Hemizygous animals are fertile, viable, and grossly normal in physical appearance and behavior.  The transgene product is expressed in excitatory neurons of the postnatal forebrain.  There is an increase in active protein, detected biochemically.  Immunohistochemistry and immunoblotting show expression in mouse forebrain (including the hippocampus, cortex, thalamus, striatum, and amygdala).  These mice display reduced extracellular regulated kinase (ERK) signaling, and have smaller and fewer dendritic spines.  Behaviorally, these mice exhibit impaired spatial learning and fear extinction, making them a potentially useful animal model of psychiatric diseases such as major depressive disorder and post-traumatic stress disorder (PTSD). 

These mice display reduced extracellular regulated kinase (ERK) signaling, and have smaller and fewer dendritic spines. Behaviorally, these mice exhibit impaired spatial learning and fear extinction, making them a potentially useful animal model of psychiatric diseases such as major depressive disorder and post-traumatic stress disorder (PTSD).

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

<a target="_blank" href="https://www.jax.org/jax-mice-and-services/customer-support" rel="noreferrer">Contact Customer Service</a> for more information.