Homozygous knockout mice exhibit craniofacial abnormalities and do not survive more than 24 hours.
Edward De Robertis, University of California, Los Angeles
Homozyous mutant mice are small and die within 24 hours of birth and display defects of the lower mandible and associated musculature, the inner ear and external audiatory meatus.
|Allele Name||targeted mutation 1, Peter Gruss|
|Allele Type||Targeted (Null/Knockout)|
|Gene Symbol and Name||Gsc, goosecoid homeobox|
|Strain of Origin||(129X1/SvJ x 129S1/Sv)F1-Kitl+|
|Molecular Note||A neomycin cassette was inserted into exon 2, disrupting sequences encoding the homeodomain.|
|Mutations Made By|| |
Dr. Peter Gruss, Max Planck Inst Biophysikalische Chemie
When maintaining a live colony, these mice are bred as heterozygotes. Homozygotes have a perinatal lethal phenotype.
When using the goosecoid KO mouse strain in a publication, please cite the originating article(s) and include JAX stock #007556 in your Materials and Methods section.