Homozygous mutants of this strain have a smaller body size and abnormal development of the inner ear leading to unbalanced gait and deafness.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | hml | Hypoplasia of the membranous labyrinth |
Homozygotes have a fail-to-thrive phenotype such that they have a smaller body size and unbalanced gait detectable at 10 days of age. Those that survive to 2 months of age can generally live up to 18 months. The inner ear has extensive hypoplasia of the membranous labyrinth, a rudimentary tectorial membrane, and enlarged scala vestibuli and severe hearing loss or complete deafness are found at 19 days of age both by failed response to sounds and auditory brainstem response analysis. Homozygotes also fail to orient in water.
The hml mutation arose spontaneously in the CByJ.Cg-Foxn1nu/J colony at The Jackson Laboratory in 1995 and was backcrossed onto the C57BL/6J background via backcross-intercross. In 2007 sperm was cryopreserved from heterozygous males at backcross generation N10.
When using the hypoplasia of the membranous labyrinth mouse strain in a publication, please cite the originating article(s) and include JAX stock #007757 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous or Wild-type for hml. |
Frozen Mouse Embryo | B6.Cg-hml/J | $2595.00 |
Frozen Mouse Embryo | B6.Cg-hml/J | $2595.00 |
Frozen Mouse Embryo | B6.Cg-hml/J | $3373.50 |
Frozen Mouse Embryo | B6.Cg-hml/J | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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