NOD.NZM2328-(D4Mit76-D4Mit59)/McdfJ

Stock number: 008065
Product name: NOD.Z4c
Strain synonyms: NOD.Zc4c
Research areas: Diabetes and Obesity Research, Immunology, Inflammation and Autoimmunity Research, Research Tools

Description

This NOD congenic strain may be useful to identify candidate genes on Chromosome 4 associated with diabetes resistance and to identify genes with common roots in multiple autoimmune diseases.

Detailed description

This NOD congenic strain, commonly referred to as NOD.Zc4c carries Chromosome 4 alleles, D4Mit76 (120Mb) through D4Mit59 (154Mb) derived from NZM2328. Diabetes incidence in this diabetes/lupus resistant strain is reported to be 7% in females and 0 for males compared to 70% in female and 40% in male NOD/Bdc control mice.

This strain is useful for identifying candidate genes associated with diabetes resistance and to identify genes with common roots in multiple autoimmune diseases.

Development

This NOD congenic stock (NOD.Zc4c) contains a genomic segment from NZM2328 introgressed into Chr 4. NOD.Zc4c was developed from the consomic Stock No. 008064 through backcrossing to NOD once and selective breeding and contains NZM2328 derived congenic interval D4Mit76 through D4Mit59. In 2008, the Type 1 Diabetes Resource received this stock at N5F7.

Allele

MGI accession ID: MGI:92912
Marker symbol: D4Mit76
Marker name: DNA segment, Chr 4, Massachusetts Institute of Technology 76
Chromosome: 4

Allele

MGI accession ID: MGI:92893
Marker symbol: D4Mit59
Marker name: DNA segment, Chr 4, Massachusetts Institute of Technology 59
Chromosome: 4