-When young, these mice look similar to wildtype mice, but as they age, their coats become shorter and more sparse. Molecular analysis shows delayed development of sebaceous glands, accelerated hair cycle and less-differentiated epidermis. This strain may be useful as a model for skin and hair development studies.
Catherine Thompson, Wyeth Research
Genetic Background | Generation |
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Allele Type |
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Transgenic (Inserted expressed sequence) |
Hemizygous mice are viable and fertile. When young, these mice look similar to wildtype mice, but as they age, their coats become shorter and more sparse. Molecular analysis shows delayed development of sebaceous glands, accelerated hair cycle and less-differentiated epidermis. RNA and protein expressed from the transgene are detected in skin as determined by Western and Northern analysis. This strain may be useful as a model for skin and hair development studies.
A 3.5 kb fragment containing the coding sequence of the rat Hr cDNA was inserted between the human keratin 14 (KRT14) promoter/rabbit beta-globin intron and the KRT14 5' UTR/polyadenylation signal. The linearized transgene was microinjected into B6SJLF2 embryos. Transgenic mice were crossed with C57BL/6 one time by the donating laboratory.
Expressed Gene | Hr, HR, lysine demethylase and nuclear receptor corepressor, rat |
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Site of Expression |
Allele Name | transgene insertion 551, Catherine C Thompson |
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Allele Type | Transgenic (Inserted expressed sequence) |
Allele Synonym(s) | K14-rHr |
Gene Symbol and Name | Tg(KRT14-Hr)551Cct, transgene insertion 551, Catherine C Thompson |
Gene Synonym(s) | |
Promoter | KRT14, keratin 14, human |
Expressed Gene | Hr, HR, lysine demethylase and nuclear receptor corepressor, rat |
Strain of Origin | (C57BL/6 x SJL)F2 |
Chromosome | UN |
Molecular Note | A 3.5 kb fragment containing the coding sequence of the rat Hr cDNA was inserted between the human keratin 14 (KRT14) promoter/rabbit beta-globin intron and the KRT14 5' UTR/polyadenylation signal.Hr protein expression is high in the skin in early postnatal development, and remains above wild-type levels as development proceeds. |
When maintaining a live colony, hemizygous mice may be bred to wildtype siblings, or to B6SDJLF1/J mice (Stock No. 100012).
When using the B6;SJL-Tg(KRT14-Hr)551Cct/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #007622 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Hemizygous or Non carrierfor Tg(KRT14-Hr)551Cct |
Frozen Mouse Embryo | B6;SJL-Tg(KRT14-Hr)551Cct/J Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | B6;SJL-Tg(KRT14-Hr)551Cct/J Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | B6;SJL-Tg(KRT14-Hr)551Cct/J Frozen Embryo | $3373.50 |
Frozen Mouse Embryo | B6;SJL-Tg(KRT14-Hr)551Cct/J Frozen Embryo | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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