These mice carry a remutation of the Ppp1r13l gene and are characterized by cardiomyopathy, including abnormal hair and damaged eyes.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Ppp1r13l | protein phosphatase 1, regulatory subunit 13 like |
Homozygotes have a coat that is sparse but not wavy. They are born with their eyelids open and develop vascular corneas. They also develop early-onset cardiomyopathy, which leads to congestive heart failure. Female homozygotes have not successfully bred and male homozygotes have significantly reduced fertility, producing one or two litters in their lifetime at best.
The waved 3 Jackson mutation arose spontaneously on the BALB/cJ inbred background in 1977 at The Jackson Laboratory and has been maintained on this background ever since.
Allele Name | waved 3 Jackson |
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Allele Type | Spontaneous |
Allele Synonym(s) | |
Gene Symbol and Name | Ppp1r13l, protein phosphatase 1, regulatory subunit 13 like |
Gene Synonym(s) | |
Strain of Origin | BALB/cJ |
Chromosome | 7 |
General Note | Phenotypic Similarity to Human Syndrome: novel autosomal recessive cardio-cutaneous syndrome (J:264272). |
Molecular Note | The underlying mutation is a 4 base pair deletion in exon 12. |
When using the waved 3 Jackson mouse strain in a publication, please cite the originating article(s) and include JAX stock #007971 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous for Ppp1r13l<wa3-J> |
Frozen Mouse Embryo | BALB/cJ-Ppp1r13l<wa3-J>/J | $2595.00 |
Frozen Mouse Embryo | BALB/cJ-Ppp1r13l<wa3-J>/J | $2595.00 |
Frozen Mouse Embryo | BALB/cJ-Ppp1r13l<wa3-J>/J | $3373.50 |
Frozen Mouse Embryo | BALB/cJ-Ppp1r13l<wa3-J>/J | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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