These mice carry a transgene that encodes tau-linked-LacZ under the control of a minimal promoter upstream of the Olfr151 transcription start site. LacZ is expressed in place of any olfactory receptor sequence.
Peter Mombaerts, Max Planck Research Unit for Neurogenetics
Genetic Background | Generation |
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Allele Type |
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Transgenic (Reporter) |
This transgene encodes tau-linked-LacZ under the control of a minimal promoter comprised of 161 base pairs upstream of the Olfr151 transcription start site and 176 base pairs of the 5' nontranslated exon 1. It does not drive expression of any olfactory receptor sequence. It is useful in mapping promoter elements important for olfactory receptor expression and the related olfactory sensory neuron development. Histology shows LacZ activity spread over a large domain of the dorsal aspect of the medial half-bulb, not coalescing into glomeruli.
This transgenic was generated by pronuclear microinjection into (C57BL/6J x CBA)F2 and was maintained on this segregating background until sperm was cryopreserved from hemizygous males.
Expressed Gene | lacZ, beta-galactosidase, E. coli |
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Site of Expression | lacZ is expressed over a large domain of the dorsal aspect of the medial half-bulb. |
Allele Name | transgene insertion 4, Peter Mombaerts |
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Allele Type | Transgenic (Reporter) |
Allele Synonym(s) | Tg-M71(161,176)-LacZpA |
Gene Symbol and Name | Tg(Olfr151-taulacZ)4Mom, transgene insertion 4, Peter Mombaerts |
Gene Synonym(s) | |
Promoter | Olfr151, olfactory receptor 151, mouse, laboratory |
Expressed Gene | lacZ, beta-galactosidase, E. coli |
Site of Expression | lacZ is expressed over a large domain of the dorsal aspect of the medial half-bulb. |
Strain of Origin | (C57BL/6J x CBA)F2 |
Chromosome | UN |
Molecular Note | A construct comprised of 161 base pairs upstream of the Olfr151 transcription start site, which includes one homeodomain and one OLF/EBP binding site, followed by the entire 5' nontranslated exon 1, which is 176 base pairs, followed by a LacZpA reporter was used for pronuclear microinjection to dissect promoter elements. |
When using the M71 Tg line IV mouse strain in a publication, please cite the originating article(s) and include JAX stock #007972 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Carrier or Non Carrier of Tg(Olfr151-tauLacZ)4Mom |
Frozen Mouse Embryo | B6;CBA-Tg(Olfr151-taulacZ)4Mom/MomJ | $2595.00 |
Frozen Mouse Embryo | B6;CBA-Tg(Olfr151-taulacZ)4Mom/MomJ | $2595.00 |
Frozen Mouse Embryo | B6;CBA-Tg(Olfr151-taulacZ)4Mom/MomJ | $3373.50 |
Frozen Mouse Embryo | B6;CBA-Tg(Olfr151-taulacZ)4Mom/MomJ | $3373.50 |
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