These mice, transgenic for this ?GC-B1? isoform of the gene, do not have a remarkable phenotype. But when bred to mice carrying a targeted knockout of the gene, this transgene rescues their severe dwarfism and early death phenotypes. These mice may be used in studies of endochondral ossification and bone development.
David L. Garbers, U.T. Southwestern Medical Center
Genetic Background | Generation |
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Allele Type |
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Transgenic (Inserted expressed sequence) |
Mice that carry this transgene are viable, fertile and do not display any gross physical or behavioral abnormalities. Mice transgenic for this "GC-B1" isoform do not have a remarkable phenotype, but when bred to mice carrying a targeted knockout of the gene, this transgene rescues their severe dwarfism and early death phenotypes. These mice may be used in studies of endochondral ossification and bone development.
A transgenic B geo expression construct incorporating the “GC-B1” isoform of the mouse gene (expressed in growth-plate chondrocytes) driven by the mouse Col2a1 (procollagen, type II, alpha 1) promoter/enhancer was introduced to B6SJLF1 embryos. The donating laboratory reports that this strain is on a mixed background composed of C57BL/6, 129S6/SvEvTac and SJL.
Expressed Gene | Npr2, natriuretic peptide receptor 2, mouse, laboratory |
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Site of Expression |
Allele Name | transgene insertion 2, David L Garbers |
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Allele Type | Transgenic (Inserted expressed sequence) |
Allele Synonym(s) | GC-B1; Tg(Col2a1-Npr2)2Gar |
Gene Symbol and Name | Tg(Col2a1-Npr2*B1)2Gar, transgene insertion 2, David L Garbers |
Gene Synonym(s) | |
Promoter | Col2a1, collagen, type II, alpha 1, mouse, laboratory |
Expressed Gene | Npr2, natriuretic peptide receptor 2, mouse, laboratory |
Strain of Origin | (C57BL/6 x SJL)F1 |
Chromosome | UN |
Molecular Note | A transgenic B-geo expression construct incorporating the GC-B1 isoform of the mouse gene (expressed in growth-plate chondrocytes) driven by the mouse Col2a1 (procollagen, type II, alpha 1) promoter/enhancer was introduced to B6SJLF1 embryos. |
When maintained as a live colony, hemizygotes or homozygotes may be bred.
When using the STOCK Tg(Col2a1-Npr2*B1)2Gar/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #007731 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Hemizygous or Non Carrier for Tg(Col2a1-Npr2*B1)2Gar |
Frozen Mouse Embryo | STOCK Tg(Col2a1-Npr2*B1)2Gar/J | $2595.00 |
Frozen Mouse Embryo | STOCK Tg(Col2a1-Npr2*B1)2Gar/J | $2595.00 |
Frozen Mouse Embryo | STOCK Tg(Col2a1-Npr2*B1)2Gar/J | $3373.50 |
Frozen Mouse Embryo | STOCK Tg(Col2a1-Npr2*B1)2Gar/J | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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