Sharpin (SHANK-associated RH domain interacting protein) encodes a key regulator of NFKB and integrin signaling.&nbsp; Mice homozygous for this recessive Sharpincpdm (chronic proliferative dermatitis) point mutation develop a severe, chronic, inflammatory skin disease beginning at 3-5 weeks of age. Mice appear runted and life span is shortened. Severe pruritus often causes self-inflicted wounds necessitating euthanasia usually before the age of 30 weeks. In addition to dermatitis, homozygotes exhibit multi-organ inflammation with eosinophilia, defective TH1 cytokine production, splenomegaly, absent Peyer's patches (adult), diminished serum immunoglobulins, and an absence of B cell follicles, follicular dendritic cells, and germinal centers in secondary lymph organs. This mutant mouse strain may be useful in studies related to eosinophilic dermatitis, inflammation, and secondary lymphoid organ development. Heterozygotes are viable and fertile, and exhibit no overt phenotype. Due to the severity of the homozygous phenotype, we are only able to ship heterozygotes.

Mice homozygous for this recessive Sharpincpdm mutation develop a severe, chronic, inflammatory skin disease beginning at 3-5 weeks of age. This mutant mouse strain may be useful in studies related to eosinophilic dermatitis, inflammation and secondary lymphoid organ development.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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