This transgene encodes the full coding sequence of Olfr16 with an IRES-tauGFP just after the stop codon resulting in bicistronic expression. This coding sequence is under the control of 9 equally spaced repeats of the HD binding sequence and the 405 base pairs of regulatory sequence just upstream of the Olfr16 transcription start site. A massive increase is found in the number of cells that express this olfactory receptor, relative to the endogenous expression pattern, but the pattern of expression remains predominantly in the dorsal main olfactory epithelium, with some transgenic lines having additional narrow ventral domain expression.

The inserted transgene in these mice contains the HD binding sequence upstream of the Olfr16 transcription start site that results in a massive increase of olfactory receptor cells with this olfactory receptor.

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