These mice carry a transgene that encodes tau-linked-LacZ under the control of a minimal promoter upstream of the Olfr713 transcription start site. LacZ is expressed in place of any olfactory receptor sequence.
Peter Mombaerts, Max Planck Research Unit for Neurogenetics
Genetic Background | Generation |
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Allele Type |
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Transgenic (Reporter) |
This transgene encodes tau-linked-LacZ under the control of a minimal promoter comprised of 143 base pairs upstream of the Olfr713 transcription start site and 163 base pairs of the 5' nontranslated exon 1. It does not drive expression of any olfactory receptor sequence. It is useful in mapping promoter elements important for olfactory receptor expression and the related olfactory sensory neuron development. Histology shows mosaic expression of LacZ in the ventral main olfactory epithelium.
This transgenic was generated by pronuclear microinjection into (C57BL/6J x CBA)F2 and was maintained on this segregating background until sperm was cryopreserved from hemizygous males.
Expressed Gene | lacZ, beta-galactosidase, E. coli |
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Site of Expression | lacZ shows mosaic expression in the ventral main olfactory epithelium. |
Allele Name | transgene insertion 4, Peter Mombaerts |
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Allele Type | Transgenic (Reporter) |
Allele Synonym(s) | Tg-P3(143,163)-LacZpA |
Gene Symbol and Name | Tg(Olfr713-taulacZ)4Mom, transgene insertion 4, Peter Mombaerts |
Gene Synonym(s) | |
Promoter | Olfr713, olfactory receptor 713, mouse, laboratory |
Expressed Gene | lacZ, beta-galactosidase, E. coli |
Site of Expression | lacZ shows mosaic expression in the ventral main olfactory epithelium. |
Strain of Origin | (C57BL/6J x CBA)F2 |
Chromosome | UN |
Molecular Note | A construct comprised of 143 base pairs upstream of the Olfr713 transcription start site followed by 163 base pairs of the 5' nontranslated exon 1, followed by a LacZpA reporter was used for pronuclear microinjection to dissect promoter elements. |
When using the P3 Tg line IV mouse strain in a publication, please cite the originating article(s) and include JAX stock #007976 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Carrier or Non Carrier of Tg(Olfr713-tauLacZ)4Mom |
Frozen Mouse Embryo | B6;CBA-Tg(Olfr713-taulacZ)4Mom/MomJ | $2595.00 |
Frozen Mouse Embryo | B6;CBA-Tg(Olfr713-taulacZ)4Mom/MomJ | $2595.00 |
Frozen Mouse Embryo | B6;CBA-Tg(Olfr713-taulacZ)4Mom/MomJ | $3373.50 |
Frozen Mouse Embryo | B6;CBA-Tg(Olfr713-taulacZ)4Mom/MomJ | $3373.50 |
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