This NOD congenic strain may be useful to identify candidate genes on Chromosome 4 associated with diabetes resistance and to identify genes with common roots in multiple autoimmune diseases.
Marcia McDuffie, Univ. of Virginia Dept. of Medicine
Genetic Background | Generation |
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001976 NOD/ShiLtJ |
|
Marker Symbol | Marker Name | |
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D4Mit59 | DNA segment, Chr 4, Massachusetts Institute of Technology 59 | |
D4Mit76 | DNA segment, Chr 4, Massachusetts Institute of Technology 76 |
This NOD congenic strain, commonly referred to as NOD.Zc4c carries Chromosome 4 alleles, D4Mit76 (120Mb) through D4Mit59 (154Mb) derived from NZM2328. Diabetes incidence in this diabetes/lupus resistant strain is reported to be 7% in females and 0 for males compared to 70% in female and 40% in male NOD/Bdc control mice.
This strain is useful for identifying candidate genes associated with diabetes resistance and to identify genes with common roots in multiple autoimmune diseases.
This NOD congenic stock (NOD.Zc4c) contains a genomic segment from NZM2328 introgressed into Chr 4. NOD.Zc4c was developed from the consomic Stock No. 008064 through backcrossing to NOD once and selective breeding and contains NZM2328 derived congenic interval D4Mit76 through D4Mit59. In 2008, the Type 1 Diabetes Resource received this stock at N5F7.
When using the NOD.Z4c mouse strain in a publication, please cite the originating article(s) and include JAX stock #008065 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Homozygous for (D4Mit76-D4Mit59), 1 pair minimum |
Frozen Mouse Embryo | NOD.NZM2328-(D4Mit76-D4Mit59)/McdfJ Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | NOD.NZM2328-(D4Mit76-D4Mit59)/McdfJ Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | NOD.NZM2328-(D4Mit76-D4Mit59)/McdfJ Frozen Embryos | $3373.50 |
Frozen Mouse Embryo | NOD.NZM2328-(D4Mit76-D4Mit59)/McdfJ Frozen Embryos | $3373.50 |
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