The A30P mutation in this transgenic strain is associated with the development of familial Parkinson's disease. The onset of hind limb mobility problems occurs around 12 months of age (sometimes earlier), induced by a loss of motor neurons and associated with the formation of insoluble alpha synuclein aggregates. This strain may be useful in studies of Parkinson's disease.
Dr. Thomas C. Sudhof, Stanford University School of Medicine
Genetic Background | Generation |
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Allele Type |
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Transgenic (Inserted expressed sequence, Humanized sequence) |
The A30P mutation in this transgenic strain is associated with the development of familial Parkinson's disease. The onset of hind limb mobility problems occurs around 12 months of age (sometimes earlier), induced by a loss of motor neurons and associated with the formation of insoluble alpha synuclein aggregates. This strain may be useful in studies of Parkinson's disease. Hemizygous mice are viable and fertile.
This transgenic strain carries the human A30P mutant SNCA (synuclein, alpha) gene under the control of a human THY1 (thymus cell antigen 1, theta) promoter. The transgenic vector was injected into B6SJLF1/J embryos. mice from founder line TS2 were reportedly backcrossed to C57BL/6 for approximately ten generations prior to sending to The Jackson Laboratory Repository. However, a 27 SNP (single nucleotide polymorphism) panel analysis performed on mutant mice rederived by The Jackson Laboratory Repository revealed that 3/27 loci are still segregating for SJL background alleles. This suggests that line TS2 was only backcrossed a few generations before arriving, and the mice are still on a mixed B6;SJL mixed genetic background.
Expressed Gene | SNCA, synuclein alpha, human |
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Site of Expression |
Allele Name | transgene insertion TS2, Thomas C Sudhof |
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Allele Type | Transgenic (Inserted expressed sequence, Humanized sequence) |
Allele Synonym(s) | TS2 |
Gene Symbol and Name | Tg(THY1-SNCA*A30P)TS2Sud, transgene insertion TS2, Thomas C Sudhof |
Gene Synonym(s) | |
Promoter | THY1, Thy-1 cell surface antigen, human |
Expressed Gene | SNCA, synuclein alpha, human |
Strain of Origin | (C57BL/6J x SJL/J)F1 |
Chromosome | UN |
Molecular Note | The transgene construct contains the human A30P mutant SNCA (synuclein, alpha) gene under the control of a human THY1 (thymus cell antigen 1, theta) promoter. |
When maintained as a live colony, hemizygotes may be bred with wildtype (noncarrier) or B6SJLF1/J hybrid mice (Stock No. 100012)
When using the TS2, UTSD#1910 mouse strain in a publication, please cite the originating article(s) and include JAX stock #008134 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Hemizygous or Non carrier for Tg(THY1-SNCA*A30P)TS2Sud |
Frozen Mouse Embryo | B6;SJL-Tg(THY1-SNCA*A30P)TS2Sud/J Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | B6;SJL-Tg(THY1-SNCA*A30P)TS2Sud/J Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | B6;SJL-Tg(THY1-SNCA*A30P)TS2Sud/J Frozen Embryo | $3373.50 |
Frozen Mouse Embryo | B6;SJL-Tg(THY1-SNCA*A30P)TS2Sud/J Frozen Embryo | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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