Hemizygous mice carrying this mutation are viable, fertile, and display no apparent defects or abnormalities. These transgenic mice express a hemaglutinin-tagged copy of the Arntl (Bmal1) gene under the control of a tetracycline-responsive promoter element (TRE or tetO). When bred with another transgenic mouse expressing reverse tetracycline-controlled transactivator protein (rtTA) or tetracycline-controlled transactivator protein (tTA) to create a bitransgenic animal, transgene expression can be regulated with the tetracycline analog, doxycycline. This strain may be useful in studies dilineating the mechanism of mammalian circadian rhythms.

These transgenic mice express a hemaglutinin-tagged copy of the Arntl (Bmal1) gene under the control of a tetracycline-responsive promoter element (TRE or tetO). When bred with another transgenic mouse expressing reverse tetracycline-controlled transactivator protein (rtTA) or tetracycline-controlled transactivator protein (tTA), transgene expression can be regulated with the tetracycline analog, doxycycline. This strain may be useful in studies dilineating the mechanism of mammalian circadian rhythms.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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