry DB. 2003. Differential requirement for CD18 in T-helper effector homing. Nat Med 9(10):1281-6. PubMed: 14502280 MGI: J:99598
Lees JR; Golumbek PT; Sim J; Dorsey D; Russell JH. 2008. Regional CNS responses to IFN-gamma determine lesion localization patterns during EAE pathogenesis. J Exp Med 205(11):2633-42. PubMed: 18852291 MGI: J:141105
Lengeling A; Pfeffer K; Balling R. 2001. The battle of two genomes: genetics of bacterial host/pathogen interactions in mice. Mamm Genome 12(4):261-71. PubMed: 11309656 MGI: J:68401
Lengi AJ; Phillips RA; Karpuzoglu E; Ahmed SA. 2007. Estrogen selectively regulates chemokines in murine splenocytes. J Leukoc Biol 81(4):1065-74. PubMed: 17185357 MGI: J:121456
Lepage AC; Buzoni-Gatel D; Bout DT; Kasper LH. 1998. Gut-derived intraepithelial lymphocytes induce long term immunity against Toxoplasma gondii. J Immunol 161(9):4902-8. PubMed: 9794424 MGI: J:50441
Leveson-Gower DB; Olson JA; Sega EI; Luong RH; Baker J; Zeiser R; Negrin RS. 2011. Low doses of natural killer T cells provide protection from acute graft-versus-host disease via an IL-4-dependent mechanism. Blood 117(11):3220-9. PubMed: 21258007 MGI: J:170509
Lewkowich IP; Rempel JD; HayGlass KT. 2005. Prevention of allergen-specific, Th2-biased immune responses in vivo: role of increased IL-12 and IL-18 responsiveness. J Immunol 175(8):4956-62. PubMed: 16210597 MGI: J:119100
Li CK; Pender SL; Pickard KM; Chance V; Holloway JA; Huett A; Goncalves NS; Mudgett JS; Dougan G; Frankel G; MacDonald TT. 2004. Impaired immunity to intestinal bacterial infection in stromelysin-1 (matrix metalloproteinase-3)-deficient mice. J Immunol 173(8):5171-9. PubMed: 15470062 MGI: J:93706
Li CR; Mueller EE; Bradley LM. 2014. Islet antigen-specific Th17 cells can induce TNF-alpha-dependent autoimmune diabetes. J Immunol 192(4):1425-32. PubMed: 24446517 MGI: J:209355
Li L; Walker TL; Zhang Y; Mackay EW; Bartlett PF. 2010. Endogenous interferon gamma directly regulates neural precursors in the non-inflammatory brain. J Neurosci 30(27):9038-50. PubMed: 20610738 MGI: J:161777
Li S; Choi HJ; Felio K; Wang CR. 2011. Autoreactive CD1b-restricted T cells: a new innate-like T-cell population that contributes to immunity against infection. Blood 118(14):3870-8. PubMed: 21860021 MGI: J:178396
Li S; Yan Y; Lin Y; Bullens DM; Rutgeerts O; Goebels J; Segers C; Boon L; Kasran A; De Vos R; Dewolf-Peeters C; Waer M; Billiau AD. 2007. Rapidly induced, T-cell independent xenoantibody production is mediated by marginal zone B cells and requires help from NK cells. Blood 110(12):3926-35. PubMed: 17630353 MGI: J:149130
Li W; Murthy AK; Guentzel MN; Seshu J; Forsthuber TG; Zhong G; Arulanandam BP. 2008. Antigen-Specific CD4+ T Cells Produce Sufficient IFN-{gamma} to Mediate Robust Protective Immunity against Genital Chlamydia muridarum Infection. J Immunol 180(5):3375-82. PubMed: 18292563 MGI: J:131578
Li X; Lees JR. 2013. Pre-existing central nervous system lesions negate cytokine requirements for regional experimental autoimmune encephalomyelitis development. Immunology 138(3):208-15. PubMed: 23121407 MGI: J:198090
Li X; McKinstry KK; Swain SL; Dalton DK. 2007. IFN-gamma acts directly on activated CD4+ T cells during mycobacterial infection to promote apoptosis by inducing components of the intracellular apoptosis machinery and by inducing extracellular proapoptotic signals. J Immunol 179(2):939-49. PubMed: 17617585 MGI: J:149401
Li Z; Pradera F; Kammertoens T; Li B; Liu S; Qin Z. 2007. Cross-talk between T cells and innate immune cells is crucial for IFN-gamma-dependent tumor rejection. J Immunol 179(3):1568-76. PubMed: 17641023 MGI: J:149949
Liao W; Lin JX; Wang L; Li P; Leonard WJ. 2011. Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages. Nat Immunol 12(6):551-9. PubMed: 21516110 MGI: J:172804
Lieberman LA; Cardillo F; Owyang AM; Rennick DM; Cua DJ; Kastelein RA; Hunter CA. 2004. IL-23 provides a limited mechanism of resistance to acute toxoplasmosis in the absence of IL-12. J Immunol 173(3):1887-93. PubMed: 15265921 MGI: J:92028
Lin AE; Ebert G; Ow Y; Preston SP; Toe JG; Cooney JP; Scott HW; Sasaki M; Saibil SD; Dissanayake D; Kim RH; Wakeham A; You-Ten A; Shahinian A; Duncan G; Silvester J; Ohashi PS; Mak TW; Pellegrini M. 2013. ARIH2 is essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system. Nat Immunol 14(1):27-33. PubMed: 23179078 MGI: J:191066
Lin X; Pease LR; Murray PD; Rodriguez M. 1998. Theiler's virus infection of genetically susceptible mice induces central nervous system-infiltrating CTLs with no apparent viral or major myelin antigenic specificity. J Immunol 160(11):5661-8. PubMed: 9605173 MGI: J:47789
Lin Y; Ritchea S; Logar A; Slight S; Messmer M; Rangel-Moreno J; Guglani L; Alcorn JF; Strawbridge H; Park SM; Onishi R; Nyugen N; Walter MJ; Pociask D; Randall TD; Gaffen SL; Iwakura Y; Kolls JK; Khader SA. 2009. Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensis. Immunity 31(5):799-810. PubMed: 19853481 MGI: J:155349
Lindeman GJ; Wittlin S; Lada H; Naylor MJ; Santamaria M; Zhang JG; Starr R; Hilton DJ; Alexander WS; Ormandy CJ; Visvader J. 2001. SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient mice. Genes Dev 15(13):1631-6. PubMed: 11445538 MGI: J:70408
Listopad JJ; Kammertoens T; Anders K; Silkenstedt B; Willimsky G; Schmidt K; Kuehl AA; Loddenkemper C; Blankenstein T. 2013. Fas expression by tumor stroma is required for cancer eradication. Proc Natl Acad Sci U S A 110(6):2276-81. PubMed: 23341634 MGI: J:193821
Litteljohn D; Mangano E; Shukla N; Hayley S. 2009. Interferon-gamma deficiency modifies the motor and co-morbid behavioral pathology and neurochemical changes provoked by the pesticide paraquat. Neuroscience 164(4):1894-906. PubMed: 19782123 MGI: J:156640
Liu C; Lou Y; Lizee G; Qin H; Liu S; Rabinovich B; Kim GJ; Wang YH; Ye Y; Sikora AG; Overwijk WW; Liu YJ; Wang G; Hwu P. 2008. Plasmacytoid dendritic cells induce NK cell-dependent, tumor antigen-specific T cell cross-priming and tumor regression in mice. J Clin Invest 118(3):1165-75. PubMed: 18259609 MGI: J:135308
Liu G; Yang K; Burns S; Shrestha S; Chi H. 2010. The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells. Nat Immunol 11(11):1047-56. PubMed: 20852647 MGI: J:166555
Liu J; Xiang Z; Ma X. 2004. Role of IFN regulatory factor-1 and IL-12 in immunological resistance to pathogenesis of N-methyl-N-nitrosourea-induced T lymphoma. J Immunol 173(2):1184-93. PubMed: 15240709 MGI: J:91927
Liu X; Leung S; Wang C; Tan Z; Wang J; Guo TB; Fang L; Zhao Y; Wan B; Qin X; Lu L; Li R; Pan H; Song M; Liu A; Hong J; Lu H; Zhang JZ. 2010. Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease. Nat Med 16(2):191-7. PubMed: 20062065 MGI: J:157081
Liu Y; Pandeswara S; Dao V; Padron A; Drerup JM; Lao S; Liu A; Hurez V; Curiel TJ. 2017. Biphasic Rapamycin Effects in Lymphoma and Carcinoma Treatment. Cancer Res 77(2):520-531. PubMed: 27737881 MGI: J:238434
Liu Y; Wang L; Kikuiri T; Akiyama K; Chen C; Xu X; Yang R; Chen W; Wang S; Shi S. 2011. Mesenchymal stem cell-based tissue regeneration is governed by recipient T lymphocytes via IFN-gamma and TNF-alpha. Nat Med 17(12):1594-601. PubMed: 22101767 MGI: J:180364
Liu Z; Demitrack ES; Keeley TM; Eaton KA; El-Zaatari M; Merchant JL; Samuelson LC. 2012. IFNgamma contributes to the development of gastric epithelial cell metaplasia in Huntingtin interacting protein 1 related (Hip1r)-deficient mice. Lab Invest 92(7):1045-57. PubMed: 22525425 MGI: J:185424
Liu Z; Falo LD Jr; You Z. 2011. Knockdown of HMGB1 in tumor cells attenuates their ability to induce regulatory T cells and uncovers naturally acquired CD8 T cell-dependent antitumor immunity. J Immunol 187(1):118-25. PubMed: 21642542 MGI: J:176186
Liu Z; Noh HS; Chen J; Kim JH; Falo LD Jr; You Z. 2008. Potent tumor-specific protection ignited by adoptively transferred CD4+ T cells. J Immunol 181(6):4363-70. PubMed: 18768895 MGI: J:139077
Liva SM; Voskuhl RR. 2001. Testosterone acts directly on CD4+ T lymphocytes to increase IL-10 production. J Immunol 167(4):2060-7. PubMed: 11489988 MGI: J:120413
Lohr J; Knoechel B; Wang JJ; Villarino AV; Abbas AK. 2006. Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease. J Exp Med 203(13):2785-91. PubMed: 17130300 MGI: J:124600
Lord GM; Rao RM; Choe H; Sullivan BM; Lichtman AH; Luscinskas FW; Glimcher LH. 2005. T-bet is required for optimal proinflammatory CD4+ T-cell trafficking. Blood 106(10):3432-9. PubMed: 16014561 MGI: J:123942
Lu Y; Giver CR; Sharma A; Li JM; Darlak KA; Owens LM; Roback JD; Galipeau J; Waller EK. 2012. IFN-gamma and indoleamine 2,3-dioxygenase signaling between donor dendritic cells and T cells regulates graft versus host and graft versus leukemia activity. Blood 119(4):1075-85. PubMed: 22130799 MGI: J:181750
Lu Y; Hong S; Li H; Park J; Hong B; Wang L; Zheng Y; Liu Z; Xu J; He J; Yang J; Qian J; Yi Q. 2012. Th9 cells promote antitumor immune responses in vivo. J Clin Invest 122(11):4160-71. PubMed: 23064366 MGI: J:193545
Lu YJ; Gross J; Bogaert D; Finn A; Bagrade L; Zhang Q; Kolls JK; Srivastava A; Lundgren A; Forte S; Thompson CM; Harney KF; Anderson PW; Lipsitch M; Malley R. 2008. Interleukin-17A mediates acquired immunity to pneumococcal colonization. PLoS Pathog 4(9):e1000159. PubMed: 18802458 MGI: J:162986
Luger D; Silver PB; Tang J; Cua D; Chen Z; Iwakura Y; Bowman EP; Sgambellone NM; Chan CC; Caspi RR. 2008. Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. J Exp Med 205(4):799-810. PubMed: 18391061 MGI: J:133969
Lukacs-Kornek V; Malhotra D; Fletcher AL; Acton SE; Elpek KG; Tayalia P; Collier AR; Turley SJ. 2011. Regulated release of nitric oxide by nonhematopoietic stroma controls expansion of the activated T cell pool in lymph nodes. Nat Immunol 12(11):1096-104. PubMed: 21926986 MGI: J:177695
Luthje K; Kallies A; Shimohakamada Y; TBelz GT; Light A; Tarlinton DM; Nutt SL. 2012. The development and fate of follicular helper T cells defined by an IL-21 reporter mouse. Nat Immunol 13(5):491-8. PubMed: 22466669 MGI: J:185372
Lv YG; Kang L; Wu G. 2016. Fluorosis increases the risk of postmenopausal osteoporosis by stimulating interferon gamma. Biochem Biophys Res Commun 479(2):372-379. PubMed: 27644876 MGI: J:239129
Ma F; Feng J; Zhang C; Li Y; Qi G; Li H; Wu Y; Fu Y; Zhao Y; Chen H; Du J; Tang H. 2014. The requirement of CD8+ T cells to initiate and augment acute cardiac inflammatory response to high blood pressure. J Immunol 192(7):3365-73. PubMed: 24600037 MGI: J:210252
MacNamara KC; Jones M; Martin O; Winslow GM. 2011. Transient activation of hematopoietic stem and progenitor cells by IFNgamma during acute bacterial infection. PLoS One 6(12):e28669. PubMed: 22194881 MGI: J:182248
Mackler AM; Barber EM; Takikawa O; Pollard JW. 2003. Indoleamine 2,3-dioxygenase is regulated by IFN-gamma in the mouse placenta during Listeria monocytogenes infection. J Immunol 170(2):823-30. PubMed: 12517946 MGI: J:127135
Maeda Y; Reddy P; Lowler KP; Liu C; Bishop DK; Ferrara JL. 2005. Critical role of host gammadelta T cells in experimental acute graft-versus-host disease. Blood 106(2):749-55. PubMed: 15797996 MGI: J:107458
Majewska-Szczepanik M; Paust S; von Andrian UH; Askenase PW; Szczepanik M. 2013. Natural killer cell-mediated contact sensitivity develops rapidly and depends on interferon-alpha, interferon-gamma and interleukin-12. Immunology 140(1):98-110. PubMed: 23659714 MGI: J:202643
Malone KE; Stohlman SA; Ramakrishna C; Macklin W; Bergmann CC. 2008. Induction of class I antigen processing components in oligodendroglia and microglia during viral encephalomyelitis. Glia 56(4):426-35. PubMed: 18205173 MGI: J:156284
Mangano EN; Litteljohn D; So R; Nelson E; Peters S; Bethune C; Bobyn J; Hayley S. 2012. Interferon-gamma plays a role in paraquat-induced neurodegeneration involving oxidative and proinflammatory pathways. Neurobiol Aging 33(7):1411-26. PubMed: 21482445 MGI: J:188214
Mann-Chandler MN; Kashyap M; Wright HV; Norozian F; Barnstein BO; Gingras S; Parganas E; Ryan JJ. 2005. IFN-gamma induces apoptosis in developing mast cells. J Immunol 175(5):3000-5. PubMed: 16116187 MGI: J:113205
Mansur DS; Kroon EG; Nogueira ML; Arantes RM; Rodrigues SC; Akira S; Gazzinelli RT; Campos MA. 2005. Lethal encephalitis in myeloid differentiation factor 88-deficient mice infected with herpes simplex virus 1. Am J Pathol 166(5):1419-26. PubMed: 15855642 MGI: J:98429
Marine JC; Topham DJ; McKay C; Wang D; Parganas E; Stravopodis D; Yoshimura A; Ihle JN. 1999. SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality. Cell 98(5):609-16. PubMed: 10490100 MGI: J:57475
Marrero J; Rhee KY; Schnappinger D; Pethe K; Ehrt S. 2010. Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection. Proc Natl Acad Sci U S A 107(21):9819-24. PubMed: 20439709 MGI: J:160289
Marshall HD; Prince AL; Berg LJ; Welsh RM. 2010. IFN-alphabeta and self-MHC divert CD8 T cells into a distinct differentiation pathway characterized by rapid acquisition of effector functions. J Immunol 185(3):1419-28. PubMed: 20592282 MGI: J:162457
Martin DL; King CL; Pearlman E; Strine E; Heinzel FP. 2000. IFN-gamma is necessary but not sufficient for anti-CD40 antibody-mediated inhibition of the Th2 response to Schistosoma mansoni eggs. J Immunol 164(2):779-85. PubMed: 10623823 MGI: J:59303
Martin ME; Caspersen K; Dumler JS. 2001. Immunopathology and ehrlichial propagation are regulated by interferon-gamma and interleukin-10 in a murine model of human granulocytic ehrlichiosis. Am J Pathol 158(5):1881-8. PubMed: 11337387 MGI: J:69104
Martin-Fontecha A; Thomsen LL; Brett S; Gerard C; Lipp M; Lanzavecchia A; Sallusto F. 2004. Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming. Nat Immunol 5(12):1260-5. PubMed: 15531883 MGI: J:94038
Martins GA; Campanelli AP; Silva RB; Tadokoro CE; Russo M; Cunha FQ; Rizzo LV; Silva JS. 2004. CD28 is required for T cell activation and IFN-gamma production by CD4+ and CD8+ T cells in response to Trypanosoma cruzi infection. Microbes Infect 6(13):1133-44. PubMed: 15488732 MGI: J:105590
Maruyama K; Nakazawa T; Cursiefen C; Maruyama Y; Van Rooijen N; D'Amore PA; Kinoshita S. 2012. The maintenance of lymphatic vessels in the cornea is dependent on the presence of macrophages. Invest Ophthalmol Vis Sci 53(6):3145-53. PubMed: 22511631 MGI: J:196828
Masocha W; Robertson B; Rottenberg ME; Mhlanga J; Sorokin L; Kristensson K. 2004. Cerebral vessel laminins and IFN-gamma define Trypanosoma brucei brucei penetration of the blood-brain barrier. J Clin Invest 114(5):689-94. PubMed: 15343387 MGI: J:92595
Masse GX; Corcuff E; Strick-Marchand H; Guy-Grand D; Tafuri-Bladt A; Albert ML; Lantz O; Di Santo JP. 2007. Gamma c cytokines condition the progressive differentiation of CD4+ T cells. Proc Natl Acad Sci U S A 104(39):15442-7. PubMed: 17855567 MGI: J:125207
Masters SL; Gerlic M; Metcalf D; Preston S; Pellegrini M; O'Donnell JA; McArthur K; Baldwin TM; Chevrier S; Nowell CJ; Cengia LH; Henley KJ; Collinge JE; Kastner DL; Feigenbaum L; Hilton DJ; Alexander WS; Kile BT; Croker BA. 2012. NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells. Immunity 37(6):1009-23. PubMed: 23219391 MGI: J:191055
Matsuda H; Takeda K; Koya T; Okamoto M; Shiraishi Y; Miyahara N; Dakhama A; Matsuda JL; Gapin L; Gelfand EW. 2010. Plasticity of invariant NKT cell regulation of allergic airway disease is dependent on IFN-gamma production. J Immunol 185(1):253-62. PubMed: 20525882 MGI: J:161618
Mattarollo SR; Rahimpour A; Choyce A; Godfrey DI; Leggatt GR; Frazer IH. 2010. Invariant NKT cells in hyperplastic skin induce a local immune suppressive environment by IFN-gamma production. J Immunol 184(3):1242-50. PubMed: 20028654 MGI: J:159537
Mattarollo SR; Yong M; Tan L; Frazer IH; Leggatt GR. 2010. Secretion of IFN-gamma but not IL-17 by CD1d-restricted NKT cells enhances rejection of skin grafts expressing epithelial cell-derived antigen. J Immunol 184(10):5663-9. PubMed: 20410490 MGI: J:160981
Matter M; Odermatt B; Yagita H; Nuoffer JM; Ochsenbein AF. 2006. Elimination of chronic viral infection by blocking CD27 signaling. J Exp Med 203(9):2145-55. PubMed: 16923852 MGI: J:124567
Maxwell JR; Yadav R; Rossi RJ; Ruby CE; Weinberg AD; Aguila HL; Vella AT. 2006. IL-18 bridges innate and adaptive immunity through IFN-gamma and the CD134 pathway. J Immunol 177(1):234-45. PubMed: 16785519 MGI: J:134442
Mayer KD; Mohrs K; Reiley W; Wittmer S; Kohlmeier JE; Pearl JE; Cooper AM; Johnson LL; Woodland DL; Mohrs M. 2008. Cutting edge: T-bet and IL-27R are critical for in vivo IFN-gamma production by CD8 T cells during infection. J Immunol 180(2):693-7. PubMed: 18178806 MGI: J:130953
McClary H; Koch R; Chisari FV; Guidotti LG. 2000. Relative sensitivity of hepatitis B virus and other hepatotropic viruses to the antiviral effects of cytokines. J Virol 74(5):2255-64. PubMed: 10666256 MGI: J:126989
McLoughlin RM; Lee JC; Kasper DL; Tzianabos AO. 2008. IFN-gamma regulated chemokine production determines the outcome of Staphylococcus aureus infection. J Immunol 181(2):1323-32. PubMed: 18606687 MGI: J:137477
McLoughlin RM; Witowski J; Robson RL; Wilkinson TS; Hurst SM; Williams AS; Williams JD; Rose-John S; Jones SA; Topley N. 2003. Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation. J Clin Invest 112(4):598-607. PubMed: 12925700 MGI: J:85159
Mead JR; You X. 1998. Susceptibility differences to Cryptosporidium parvum infection in two strains of gamma interferon knockout mice. J Parasitol 84(5):1045-8. PubMed: 9794653 MGI: J:50832
Medoff BD; Sauty A; Tager AM; Maclean JA; Smith RN; Mathew A; Dufour JH; Luster AD. 2002. IFN-gamma-inducible protein 10 (CXCL10) contributes to airway hyperreactivity and airway inflammation in a mouse model of asthma. J Immunol 168(10):5278-86. PubMed: 11994485 MGI: J:125569
Meissner NN; Lund FE; Han S; Harmsen A. 2005. CD8 T cell-mediated lung damage in response to the extracellular pathogen pneumocystis is dependent on MHC class I expression by radiation-resistant lung cells. J Immunol 175(12):8271-9. PubMed: 16339567 MGI: J:122256
Mencacci A; Montagnoli C; Bacci A; Cenci E; Pitzurra L; Spreca A; Kopf M; Sharpe AH; Romani L. 2002. CD80+Gr-1+ myeloid cells inhibit development of antifungal Th1 immunity in mice with candidiasis. J Immunol 169(6):3180-90. PubMed: 12218136 MGI: J:120204
Messingham KA; Badovinac VP; Jabbari A; Harty JT. 2007. A role for IFN-gamma from antigen-specific CD8+ T cells in protective immunity to Listeria monocytogenes. J Immunol 179(4):2457-66. PubMed: 17675507 MGI: J:151292
Metcalf D; Alexander WS; Ryan PJ; Mifsud S; Di Rago L. 2001. Production of colony-stimulating factors and il-5 by organs from three types of mice with inflammatory disease due to loss of the suppressor of cytokine signaling-1. J Immunol 167(8):4661-7. PubMed: 11591796 MGI: J:72058
Metcalf D; Di Rago L; Mifsud S; Hartley L; Alexander WS. 2000. The development of fatal myocarditis and polymyositis in mice heterozygous for IFN-gamma and lacking the SOCS-1 gene. Proc Natl Acad Sci U S A 97(16):9174-9. PubMed: 10908669 MGI: J:63845
Metcalf D; Mifsud S; Di Rago L; Nicola NA; Hilton DJ; Alexander WS. 2002. Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1). Proc Natl Acad Sci U S A 99(2):943-8. PubMed: 11782537 MGI: J:73987
Miao EA; Leaf IA; Treuting PM; Mao DP; Dors M; Sarkar A; Warren SE; Wewers MD; Aderem A. 2010. Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. Nat Immunol 11(12):1136-42. PubMed: 21057511 MGI: J:167323
Michailowsky V; Celes MR; Marino AP; Silva AA; Vieira LQ; Rossi MA; Gazzinelli RT; Lannes-Vieira J; Silva JS. 2004. Intercellular adhesion molecule 1 deficiency leads to impaired recruitment of T lymphocytes and enhanced host susceptibility to infection with Trypanosoma cruzi. J Immunol 173(1):463-70. PubMed: 15210806 MGI: J:90958
Mikkelsen M; Holst PJ; Bukh J; Thomsen AR; Christensen JP. 2011. Enhanced and Sustained CD8+ T Cell Responses with an Adenoviral Vector-Based Hepatitis C Virus Vaccine Encoding NS3 Linked to the MHC Class II Chaperone Protein Invariant Chain. J Immunol 186(4):2355-64. PubMed: 21257961 MGI: J:168988
Miller HE; Robinson RT. 2012. Early Control of Mycobacterium tuberculosis Infection Requires il12rb1 Expression by rag1-Dependent Lineages. Infect Immun 80(11):3828-41. PubMed: 22907814 MGI: J:187984
Millward JM; Lobner M; Wheeler RD; Owens T. 2010. Inflammation in the central nervous system and Th17 responses are inhibited by IFN-gamma-Induced IL-18 binding protein. J Immunol 185(4):2458-66. PubMed: 20644165 MGI: J:162621
Mishra BB; Rathinam VA; Martens GW; Martinot AJ; Kornfeld H; Fitzgerald KA; Sassetti CM. 2013. Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1beta. Nat Immunol 14(1):52-60. PubMed: 23160153 MGI: J:191074
Mitchell AJ; Yau B; McQuillan JA; Ball HJ; Too LK; Abtin A; Hertzog P; Leib SL; Jones CA; Gerega SK; Weninger W; Hunt NH. 2012. Inflammasome-dependent IFN-gamma drives pathogenesis in Streptococcus pneumoniae meningitis. J Immunol 189(10):4970-80. PubMed: 23071286 MGI: J:190696
Mittal D; Kassianos AJ; Tran LS; Bergot AS; Gosmann C; Hofmann J; Blumenthal A; Leggatt GR; Frazer IH. 2013. Indoleamine 2,3-dioxygenase activity contributes to local immune suppression in the skin expressing human papillomavirus oncoprotein e7. J Invest Dermatol 133(12):2686-94. PubMed: 23652797 MGI: J:202874
Mizoguchi A; Mizoguchi E; Bhan AK. 1999. The critical role of interleukin 4 but not interferon gamma in the pathogenesis of colitis in T-cell receptor alpha mutant mice. Gastroenterology 116(2):320-6. PubMed: 9922312 MGI: J:92347
Mizoguchi A; Ogawa A; Takedatsu H; Sugimoto K; Shimomura Y; Shirane K; Nagahama K; Nagaishi T; Mizoguchi E; Blumberg RS; Bhan AK. 2007. Dependence of intestinal granuloma formation on unique myeloid DC-like cells. J Clin Invest 117(3):605-15. PubMed: 17318261 MGI: J:120740
Mochizuki K; Meng L; Mochizuki I; Tong Q; He S; Liu Y; Purushe J; Fung H; Zaidi MR; Zhang Y; Reshef R; Blazar BR; Yagita H; Mineishi S; Zhang Y. 2016. Programming of donor T cells using allogeneic delta-like ligand 4-positive dendritic cells to reduce GVHD in mice. Blood 127(25):3270-80. PubMed: 27143255 MGI: J:234782
Molesworth-Kenyon S; Mates A; Yin R; Strieter R; Oakes J; Lausch R. 2005. CXCR3, IP-10, and Mig are required for CD4+ T cell recruitment during the DTH response to HSV-1 yet are independent of the mechanism for viral clearance. Virology 333(1):1-9. PubMed: 15708587 MGI: J:101825
Molesworth-Kenyon SJ; Oakes JE; Lausch RN. 2005. A novel role for neutrophils as a source of T cell-recruiting chemokines IP-10 and Mig during the DTH response to HSV-1 antigen. J Leukoc Biol 77(4):552-9. PubMed: 15629884 MGI: J:97440
Molesworth-Kenyon SJ; Yin R; Oakes JE; Lausch RN. 2008. IL-17 receptor signaling influences virus-induced corneal inflammation. J Leukoc Biol 83(2):401-8. PubMed: 17998300 MGI: J:131214
Montagnoli C; Fallarino F; Gaziano R; Bozza S; Bellocchio S; Zelante T; Kurup WP; Pitzurra L; Puccetti P; Romani L. 2006. Immunity and tolerance to Aspergillus involve functionally distinct regulatory T cells and tryptophan catabolism. J Immunol 176(3):1712-23. PubMed: 16424201 MGI: J:126452
Montandon R; Korniotis S; Layseca-Espinosa E; Gras C; Megret J; Ezine S; Dy M; Zavala F. 2013. Innate pro-B-cell progenitors protect against type 1 diabetes by regulating autoimmune effector T cells. Proc Natl Acad Sci U S A 110(24):E2199-208. PubMed: 23716674 MGI: J:197396
Moreira AP; Campanelli AP; Cavassani KA; Souto JT; Ferreira BR; Martinez R; Rossi MA; Silva JS. 2006. Intercellular adhesion molecule-1 is required for the early formation of granulomas and participates in the resistance of mice to the infection with the fungus Paracoccidioides brasiliensis. Am J Pathol 169(4):1270-81. PubMed: 17003484 MGI: J:113377
Moreno SE; Alves-Filho JC; Alfaya TM; da Silva JS; Ferreira SH; Liew FY. 2006. IL-12, but not IL-18, is critical to neutrophil activation and resistance to polymicrobial sepsis induced by cecal ligation and puncture. J Immunol 177(5):3218-24. PubMed: 16920961 MGI: J:139542
Moretto MM; Weiss LM; Combe CL; Khan IA. 2007. IFN-gamma-producing dendritic cells are important for priming of gut intraepithelial lymphocyte response against intracellular parasitic infection. J Immunol 179(4):2485-92. PubMed: 17675510 MGI: J:151290
Mori T; Kabashima K; Yoshiki R; Sugita K; Shiraishi N; Onoue A; Kuroda E; Kobayashi M; Yamashita U; Tokura Y. 2008. Cutaneous hypersensitivities to hapten are controlled by IFN-gamma-upregulated keratinocyte Th1 chemokines and IFN-gamma-downregulated langerhans cell Th2 chemokines. J Invest Dermatol 128(7):1719-27. PubMed: 18239613 MGI: J:137532
Mori Y; Kodaka T; Kato T; Kanagawa EM; Kanagawa O. 2009. Critical role of IFN-gamma in CFA-mediated protection of NOD mice from diabetes development. Int Immunol 21(11):1291-9. PubMed: 19778991 MGI: J:154177
Morimoto Y; Bian Y; Gao P; Yashiro-Ohtani Y; Zhou XY; Ono S; Nakahara H; Kogo M; Hamaoka T; Fujiwara H. 2005. Induction of surface CCR4 and its functionality in mouse Th2 cells is regulated differently during Th2 development. J Leukoc Biol 78(3):753-61. PubMed: 16126843 MGI: J:100501
Morton J; Coles B; Wright K; Gallimore A; Morrow JD; Terry ES; Anning PB; Morgan BP; Dioszeghy V; Kuhn H; Chaitidis P; Hobbs AJ; Jones SA; O'Donnell VB. 2008. Circulating neutrophils maintain physiological blood pressure by suppressing bacteria and IFNgamma-dependent iNOS expression in the vasculature of healthy mice. Blood 111(10):5187-94. PubMed: 18281503 MGI: J:135580
Mota BE; Gallardo-Romero N; Trindade G; Keckler MS; Karem K; Carroll D; Campos MA; Vieira LQ; da Fonseca FG; Ferreira PC; Bonjardim CA; Damon IK; Kroon EG. 2011. Adverse Events Post Smallpox-Vaccination: Insights from Tail Scarification Infection in Mice with Vaccinia virus. PLoS One 6(4):e18924. PubMed: 21526210 MGI: J:172270
Mott KR; Underhill D; Wechsler SL; Ghiasi H. 2008. Lymphoid-related CD11c+ CD8alpha+ dendritic cells are involved in enhancing herpes simplex virus type 1 latency. J Virol 82(20):9870-9. PubMed: 18667491 MGI: J:153404
Mount MP; Lira A; Grimes D; Smith PD; Faucher S; Slack R; Anisman H; Hayley S; Park DS. 2007. Involvement of interferon-gamma in microglial-mediated loss of dopaminergic neurons. J Neurosci 27(12):3328-37. PubMed: 17376993 MGI: J:119447
Mullarky IK; Szaba FM; Berggren KN; Kummer LW; Wilhelm LB; Parent MA; Johnson LL; Smiley ST. 2006. Tumor necrosis factor alpha and gamma interferon, but not hemorrhage or pathogen burden, dictate levels of protective fibrin deposition during infection. Infect Immun 74(2):1181-8. PubMed: 16428767 MGI: J:104988
Mullarky IK; Szaba FM; Kummer LW; Wilhelm LB; Parent MA; Johnson LL; Smiley ST. 2007. Gamma interferon suppresses erythropoiesis via interleukin-15. Infect Immun 75(5):2630-3. PubMed: 17307940 MGI: J:121876
Muller AJ; Filipe-Santos O; Eberl G; Aebischer T; Spath GF; Bousso P. 2012. CD4+ T cells rely on a cytokine gradient to control intracellular pathogens beyond sites of antigen presentation. Immunity 37(1):147-57. PubMed: 22727490 MGI: J:187413
Muralimohan G; Vella AT. 2006. A role for IFNgamma in differential superantigen stimulation of conventional versus plasmacytoid DCs. Cell Immunol 242(1):9-22. PubMed: 17045255 MGI: J:116765
Muranski P; Boni A; Antony PA; Cassard L; Irvine KR; Kaiser A; Paulos CM; Palmer DC; Touloukian CE; Ptak K; Gattinoni L; Wrzesinski C; Hinrichs CS; Kerstann KW; Feigenbaum L; Chan CC; Restifo NP. 2008. Tumor-specific Th17-polarized cells eradicate large established melanoma. Blood 112(2):362-73. PubMed: 18354038 MGI: J:138466
Murray HW; Montelibano C; Peterson R; Sypek JP. 2000. Interleukin-12 regulates the response to chemotherapy in experimental visceral leishmaniasis J Infect Dis 182(5):1497-502. PubMed: 11023473 MGI: J:65560
Murray PJ; Young RA; Daley GQ. 1998. Hematopoietic remodeling in interferon-gamma-deficient mice infected with mycobacteria. Blood 91(8):2914-24. PubMed: 9531602 MGI: J:47459
Murugaiyan G; Beynon V; Pires Da Cunha A; Joller N; Weiner HL. 2012. IFN-gamma limits Th9-mediated autoimmune inflammation through dendritic cell modulation of IL-27. J Immunol 189(11):5277-83. PubMed: 23125412 MGI: J:190977
Murugaiyan G; Mittal A; Weiner HL. 2010. Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation. Proc Natl Acad Sci U S A 107(25):11495-500. PubMed: 20534530 MGI: J:161596
Myers L; Croft M; Kwon BS; Mittler RS; Vella AT. 2005. Peptide-specific CD8 T regulatory cells use IFN-gamma to elaborate TGF-beta-based suppression. J Immunol 174(12):7625-32. PubMed: 15944263 MGI: J:100786
Nagano H; Mitchell RN; Taylor MK; Hasegawa S; Tilney NL; Libby P. 1997. Interferon-gamma deficiency prevents coronary arteriosclerosis but not myocardial rejection in transplanted mouse hearts. J Clin Invest 100(3):550-7. PubMed: 9239401 MGI: J:42090
Nagayama Y; Saitoh O; McLachlan SM; Rapoport B; Kano H; Kumazawa Y. 2004. TSH receptor-adenovirus-induced Graves' hyperthyroidism is attenuated in both interferon-gamma and interleukin-4 knockout mice; implications for the Th1/Th2 paradigm. Clin Exp Immunol 138(3):417-22. PubMed: 15544617 MGI: J:94577
Naka T; Tsutsui H; Fujimoto M; Kawazoe Y; Kohzaki H; Morita Y; Nakagawa R; Narazaki M; Adachi K; Yoshimoto T; Nakanishi K; Kishimoto T. 2001. SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-gamma and IL-4 signaling in vivo. Immunity 14(5):535-45. PubMed: 11371356 MGI: J:69472
Nakae S; Iwakura Y; Suto H; Galli SJ. 2007. Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17. J Leukoc Biol 81(5):1258-68. PubMed: 17307864 MGI: J:121718
Nakae S; Suto H; Berry GJ; Galli SJ. 2007. Mast cell-derived TNF can promote Th17 cell-dependent neutrophil recruitment in ovalbumin-challenged OTII mice. Blood 109(9):3640-8. PubMed: 17197430 MGI: J:145332
Nakagawa MM; Thummar K; Mandelbaum J; Pasqualucci L; Rathinam CV. 2015. Lack of the ubiquitin-editing enzyme A20 results in loss of hematopoietic stem cell quiescence. J Exp Med 212(2):203-16. PubMed: 25624445 MGI: J:219699
Nakanishi Y; Lu B; Gerard C; Iwasaki A. 2009. CD8(+) T lymphocyte mobilization to virus-infected tissue requires CD4(+) T-cell help. Nature 462(7272):510-3. PubMed: 19898495 MGI: J:155104
Nakayamada S; Kanno Y; Takahashi H; Jankovic D; Lu KT; Johnson TA; Sun HW; Vahedi G; Hakim O; Handon R; Schwartzberg PL; Hager GL; O'Shea JJ. 2011. Early Th1 Cell Differentiation Is Marked by a Tfh Cell-like Transition. Immunity 35(6):919-31. PubMed: 22195747 MGI: J:179278
Nance S; Cross R; Fitzpatrick E. 2004. Chemokine production during hypersensitivity pneumonitis. Eur J Immunol 34(3):677-85. PubMed: 14991597 MGI: J:88361
Nansen A; Jensen T; Christensen JP; Andreasen SO; Ropke C; Marker O; Thomsen AR. 1999. Compromised virus control and augmented perforin-mediated immunopathology in IFN-gamma-deficient mice infected with lymphocytic choriomeningitis virus. J Immunol 163(11):6114-22. PubMed: 10570301 MGI: J:58651
Nausch N; Galani IE; Schlecker E; Cerwenka A. 2008. Mononuclear myeloid-derived 'suppressor' cells express RAE-1 and activate natural killer cells. Blood 112(10):4080-9. PubMed: 18753637 MGI: J:142461
Nava P; Koch S; Laukoetter MG; Lee WY; Kolegraff K; Capaldo CT; Beeman N; Addis C; Gerner-Smidt K; Neumaier I; Skerra A; Li L; Parkos CA; Nusrat A. 2010. Interferon-gamma regulates intestinal epithelial homeostasis through converging beta-catenin signaling pathways. Immunity 32(3):392-402. PubMed: 20303298 MGI: J:158902
Nechushtan H; Pham D; Zhang Y; Morgensztern D; Yi KH; Shin SU; Federoff HJ; Bowers WJ; Tolba KA; Rosenblatt JD. 2008. Augmentation of anti-tumor responses of adoptively transferred CD8+T cells in the lymphopenic setting by HSV amplicon transduction. Cancer Immunol Immunother 57(5):663-75. PubMed: 17952436 MGI: J:131193
Nelson MH; Bird MD; Chu CF; Johnson AJ; Friedrich BM; Allman WR; Milligan GN. 2011. Rapid clearance of herpes simplex virus type 2 by CD8+ T cells requires high level expression of effector T cell functions. J Reprod Immunol 89(1):10-7. PubMed: 21444117 MGI: J:175956
Nemeth K; Leelahavanichkul A; Yuen PS; Mayer B; Parmelee A; Doi K; Robey PG; Leelahavanichkul K; Koller BH; Brown JM; Hu X; Jelinek I; Star RA; Mezey E. 2009. Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production. Nat Med 15(1):42-9. PubMed: 19098906 MGI: J:146566
Nesbeth Y; Scarlett U; Cubillos-Ruiz J; Martinez D; Engle X; Turk MJ; Conejo-Garcia JR. 2009. CCL5-mediated endogenous antitumor immunity elicited by adoptively transferred lymphocytes and dendritic cell depletion. Cancer Res 69(15):6331-8. PubMed: 19602595 MGI: J:150956
Netea MG; Fantuzzi G; Kullberg BJ; Stuyt RJ; Pulido EJ; McIntyre RC Jr; Joosten LA; Van der Meer JW; Dinarello CA. 2000. Neutralization of IL-18 reduces neutrophil tissue accumulation and protects mice against lethal Escherichia coli and Salmonella typhimurium endotoxemia. J Immunol 164(5):2644-9. PubMed: 10679104 MGI: J:126998
Nguyen HH; van Ginkel FW; Vu HL; Novak MJ; McGhee JR; Mestecky J. 2000. Gamma interferon is not required for mucosal cytotoxic T-lymphocyte responses or heterosubtypic immunity to influenza A virus infection in mice. J Virol 74(12):5495-501. PubMed: 10823854 MGI: J:62303
Nishimoto S; Kotani H; Tsuruta S; Shimizu N; Ito M; Shichita T; Morita R; Takahashi H; Amagai M; Yoshimura A. 2013. Th17 cells carrying TCR recognizing epidermal autoantigen induce psoriasis-like skin inflammation. J Immunol 191(6):3065-72. PubMed: 23956432 MGI: J:205874
Nolte MA; Arens R; van Os R; van Oosterwijk M; Hooibrink B; van Lier RA; van Oers MH. 2005. Immune activation modulates hematopoiesis through interactions between CD27 and CD70. Nat Immunol 6(4):412-8. PubMed: 15723067 MGI: J:97606
North RJ. 1998. Mice incapable of making IL-4 or IL-10 display normal resistance to infection with Mycobacterium tuberculosis. Clin Exp Immunol 113(1):55-8. PubMed: 9697983 MGI: J:114201
Novais FO; Carvalho LP; Graff JW; Beiting DP; Ruthel G; Roos DS; Betts MR; Goldschmidt MH; Wilson ME; de Oliveira CI; Scott P. 2013. Cytotoxic T cells mediate pathology and metastasis in cutaneous leishmaniasis. PLoS Pathog 9(7):e1003504. PubMed: 23874205 MGI: J:213470
Numasaki M; Tagawa M; Iwata F; Suzuki T; Nakamura A; Okada M; Iwakura Y; Aiba S; Yamaya M. 2007. IL-28 elicits antitumor responses against murine fibrosarcoma. J Immunol 178(8):5086-98. PubMed: 17404291 MGI: J:145280
Nurieva RI; Chung Y; Hwang D; Yang XO; Kang HS; Ma L; Wang YH; Watowich SS; Jetten AM; Tian Q; Dong C. 2008. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 29(1):138-49. PubMed: 18599325 MGI: J:137869
O'Connor RA; Li X; Blumerman S; Anderton SM; Noelle RJ; Dalton DK. 2012. Adjuvant Immunotherapy of Experimental Autoimmune Encephalomyelitis: Immature Myeloid Cells Expressing CXCL10 and CXCL16 Attract CXCR3+CXCR6+ and Myelin-Specific T Cells to the Draining Lymph Nodes Rather Than the Central Nervous System. J Immunol 188(5):2093-101. PubMed: 22287719 MGI: J:181244
O'Connor RA; Wittmer S; Dalton DK. 2005. Infection-induced apoptosis deletes bystander CD4(+) T cells: a mechanism for suppression of autoimmunity during BCG infection. J Autoimmun 24(2):93-100. PubMed: 15829401 MGI: J:97542
O'Konek JJ; Illarionov P; Khursigara DS; Ambrosino E; Izhak L; Castillo BF 2nd; Raju R; Khalili M; Kim HY; Howell AR; Besra GS; Porcelli SA; Berzofsky JA; Terabe M. 2011. Mouse and human iNKT cell agonist beta-mannosylceramide reveals a distinct mechanism of tumor immunity. J Clin Invest 121(2):683-94. PubMed: 21245578 MGI: J:171830
Obar JJ; Jellison ER; Sheridan BS; Blair DA; Pham QM; Zickovich JM; Lefrancois L. 2011. Pathogen-induced inflammatory environment controls effector and memory CD8+ T cell differentiation. J Immunol 187(10):4967-78. PubMed: 21987662 MGI: J:179638
Obayashi K; Doi T; Koyasu S. 2007. Dendritic cells suppress IgE production in B cells. Int Immunol 19(2):217-26. PubMed: 17208926 MGI: J:117872
Ochiai E; Sa Q; Brogli M; Kudo T; Wang X; Dubey JP; Suzuki Y. 2015. CXCL9 Is Important for Recruiting Immune T Cells into the Brain and Inducing an Accumulation of the T Cells to the Areas of Tachyzoite Proliferation to Prevent Reactivation of Chronic Cerebral Infection with Toxoplasma gondii. Am J Pathol 185(2):314-24. PubMed: 25432064 MGI: J:218180
Ochoa-Reparaz J; Sentissi J; Trunkle T; Riccardi C; Pascual DW. 2007. Attenuated Coxiella burnetii phase II causes a febrile response in gamma interferon knockout and Toll-like receptor 2 knockout mice and protects against reinfection. Infect Immun 75(12):5845-58. PubMed: 17893129 MGI: J:127651
Oghumu S; Terrazas CA; Varikuti S; Kimble J; Vadia S; Yu L; Seveau S; Satoskar AR. 2015. CXCR3 expression defines a novel subset of innate CD8+ T cells that enhance immunity against bacterial infection and cancer upon stimulation with IL-15. FASEB J 29(3):1019-28. PubMed: 25466888 MGI: J:219639
Oh SJ; Chung DH. 2011. Invariant NKT cells producing IL-4 or IL-10, but not IFN-gamma, inhibit the Th1 response in experimental autoimmune encephalomyelitis, whereas none of these cells inhibits the Th17 response. J Immunol 186(12):6815-21. PubMed: 21572032 MGI: J:175480
Ohteki T; Tada H; Ishida K; Sato T; Maki C; Yamada T; Hamuro J; Koyasu S. 2006. Essential roles of DC-derived IL-15 as a mediator of inflammatory responses in vivo. J Exp Med 203(10):2329-38. PubMed: 16966429 MGI: J:124624
Okamoto M; Kato S; Oizumi K; Kinoshita M; Inoue Y; Hoshino K; Akira S; McKenzie AN; Young HA; Hoshino T. 2002. Interleukin 18 (IL-18) in synergy with IL-2 induces lethal lung injury in mice: a potential role for cytokines, chemokines, and natural killer cells in the pathogenesis of interstitial pneumonia. Blood 99(4):1289-98. PubMed: 11830478 MGI: J:74714
Olalekan SA; Cao Y; Hamel KM; Finnegan A. 2015. B cells expressing IFN-gamma suppress Treg-cell differentiation and promote autoimmune experimental arthritis. Eur J Immunol 45(4):988-98. PubMed: 25645456 MGI: J:229645
Olson JA; Leveson-Gower DB; Gill S; Baker J; Beilhack A; Negrin RS. 2010. NK cells mediate reduction of GVHD by inhibiting activated, alloreactive T cells while retaining GVT effects. Blood 115(21):4293-301. PubMed: 20233969 MGI: J:160227
Olson MR; Hartwig SM; Varga SM. 2008. The number of respiratory syncytial virus (RSV)-specific memory CD8 T cells in the lung is critical for their ability to inhibit RSV vaccine-enhanced pulmonary eosinophilia. J Immunol 181(11):7958-68. PubMed: 19017987 MGI: J:142376
Ong S; Ligons DL; Barin JG; Wu L; Talor MV; Diny N; Fontes JA; Gebremariam E; Kass DA; Rose NR; Cihakova D. 2015. Natural killer cells limit cardiac inflammation and fibrosis by halting eosinophil infiltration. Am J Pathol 185(3):847-61. PubMed: 25622543 MGI: J:219562
Ordway D; Henao-Tamayo M; Smith E; Shanley C; Harton M; Troudt J; Bai X; Basaraba RJ; Orme IM; Chan ED. 2008. Animal model of Mycobacterium abscessus lung infection. J Leukoc Biol 83(6):1502-11. PubMed: 18310351 MGI: J:136571
Ortaldo JR; Winkler-Pickett R; Wigginton J; Horner M; Bere EW; Mason AT; Bhat N; Cherry J; Sanford M; Hodge DL; Young HA. 2006. Regulation of ITAM-positive receptors: role of IL-12 and IL-18. Blood 107(4):1468-75. PubMed: 16249390 MGI: J:129310
Ortega SB; Kashi VP; Tyler AF; Cunnusamy K; Mendoza JP; Karandikar NJ. 2013. The disease-ameliorating function of autoregulatory CD8 T cells is mediated by targeting of encephalitogenic CD4 T cells in experimental autoimmune encephalomyelitis. J Immunol 191(1):117-26. PubMed: 23733879 MGI: J:205352
Osawa E; Nakajima A; Fujisawa T; Kawamura YI; Toyama-Sorimachi N; Nakagama H; Dohi T. 2006. Predominant T helper type 2-inflammatory responses promote murine colon cancers. Int J Cancer 118(9):2232-6. PubMed: 16331625 MGI: J:107259
Ostrand-Rosenberg S; Sinha P; Clements V; Dissanayake SI; Miller S; Davis C; Danna E. 2004. Signal transducer and activator of transcription 6 (Stat6) and CD1: inhibitors of immunosurveillance against primary tumors and metastatic disease. Cancer Immunol Immunother 53(2):86-91. PubMed: 14593499 MGI: J:86509
Ousman SS; Wang J; Campbell IL. 2005. Differential regulation of interferon regulatory factor (IRF)-7 and IRF-9 gene expression in the central nervous system during viral infection. J Virol 79(12):7514-27. PubMed: 15919906 MGI: J:98854
Ouyang W; Liao W; Luo CT; Yin N; Huse M; Kim MV; Peng M; Chan P; Ma Q; Mo Y; Meijer D; Zhao K; Rudensky AY; Atwal G; Zhang MQ; Li MO. 2012. Novel Foxo1-dependent transcriptional programs control T(reg) cell function. Nature 491(7425):554-9. PubMed: 23135404 MGI: J:189962
Overacre-Delgoffe AE; Chikina M; Dadey RE; Yano H; Brunazzi EA; Shayan G; Horne W; Moskovitz JM; Kolls JK; Sander C; Shuai Y; Normolle DP; Kirkwood JM; Ferris RL; Delgoffe GM; Bruno TC; Workman CJ; Vignali DAA. 2017. Interferon-gamma Drives Treg Fragility to Promote Anti-tumor Immunity. Cell 169(6):1130-1141.e11. PubMed: 28552348 MGI: J:243571
Paiva CN; Arras RH; Lessa LP; Gibaldi D; Alves L; Metz CN; Gazzinelli R; Pyrrho AS; Lannes-Vieira J; Bozza MT. 2007. Unraveling the lethal synergism between Trypanosoma cruzi infection and LPS: a role for increased macrophage reactivity. Eur J Immunol 37(5):1355-64. PubMed: 17390393 MGI: J:123561
Panchanathan V; Chaudhri G; Karupiah G. 2006. Protective immunity against secondary poxvirus infection is dependent on antibody but not on CD4 or CD8 T-cell function. J Virol 80(13):6333-8. PubMed: 16775321 MGI: J:153332
Parent MA; Wilhelm LB; Kummer LW; Szaba FM; Mullarky IK; Smiley ST. 2006. Gamma interferon, tumor necrosis factor alpha, and nitric oxide synthase 2, key elements of cellular immunity, perform critical protective functions during humoral defense against lethal pulmonary Yersinia pestis infection. Infect Immun 74(6):3381-6. PubMed: 16714568 MGI: J:109236
Park H; Li Z; Yang XO; Chang SH; Nurieva R; Wang YH; Wang Y; Hood L; Zhu Z; Tian Q; Dong C. 2005. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 6(11):1133-41. PubMed: 16200068 MGI: J:112600
Park IK; Shultz LD; Letterio JJ; Gorham JD. 2005. TGF-beta1 inhibits T-bet induction by IFN-gamma in murine CD4+ T cells through the protein tyrosine phosphatase Src homology region 2 domain-containing phosphatase-1. J Immunol 175(9):5666-74. PubMed: 16237056 MGI: J:119358
Park JH; Adoro S; Guinter T; Erman B; Alag AS; Catalfamo M; Kimura MY; Cui Y; Lucas PJ; Gress RE; Kubo M; Hennighausen L; Feigenbaum L; Singer A. 2010. Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells. Nat Immunol 11(3):257-64. PubMed: 20118929 MGI: J:158504
Park JS; Jung YO; Oh HJ; Park SJ; Heo YJ; Kang CM; Kwok SK; Ju JH; Park KS; Cho ML; Sung YC; Park SH; Kim HY. 2012. Interleukin-27 suppresses osteoclastogenesis via induction of interferon-gamma. Immunology 137(4):326-35. PubMed: 22812379 MGI: J:189620
Park SJ; Hughes MA; Burdick M; Strieter RM; Mehrad B. 2009. Early NK cell-derived IFN-{gamma} is essential to host defense in neutropenic invasive aspergillosis. J Immunol 182(7):4306-12. PubMed: 19299730 MGI: J:147121
Park Y; Kim HS; Ahn JY; Yun D; Cho ML; Hong S; Kim HY; Chung DH. 2010. IL-12p35 promotes antibody-induced joint inflammation by activating NKT cells and suppressing TGF-beta. J Immunol 185(3):1476-84. PubMed: 20581146 MGI: J:162473
Parra B; Hinton DR; Marten NW; Bergmann CC; Lin MT; Yang CS; Stohlman SA. 1999. IFN-gamma is required for viral clearance from central nervous system oligodendroglia. J Immunol 162(3):1641-7. PubMed: 9973424 MGI: J:112048
Pasquevich KA; Bieber K; Gunter M; Grauer M; Potz O; Schleicher U; Biedermann T; Beer-Hammer S; Buhring HJ; Rammensee HG; Zender L; Autenrieth IB; Lengerke C; Autenrieth SE. 2015. Innate immune system favors emergency monopoiesis at the expense of DC-differentiation to control systemic bacterial infection in mice. Eur J Immunol 45(10):2821-33. PubMed: 26138432 MGI: J:233063
Paunicka K; Chen PW; Niederkorn JY. 2012. Role of IFN-gamma in the establishment of anterior chamber-associated immune deviation (ACAID)-induced CD8+ T regulatory cells. J Leukoc Biol 91(3):475-83. PubMed: 22180630 MGI: J:181507
Paust HJ; Turner JE; Riedel JH; Disteldorf E; Peters A; Schmidt T; Krebs C; Velden J; Mittrucker HW; Steinmetz OM; Stahl RA; Panzer U. 2012. Chemokines play a critical role in the cross-regulation of Th1 and Th17 immune responses in murine crescentic glomerulonephritis. Kidney Int 82(1):72-83. PubMed: 22495297 MGI: J:198177
Pearl JE; Saunders B; Ehlers S; Orme IM; Cooper AM. 2001. Inflammation and lymphocyte activation during mycobacterial infection in the interferon-gamma-deficient mouse. Cell Immunol 211(1):43-50. PubMed: 11585387 MGI: J:71972
Peng SL; Moslehi J; Craft J. 1997. Roles of interferon-gamma and interleukin-4 in murine lupus. J Clin Invest 99(8):1936-46. PubMed: 9109438 MGI: J:39600
Peng W; Liu C; Xu C; Lou Y; Chen J; Yang Y; Yagita H; Overwijk WW; Lizee G; Radvanyi L; Hwu P. 2012. PD-1 blockade enhances T-cell migration to tumors by elevating IFN-gamma inducible chemokines. Cancer Res 72(20):5209-18. PubMed: 22915761 MGI: J:191805
Perona-Wright G; Mohrs K; Mohrs M. 2010. Sustained signaling by canonical helper T cell cytokines throughout the reactive lymph node. Nat Immunol 11(6):520-6. PubMed: 20418876 MGI: J:160618
Perry LL; Feilzer K; Caldwell HD. 1997. Immunity to Chlamydia trachomatis is mediated by T helper 1 cells through IFN-gamma-dependent and -independent pathways. J Immunol 158(7):3344-52. PubMed: 9120292 MGI: J:110834
Peske JD; Thompson ED; Gemta L; Baylis RA; Fu YX; Engelhard VH. 2015. Effector lymphocyte-induced lymph node-like vasculature enables naive T-cell entry into tumours and enhanced anti-tumour immunity. Nat Commun 6:7114. PubMed: 25968334 MGI: J:224877
Petritus PM; Burns JM Jr. 2008. Suppression of lethal Plasmodium yoelii malaria following protective immunization requires antibody-, IL-4-, and IFN-gamma-dependent responses induced by vaccination and/or challenge infection. J Immunol 180(1):444-53. PubMed: 18097046 MGI: J:130916
Petro M; Kish D; Guryanova OA; Ilyinskaya G; Kondratova A; Fairchild RL; Gorbachev AV. 2013. Cutaneous Tumors Cease CXCL9/Mig Production as a Result of IFN-gamma-Mediated Immunoediting. J Immunol 190(2):832-41. PubMed: 23241877 MGI: J:191044
Petry F; Jakobi V; Wagner S; Tessema TS; Thiel S; Loos M. 2008. Binding and activation of human and mouse complement by Cryptosporidium parvum (Apicomplexa) and susceptibility of C1q- and MBL-deficient mice to infection. Mol Immunol 45(12):3392-400. PubMed: 18501966 MGI: J:137680
Phares TW; Ramakrishna C; Parra GI; Epstein A; Chen L; Atkinson R; Stohlman SA; Bergmann CC. 2009. Target-dependent B7-H1 regulation contributes to clearance of central nervous system infection and dampens morbidity. J Immunol 182(9):5430-8. PubMed: 19380790 MGI: J:147948
Pilione MR; Harvill ET. 2006. The Bordetella bronchiseptica type III secretion system inhibits gamma interferon production that is required for efficient antibody-mediated bacterial clearance. Infect Immun 74(2):1043-9. PubMed: 16428751 MGI: J:105004
Pilz A; Kratky W; Stockinger S; Simma O; Kalinke U; Lingnau K; von Gabain A; Stoiber D; Sexl V; Kolbe T; Rulicke T; Muller M; Decker T. 2009. Dendritic cells require STAT-1 phosphorylated at its transactivating domain for the induction of peptide-specific CTL. J Immunol 183(4):2286-93. PubMed: 19620292 MGI: J:151558
Plitas G; Chaudhry UI; Kingham TP; Raab JR; DeMatteo RP. 2007. NK dendritic cells are innate immune responders to Listeria monocytogenes infection. J Immunol 178(7):4411-6. PubMed: 17371998 MGI: J:145143
Polchert D; Sobinsky J; Douglas G; Kidd M; Moadsiri A; Reina E; Genrich K; Mehrotra S; Setty S; Smith B; Bartholomew A. 2008. IFN-gamma activation of mesenchymal stem cells for treatment and prevention of graft versus host disease. Eur J Immunol 38(6):1745-55. PubMed: 18493986 MGI: J:136408
Pomeroy C; Delong D; Clabots C; Riciputi P; Filice GA. 1998. Role of interferon-gamma in murine cytomegalovirus infection. J Lab Clin Med 132(2):124-33. PubMed: 9708573 MGI: J:49105
Ponomarev ED; Novikova M; Yassai M; Szczepanik M; Gorski J; Dittel BN. 2004. Gamma delta T cell regulation of IFN-gamma production by central nervous system-infiltrating encephalitogenic T cells: correlation with recovery from experimental autoimmune encephalomyelitis. J Immunol 173(3):1587-95. PubMed: 15265886 MGI: J:92038
Poovassery J; Moore JM. 2009. Association of malaria-induced murine pregnancy failure with robust peripheral and placental cytokine responses. Infect Immun 77(11):4998-5006. PubMed: 19687196 MGI: J:154201
Poovassery JS; Sarr D; Smith G; Nagy T; Moore JM. 2009. Malaria-induced murine pregnancy failure: distinct roles for IFN-gamma and TNF. J Immunol 183(8):5342-9. PubMed: 19783682 MGI: J:153598
Portillo JA; Feliciano LM; Okenka G; Heinzel F; Subauste MC; Subauste CS. 2012. CD40 and tumour necrosis factor-alpha co-operate to up-regulate inducuble nitric oxide synthase expression in macrophages. Immunology 135(2):140-50. PubMed: 22044243 MGI: J:181390
Poudrier J; Weng X; Kay DG; Pare G; Calvo EL; Hanna Z; Kosco-Vilbois MH; Jolicoeur P. 2001. The AIDS disease of CD4C/HIV transgenic mice shows impaired germinal centers and autoantibodies and develops in the absence of IFN-gamma and IL-6. Immunity 15(2):173-85. PubMed: 11520454 MGI: J:131516
Prajeeth CK; Haeberlein S; Sebald H; Schleicher U; Bogdan C. 2011. Leishmania-infected macrophages are targets of NK cell-derived cytokines but not of NK cell cytotoxicity. Infect Immun 79(7):2699-708. PubMed: 21518784 MGI: J:173486
Purdy A; Case L; Duvall M; Overstrom-Coleman M; Monnier N; Chervonsky A; Golovkina T. 2003. Unique Resistance of I/LnJ Mice to a Retrovirus Is Due to Sustained Interferon gamma-dependent Production of Virus-neutralizing Antibodies. J Exp Med 197(2):233-43. PubMed: 12538662 MGI: J:81554
Purushothaman D; Marcel N; Garg M; Venkataraman R; Sarin A. 2013. Apoptotic Programs Are Determined during Lineage Commitment of CD4+ T Effectors: Selective Regulation of T Effector-Memory Apoptosis by Inducible Nitric Oxide Synthase. J Immunol 190(1):97-105. PubMed: 23225886 MGI: J:190816
Putz EM; Gotthardt D; Hoermann G; Csiszar A; Wirth S; Berger A; Straka E; Rigler D; Wallner B; Jamieson AM; Pickl WF; Zebedin-Brandl EM; Muller M; Decker T; Sexl V. 2013. CDK8-mediated STAT1-S727 phosphorylation restrains NK cell cytotoxicity and tumor surveillance. Cell Rep 4(3):437-44. PubMed: 23933255 MGI: J:201893
Qian Q; Cutler JE. 1997. Gamma interferon is not essential in host defense against disseminated candidiasis in mice. Infect Immun 65(5):1748-53. PubMed: 9125557 MGI: J:39881
Qiu H; Kuolee R; Harris G; Zhou H; Miller H; Patel GB; Chen W. 2011. Acinetobacter baumannii Infection Inhibits Airway Eosinophilia and Lung Pathology in a Mouse Model of Allergic Asthma. PLoS One 6(7):e22004. PubMed: 21789200 MGI: J:174930
Quezada SA; Simpson TR; Peggs KS; Merghoub T; Vider J; Fan X; Blasberg R; Yagita H; Muranski P; Antony PA; Restifo NP; Allison JP. 2010. Tumor-reactive CD4(+) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts. J Exp Med 207(3):637-50. PubMed: 20156971 MGI: J:158560
Quick ML; Wong L; Mukherjee S; Done JD; Schaeffer AJ; Thumbikat P. 2013. Th1-Th17 cells contribute to the development of uropathogenic Escherichia coli-induced chronic pelvic pain. PLoS One 8(4):e60987. PubMed: 23577183 MGI: J:199930
Raisanen-Sokolowski A; Mottram PL; Glysing-Jensen T; Satoskar A; Russell ME. 1997. Heart transplants in interferon-gamma, interleukin 4, and interleukin 10 knockout mice. Recipient environment alters graft rejection. J Clin Invest 100(10):2449-56. PubMed: 9366559 MGI: J:44346
Ramanathan S; Dubois S; Gagnon J; Leblanc C; Mariathasan S; Ferbeyre G; Rottapel R; Ohashi PS; Ilangumaran S. 2010. Regulation of cytokine-driven functional differentiation of CD8 T cells by suppressor of cytokine signaling 1 controls autoimmunity and preserves their proliferative capacity toward foreign antigens. J Immunol 185(1):357-66. PubMed: 20519645 MGI: J:161432
Ramanathan S; Gagnon J; Leblanc C; Rottapel R; Ilangumaran S. 2006. Suppressor of cytokine signaling 1 stringently regulates distinct functions of IL-7 and IL-15 in vivo during T lymphocyte development and homeostasis. J Immunol 176(7):4029-41. PubMed: 16547238 MGI: J:108365
Ramassar V; Goes N; Hobart M; Halloran PF. 1996. Evidence for the in vivo role of class II transactivator in basal and IFN-gamma induced class II expression in mouse tissue. Transplantation 62(12):1901-7. PubMed: 8990384 MGI: J:37404
Ramirez-Montagut T; Chow A; Hirschhorn-Cymerman D; Terwey TH; Kochman AA; Lu S; Miles RC; Sakaguchi S; Houghton AN; van den Brink MR. 2006. Glucocorticoid-induced TNF receptor family related gene activation overcomes tolerance/ignorance to melanoma differentiation antigens and enhances antitumor immunity. J Immunol 176(11):6434-42. PubMed: 16709800 MGI: J:131776
Raundhal M; Morse C; Khare A; Oriss TB; Milosevic J; Trudeau J; Huff R; Pilewski J; Holguin F; Kolls J; Wenzel S; Ray P; Ray A. 2015. High IFN-gamma and low SLPI mark severe asthma in mice and humans. J Clin Invest 125(8):3037-50. PubMed: 26121748 MGI: J:224538
Reboldi A; Coisne C; Baumjohann D; Benvenuto F; Bottinelli D; Lira S; Uccelli A; Lanzavecchia A; Engelhardt B; Sallusto F. 2009. C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE. Nat Immunol 10(5):514-23. PubMed: 19305396 MGI: J:148286
Reddy P; Teshima T; Kukuruga M; Ordemann R; Liu C; Lowler K; Ferrara JL. 2001. Interleukin-18 regulates acute graft-versus-host disease by enhancing Fas-mediated donor T cell apoptosis. J Exp Med 194(10):1433-40. PubMed: 11714750 MGI: J:114012
Reeve VE; Bosnic M; Nishimura N. 1999. Interferon-gamma is involved in photoimmunoprotection by UVA (320-400 nm) radiation in mice. J Invest Dermatol 112(6):945-50. PubMed: 10383743 MGI: J:55740
Reid-Yu SA; Small CL; Coombes BK. 2013. CD3(-) NK1.1(+) cells aid in the early induction of a Th1 response to an attaching and effacing enteric pathogen. Eur J Immunol 43(10):2638-49. PubMed: 23775576 MGI: J:201699
Richter K; Hausmann J; Staeheli P. 2009. Interferon-gamma prevents death of bystander neurons during CD8 T cell responses in the brain. Am J Pathol 174(5):1799-807. PubMed: 19359516 MGI: J:147967
Rigato PO; de Alencar BC; de Vasconcelos JR; Dominguez MR; Araujo AF; Machado AV; Gazzinelli RT; Bruna-Romero O; Rodrigues MM. 2011. Heterologous Plasmid DNA Prime-Recombinant Human Adenovirus 5 Boost Vaccination Generates a Stable Pool of Protective Long-Lived CD8+ T Effector Memory Cells Specific for a Human Parasite, Trypanosoma cruzi. Infect Immun 79(5):2120-30. PubMed: 21357719 MGI: J:171948
Rijneveld AW; Lauw FN; Schultz MJ; Florquin S; Te Velde AA; Speelman P; Van Deventer SJ; Van Der Poll T. 2002. The role of interferon-gamma in murine pneumococcal pneumonia. J Infect Dis 185(1):91-7. PubMed: 11756986 MGI: J:73620
Ring GH; Dai Z; Saleem S; Baddoura FK; Lakkis FG. 1999. Increased susceptibility to immunologically mediated glomerulonephritis in IFN-gamma-deficient mice. J Immunol 163(4):2243-8. PubMed: 10438967 MGI: J:118730
Ripley BJ; Fujimoto M; Serada S; Ohkawara T; Nishikawa T; Terabe F; Matsukawa Y; Stephanou A; Knight RA; Isenberg DA; Latchman DS; Kishimoto T; Naka T. 2010. Green tea polyphenol epigallocatechin gallate inhibits cell signaling by inducing SOCS1 gene expression. Int Immunol 22(5):359-66. PubMed: 20190037 MGI: J:159636
Rivera A; Hohl TM; Collins N; Leiner I; Gallegos A; Saijo S; Coward JW; Iwakura Y; Pamer EG. 2011. Dectin-1 diversifies Aspergillus fumigatus-specific T cell responses by inhibiting T helper type 1 CD4 T cell differentiation. J Exp Med 208(2):369-81. PubMed: 21242294 MGI: J:176853
Rizzo A; Waldner MJ; Stolfi C; Sarra M; Fina D; Becker C; Neurath MF; Macdonald TT; Pallone F; Monteleone G; Fantini MC. 2011. Smad7 Expression in T cells Prevents Colitis-Associated Cancer. Cancer Res 71(24):7423-32. PubMed: 22028324 MGI: J:178845
Robinson RT; Wang J; Cripps JG; Milks MW; English KA; Pearson TA; Gorham JD. 2009. End-organ damage in a mouse model of fulminant liver inflammation requires CD4+ T cell production of IFN-gamma but is independent of Fas. J Immunol 182(5):3278-84. PubMed: 19234226 MGI: J:146230
Rocha VZ; Folco EJ; Sukhova G; Shimizu K; Gotsman I; Vernon AH; Libby P. 2008. Interferon-gamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesity. Circ Res 103(5):467-76. PubMed: 18658050 MGI: J:152646
Roda JM; Parihar R; Lehman A; Mani A; Tridandapani S; Carson WE 3rd. 2006. Interleukin-21 enhances NK cell activation in response to antibody-coated targets. J Immunol 177(1):120-9. PubMed: 16785506 MGI: J:134405
Rodeghero R; Cao Y; Olalekan SA; Iwakua Y; Glant TT; Finnegan A. 2013. Location of CD4+ T cell priming regulates the differentiation of Th1 and Th17 cells and their contribution to arthritis. J Immunol 190(11):5423-35. PubMed: 23630349 MGI: J:204778
Rodriguez M; Zoecklein LJ; Howe CL; Pavelko KD; Gamez JD; Nakane S; Papke LM. 2003. Gamma interferon is critical for neuronal viral clearance and protection in a susceptible mouse strain following early intracranial Theiler's murine encephalomyelitis virus infection. J Virol 77(22):12252-65. PubMed: 14581562 MGI: J:86326
Rodriguez-Galan MC; Bream JH; Farr A; Young HA. 2005. Synergistic effect of IL-2, IL-12, and IL-18 on thymocyte apoptosis and Th1/Th2 cytokine expression. J Immunol 174(5):2796-804. PubMed: 15728489 MGI: J:97710
Roelofs-Haarhuis K; Wu X; Gleichmann E. 2004. Oral tolerance to nickel requires CD4+ invariant NKT cells for the infectious spread of tolerance and the induction of specific regulatory T cells. J Immunol 173(2):1043-50. PubMed: 15240692 MGI: J:91933
Rolan HG; Tsolis RM. 2007. Mice lacking components of adaptive immunity show increased Brucella abortus virB mutant colonization. Infect Immun 75(6):2965-73. PubMed: 17420243 MGI: J:121919
Romero CR; Herzig DS; Etogo A; Nunez J; Mahmoudizad R; Fang G; Murphey ED; Toliver-Kinsky T; Sherwood ER. 2010. The role of interferon-gamma in the pathogenesis of acute intra-abdominal sepsis. J Leukoc Biol 88(4):725-35. PubMed: 20628064 MGI: J:165614
Rosas LE; Snider HM; Barbi J; Satoskar AA; Lugo-Villarino G; Keiser T; Papenfuss T; Durbin JE; Radzioch D; Glimcher LH; Satoskar AR. 2006. Cutting edge: STAT1 and T-bet play distinct roles in determining outcome of visceral leishmaniasis caused by Leishmania donovani. J Immunol 177(1):22-5. PubMed: 16785492 MGI: J:134384
Rosenzweig HL; Kawaguchi T; Martin TM; Planck SR; Davey MP; Rosenbaum JT. 2009. Nucleotide oligomerization domain-2 (NOD2)-induced uveitis: dependence on IFN-gamma. Invest Ophthalmol Vis Sci 50(4):1739-45. PubMed: 19098321 MGI: J:146921
Rosypal AC; Lindsay DS; Duncan R Jr; Ahmed SA; Zajac AM; Dubey JP. 2002. Mice lacking the gene for inducible or endothelial nitric oxide are resistant to sporocyst induced Sarcocystis neurona infections. Vet Parasitol 103(4):315-21. PubMed: 11777610 MGI: J:106322
Rothfuchs AG; Trumstedt C; Mattei F; Schiavoni G; Hidmark A; Wigzell H; Rottenberg ME. 2006. STAT1 regulates IFN-alpha beta- and IFN-gamma-dependent control of infection with Chlamydia pneumoniae by nonhemopoietic cells. J Immunol 176(11):6982-90. PubMed: 16709859 MGI: J:131788
Rothhammer V; Heink S; Petermann F; Srivastava R; Claussen MC; Hemmer B; Korn T. 2011. Th17 lymphocytes traffic to the central nervous system independently of alpha4 integrin expression during EAE. J Exp Med 208(12):2465-76. PubMed: 22025301 MGI: J:178760
Rottman M; Soudais C; Vogt G; Renia L; Emile JF; Decaluwe H; Gaillard JL; Casanova JL. 2008. IFN-gamma mediates the rejection of haematopoietic stem cells in IFN-gammaR1-deficient hosts. PLoS Med 5(1):e26. PubMed: 18232731 MGI: J:134158
Rudmann DG; Preston AM; Moore MW; Beck JM. 1998. Susceptibility to Pneumocystis carinii in mice is dependent on simultaneous deletion of IFN-gamma and type 1 and 2 TNF receptor genes. J Immunol 161(1):360-6. PubMed: 9647244 MGI: J:119206
Rudner LA; Lin JT; Park IK; Cates JM; Dyer DA; Franz DM; French MA; Duncan EM; White HD; Gorham JD. 2003. Necroinflammatory Liver Disease in BALB/c Background, TGF-beta1-Deficient Mice Requires CD4(+) T Cells. J Immunol 170(9):4785-92. PubMed: 12707360 MGI: J:83022
Russell MS; Dudani R; Krishnan L; Sad S. 2009. IFN-gamma expressed by T cells regulates the persistence of antigen presentation by limiting the survival of dendritic cells. J Immunol 183(12):7710-8. PubMed: 19923462 MGI: J:157498
Rutigliano JA; Graham BS. 2004. Prolonged production of TNF-alpha exacerbates illness during respiratory syncytial virus infection. J Immunol 173(5):3408-17. PubMed: 15322205 MGI: J:92711
Rutitzky LI; Lopes da Rosa JR; Stadecker MJ. 2005. Severe CD4 T cell-mediated immunopathology in murine schistosomiasis is dependent on IL-12p40 and correlates with high levels of IL-17. J Immunol 175(6):3920-6. PubMed: 16148138 MGI: J:116693
Rutitzky LI; Stadecker MJ. 2011. Exacerbated egg-induced immunopathology in murine Schistosoma mansoni infection is primarily mediated by IL-17 and restrained by IFN-gamma. Eur J Immunol 41(9):2677-87. PubMed: 21660933 MGI: J:176818
Sabatino JJ Jr; Shires J; Altman JD; Ford ML; Evavold BD. 2008. Loss of IFN-{gamma} Enables the Expansion of Autoreactive CD4+ T Cells to Induce Experimental Autoimmune Encephalomyelitis by a Nonencephalitogenic Myelin Variant Antigen. J Immunol 180(7):4451-7. PubMed: 18354166 MGI: J:132970
Sabino GJ; Hwang SJ; McAllister SC; Mena P; Furie MB. 2011. Interferon-gamma Influences the Composition of Leukocytic Infiltrates in Murine Lyme Carditis. Am J Pathol 179(4):1917-28. PubMed: 21820995 MGI: J:176303
Saito TI; Li HW; Sykes M. 2010. Invariant NKT cells are required for antitumor responses induced by host-versus-graft responses. J Immunol 185(4):2099-105. PubMed: 20631307 MGI: J:162553
Salagianni M; Wong KL; Thomas MJ; Noble A; Kemeny DM. 2007. An essential role for IL-18 in CD8 T cell-mediated suppression of IgE responses. J Immunol 178(8):4771-8. PubMed: 17404257 MGI: J:145203
Salazar-Mather TP; Hamilton TA; Biron CA. 2000. A chemokine-to-cytokine-to-chemokine cascade critical in antiviral defense. J Clin Invest 105(7):985-93. PubMed: 10749577 MGI: J:120540
Saleh MA; McMaster WG; Wu J; Norlander AE; Funt SA; Thabet SR; Kirabo A; Xiao L; Chen W; Itani HA; Michell D; Huan T; Zhang Y; Takaki S; Titze J; Levy D; Harrison DG; Madhur MS. 2015. Lymphocyte adaptor protein LNK deficiency exacerbates hypertension and end-organ inflammation. J Clin Invest 125(3):1189-202. PubMed: 25664851 MGI: J:220548
Sangaletti S; Tripodo C; Chiodoni C; Guarnotta C; Cappetti B; Casalini P; Piconese S; Parenza M; Guiducci C; Vitali C; Colombo MP. 2012. Neutrophil extracellular traps mediate transfer of cytoplasmic neutrophil antigens to myeloid dendritic cells toward ANCA induction and associated autoimmunity. Blood 120(15):3007-18. PubMed: 22932797 MGI: J:192930
Santiago HC; Feng CG; Bafica A; Roffe E; Arantes RM; Cheever A; Taylor G; Vieira LQ; Aliberti J; Gazzinelli RT; Sher A. 2005. Mice deficient in LRG-47 display enhanced susceptibility to Trypanosoma cruzi infection associated with defective hemopoiesis and intracellular control of parasite growth. J Immunol 175(12):8165-72. PubMed: 16339555 MGI: J:122278
Santiago Hda C; Oliveira CF; Santiago L; Ferraz FO; de Souza Dda G; de-Freitas LA; Afonso LC; Teixeira MM; Gazzinelli RT; Vieira LQ. 2004. Involvement of the chemokine RANTES (CCL5) in resistance to experimental infection with Leishmania major. Infect Immun 72(8):4918-23. PubMed: 15271961 MGI: J:91807
Sarasin-Filipowicz M; Wang X; Yan M; Duong FH; Poli V; Hilton DJ; Zhang DE; Heim MH. 2009. Alpha interferon induces long-lasting refractoriness of JAK-STAT signaling in the mouse liver through induction of USP18/UBP43. Mol Cell Biol 29(17):4841-51. PubMed: 19564419 MGI: J:152613
Sarawar SR; Cardin RD; Brooks JW; Mehrpooya M; Hamilton-Easton AM; Mo XY; Doherty PC. 1997. Gamma interferon is not essential for recovery from acute infection with murine gammaherpesvirus 68. J Virol 71(5):3916-21. PubMed: 9094668 MGI: J:39478
Sardinha LR; Elias RM; Mosca T; Bastos KR; Marinho CR; D'Imperio Lima MR; Alvarez JM. 2006. Contribution of NK, NK T, gammadelta T, and alphabeta T cells to the gamma interferon response required for liver protection against Trypanosoma cruzi. Infect Immun 74(4):2031-42. PubMed: 16552032 MGI: J:107423
Savinov AY; Wong FS; Chervonsky AV. 2001. IFN-gamma Affects Homing of Diabetogenic T Cells. J Immunol 167(11):6637-43. PubMed: 11714835 MGI: J:72818
Scapini P; Hu Y; Chu CL; Migone TS; Defranco AL; Cassatella MA; Lowell CA. 2010. Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice. J Exp Med 207(8):1757-73. PubMed: 20624892 MGI: J:163472
Scharton-Kersten T; Contursi C; Masumi A; Sher A; Ozato K. 1997. Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 induction. J Exp Med 186(9):1523-34. PubMed: 9348310 MGI: J:111178
Scharton-Kersten TM; Wynn TA; Denkers EY; Bala S; Grunvald E; Hieny S; Gazzinelli RT; Sher A. 1996. In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection. J Immunol 157(9):4045-54. PubMed: 8892638 MGI: J:110826
Scheckelhoff M; Deepe GS Jr. 2005. A deficiency in gamma interferon or interleukin-10 modulates T-Cell-dependent responses to heat shock protein 60 from Histoplasma capsulatum. Infect Immun 73(4):2129-34. PubMed: 15784555 MGI: J:97204
Schenkel JM; Fraser KA; Vezys V; Masopust D. 2013. Sensing and alarm function of resident memory CD8(+) T cells. Nat Immunol 14(5):509-13. PubMed: 23542740 MGI: J:196440
Schiffmann S; Ferreiros N; Birod K; Eberle M; Schreiber Y; Pfeilschifter W; Ziemann U; Pierre S; Scholich K; Grosch S; Geisslinger G. 2012. Ceramide synthase 6 plays a critical role in the development of experimental autoimmune encephalomyelitis. J Immunol 188(11):5723-33. PubMed: 22544924 MGI: J:188736
Schindler H; Lutz MB; Rollinghoff M; Bogdan C. 2001. The production of IFN-gamma by IL-12/IL-18-activated macrophages requires STAT4 signaling and is inhibited by IL-4. J Immunol 166(5):3075-82. PubMed: 11207258 MGI: J:126694
Schmidt C; Hocherl K; Bucher M. 2007. Cytokine-mediated regulation of urea transporters during experimental endotoxemia. Am J Physiol Renal Physiol 292(5):F1479-89. PubMed: 17229673 MGI: J:121446
Schmitt EG; Haribhai D; Jeschke JC; Co DO; Ziegelbauer J; Yan K; Iwakura Y; Mishra MK; Simpson P; Salzman NH; Williams CB. 2013. Chronic follicular bronchiolitis requires antigen-specific regulatory T cell control to prevent fatal disease progression. J Immunol 191(11):5460-76. PubMed: 24163409 MGI: J:207015
Schwarze J; Cieslewicz G; Hamelmann E; Joetham A; Shultz LD; Lamers MC; Gelfand EW. 1999. IL-5 and eosinophils are essential for the development of airway hyperresponsiveness following acute respiratory syncytial virus infection. J Immunol 162(5):2997-3004. PubMed: 10072551 MGI: J:110844
Scott MJ; Hoth JJ; Stagner MK; Gardner SA; Peyton JC; Cheadle WG. 2004. CD40-CD154 interactions between macrophages and natural killer cells during sepsis are critical for macrophage activation and are not interferon gamma dependent. Clin Exp Immunol 137(3):469-77. PubMed: 15320895 MGI: J:92312
Scurlock AM; Frazer LC; Andrews CW Jr; O'Connell CM; Foote IP; Bailey SL; Chandra-Kuntal K; Kolls JK; Darville T. 2011. Interleukin-17 Contributes to Generation of Th1 Immunity and Neutrophil Recruitment during Chlamydia muridarum Genital Tract Infection but Is Not Required for Macrophage Influx or Normal Resolution of Infection. Infect Immun 79(3):1349-62. PubMed: 21149587 MGI: J:169254
Segal BM; Dwyer BK; Shevach EM. 1998. An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease. J Exp Med 187(4):537-46. PubMed: 9463404 MGI: J:118559
Segawa S; Goto D; Yoshiga Y; Horikoshi M; Sugihara M; Hayashi T; Chino Y; Matsumoto I; Ito S; Sumida T. 2011. Involvement of NK 1.1-positive gammadeltaT cells in interleukin-18 plus interleukin-2-induced interstitial lung disease. Am J Respir Cell Mol Biol 45(3):659-66. PubMed: 21257923 MGI: J:190220
Seif AE; Barrett DM; Milone M; Brown VI; Grupp SA; Reid GS. 2009. Long-term protection from syngeneic acute lymphoblastic leukemia by CpG ODN-mediated stimulation of innate and adaptive immune responses. Blood 114(12):2459-66. PubMed: 19636062 MGI: J:152910
Sercan O; Stoycheva D; Hammerling GJ; Arnold B; Schuler T. 2010. IFN-gamma receptor signaling regulates memory CD8+ T cell differentiation. J Immunol 184(6):2855-62. PubMed: 20164422 MGI: J:160112
Serreze DV; Chapman HD; Post CM; Johnson EA; Suarez-Pinzon WL; Rabinovitch A. 2001. Th1 to Th2 cytokine shifts in nonobese diabetic mice: sometimes an outcome, rather than the cause, of diabetes resistance elicited by immunostimulation. J Immunol 166(2):1352-9. PubMed: 11145720 MGI: J:109883
Serreze DV; Wasserfall C; Ottendorfer EW; Stalvey M; Pierce MA; Gauntt C; O'Donnell B; Flanagan JB; Campbell-Thompson M; Ellis TM; Atkinson MA. 2005. Diabetes acceleration or prevention by a coxsackievirus B4 infection: critical requirements for both interleukin-4 and gamma interferon. J Virol 79(2):1045-52. PubMed: 15613333 MGI: J:95105
Seymour BW; Gershwin LJ; Coffman RL. 1998. Aerosol-induced immunoglobulin (Ig)-E unresponsiveness to ovalbumin does not require CD8+ or T cell receptor (TCR)-gamma/delta+ T cells or interferon (IFN)-gamma in a murine model of allergen sensitization. J Exp Med 187(5):721-31. PubMed: 9480982 MGI: J:46078
Shafiani S; Dinh C; Ertelt JM; Moguche AO; Siddiqui I; Smigiel KS; Sharma P; Campbell DJ; Way SS; Urdahl KB. 2013. Pathogen-specific Treg cells expand early during mycobacterium tuberculosis infection but are later eliminated in response to Interleukin-12. Immunity 38(6):1261-70. PubMed: 23791647 MGI: J:207578
Shang XZ; Ma KY; Radewonuk J; Li J; Song XY; Griswold DE; Emmell E; Li L. 2006. IgE isotype switch and IgE production are enhanced in IL-21-deficient but not IFN-gamma-deficient mice in a Th2-biased response. Cell Immunol 241(2):66-74. PubMed: 16979605 MGI: J:114783
Shaw PJ; Ditewig AC; Waring JF; Liguori MJ; Blomme EA; Ganey PE; Roth RA. 2009. Coexposure of mice to trovafloxacin and lipopolysaccharide, a model of idiosyncratic hepatotoxicity, results in a unique gene expression profile and interferon gamma-dependent liver injury. Toxicol Sci 107(1):270-80. PubMed: 18930950 MGI: J:144560
Shi FD; Takeda K; Akira S; Sarvetnick N; Ljunggren HG. 2000. IL-18 directs autoreactive T cells and promotes autodestruction in the central nervous system via induction of IFN-gamma by NK cells. J Immunol 165(6):3099-104. PubMed: 10975822 MGI: J:64550
Shi FD; Wang HB; Li H; Hong S; Taniguchi M; Link H; Van Kaer L; Ljunggren HG. 2000. Natural killer cells determine the outcome of B cell-mediated autoimmunity. Nat Immunol 1(3):245-51. PubMed: 10973283 MGI: J:64350
Shi M; Ye Z; Umeshappa KS; Moyana T; Xiang J. 2007. Alpha tumor necrosis factor contributes to CD8(+) T cell survival in the transition phase. Biochem Biophys Res Commun 360(3):702-7. PubMed: 17618911 MGI: J:123025
Shi S; Blumenthal A; Hickey CM; Gandotra S; Levy D; Ehrt S. 2005. Expression of many immunologically important genes in Mycobacterium tuberculosis-infected macrophages is independent of both TLR2 and TLR4 but dependent on IFN-alphabeta receptor and STAT1. J Immunol 175(5):3318-28. PubMed: 16116224 MGI: J:113220
Shi X; Cao S; Mitsuhashi M; Xiang Z; Ma X. 2004. Genome-wide analysis of molecular changes in IL-12-induced control of mammary carcinoma via IFN-gamma-independent mechanisms. J Immunol 172(7):4111-22. PubMed: 15034023 MGI: J:88715
Shichita T; Sugiyama Y; Ooboshi H; Sugimori H; Nakagawa R; Takada I; Iwaki T; Okada Y; Iida M; Cua DJ; Iwakura Y; Yoshimura A. 2009. Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury. Nat Med 15(8):946-50. PubMed: 19648929 MGI: J:152082
Shimizu K; Asakura M; Fujii S. 2011. Prolonged antitumor NK cell reactivity elicited by CXCL10-expressing dendritic cells licensed by CD40L+ CD4+ memory T cells. J Immunol 186(10):5927-37. PubMed: 21460206 MGI: J:173107
Shin H; Kumamoto Y; Gopinath S; Iwasaki A. 2016. CD301b+ dendritic cells stimulate tissue-resident memory CD8+ T cells to protect against genital HSV-2. Nat Commun 7:13346. PubMed: 27827367 MGI: J:242721
Shreiner AB; Murdock BJ; Sadighi Akha AA; Falkowski NR; Christensen PJ; White ES; Hogaboam CM; Huffnagle GB. 2012. Repeated Exposure to Aspergillus fumigatus Conidia Results in CD4+ T Cell-Dependent and -Independent Pulmonary Arterial Remodeling in a Mixed Th1/Th2/Th17 Microenvironment That Requires Interleukin-4 (IL-4) and IL-10. Infect Immun 80(1):388-97. PubMed: 22064716 MGI: J:179004
Shurin MR; Potapovich AI; Tyurina YY; Tourkova IL; Shurin GV; Kagan VE. 2009. Recognition of live phosphatidylserine-labeled tumor cells by dendritic cells: a novel approach to immunotherapy of skin cancer. Cancer Res 69(6):2487-96. PubMed: 19276376 MGI: J:147072
Siegmund B; Sennello JA; Lehr HA; Senaldi G; Dinarello CA; Fantuzzi G. 2004. Frontline: Interferon regulatory factor-1 as a protective gene in intestinal inflammation: role of TCR gamma delta T cells and interleukin-18-binding protein. Eur J Immunol 34(9):2356-64. PubMed: 15307168 MGI: J:91767
Siemsen DW; Dobrinen E; Han S; Chiocchi K; Meissner N; Swain SD. 2016. Vascular Dysfunction in Pneumocystis-Associated Pulmonary Hypertension Is Related to Endothelin Response and Adrenomedullin Concentration. Am J Pathol 186(2):259-69. PubMed: 26687815 MGI: J:229679
Silva NM; Vieira JC; Carneiro CM; Tafuri WL. 2009. Toxoplasma gondii: the role of IFN-gamma, TNFRp55 and iNOS in inflammatory changes during infection. Exp Parasitol 123(1):65-72. PubMed: 19501090 MGI: J:156567
Silva RA; Pais TF; Appelberg R. 1998. Evaluation of IL-12 in immunotherapy and vaccine design in experimental Mycobacterium avium infections. J Immunol 161(10):5578-85. PubMed: 9820535 MGI: J:115036
Simkins HM; Hyde E; Farrand KJ; Ong ML; Degli-Esposti MA; Hermans IF; Ronchese F. 2011. Administration of {alpha}-galactosylceramide impairs the survival of dendritic cell subpopulations in vivo. J Leukoc Biol 89(5):753-62. PubMed: 21297009 MGI: J:172098
Simma O; Zebedin E; Neugebauer N; Schellack C; Pilz A; Chang-Rodriguez S; Lingnau K; Weisz E; Putz EM; Pickl WF; Felzmann T; Muller M; Decker T; Sexl V; Stoiber D. 2009. Identification of an indispensable role for tyrosine kinase 2 in CTL-mediated tumor surveillance. Cancer Res 69(1):203-11. PubMed: 19118004 MGI: J:143032
Simmons CP; Goncalves NS; Ghaem-Maghami M; Bajaj-Elliott M; Clare S; Neves B; Frankel G; Dougan G; MacDonald TT. 2002. Impaired resistance and enhanced pathology during infection with a noninvasive, attaching-effacing enteric bacterial pathogen, Citrobacter rodentium, in mice lacking IL-12 or IFN-gamma. J Immunol 168(4):1804-12. PubMed: 11823513 MGI: J:74480
Simmons CP; Mastroeni P; Fowler R; Ghaem-maghami M; Lycke N; Pizza M; Rappuoli R; Dougan G. 1999. MHC class I-restricted cytotoxic lymphocyte responses induced by enterotoxin-based mucosal adjuvants. J Immunol 163(12):6502-10. PubMed: 10586042 MGI: J:58977
Sinha P; Parker KH; Horn L; Ostrand-Rosenberg S. 2012. Tumor-induced myeloid-derived suppressor cell function is independent of IFN-gamma and IL-4Ralpha. Eur J Immunol 42(8):2052-9. PubMed: 22673957 MGI: J:187851
Sinha S; Guo Y; Thet S; Yuan D. 2012. IFN type I and type II independent enhancement of B cell TLR7 expression by natural killer cells. J Leukoc Biol 92(4):713-22. PubMed: 22636319 MGI: J:189565
Sjokvist Ottsjo L; Flach CF; Nilsson S; Malefyt Rde W; Walduck AK; Raghavan S. 2015. Defining the Roles of IFN-gamma and IL-17A in Inflammation and Protection against Helicobacter pylori Infection. PLoS One 10(7):e0131444. PubMed: 26168305 MGI: J:238536
Skoberne M; Geginat G. 2002. Efficient in vivo presentation of Listeria monocytogenes- derived CD4 and CD8 T cell epitopes in the absence of IFN-gamma. J Immunol 168(4):1854-60. PubMed: 11823519 MGI: J:74477
Skyberg JA; Rollins MF; Samuel JW; Sutherland MD; Belisle JT; Pascual DW. 2013. Interleukin-17 Protects against the Francisella tularensis Live Vaccine Strain but Not against a Virulent F. tularensis Type A Strain. Infect Immun 81(9):3099-105. PubMed: 23774604 MGI: J:199831
Skyberg JA; Thornburg T; Kochetkova I; Layton W; Callis G; Rollins MF; Riccardi C; Becker T; Golden S; Pascual DW. 2012. IFN-gamma-deficient mice develop IL-1-dependent cutaneous and musculoskeletal inflammation during experimental brucellosis. J Leukoc Biol 92(2):375-87. PubMed: 22636321 MGI: J:186167
Smeltz RB; Chen J; Shevach EM. 2005. Transforming growth factor-beta1 enhances the interferon-gamma-dependent, interleukin-12-independent pathway of T helper 1 cell differentiation. Immunology 114(4):484-92. PubMed: 15804285 MGI: J:97437
Smith AL; Hayday AC. 2000. Genetic dissection of primary and secondary responses to a widespread natural pathogen of the gut, Eimeria vermiformis. Infect Immun 68(11):6273-80. PubMed: 11035735 MGI: J:133107
Smith LM; Bonafonte MT; Mead JR. 2000. Cytokine expression and specific lymphocyte proliferation in two strains of Cryptosporidium parvum-infected gamma-interferon knockout mice. J Parasitol 86(2):300-7. PubMed: 10780549 MGI: J:62349
Smyth MJ; Swann J; Cretney E; Zerafa N; Yokoyama WM; Hayakawa Y. 2005. NKG2D function protects the host from tumor initiation. J Exp Med 202(5):583-8. PubMed: 16129707 MGI: J:100684
Smyth MJ; Wallace ME; Nutt SL; Yagita H; Godfrey DI; Hayakawa Y. 2005. Sequential activation of NKT cells and NK cells provides effective innate immunotherapy of cancer. J Exp Med 201(12):1973-85. PubMed: 15967825 MGI: J:99284
Smythies LE; Waites KB; Lindsey JR; Harris PR; Ghiara P; Smith PD. 2000. Helicobacter pylori-induced mucosal inflammation is Th1 mediated and exacerbated in IL-4, but not IFN-gamma, gene-deficient mice. J Immunol 165(2):1022-9. PubMed: 10878379 MGI: J:120556
Sorensen EW; Gerber SA; Frelinger JG; Lord EM. 2010. IL-12 suppresses vascular endothelial growth factor receptor 3 expression on tumor vessels by two distinct IFN-gamma-dependent mechanisms. J Immunol 184(4):1858-66. PubMed: 20061409 MGI: J:159492
Souto JT; Figueiredo F; Furlanetto A; Pfeffer K; Rossi MA; Silva JS. 2000. Interferon-gamma and tumor necrosis factor-alpha determine resistance to Paracoccidioides brasiliensis infection in mice. Am J Pathol 156(5):1811-20. PubMed: 10793093 MGI: J:108248
Spanier JA; Nashold FE; Olson JK; Hayes CE. 2012. The Ifng gene is essential for Vdr gene expression and vitamin D(3)-mediated reduction of the pathogenic T cell burden in the central nervous system in experimental autoimmune encephalomyelitis, a multiple sclerosis model. J Immunol 189(6):3188-97. PubMed: 22896638 MGI: J:189942
Spear P; Barber A; Rynda-Apple A; Sentman CL. 2012. Chimeric antigen receptor T cells shape myeloid cell function within the tumor microenvironment through IFN-gamma and GM-CSF. J Immunol 188(12):6389-98. PubMed: 22586039 MGI: J:188969
Spergel JM; Mizoguchi E; Oettgen H; Bhan AK; Geha RS. 1999. Roles of TH1 and TH2 cytokines in a murine model of allergic dermatitis. J Clin Invest 103(8):1103-11. PubMed: 10207161 MGI: J:119611
St John AL; Abraham SN. 2009. Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines. Nat Med 15(11):1259-65. PubMed: 19855398 MGI: J:155766
Staehli F; Ludigs K; Heinz LX; Seguin-Estevez Q; Ferrero I; Braun M; Schroder K; Rebsamen M; Tardivel A; Mattmann C; MacDonald HR; Romero P; Reith W; Guarda G; Tschopp J. 2012. NLRC5 deficiency selectively impairs MHC class I- dependent lymphocyte killing by cytotoxic T cells. J Immunol 188(8):3820-8. PubMed: 22412192 MGI: J:184076
Stange J; Hepworth MR; Rausch S; Zajic L; Kuhl AA; Uyttenhove C; Renauld JC; Hartmann S; Lucius R. 2012. IL-22 Mediates Host Defense against an Intestinal Intracellular Parasite in the Absence of IFN-gamma at the Cost of Th17-Driven Immunopathology. J Immunol 188(5):2410-8. PubMed: 22266282 MGI: J:181287
Starr R; Fuchsberger M; Lau LS; Uldrich AP; Goradia A; Willson TA; Verhagen AM; Alexander WS; Smyth MJ. 2009. SOCS-1 binding to tyrosine 441 of IFN-gamma receptor subunit 1 contributes to the attenuation of IFN-gamma signaling in vivo. J Immunol 183(7):4537-44. PubMed: 19734231 MGI: J:152785
Steinbach K; Vincenti I; Kreutzfeldt M; Page N; Muschaweckh A; Wagner I; Drexler I; Pinschewer D; Korn T; Merkler D. 2016. Brain-resident memory T cells represent an autonomous cytotoxic barrier to viral infection. J Exp Med 213(8):1571-87. PubMed: 27377586 MGI: J:236474
Stern ME; Siemasko K; Gao J; Duong A; Beauregard C; Calder V; Niederkorn JY. 2005. Role of interferon-gamma in a mouse model of allergic conjunctivitis. Invest Ophthalmol Vis Sci 46(9):3239-46. PubMed: 16123425 MGI: J:101339
Stoermer Burrack KA; Hawman DW; Jupille HJ; Oko L; Minor M; Shives KD; Gunn BM; Long KM; Morrison TE. 2014. Attenuating mutations in nsP1 reveal tissue-specific mechanisms for control of Ross River virus infection. J Virol 88(7):3719-32. PubMed: 24429363 MGI: J:213015
Storm P; Bartholdy C; Sorensen MR; Christensen JP; Thomsen AR. 2006. Perforin-deficient CD8+ T cells mediate fatal lymphocytic choriomeningitis despite impaired cytokine production. J Virol 80(3):1222-30. PubMed: 16414999 MGI: J:153336
Strbo N; Oizumi S; Sotosek-Tokmadzic V; Podack ER. 2003. Perforin is required for innate and adaptive immunity induced by heat shock protein gp96. Immunity 18(3):381-90. PubMed: 12648455 MGI: J:82494
Street SE; Cretney E; Smyth MJ. 2001. Perforin and interferon-gamma activities independently control tumor initiation, growth, and metastasis. Blood 97(1):192-7. PubMed: 11133760 MGI: J:68550
Street SE; Trapani JA; MacGregor D; Smyth MJ. 2002. Suppression of lymphoma and epithelial malignancies effected by interferon gamma. J Exp Med 196(1):129-34. PubMed: 12093877 MGI: J:77491
Strutt TM; McKinstry KK; Dibble JP; Winchell C; Kuang Y; Curtis JD; Huston G; Dutton RW; Swain SL. 2010. Memory CD4+ T cells induce innate responses independently of pathogen. Nat Med 16(5):558-64, 1p following 564. PubMed: 20436484 MGI: J:160609
Stuller KA; Cush SS; Flano E. 2010. Persistent gamma-herpesvirus infection induces a CD4 T cell response containing functionally distinct effector populations. J Immunol 184(7):3850-6. PubMed: 20208003 MGI: J:160066
Su SB; Grajewski RS; Luger D; Agarwal RK; Silver PB; Tang J; Tuo J; Chan CC; Caspi RR. 2007. Altered chemokine profile associated with exacerbated autoimmune pathology under conditions of genetic interferon-gamma deficiency. Invest Ophthalmol Vis Sci 48(10):4616-25. PubMed: 17898285 MGI: J:126928
Subleski JJ; Hall VL; Wolfe TB; Scarzello AJ; Weiss JM; Chan T; Hodge DL; Back TC; Ortaldo JR; Wiltrout RH. 2011. TCR-dependent and -independent activation underlie liver-specific regulation of NKT cells. J Immunol 186(2):838-47. PubMed: 21148802 MGI: J:168779
Sun J; Dodd H; Moser EK; Sharma R; Braciale TJ. 2011. CD4(+) T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs. Nat Immunol 12(4):327-34. PubMed: 21297642 MGI: J:170347
Sun J; Sukhova GK; Wolters PJ; Yang M; Kitamoto S; Libby P; MacFarlane LA; Mallen-St Clair J; Shi GP. 2007. Mast cells promote atherosclerosis by releasing proinflammatory cytokines. Nat Med 13(6):719-24. PubMed: 17546038 MGI: J:125116
Sun J; Sukhova GK; Yang M; Wolters PJ; MacFarlane LA; Libby P; Sun C; Zhang Y; Liu J; Ennis TL; Knispel R; Xiong W; Thompson RW; Baxter BT; Shi GP. 2007. Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice. J Clin Invest 117(11):3359-68. PubMed: 17932568 MGI: J:127400
Sun K; Hsiao HH; Li M; Ames E; Bouchlaka M; Welniak LA; Hagino T; Jagdeo J; Pai CC; Chen M; Blazar BR; Abedi M; Murphy WJ. 2012. IFN-gamma receptor-deficient donor T cells mediate protection from graft-versus-host disease and preserve graft-versus-tumor responses after allogeneic bone marrow transplantation. J Immunol 189(4):2033-42. PubMed: 22778394 MGI: J:189757
Sun K; Metzger DW. 2008. Inhibition of pulmonary antibacterial defense by interferon-gamma during recovery from influenza infection. Nat Med 14(5):558-64. PubMed: 18438414 MGI: J:136669
Sun K; Ye J; Perez DR; Metzger DW. 2011. Seasonal FluMist vaccination induces cross-reactive T cell immunity against H1N1 (2009) influenza and secondary bacterial infections. J Immunol 186(2):987-93. PubMed: 21160043 MGI: J:168768
Sun R; Gao B. 2004. Negative regulation of liver regeneration by innate immunity (natural killer cells/interferon-gamma). Gastroenterology 127(5):1525-39. PubMed: 15521020 MGI: J:107757
Sutherland AP; Joller N; Michaud M; Liu SM; Kuchroo VK; Grusby MJ. 2013. IL-21 Promotes CD8+ CTL Activity via the Transcription Factor T-bet. J Immunol 190(8):3977-84. PubMed: 23479229 MGI: J:194899
Svensson M; Zubairi S; Maroof A; Kazi F; Taniguchi M; Kaye PM. 2005. Invariant NKT cells are essential for the regulation of hepatic CXCL10 gene expression during Leishmania donovani infection. Infect Immun 73(11):7541-7. PubMed: 16239557 MGI: J:104288
Swain SD; Meissner NN; Siemsen DW; McInnerney K; Harmsen AG. 2012. Pneumocystis elicits a STAT6-dependent, strain-specific innate immune response and airway hyperresponsiveness. Am J Respir Cell Mol Biol 46(3):290-8. PubMed: 21960549 MGI: J:194583
Swain SD; Siemsen DW; Pullen RR; Han S. 2014. CD4+ T cells and IFN-gamma are required for the development of Pneumocystis-associated pulmonary hypertension. Am J Pathol 184(2):483-93. PubMed: 24361497 MGI: J:206386
Swamynathan S; Buela KA; Kinchington P; Lathrop KL; Misawa H; Hendricks RL; Swamynathan SK. 2012. Klf4 regulates the expression of Slurp1, which functions as an immunomodulatory peptide in the mouse cornea. Invest Ophthalmol Vis Sci 53(13):8433-46. PubMed: 23139280 MGI: J:214274
Swann JB; Vesely MD; Silva A; Sharkey J; Akira S; Schreiber RD; Smyth MJ. 2008. Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis. Proc Natl Acad Sci U S A 105(2):652-6. PubMed: 18178624 MGI: J:131026
Takabayshi K; Corr M; Hayashi T; Redecke V; Beck L; Guiney D; Sheppard D; Raz E. 2006. Induction of a homeostatic circuit in lung tissue by microbial compounds. Immunity 24(4):475-87. PubMed: 16618605 MGI: J:113350
Takahashi H; Kouno M; Nagao K; Wada N; Hata T; Nishimoto S; Iwakura Y; Yoshimura A; Yamada T; Kuwana M; Fujii H; Koyasu S; Amagai M. 2011. Desmoglein 3-specific CD4+ T cells induce pemphigus vulgaris and interface dermatitis in mice. J Clin Invest 121(9):3677-88. PubMed: 21821914 MGI: J:178257
Takeda K; Cretney E; Hayakawa Y; Ota T; Akiba H; Ogasawara K; Yagita H; Kinoshita K; Okumura K; Smyth MJ. 2005. TRAIL identifies immature natural killer cells in newborn mice and adult mouse liver. Blood 105(5):2082-9. PubMed: 15536146 MGI: J:98142
Takeda K; Nakayama M; Sakaki M; Hayakawa Y; Imawari M; Ogasawara K; Okumura K; Smyth MJ. 2011. IFN-gamma production by lung NK cells is critical for the natural resistance to pulmonary metastasis of B16 melanoma in mice. J Leukoc Biol 90(4):777-85. PubMed: 21712396 MGI: J:177544
Takeda K; Smyth MJ; Cretney E; Hayakawa Y; Yamaguchi N; Yagita H; Okumura K. 2001. Involvement of tumor necrosis factor-related apoptosis-inducing ligand in NK cell-mediated and IFN-gamma-dependent suppression of subcutaneous tumor growth. Cell Immunol 214(2):194-200. PubMed: 12088418 MGI: J:76563
Tanaka K; Ichiyama K; Hashimoto M; Yoshida H; Takimoto T; Takaesu G; Torisu T; Hanada T; Yasukawa H; Fukuyama S; Inoue H; Nakanishi Y; Kobayashi T; Yoshimura A. 2008. Loss of Suppressor of Cytokine Signaling 1 in Helper T Cells Leads to Defective Th17 Differentiation by Enhancing Antagonistic Effects of IFN-{gamma} on STAT3 and Smads. J Immunol 180(6):3746-56. PubMed: 18322180 MGI: J:132905
Tang H; Sharp GC; Peterson KP; Braley-Mullen H. 1998. IFN-gamma-deficient mice develop severe granulomatous experimental autoimmune thyroiditis with eosinophil infiltration in thyroids. J Immunol 160(10):5105-12. PubMed: 9590262 MGI: J:47481
Tarallo V; Hirano Y; Gelfand BD; Dridi S; Kerur N; Kim Y; Cho WG; Kaneko H; Fowler BJ; Bogdanovich S; Albuquerque RJ; Hauswirth WW; Chiodo VA; Kugel JF; Goodrich JA; Ponicsan SL; Chaudhuri G; Murphy MP; Dunaief JL; Ambati BK; Ogura Y; Yoo JW; Lee DK; Provost P; Hinton DR; Nunez G; Baffi JZ; Kleinman ME; Ambati J. 2012. DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. Cell 149(4):847-59. PubMed: 22541070 MGI: J:186198
Tarrant TK; Silver PB; Wahlsten JL; Rizzo LV; Chan CC; Wiggert B; Caspi RR. 1999. Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon gamma, nitric oxide, and apoptosis. J Exp Med 189(2):219-30. PubMed: 9892605 MGI: J:119614
Tatum AM; Mylin LM; Bender SJ; Fischer MA; Vigliotti BA; Tevethia MJ; Tevethia SS; Schell TD. 2008. CD8+ T cells targeting a single immunodominant epitope are sufficient for elimination of established SV40 T antigen-induced brain tumors. J Immunol 181(6):4406-17. PubMed: 18768900 MGI: J:142961
Taylor AP; Murray HW. 1997. Intracellular antimicrobial activity in the absence of interferon-gamma: effect of interleukin-12 in experimental visceral leishmaniasis in interferon-gamma gene-disrupted mice. J Exp Med 185(7):1231-9. PubMed: 9104810 MGI: J:40241
Tchaptchet S; Gumenscheimer M; Kalis C; Freudenberg N; Holscher C; Kirschning CJ; Lamers M; Galanos C; Freudenberg MA. 2012. TLR9-dependent and independent pathways drive activation of the immune system by Propionibacterium acnes. PLoS One 7(6):e39155. PubMed: 22745710 MGI: J:187937
Teng MW; Andrews DM; McLaughlin N; von Scheidt B; Ngiow SF; Moller A; Hill GR; Iwakura Y; Oft M; Smyth MJ. 2010. IL-23 suppresses innate immune response independently of IL-17A during carcinogenesis and metastasis. Proc Natl Acad Sci U S A 107(18):8328-33. PubMed: 20404142 MGI: J:160332
Teng MW; von Scheidt B; Duret H; Towne JE; Smyth MJ. 2011. Anti-IL-23 Monoclonal Antibody Synergizes in Combination with Targeted Therapies or IL-2 to Suppress Tumor Growth and Metastases. Cancer Res 71(6):2077-86. PubMed: 21282337 MGI: J:170103
Teske S; Bohn AA; Hogaboam JP; Lawrence BP. 2008. Aryl hydrocarbon receptor targets pathways extrinsic to bone marrow cells to enhance neutrophil recruitment during influenza virus infection. Toxicol Sci 102(1):89-99. PubMed: 18007012 MGI: J:133909
Tesselaar K; Arens R; van Schijndel GM; Baars PA; van der Valk MA; Borst J; van Oers MH; van Lier RA. 2003. Lethal T cell immunodeficiency induced by chronic costimulation via CD27-CD70 interactions. Nat Immunol 4(1):49-54. PubMed: 12469117 MGI: J:82292
Textor A; Schmidt K; Kloetzel PM; Weissbrich B; Perez C; Charo J; Anders K; Sidney J; Sette A; Schumacher TN; Keller C; Busch DH; Seifert U; Blankenstein T. 2016. Preventing tumor escape by targeting a post-proteasomal trimming independent epitope. J Exp Med 213(11):2333-2348. PubMed: 27697836 MGI: J:237415
Thomas MJ; Noble A; Sawicka E; Askenase PW; Kemeny DM. 2002. CD8 T cells inhibit IgE via dendritic cell IL-12 induction that promotes Th1 T cell counter-regulation. J Immunol 168(1):216-23. PubMed: 11751965 MGI: J:131005
Timoshanko JR; Holdsworth SR; Kitching AR; Tipping PG. 2002. IFN-gamma production by intrinsic renal cells and bone marrow-derived cells is required for full expression of crescentic glomerulonephritis in mice. J Immunol 168(8):4135-41. PubMed: 11937574 MGI: J:125655
Tishon A; Lewicki H; Rall G; Von Herrath M; Oldstone MB. 1995. An essential role for type 1 interferon-gamma in terminating persistent viral infection. Virology 212(1):244-50. PubMed: 7676639 MGI: J:110746
Tongren JE; Corran PH; Jarra W; Langhorne J; Riley EM. 2005. Epitope-specific regulation of immunoglobulin class switching in mice immunized with malarial merozoite surface proteins. Infect Immun 73(12):8119-29. PubMed: 16299306 MGI: J:104297
Tran EH; Prince EN; Owens T. 2000. IFN-gamma shapes immune invasion of the central nervous system via regulation of chemokines. J Immunol 164(5):2759-68. PubMed: 10679118 MGI: J:60605
Trembleau S; Penna G; Gregori S; Giarratana N; Adorini L. 2003. IL-12 Administration Accelerates Autoimmune Diabetes in Both Wild-Type and IFN-gamma-Deficient Nonobese Diabetic Mice, Revealing Pathogenic and Protective Effects of IL-12-Induced IFN-gamma. J Immunol 170(11):5491-501. PubMed: 12759426 MGI: J:83456
Trimnell A; Takagi A; Gupta M; Richie TL; Kappe SH; Wang R. 2009. Genetically attenuated parasite vaccines induce contact-dependent CD8+ T cell killing of Plasmodium yoelii liver stage-infected hepatocytes. J Immunol 183(9):5870-8. PubMed: 19812194 MGI: J:156626
Tsai S; Shameli A; Yamanouchi J; Clemente-Casares X; Wang J; Serra P; Yang Y; Medarova Z; Moore A; Santamaria P. 2010. Reversal of autoimmunity by boosting memory-like autoregulatory T cells. Immunity 32(4):568-80. PubMed: 20381385 MGI: J:179859
Tu CL; Crumrine DA; Man MQ; Chang W; Elalieh H; You M; Elias PM; Bikle DD. 2012. Ablation of the calcium-sensing receptor in keratinocytes impairs epidermal differentiation and barrier function. J Invest Dermatol 132(10):2350-9. PubMed: 22622426 MGI: J:189566
Tu E; Ang DK; Bellingham SA; Hogan TV; Teng MW; Smyth MJ; Hill AF; van Driel IR. 2012. Both IFN-gamma and IL-17 are required for the development of severe autoimmune gastritis. Eur J Immunol 42(10):2574-83. PubMed: 22777705 MGI: J:188007
Tu SP; Quante M; Bhagat G; Takaishi S; Cui G; Yang XD; Muthuplani S; Shibata W; Fox JG; Pritchard DM; Wang TC. 2011. IFN-{gamma} Inhibits Gastric Carcinogenesis by Inducing Epithelial Cell Autophagy and T-Cell Apoptosis. Cancer Res 71(12):4247-4259. PubMed: 21512143 MGI: J:173758
Tung J; Sant AJ. 2013. Orchestration of CD4 T cell epitope preferences after multipeptide immunization. J Immunol 191(2):764-72. PubMed: 23772029 MGI: J:204957
Turner J; Orme IM. 2004. The expression of early resistance to an infection with Mycobacterium tuberculosis by old mice is dependent on IFN type II (IFN-gamma) but not IFN type I. Mech Ageing Dev 125(1):1-9. PubMed: 14706232 MGI: J:121050
Turner SJ; Olivas E; Gutierrez A; Diaz G; Doherty PC. 2007. Disregulated influenza A virus-specific CD8+ T cell homeostasis in the absence of IFN-gamma signaling. J Immunol 178(12):7616-22. PubMed: 17548597 MGI: J:148590
Tzianabos AO; Holsti MA; Zheng XX; Stucchi AF; Kuchroo VK; Strom TB; Glimcher LH; Cruikshank WW. 2008. Functional Th1 cells are required for surgical adhesion formation in a murine model. J Immunol 180(10):6970-6. PubMed: 18453619 MGI: J:134863
Ueno K; Kinjo Y; Okubo Y; Aki K; Urai M; Kaneko Y; Shimizu K; Wang DN; Okawara A; Nara T; Ohkouchi K; Mizuguchi Y; Kawamoto S; Kamei K; Ohno H; Niki Y; Shibuya K; Miyazaki Y. 2015. Dendritic cell-based immunization ameliorates pulmonary infection with highly virulent Cryptococcus gattii. Infect Immun 83(4):1577-86. PubMed: 25644007 MGI: J:229647
Valaperti A; Marty RR; Kania G; Germano D; Mauermann N; Dirnhofer S; Leimenstoll B; Blyszczuk P; Dong C; Mueller C; Hunziker L; Eriksson U. 2008. CD11b+ monocytes abrogate Th17 CD4+ T cell-mediated experimental autoimmune myocarditis. J Immunol 180(4):2686-95. PubMed: 18250481 MGI: J:131968
Van Kaer L; Rabacal WA; Scott Algood HM; Parekh VV; Olivares-Villagomez D. 2013. In vitro induction of regulatory CD4+CD8alpha+ T cells by TGF-beta, IL-7 and IFN-gamma. PLoS One 8(7):e67821. PubMed: 23844100 MGI: J:204307
Van Uden JH; Tran CH; Carson DA; Raz E. 2001. Type I interferon is required to mount an adaptive response to immunostimulatory DNA. Eur J Immunol 31(11):3281-90. PubMed: 11745345 MGI: J:72586
VanLith ML; Kohlgraf KG; Sivinski CL; Tempero RM; Hollingsworth MA. 2002. MUC1-specific anti-tumor responses: molecular requirements for CD4-mediated responses. Int Immunol 14(8):873-82. PubMed: 12147624 MGI: J:113544
Verri WA Jr; Cunha TM; Ferreira SH; Wei X; Leung BP; Fraser A; McInnes IB; Liew FY; Cunha FQ. 2007. IL-15 mediates antigen-induced neutrophil migration by triggering IL-18 production. Eur J Immunol 37(12):3373-80. PubMed: 17979156 MGI: J:128427
Verri WA Jr; Cunha TM; Magro DA; Domingues AC; Vieira SM; Souza GR; Liew FY; Ferreira SH; Cunha FQ. 2008. Role of IL-18 in overt pain-like behaviour in mice. Eur J Pharmacol 588(2-3):207-12. PubMed: 18511039 MGI: J:145658
Verri WA Jr; Guerrero AT; Fukada SY; Valerio DA; Cunha TM; Xu D; Ferreira SH; Liew FY; Cunha FQ. 2008. IL-33 mediates antigen-induced cutaneous and articular hypernociception in mice. Proc Natl Acad Sci U S A 105(7):2723-8. PubMed: 18250323 MGI: J:131928
Villalta SA; Deng B; Rinaldi C; Wehling-Henricks M; Tidball JG. 2011. IFN-gamma promotes muscle damage in the mdx mouse model of Duchenne muscular dystrophy by suppressing M2 macrophage activation and inhibiting muscle cell proliferation. J Immunol 187(10):5419-28. PubMed: 22013114 MGI: J:179601
Villarino AV; Gallo E; Abbas AK. 2010. STAT1-activating cytokines limit Th17 responses through both T-bet-dependent and -independent mechanisms. J Immunol 185(11):6461-71. PubMed: 20974984 MGI: J:167369
Villegas-Mendez A; Greig R; Shaw TN; de Souza JB; Gwyer Findlay E; Stumhofer JS; Hafalla JC; Blount DG; Hunter CA; Riley EM; Couper KN. 2012. IFN-gamma-producing CD4+ T cells promote experimental cerebral malaria by modulating CD8+ T cell accumulation within the brain. J Immunol 189(2):968-79. PubMed: 22723523 MGI: J:189794
Villegas-Mendez A; de Souza JB; Murungi L; Hafalla JC; Shaw TN; Greig R; Riley EM; Couper KN. 2011. Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection. J Immunol 187(6):2885-97. PubMed: 21880980 MGI: J:179223
Von Herrath MG; Coon B; Oldstone MB. 1997. Low-affinity cytotoxic T-lymphocytes require IFN-gamma to clear an acute viral infection. Virology 229(2):349-59. PubMed: 9126248 MGI: J:127684
Wakil AE; Wang ZE; Ryan JC; Fowell DJ; Locksley RM. 1998. Interferon gamma derived from CD4(+) T cells is sufficient to mediate T helper cell type 1 development. J Exp Med 188(9):1651-6. PubMed: 9802977 MGI: J:50765
Wald O; Weiss ID; Wald H; Shoham H; Bar-Shavit Y; Beider K; Galun E; Weiss L; Flaishon L; Shachar I; Nagler A; Lu B; Gerard C; Gao JL; Mishani E; Farber J; Peled A. 2006. IFN-gamma acts on T cells to induce NK cell mobilization and accumulation in target organs. J Immunol 176(8):4716-29. PubMed: 16585565 MGI: J:131189
Walter MJ; Morton JD; Kajiwara N; Agapov E; Holtzman MJ. 2002. Viral induction of a chronic asthma phenotype and genetic segregation from the acute response. J Clin Invest 110(2):165-75. PubMed: 12122108 MGI: J:120696
Wang B; Xiong Q; Shi Q; Le X; Xie K. 2001. Genetic disruption of host interferon-gamma drastically enhances the metastasis of pancreatic adenocarcinoma through impaired expression of inducible nitric oxide synthase. Oncogene 20(47):6930-7. PubMed: 11687972 MGI: J:72687
Wang C; Xiao M; Liu X; Ni C; Liu J; Erben U; Qin Z. 2013. IFN-gamma-mediated downregulation of LXA4 is necessary for the maintenance of nonresolving inflammation and papilloma persistence. Cancer Res 73(6):1742-51. PubMed: 23319805 MGI: J:196903
Wang H; Asavaroengchai W; Yeap BY; Wang MG; Wang S; Sykes M; Yang YG. 2009. Paradoxical effects of IFN-gamma in graft-versus-host disease reflect promotion of lymphohematopoietic graft-versus-host reactions and inhibition of epithelial tissue injury. Blood 113(15):3612-9. PubMed: 19211507 MGI: J:148289
Wang J; Cho S; Ueno A; Cheng L; Xu BY; Desrosiers MD; Shi Y; Yang Y. 2008. Ligand-dependent induction of noninflammatory dendritic cells by anergic invariant NKT cells minimizes autoimmune inflammation. J Immunol 181(4):2438-45. PubMed: 18684934 MGI: J:140188
Wang L; Yi T; Zhang W; Pardoll DM; Yu H. 2010. IL-17 enhances tumor development in carcinogen-induced skin cancer. Cancer Res 70(24):10112-20. PubMed: 21159633 MGI: J:167606
Wang Q; Ma X; Chen Y; Zhang L; Jiang M; Li X; Xiang R; Miao R; Hajjar DP; Duan Y; Han J. 2014. Identification of interferon-gamma as a new molecular target of liver X receptor. Biochem J 459(2):345-54. PubMed: 24438183 MGI: J:212198
Wang S; Fan Y; Brunham RC; Yang X. 1999. IFN-gamma knockout mice show Th2-associated delayed-type hypersensitivity and the inflammatory cells fail to localize and control chlamydial infection. Eur J Immunol 29(11):3782-92. PubMed: 10556835 MGI: J:58372
Wang W; Milani M; Ostlie N; Okita D; Agarwal RK; Caspi RR; Conti-Fine BM. 2007. C57BL/6 mice genetically deficient in IL-12/IL-23 and IFN-gamma are susceptible to experimental autoimmune myasthenia gravis, suggesting a pathogenic role of non-Th1 cells. J Immunol 178(11):7072-80. PubMed: 17513756 MGI: J:143019
Wang Y; Lobigs M; Lee E; Koskinen A; Mullbacher A. 2006. CD8(+) T cell-mediated immune responses in West Nile virus (Sarafend strain) encephalitis are independent of gamma interferon. J Gen Virol 87(Pt 12):3599-609. PubMed: 17098975 MGI: J:135928
Wang Z; Hong J; Sun W; Xu G; Li N; Chen X; Liu A; Xu L; Sun B; Zhang JZ. 2006. Role of IFN-gamma in induction of Foxp3 and conversion of CD4+ CD25- T cells to CD4+ Tregs. J Clin Invest 116(9):2434-41. PubMed: 16906223 MGI: J:114448
Wang ZE; Reiner SL; Zheng S; Dalton DK; Locksley RM. 1994. CD4+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major. J Exp Med 179(4):1367-71. PubMed: 7908325 MGI: J:18801
Warfield KL; Olinger G; Deal EM; Swenson DL; Bailey M; Negley DL; Hart MK; Bavari S. 2005. Induction of humoral and CD8+ T cell responses are required for protection against lethal Ebola virus infection. J Immunol 175(2):1184-91. PubMed: 16002721 MGI: J:100701
Watt SV; Andrews DM; Takeda K; Smyth MJ; Hayakawa Y. 2008. IFN-gamma-dependent recruitment of mature CD27(high) NK cells to lymph nodes primed by dendritic cells. J Immunol 181(8):5323-30. PubMed: 18832688 MGI: J:140770
Weaver LK; Chu N; Behrens EM. 2016. TLR9-mediated inflammation drives a Ccr2-independent peripheral monocytosis through enhanced extramedullary monocytopoiesis. Proc Natl Acad Sci U S A 113(39):10944-9. PubMed: 27621476 MGI: J:238341
Weber SE; Tian H; Pirofski LA. 2011. CD8+ cells enhance resistance to pulmonary serotype 3 Streptococcus pneumoniae infection in mice. J Immunol 186(1):432-42. PubMed: 21135172 MGI: J:168003
Weiss JM; Back TC; Scarzello AJ; Subleski JJ; Hall VL; Stauffer JK; Chen X; Micic D; Alderson K; Murphy WJ; Wiltrout RH. 2009. Successful immunotherapy with IL-2/anti-CD40 induces the chemokine-mediated mitigation of an immunosuppressive tumor microenvironment. Proc Natl Acad Sci U S A 106(46):19455-60. PubMed: 19892741 MGI: J:154752
Wendel M; Galani IE; Suri-Payer E; Cerwenka A. 2008. Natural killer cell accumulation in tumors is dependent on IFN-gamma and CXCR3 ligands. Cancer Res 68(20):8437-45. PubMed: 18922917 MGI: J:140551
Wensky AK; Furtado GC; Marcondes MC; Chen S; Manfra D; Lira SA; Zagzag D; Lafaille JJ. 2005. IFN-gamma determines distinct clinical outcomes in autoimmune encephalomyelitis. J Immunol 174(3):1416-23. PubMed: 15661899 MGI: J:110017
Whitman SC; Ravisankar P; Daugherty A. 2002. Interleukin-18 enhances atherosclerosis in apolipoprotein E(-/-) mice through release of interferon-gamma. Circ Res 90(2):E34-8. PubMed: 11834721 MGI: J:109710
Whitmire JK; Benning N; Whitton JL. 2005. Cutting edge: early IFN-gamma signaling directly enhances primary antiviral CD4+ T cell responses. J Immunol 175(9):5624-8. PubMed: 16237051 MGI: J:119361
Whitmire JK; Eam B; Benning N; Whitton JL. 2007. Direct interferon-gamma signaling dramatically enhances CD4+ and CD8+ T cell memory. J Immunol 179(2):1190-7. PubMed: 17617612 MGI: J:149391
Wickstrum JR; Bokhari SM; Fischer JL; Pinson DM; Yeh HW; Horvat RT; Parmely MJ. 2009. Francisella tularensis induces extensive caspase-3 activation and apoptotic cell death in the tissues of infected mice. Infect Immun 77(11):4827-36. PubMed: 19703976 MGI: J:154196
Wieland CW; Florquin S; Pater JM; Weijer S; van der Poll T. 2006. CD4+ cells play a limited role in murine lung infection with Mycobacterium kansasii. Am J Respir Cell Mol Biol 34(2):167-73. PubMed: 16195537 MGI: J:120194
Wigginton JM; Lee JK; Wiltrout TA; Alvord WG; Hixon JA; Subleski J; Back TC; Wiltrout RH. 2002. Synergistic engagement of an ineffective endogenous anti-tumor immune response and induction of IFN-gamma and Fas-ligand-dependent tumor eradication by combined administration of IL-18 and IL-2. J Immunol 169(8):4467-74. PubMed: 12370382 MGI: J:109850
Wildbaum G; Zohar Y; Karin N. 2010. Antigen-specific CD25- Foxp3- IFN-gamma(high) CD4+ T cells restrain the development of experimental allergic encephalomyelitis by suppressing Th17. Am J Pathol 176(6):2764-75. PubMed: 20382706 MGI: J:161337
Williams DM; Grubbs BG; Pack E; Kelly K; Rank RG. 1997. Humoral and cellular immunity in secondary infection due to murine Chlamydia trachomatis. Infect Immun 65(7):2876-82. PubMed: 9199462 MGI: J:41109
Wilson ME; Recker TJ; Rodriguez NE; Young BM; Burnell KK; Streit JA; Kline JN. 2002. The TGF-beta response to Leishmania chagasi in the absence of IL-12. Eur J Immunol 32(12):3556-65. PubMed: 12516540 MGI: J:80857
Wilson MS; Madala SK; Ramalingam TR; Gochuico BR; Rosas IO; Cheever AW; Wynn TA. 2010. Bleomycin and IL-1beta-mediated pulmonary fibrosis is IL-17A dependent. J Exp Med 207(3):535-52. PubMed: 20176803 MGI: J:158818
Wohler JE; Smith SS; Zinn KR; Bullard DC; Barnum SR. 2009. Gammadelta T cells in EAE: early trafficking events and cytokine requirements. Eur J Immunol 39(6):1516-26. PubMed: 19384874 MGI: J:149481
Wohlleben G; Erb KJ. 2004. The absence of IFN-gamma leads to increased Th2 responses after influenza A virus infection characterized by an increase in CD4+ but not CD8+ T cells producing IL-4 or IL-5 in the lung. Immunol Lett 95(2):161-6. PubMed: 15388256 MGI: J:113759
Wolfe DN; Karanikas AT; Hester SE; Kennett MJ; Harvill ET. 2010. IL-10 induction by Bordetella parapertussis limits a protective IFN-gamma response. J Immunol 184(3):1392-400. PubMed: 20042578 MGI: J:159527
Wong N; Fam BC; Cempako GR; Steinberg GR; Walder K; Kay TW; Proietto J; Andrikopoulos S. 2011. Deficiency in Interferon-{gamma} Results in Reduced Body Weight and Better Glucose Tolerance in Mice. Endocrinology 152(10):3690-9. PubMed: 21791564 MGI: J:177070
Woodward EA; Prele CM; Nicholson SE; Kolesnik TB; Hart PH. 2010. The anti-inflammatory effects of interleukin-4 are not mediated by suppressor of cytokine signalling-1 (SOCS1). Immunology 131(1):118-27. PubMed: 20406299 MGI: J:166409
Woolard MD; Hodge LM; Jones HP; Schoeb TR; Simecka JW. 2004. The upper and lower respiratory tracts differ in their requirement of IFN-gamma and IL-4 in controlling respiratory mycoplasma infection and disease. J Immunol 172(11):6875-83. PubMed: 15153506 MGI: J:90522
Woolard MD; Hudig D; Tabor L; Ivey JA; Simecka JW. 2005. NK cells in gamma-interferon-deficient mice suppress lung innate immunity against Mycoplasma spp. Infect Immun 73(10):6742-51. PubMed: 16177352 MGI: J:104216
Wu HJ; Ivanov II; Darce J; Hattori K; Shima T; Umesaki Y; Littman DR; Benoist C; Mathis D. 2010. Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity 32(6):815-27. PubMed: 20620945 MGI: J:162394
Wu HJ; Sawaya H; Binstadt B; Brickelmaier M; Blasius A; Gorelik L; Mahmood U; Weissleder R; Carulli J; Benoist C; Mathis D. 2007. Inflammatory arthritis can be reined in by CpG-induced DC-NK cell cross talk. J Exp Med 204(8):1911-22. PubMed: 17646407 MGI: J:125952
Wu J; Yang J; Yang K; Wang H; Gorentla B; Shin J; Qiu Y; Que LG; Foster WM; Xia Z; Chi H; Zhong XP. 2014. iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions. J Clin Invest 124(4):1685-98. PubMed: 24614103 MGI: J:209612
Wu LL; Peng WH; Kuo WT; Huang CY; Ni YH; Lu KS; Turner JR; Yu LC. 2014. Commensal bacterial endocytosis in epithelial cells is dependent on myosin light chain kinase-activated brush border fanning by interferon-gamma. Am J Pathol 184(8):2260-74. PubMed: 24911373 MGI: J:213483
Wu X; Hou W; Sun S; Bi E; Wang Y; Shi M; Zang J; Dong C; Sun B. 2006. Novel function of IFN-gamma: negative regulation of dendritic cell migration and T cell priming. J Immunol 177(2):934-43. PubMed: 16818748 MGI: J:134949
Wuthrich M; Filutowicz HI; Warner T; Klein BS. 2002. Requisite elements in vaccine immunity to Blastomyces dermatitidis: plasticity uncovers vaccine potential in immune-deficient hosts. J Immunol 169(12):6969-76. PubMed: 12471131 MGI: J:118419
Wuthrich M; Gern B; Hung CY; Ersland K; Rocco N; Pick-Jacobs J; Galles K; Filutowicz H; Warner T; Evans M; Cole G; Klein B. 2011. Vaccine-induced protection against 3 systemic mycoses endemic to North America requires Th17 cells in mice. J Clin Invest 121(2):554-68. PubMed: 21206087 MGI: J:171835
Xia S; Guo Z; Xu X; Yi H; Wang Q; Cao X. 2008. Hepatic microenvironment programs hematopoietic progenitor differentiation into regulatory dendritic cells, maintaining liver tolerance. Blood 112(8):3175-85. PubMed: 18669892 MGI: J:140215
Xia S; Guo Z; Yao Y; Xu X; Yi H; Xia D; Cao X. 2008. Liver stroma enhances activation of TLR3-triggered NK cells through fibronectin. Mol Immunol 45(10):2831-8. PubMed: 18384880 MGI: J:134496
Xu S; Han Y; Xu X; Bao Y; Zhang M; Cao X. 2010. IL-17A-producing gammadeltaT cells promote CTL responses against Listeria monocytogenes infection by enhancing dendritic cell cross-presentation. J Immunol 185(10):5879-87. PubMed: 20956351 MGI: J:165775
Xu X; Yi H; Guo Z; Qian C; Xia S; Yao Y; Cao X. 2012. Splenic stroma-educated regulatory dendritic cells induce apoptosis of activated CD4 T cells via Fas ligand-enhanced IFN-gamma and nitric oxide. J Immunol 188(3):1168-77. PubMed: 22205032 MGI: J:180753
Yamada J; Hamuro J; Fukushima A; Ohteki T; Terai K; Iwakura Y; Yagita H; Kinoshita S. 2009. MHC-matched corneal allograft rejection in an IFN-gamma/IL-17-independent manner in C57BL/6 mice. Invest Ophthalmol Vis Sci 50(5):2139-46. PubMed: 19136699 MGI: J:151042
Yamada M; Kubo H; Kobayashi S; Ishizawa K; Sasaki H. 2004. Interferon-gamma: a key contributor to hyperoxia-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol 287(5):L1042-7. PubMed: 15257986 MGI: J:108148
Yan Y; Zhang GX; Gran B; Fallarino F; Yu S; Li H; Cullimore ML; Rostami A; Xu H. 2010. IDO Upregulates Regulatory T Cells via Tryptophan Catabolite and Suppresses Encephalitogenic T Cell Responses in Experimental Autoimmune Encephalomyelitis. J Immunol 185(10):5953-61. PubMed: 20944000 MGI: J:165630
Yang CY; Leung PS; Yang GX; Kenny TP; Zhang W; Coppel R; Norman GL; Ansari AA; Mackay IR; Worman HJ; Gershwin ME. 2012. Epitope-specific anti-nuclear antibodies are expressed in a mouse model of primary biliary cirrhosis and are cytokine-dependent. Clin Exp Immunol 168(3):261-7. PubMed: 22519587 MGI: J:184866
Yang MC; Chang CP; Lei HY. 2010. Endothelial cells are damaged by autophagic induction before hepatocytes in Con A-induced acute hepatitis. Int Immunol 22(8):661-70. PubMed: 20547544 MGI: J:162090
Yang PL; Althage A; Chung J; Maier H; Wieland S; Isogawa M; Chisari FV. 2010. Immune effectors required for hepatitis B virus clearance. Proc Natl Acad Sci U S A 107(2):798-802. PubMed: 20080755 MGI: J:156523
Yang T; Stark P; Janik K; Wigzell H; Rottenberg ME. 2008. SOCS-1 Protects against Chlamydia pneumoniae-Induced Lethal Inflammation but Hampers Effective Bacterial Clearance. J Immunol 180(6):4040-9. PubMed: 18322213 MGI: J:132932
Yang W; Yao Y; Yang YQ; Lu FT; Li L; Wang YH; Nakajima T; Tsuneyama K; Ridgway WM; Gershwin ME; Lian ZX. 2014. Differential modulation by IL-17A of Cholangitis versus Colitis in IL-2Ralpha deleted mice. PLoS One 9(8):e105351. PubMed: 25133396 MGI: J:223143
Yang Y; Ochando JC; Bromberg JS; Ding Y. 2007. Identification of a distant T-bet enhancer responsive to IL-12/Stat4 and IFNgamma/Stat1 signals. Blood 110(7):2494-500. PubMed: 17575072 MGI: J:147019
Yang Y; Weiner J; Liu Y; Smith AJ; Huss DJ; Winger R; Peng H; Cravens PD; Racke MK; Lovett-Racke AE. 2009. T-bet is essential for encephalitogenicity of both Th1 and Th17 cells. J Exp Med 206(7):1549-64. PubMed: 19546248 MGI: J:150271
Ye P; Chen W; Wu J; Huang X; Li J; Wang S; Liu Z; Wang G; Yang X; Zhang P; Lv Q; Xia J. 2013. GM-CSF contributes to aortic aneurysms resulting from SMAD3 deficiency. J Clin Invest 123(5):2317-31. PubMed: 23585475 MGI: J:201455
Yeganeh M; Gui Y; Kandhi R; Bobbala D; Tobelaim WS; Saucier C; Yoshimura A; Ferbeyre G; Ramanathan S; Ilangumaran S. 2016. Suppressor of cytokine signaling 1-dependent regulation of the expression and oncogenic functions of p21 in the liver. Oncogene :. PubMed: 26725321 MGI: J:227978
Yeh WI; McWilliams IL; Harrington LE. 2011. Autoreactive Tbet-positive CD4 T cells develop independent of classic Th1 cytokine signaling during experimental autoimmune encephalomyelitis. J Immunol 187(10):4998-5006. PubMed: 21984703 MGI: J:179641
Yi T; Chen Y; Wang L; Du G; Huang D; Zhao D; Johnston H; Young J; Todorov I; Umetsu DT; Chen L; Iwakura Y; Kandeel F; Forman S; Zeng D. 2009. Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease. Blood 114(14):3101-12. PubMed: 19602708 MGI: J:153264
Yilmaz G; Arumugam TV; Stokes KY; Granger DN. 2006. Role of T lymphocytes and interferon-gamma in ischemic stroke. Circulation 113(17):2105-12. PubMed: 16636173 MGI: J:122450
Yokota N; Burne-Taney M; Racusen L; Rabb H. 2003. Contrasting roles for STAT4 and STAT6 signal transduction pathways in murine renal ischemia-reperfusion injury. Am J Physiol Renal Physiol 285(2):F319-25. PubMed: 12709397 MGI: J:84825
Yu M; Eckart MR; Morgan AA; Mukai K; Butte AJ; Tsai M; Galli SJ. 2011. Identification of an IFN-gamma/mast cell axis in a mouse model of chronic asthma. J Clin Invest 121(8):3133-43. PubMed: 21737883 MGI: J:176170
Yu Q; Park JH; Doan LL; Erman B; Feigenbaum L; Singer A. 2006. Cytokine signal transduction is suppressed in preselection double-positive thymocytes and restored by positive selection. J Exp Med 203(1):165-75. PubMed: 16390939 MGI: J:118814
Yu Q; Xu M; Sen JM. 2007. Beta-catenin expression enhances IL-7 receptor signaling in thymocytes during positive selection. J Immunol 179(1):126-31. PubMed: 17579030 MGI: J:149422
Yu S; Sharp GC; Braley-Mullen H. 2006. Thyrocytes responding to IFN-gamma are essential for development of lymphocytic spontaneous autoimmune thyroiditis and inhibition of thyrocyte hyperplasia. J Immunol 176(2):1259-65. PubMed: 16394017 MGI: J:126438
Yu S; Sharp GC; Braley-Mullen H. 2008. TGF-beta promotes thyroid epithelial cell hyperplasia and fibrosis in IFN-gamma-deficient NOD.H-2h4 mice. J Immunol 181(3):2238-45. PubMed: 18641364 MGI: J:139224
Yu S; Sharp GC; Braley-Mullen H. 2006. Thyroid epithelial cell hyperplasia in IFN-gamma deficient NOD.H-2h4 mice. Clin Immunol 118(1):92-100. PubMed: 16150647 MGI: J:107231
Zand MS; Li Y; Hancock W; Li XC; Roy-Chaudhury P; Zheng XX; Strom TB. 2000. Interleukin-2 and interferon-gamma double knockout mice reject heterotopic cardiac allografts Transplantation 70(9):1378-81. PubMed: 11087156 MGI: J:65781
Zehntner SP; Brickman C; Bourbonniere L; Remington L; Caruso M; Owens T. 2005. Neutrophils that infiltrate the central nervous system regulate T cell responses. J Immunol 174(8):5124-31. PubMed: 15814744 MGI: J:98148
Zelante T; De Luca A; Bonifazi P; Montagnoli C; Bozza S; Moretti S; Belladonna ML; Vacca C; Conte C; Mosci P; Bistoni F; Puccetti P; Kastelein RA; Kopf M; Romani L. 2007. IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance. Eur J Immunol 37(10):2695-706. PubMed: 17899546 MGI: J:125340
Zeng H; Yang K; Cloer C; Neale G; Vogel P; Chi H. 2013. mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function. Nature 499(7459):485-90. PubMed: 23812589 MGI: J:204754
Zeng X; Moore TA; Newstead MW; Deng JC; Kunkel SL; Luster AD; Standiford TJ. 2005. Interferon-inducible protein 10, but not monokine induced by gamma interferon, promotes protective type 1 immunity in murine Klebsiella pneumoniae pneumonia. Infect Immun 73(12):8226-36. PubMed: 16299319 MGI: J:104304
Zeng XL; Nagavalli A; Smith CJ; Howard JF; Su MA. 2013. Divergent effects of T cell costimulation and inflammatory cytokine production on autoimmune peripheral neuropathy provoked by aire deficiency. J Immunol 190(8):3895-904. PubMed: 23487421 MGI: J:194890
Zhang C; Feng Y; Yang H; Koga H; Teitelbaum DH. 2009. The bone morphogenetic protein signaling pathway is upregulated in a mouse model of total parenteral nutrition. J Nutr 139(7):1315-21. PubMed: 19498022 MGI: J:150055
Zhang H; Zhang F; Zhu Z; Luong D; Meadows GG. 2015. Chronic alcohol consumption enhances iNKT cell maturation and activation. Toxicol Appl Pharmacol 282(2):139-50. PubMed: 25499027 MGI: J:219212
Zhang J; Alcaide P; Liu L; Sun J; He A; Luscinskas FW; Shi GP. 2011. Regulation of endothelial cell adhesion molecule expression by mast cells, macrophages, and neutrophils. PLoS One 6(1):e14525. PubMed: 21264293 MGI: J:169463
Zhang JG; Metcalf D; Rakar S; Asimakis M; Greenhalgh CJ; Willson TA; Starr R; Nicholson SE; Carter W; Alexander WS; Hilton DJ; Nicola NA. 2001. The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action invivo. Proc Natl Acad Sci U S A 98(23):13261-5. PubMed: 11606785 MGI: J:72528
Zhang T; Sentman CL. 2013. Mouse Tumor Vasculature Expresses NKG2D Ligands and Can Be Targeted by Chimeric NKG2D-Modified T Cells. J Immunol 190(5):2455-63. PubMed: 23355740 MGI: J:193469
Zhang X; Chen W; De Paiva CS; Corrales RM; Volpe EA; McClellan AJ; Farley WJ; Li DQ; Pflugfelder SC. 2011. Interferon-gamma exacerbates dry eye-induced apoptosis in conjunctiva through dual apoptotic pathways. Invest Ophthalmol Vis Sci 52(9):6279-85. PubMed: 21474767 MGI: J:181423
Zhang X; Chen W; De Paiva CS; Volpe EA; Gandhi NB; Farley WJ; Li DQ; Niederkorn JY; Stern ME; Pflugfelder SC. 2011. Desiccating Stress Induces CD4(+) T-Cell-Mediated Sjogren's Syndrome-Like Corneal Epithelial Apoptosis via Activation of the Extrinsic Apoptotic Pathway by Interferon-gamma. Am J Pathol 179(4):1807-14. PubMed: 21843497 MGI: J:176297
Zhang Y; Jones M; McCabe A; Winslow GM; Avram D; Macnamara KC. 2013. MyD88 Signaling in CD4 T Cells Promotes IFN-gamma Production and Hematopoietic Progenitor Cell Expansion in Response to Intracellular Bacterial Infection. J Immunol 190(9):4725-35. PubMed: 23526822 MGI: J:195524
Zhou HF; Yan H; Cannon JL; Springer LE; Green JM; Pham CT. 2013. CD43-mediated IFN-gamma production by CD8+ T cells promotes abdominal aortic aneurysm in mice. J Immunol 190(10):5078-85. PubMed: 23585675 MGI: J:202563
Zhou P; Miller G; Seder RA. 1998. Factors involved in regulating primary and secondary immunity to infection with Histoplasma capsulatum: TNF-alpha plays a critical role in maintaining secondary immunity in the absence of IFN-gamma. J Immunol 160(3):1359-68. PubMed: 9570555 MGI: J:123438
Zhou Q; Gault RA; Kozel TR; Murphy WJ. 2006. Immunomodulation with CD40 stimulation and interleukin-2 protects mice from disseminated cryptococcosis. Infect Immun 74(4):2161-8. PubMed: 16552046 MGI: J:107399
Zhou S; Kurt-Jones EA; Cerny AM; Chan M; Bronson RT; Finberg RW. 2009. MyD88 intrinsically regulates CD4 T-cell responses. J Virol 83(4):1625-34. PubMed: 19052080 MGI: J:153385
Zhu B; Bando Y; Xiao S; Yang K; Anderson AC; Kuchroo VK; Khoury SJ. 2007. CD11b+Ly-6C(hi) suppressive monocytes in experimental autoimmune encephalomyelitis. J Immunol 179(8):5228-37. PubMed: 17911608 MGI: J:153031
Zhu PJ; Huang W; Kalikulov D; Yoo JW; Placzek AN; Stoica L; Zhou H; Bell JC; Friedlander MJ; Krnjevic K; Noebels JL; Costa-Mattioli M. 2011. Suppression of PKR Promotes Network Excitability and Enhanced Cognition by Interferon-gamma-Mediated Disinhibition. Cell 147(6):1384-96. PubMed: 22153080 MGI: J:178915
Zhu Q; Thomson CW; Rosenthal KL; McDermott MR; Collins SM; Gauldie J. 2008. Immunization with adenovirus at the large intestinal mucosa as an effective vaccination strategy against sexually transmitted viral infection. Mucosal Immunol 1(1):78-88. PubMed: 19079163 MGI: J:191928
Zhu Y; Zhu G; Luo L; Flies AS; Chen L. 2007. CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype. Blood 109(11):4882-9. PubMed: 17244673 MGI: J:145439
Zilocchi C; Stoppacciaro A; Chiodoni C; Parenza M; Terrazzini N; Colombo MP. 1998. Interferon gamma-independent rejection of interleukin 12-transduced carcinoma cells requires CD4+ T cells and Granulocyte/Macrophage colony-stimulating factor. J Exp Med 188(1):133-43. PubMed: 9653090 MGI: J:115144
Zimmerer JM; Lesinski GB; Kondadasula SV; Karpa VI; Lehman A; Raychaudhury A; Becknell B; Carson WE 3rd. 2007. IFN-alpha-induced signal transduction, gene expression, and antitumor activity of immune effector cells are negatively regulated by suppressor of cytokine signaling proteins. J Immunol 178(8):4832-45. PubMed: 17404264 MGI: J:145200
Zimmerer JM; Pham TA; Sanders VM; Bumgardner GL. 2010. CD8+ T cells negatively regulate IL-4-dependent, IgG1-dominant posttransplant alloantibody production. J Immunol 185(12):7285-92. PubMed: 21084663 MGI: J:167458
Zinselmeyer BH; Heydari S; Sacristan C; Nayak D; Cammer M; Herz J; Cheng X; Davis SJ; Dustin ML; McGavern DB. 2013. PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis. J Exp Med 210(4):757-74. PubMed: 23530125 MGI: J:198217
Zoller EE; Lykens JE; Terrell CE; Aliberti J; Filipovich AH; Henson PM; Jordan MB. 2011. Hemophagocytosis causes a consumptive anemia of inflammation. J Exp Med 208(6):1203-14. PubMed: 21624938 MGI: J:176823
van Den Broek M; Bachmann MF; Kohler G; Barner M; Escher R; Zinkernagel R; Kopf M. 2000. IL-4 and IL-10 antagonize IL-12-mediated protection against acute vaccinia virus infection with a limited role of IFN-gamma and nitric oxide synthetase 2. J Immunol 164(1):371-8. PubMed: 10605032 MGI: J:125984
van Schaik SM; Abbas AK. 2007. Role of T cells in a murine model of Escherichia coli sepsis. Eur J Immunol 37(11):3101-10. PubMed: 17948264 MGI: J:126313

Donating Investigator

Genetic overview

Research Applications

Base Price

Detailed Description

Development

Control Suggestions

Additional Information

Selected References

Ifngtm1Ts

Allele Symbol: Ifngtm1Ts

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Ifngtm1Ts related

Mammalian Phenotype Terms by Genotype

Genotype: Ifngtm1Ts/Ifngtm1Tsinvolves: 129S7/SvEvBrd * C57BL/6

growth/size/body region phenotype

immune system phenotype

neoplasm

craniofacial phenotype

skeleton phenotype

hematopoietic system phenotype

integument phenotype

cellular phenotype

mortality/aging

Genotype: Ifngtm1Ts/Ifngtm1Tsinvolves: 129S7/SvEvBrd * BALB/c

immune system phenotype

respiratory system phenotype

hematopoietic system phenotype

Genotype: Ifngtm1Ts/Ifngtm1Tsinvolves: 129S7/SvEvBrd * A/WySn * C57BL/10SnSg * Swiss

immune system phenotype

homeostasis/metabolism phenotype

hematopoietic system phenotype

Genotype: Ifngtm1Ts/Ifngtm1Tsinvolves: 129S7/SvEvBrd * NOD

immune system phenotype

Genotype: Ifngtm1Ts/Ifngtm1TsB6.129S7-Ifngtm1Ts/J

mortality/aging

immune system phenotype

behavior/neurological phenotype

cellular phenotype

renal/urinary system phenotype

homeostasis/metabolism phenotype

muscle phenotype

digestive/alimentary phenotype

hematopoietic system phenotype

Genotype: Ifngtm1Ts/Ifngtm1Tsinvolves: 129S7/SvEvBrd * C57BL/6J

mortality/aging

immune system phenotype

Genotype: Ifngtm1Ts/Ifngtm1TsC.129S7(B6)-Ifngtm1Ts/J

mortality/aging

immune system phenotype

behavior/neurological phenotype

neoplasm

reproductive system phenotype

homeostasis/metabolism phenotype

embryo phenotype

hematopoietic system phenotype

endocrine/exocrine gland phenotype

Genotype: Ifngtm1Ts/Ifngtm1TsC.129S7-Ifngtm1Ts

respiratory system phenotype

mortality/aging

immune system phenotype

neoplasm

hematopoietic system phenotype

Genotype: Ifngtm1Ts/Ifngtm1Tsinvolves: 129S7/SvEvBrd

mortality/aging

immune system phenotype

vision/eye phenotype

homeostasis/metabolism phenotype

cardiovascular system phenotype

hematopoietic system phenotype

Genotype: Ifngtm1Ts/Ifngtm1TsB6.129S7-Ifngtm1Ts

endocrine/exocrine gland phenotype

mortality/aging

neoplasm

immune system phenotype

hematopoietic system phenotype

References

Additional - Ifngtm1Ts related

Ifng^tm1Ts

Allele Symbol: Ifng^tm1Ts

Genotype: Ifng^tm1Ts related

Genotype: Ifng^tm1Ts/Ifng^tm1Ts
involves: 129S7/SvEvBrd * C57BL/6

Genotype: Ifng^tm1Ts/Ifng^tm1Ts
involves: 129S7/SvEvBrd * BALB/c

Genotype: Ifng^tm1Ts/Ifng^tm1Ts
involves: 129S7/SvEvBrd * A/WySn * C57BL/10SnSg * Swiss

Genotype: Ifng^tm1Ts/Ifng^tm1Ts
involves: 129S7/SvEvBrd * NOD

Genotype: Ifng^tm1Ts/Ifng^tm1Ts
B6.129S7-Ifng^tm1Ts/J

Genotype: Ifng^tm1Ts/Ifng^tm1Ts
involves: 129S7/SvEvBrd * C57BL/6J

Genotype: Ifng^tm1Ts/Ifng^tm1Ts
C.129S7(B6)-Ifng^tm1Ts/J

Genotype: Ifng^tm1Ts/Ifng^tm1Ts
C.129S7-Ifng^tm1Ts

Genotype: Ifng^tm1Ts/Ifng^tm1Ts
involves: 129S7/SvEvBrd

Genotype: Ifng^tm1Ts/Ifng^tm1Ts
B6.129S7-Ifng^tm1Ts

Additional - Ifng^tm1Ts related