JAX
Mouse Strain Datasheet - 007906
B6.Cg-Gt(ROSA)26Sortm6(CAG-ZsGreen1)Hze/J
- Stock No:
- 007906 |
- Ai6 or Ai6(RCL-ZsGreen)
Also Known As: Ai6 or Ai6(RCL-ZsGreen)
These Ai6 mice harbor a targeted mutation of the Gt(ROSA)26Sor locus with a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven enhanced green fluorescent protein (ZsGreen1), and may be useful as a Cre reporter strain. ZsGreen1 is expressed following Cre-mediated recombination.
Due to demand, this colony is being expanded. An estimated distribution date is provided above.
Donating Investigator
Hongkui Zeng, Allen Institute for Brain Science
Genetic overview
| Genetic Background | Generation |
|---|---|
|
N5F2pN1F6
|
Gt(ROSA)26Sortm6(CAG-ZsGreen1)Hze
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Targeted (Conditional ready (e.g. floxed), Reporter) | Gt(ROSA)26Sor | gene trap ROSA 26, Philippe Soriano |
Important Note
Due to demand, this colony is being expanded. An estimated distribution date is provided above.
Detailed Description
Ai6 mice hemizygous for this Rosa-CAG-LSL-ZsGreen1-WPRE conditional allele are viable and fertile. A loxP-flanked STOP cassette prevents transcription of the downstream enhanced green fluorescent protein (ZsGreen1). When bred to mice that express Cre recombinase, the resulting offspring will have the STOP cassette deleted in the cre-expressing tissue(s); resulting in expression of ZsGreen1. Because this CAG promoter driven reporter construct was targeted for insertion into the Gt(ROSA)26Sor locus, ZsGreen1 expression is determined by which tissue(s) express Cre recombinase. The donating investigator reports that Ai6 mice do not express ZsGreen1 prior to introduction of Cre recombinase and ZsGreen1 expression following exposure to cre can be detected by fluorescence and mRNA (in situ hybridization). Bright fluorescence is observed mainly in cell bodies. Of note, the FRT sites flanking the mutation allow for additional targeted replacement of the reporter sequences through Flp-mediated recombination if so desired. Similarly, the attB/attP-flanked selection cassette may be removed by introduction of the site-specific bacteriophage PhiC31 integrase if so desired. These Ai6 mice are useful as a Cre reporter strain; expressing the enhanced green fluorescent protein, ZsGreen1, following Cre-mediated recombination.
For characterization information, see images at the Allen Institute for Brain Science website (Ai6 images).
Development
The Rosa-CAG-LSL-ZsGreen1-WPRE targeting vector was designed with (from 5' to 3') a CMV-IE enhancer/chicken beta-actin/rabbit beta-globin hybrid promoter (CAG), an FRT site, a loxP-flanked STOP cassette (with stop codons in all 3 reading frames and a triple polyA signal), ZsGreen1 sequence (from pZsGreen1-N1 (Clontech); a human codon optimized/enhanced green fluorescent protein engineered for brighter fluorescence and higher expression in mammalian cells), a woodchuck hepatitis virus post-transcriptional regulatory element (WPRE; to enhance the mRNA transcript stability), a polyA signal, and an attB/attP-flanked PGK-FRT-Neo-polyA cassette. This entire construct was inserted between exons 1 and 2 of the Gt(ROSA)26Sor locus via electroporation of (129S6/SvEvTac x C57BL/6)F1-derived G4 embryonic stem (ES) cells. Correctly targeted ES cells (clone Ai6) were selected and chimeric males were bred to Cre-transgenic females (expressing cre in non-germ cells from mixed genetic backgrounds). The resulting Ai6 mice (still retaining the floxed-STOP cassette and not harboring the Cre transgene) were then backcrossed to C57BL/6J for at least 1 generation prior to arrival at The Jackson Laboratory. Upon arrival, mice were further backcrossed to C57BL/6J inbred mice (Stock No. 000664) to generate this congenic colony.
Expression Data
| Expressed Gene | GFP, Green Fluorescent Protein, |
|---|---|
| Site of Expression | A floxed STOP prevents transcription of enhanced green fluorescent protein (ZsGreen1) until mice are bred to a Cre strain. Resulting offspring express ZsGreen1 in a pattern dictated by the Cre promoter. |
Control Suggestions
Selected References
- Madisen L; Zwingman TA; Sunkin SM; Oh SW; Zariwala HA; Gu H; Ng LL; Palmiter RD; Hawrylycz MJ; Jones AR; Lein ES; Zeng H. 2010. A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat Neurosci 13(1):133-40. PubMed: 20023653MGI: J:155793
Gt(ROSA)26Sortm6(CAG-ZsGreen1)Hze
Allele Symbol: Gt(ROSA)26Sortm6(CAG-ZsGreen1)Hze
| Allele Name | targeted mutation 6, Hongkui Zeng |
|---|---|
| Allele Type | Targeted (Conditional ready (e.g. floxed), Reporter) |
| Allele Synonym(s) | Ai6; R26floxstop-EGFP; R26ZsGreen; ROSA26LoxP-STOP-LoxP-ZsGreen1; Rosa-CAG-LSL-ZsGreen1-WPRE; RosaZsG; Rs-ZsGreen-R; ZsGrn |
| Gene Symbol and Name | Gt(ROSA)26Sor, gene trap ROSA 26, Philippe Soriano |
| Gene Synonym(s) | AV258896; Gtrgeo26; Gtrgeo26; Gtrosa26; Gtrosa26; R26; ROSA26; SETD5-AS1; Thumpd3as1; beta geo; expressed sequence AV258896; gene trap ROSA 26; gene trap ROSA b-geo 26 |
| Expressed Gene | GFP, Green Fluorescent Protein, |
| Site of Expression | A floxed STOP prevents transcription of enhanced green fluorescent protein (ZsGreen1) until mice are bred to a Cre strain. Resulting offspring express ZsGreen1 in a pattern dictated by the Cre promoter. |
| Strain of Origin | (129S6/SvEvTac x C57BL/6NCrl)F1 |
| Chromosome | 6 |
| Molecular Note | The Rosa-CAG-LSL-ZsGreen1-WPRE targeting vector was designed with (from 5' to 3') a CMV-IE enhancer/chicken beta-actin/rabbit beta-globin hybrid promoter (CAG), an FRT site, a loxP-flanked STOP cassette (with stop codons in all 3 reading frames and a triple polyA signal), ZsGreen1 sequence (from pZsGreen1-N1 (Clontech); a human codon optimized/enhanced green fluorescent protein engineered for brighter fluorescence and higher expression in mammalian cells), a woodchuck hepatitis virus post-transcriptional regulatory element (WPRE; to enhance the mRNA transcript stability), a polyA signal, and an attB/attP-flanked PGK-FRT-Neo-polyA cassette. This entire construct was inserted between exons 1 and 2 of the Gt(ROSA)26Sor locus. |
| Mutations Made By | Hongkui Zeng, Allen Institute for Brain Science |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Neurobiology Research
- Cre-lox System
- loxP-flanked Sequences
- loxP-flanked Sequences: Test/Reporter
- Fluorescent protein expression in neural tissue
- Cre-lox System
- Research Tools
- Cre-lox System
- loxP-flanked Sequences
- loxP-flanked Sequences: Test/Reporter
- Developmental Biology Research
- Cre-lox System
- transplantation marker for embryonic and adult tissue
- Diabetes and Obesity Research
- loxP
- FLP-FRT System
- FRT-flanked Sequences
- Fluorescent Proteins
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
- Tissue/Cell Markers
- Tissue/Cell Markers: Cre-lox System
- Tissue/Cell Markers: cell marker for bone marrow transplantation
- Tissue/Cell Markers: transplantation marker for embryonic and adult tissue
- Reproductive Biology Research
- Cre-lox System
- transplantation marker for embryonic and adult tissue
- Cre-lox System
Genotype: GFP related
- Research Tools
- Fluorescent Proteins
Mammalian Phenotype Terms by Genotype
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Gt(ROSA)26Sortm6(CAG-ZsGreen1)Hze/Gt(ROSA)26Sor+
involves: 129S6/SvEvTac * C57BL/6NCr
normal phenotype
- no abnormal phenotype detected
- mice are viable and fertile; used for cre reporter expression analysis (MGI Ref ID J:155793)
References
- Madisen L; Zwingman TA; Sunkin SM; Oh SW; Zariwala HA; Gu H; Ng LL; Palmiter RD; Hawrylycz MJ; Jones AR; Lein ES; Zeng H. 2010. A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat Neurosci 13(1):133-40. PubMed: 20023653MGI: J:155793
Additional - Gt(ROSA)26Sortm6(CAG-ZsGreen1)Hze related
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