C57BL/6J-Hps3^coa-8J/GrsrJ

Stock number: 007711
Product name: cocoa 8 Jackson
Research areas: Dermatology Research, Hematological Research

Description

Mice homozygous for the cocoa 8 Jackson mutation have hypopigmentation resulting in a diluted coat color and pale ears, feet and tail.

Detailed description

Mice homozygous for the Hps3^coa-8J mutation have a lighter coat color than littermate controls and can be recognized when their first coat of hair comes in at about 10 days of age. Heterozygotes have a normal C57BL/6J coat color (black). Both heterozygous and homozygous mice live a normal lifespan and breed well.

Development

The cocoa 8 Jackson mutation arose spontaneously in the C57BL/6J strain at The Jackson Laboratory in 2005 and has been maintained on that background.

Allele

Symbol: Hps3^coa-8J
Name: cocoa 8 Jackson
MGI accession ID: MGI:3722183
Generation method: Spontaneous
Marker symbol: Hps3
Marker name: HPS3, biogenesis of lysosomal organelles complex 2 subunit 1
Chromosome: 3
Strain of origin: C57BL/6J
Molecular note: A non-complementation with cocoa 7 Jackson proved that this is an allele of Hps.