NOD.L-(D11Mit314-D11Mit339)(D11Mit325-D11Mit42)/McdfJ

Stock number: 008059
Product name: NOD.Lc11i or DR3i
Strain synonyms: NOD.DR3i, NOD.Lc11i
Research areas: Diabetes and Obesity Research, Immunology, Inflammation and Autoimmunity Research, Research Tools

Description

Stock No.'s 008053, 008054, 008055, 008056, 008057, 008058, 008059 and 008060, are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD/Bdc background. These strains experience significantly reduced diabetes and are useful for identifying candidate genes within the Idd4 subloci.

Detailed description

This NOD congenic strain, commonly referred to as NOD.Lc11i or DR3i, carries two C57L/J derived congenic intervals on Chromosome 11, D11Mit314 (51Mb) through D11Mit339 (63Mb) and D11Mit325 ((86Mb) through D11Mit42 (112Mb) that encodes C57L/J derived Csf2 and Stat5a, Stat5b, Stat3. The donating investigator reports diabetes incidence in females to be 4% compared to 70% in NOD control mice (Davoodi-Semiromi et al. 2007).

This strain is useful to further study the roles of Csf2 and Stat5a, Stat5b, Stat3 in autoimmune diabetes.

Development

This NOD congenic stock (NOD.Lc11i, DR3i) contains a genomic segment from C57L/J introgressed into Chromosome 11. Seven additional stocks (Stock No's 008054, 008055, 008056, 008057, 008058, 008059, and 008060) were developed from Stock No. 008053 through backcrossing to NOD once followed by selective breeding. This model, Stock No. 008059, is a double congenic containing C57L/J congenic intervals D11Mit314 (51Mb) through D11Mit339 (63Mb) and D11Mit325 (99Mb) through DllMit42 (113Mb) encoding C57L/J derived Csf2 and from the Idd4.1 and Idd4.2 overlap through Stat5a/Stat5b/Stat3 alleles. In 2008, the Type 1 Diabetes Resource received this stock at N6F7.

Allele

MGI accession ID: MGI:102283
Marker symbol: D11Mit339
Marker name: DNA Segment, Chr 11, Massachusetts Institute of Technology 339
Chromosome: 11

Allele

MGI accession ID: MGI:96406
Marker symbol: Idd4
Marker name: insulin dependent diabetes susceptibility 4
Chromosome: 11

Allele

MGI accession ID: MGI:89126
Marker symbol: D11Mit42
Marker name: DNA segment, Chr 11, Massachusetts Institute of Technology 42
Chromosome: 11

Allele

MGI accession ID: MGI:102279
Marker symbol: D11Mit314
Marker name: DNA Segment, Chr 11, Massachusetts Institute of Technology 314
Chromosome: 11

Allele

MGI accession ID: MGI:102292
Marker symbol: D11Mit325
Marker name: DNA Segment, Chr 11, Massachusetts Institute of Technology 325
Chromosome: 11