This NOD congenic strain may be useful to identify candidate genes on Chromosome 17 associated with diabetes resistance and to identify genes with common roots in multiple autoimmune diseases.
Marcia McDuffie, Univ. of Virginia Dept. of Medicine
This NOD consomic strain, commonly referred to as NOD.Zc17 carries Chromosome 17 alleles, D17Mit164 (38Mb) through D17Mit73 (79Mb) derived from NZM2328. Diabetes incidence in this diabetes/lupus resistant strain is reported to be 0 in both females and males compared to 70% in female and 40% in male NOD/Bdc control mice. This strain will be useful to identify candidate genes associated with diabetes resistance and to identify genes with common roots in multiple autoimmune diseases.
This NOD consomic stock contains Chromosome 17 derived from NZM2328, a lupus nephritis susceptible strain. Donating investigator reports (NZM2328 X NOD) F2 females homozygous for NOD derived H2g7, MHC class I K and MHC class II- I AB alleles were selected for backcrossing to NOD/Bdc. This diabetes resistant line was analyzed using microsatellite markers. Microsatellite marker analysis identified D17Mit164 (38Mb) through D17Mit73 (79Mb) to be of NZM2328 origin. In 2008, the Type 1 Diabetes Resource received this stock at N4F21.
Currently there are no related genes or alleles for this strain.