JAX
Mouse Strain Datasheet - 007252
B6Ei.129S4-Tg(Prm-cre)58Og/EiJ
This strain expresses Cre-recombinase in the male germ line.
Read More +Genetic overview
| Genetic Background | Generation |
|---|---|
|
|
Tg(Prm-cre)58Og
| Allele Type |
|---|
| Transgenic (Recombinase-expressing) |
Detailed Description
Embryonic stem cells containing recombinase transgenes that are expressed in the male germ line, but not in other tissues or in the embryonic stem cells themselves, substantially simplify the production of subtle or conditional mutations in mice. This strain shows that transgenes comprised of the mouse protamine 1 promoter and the Cre recombinase coding sequence mediate the efficient recombination of a Cre target transgene in the male germ line, but not in other tissues. This system can be used for reducing the time, effort, and resources required to produce homologously recombined alleles in mice that have been secondarily rearranged by site-specific recombinase.
In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain above. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.
Development
The PrmCre transgene was designed with the mouse protamine 1 promoter upstream of a modified Cre recombinase coding sequence (modified to contain a consensus translation start site, 11 codons for a human c-myc epitope, 7 codons for a minimal simian virus 40 nuclear localization signal, and a polyadenylation signal). This transgene was microinjected into pronuclei of fertilized 129/SvJae oocytes, and the resulting transgenic offspring were bred to 129/SvJae mice. Founder line 58 mice (with a single copy of the transgene) were backcrossed to 129Sv/Jae for many generations prior to arrival at The Jackson Laboratory (as Stock No. 003328. Upon arrival, some mice were backcrossed to C57BL/6EiJ (Stock No. 000924) to generate this congenic colony.
Expression Data
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
|---|---|
| Site of Expression | male germ line |
Control Suggestions
- Noncarrier
- Wild-type from the colony
Approximate Controls
Additional Information
Tg(Prm-cre)58Og
Allele Symbol: Tg(Prm-cre)58Og
| Allele Name | transgene insertion 58, Stephen O'Gorman |
|---|---|
| Allele Type | Transgenic (Recombinase-expressing) |
| Allele Synonym(s) | Prm-cre; Prm1cre; PrmCre; Pro Cre; Tg(Prm-cre)580 g; TgNPro:Cre |
| Gene Symbol and Name | Tg(Prm-cre)58Og, transgene insertion 58, Stephen O'Gorman |
| Gene Synonym(s) | Prm-cre; Prm1cre; PrmCre |
| Promoter | Prm1, protamine 1, mouse, laboratory |
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
| Site of Expression | male germ line |
| Strain of Origin | 129S4/SvJae |
| Chromosome | UN |
| Molecular Note | This transgene expresses Cre recombinase under the control of the mouse protamine (Prm1) promoter. The transgene directs expression of Cre recombinase in the male germ cells and not in other tissues. |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Research Tools
- Cre-lox System
Genotype: cre related
- Research Tools
- Cre-lox System
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
References
Additional - Tg(Prm-cre)58Og related
- Adams JW; Wang J; Davis JR; Liaw C; Gaidarov I; Gatlin J; Dalton ND; Gu Y; Ross J Jr; Behan D; Chien K; Connolly D. 2008. Myocardial expression, signaling, and function of GPR22: a protective role for an orphan G protein-coupled receptor. Am J Physiol Heart Circ Physiol 295(2):H509-21. PubMed: 18539757MGI: J:138227
- An W; Han JS; Schrum CM; Maitra A; Koentgen F; Boeke JD. 2008. Conditional activation of a single-copy L1 transgene in mice by Cre. Genesis 46(7):373-83. PubMed: 18615728MGI: J:138548
- Atasoy D; Schoch S; Ho A; Nadasy KA; Liu X; Zhang W; Mukherjee K; Nosyreva ED; Fernandez-Chacon R; Missler M; Kavalali ET; Sudhof TC. 2007. Deletion of CASK in mice is lethal and impairs synaptic function. Proc Natl Acad Sci U S A 104(7):2525-30. PubMed: 17287346MGI: J:117978
- Baek WY; de Crombrugghe B; Kim JE. 2010. Postnatally induced inactivation of Osterix in osteoblasts results in the reduction of bone formation and maintenance. Bone 46(4):920-8. PubMed: 20026264MGI: J:162059
- Banerjee I; Zhang J; Moore-Morris T; Pfeiffer E; Buchholz KS; Liu A; Ouyang K; Stroud MJ; Gerace L; Evans SM; McCulloch A; Chen J. 2014. Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response. PLoS Genet 10(2):e1004114. PubMed: 24586179MGI: J:211007
- Bao J; Zhang Y; Schuster AS; Ortogero N; Nilsson EE; Skinner MK; Yan W. 2014. Conditional inactivation of Miwi2 reveals that MIWI2 is only essential for prospermatogonial development in mice. Cell Death Differ 21(5):783-96. PubMed: 24464225MGI: J:229360
- Bark C; Bellinger FP; Kaushal A; Mathews JR; Partridge LD; Wilson MC. 2004. Developmentally regulated switch in alternatively spliced SNAP-25 isoforms alters facilitation of synaptic transmission. J Neurosci 24(40):8796-805. PubMed: 15470145MGI: J:94005
- Batista F; Lu L; Williams SA; Stanley P. 2012. Complex N-glycans are essential, but core 1 and 2 mucin O-glycans, O-fucose glycans, and NOTCH1 are dispensable, for mammalian spermatogenesis. Biol Reprod 86(6):179. PubMed: 22492969MGI: J:185823
- Bharti K; Gasper M; Ou J; Brucato M; Clore-Gronenborn K; Pickel J; Amheiter H. 2012. A regulatory loop involving PAX6, MITF, and WNT signaling controls retinal pigment epithelium development PLoS Genet :1-59. MGI: J:182723
- Bhattaram P; Penzo-Mendez A; Sock E; Colmenares C; Kaneko KJ; Vassilev A; Depamphilis ML; Wegner M; Lefebvre V. 2010. Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors. Nat Commun 1:9. PubMed: 20596238MGI: J:175338
- Bikoff JB; Gabitto MI; Rivard AF; Drobac E; Machado TA; Miri A; Brenner-Morton S; Famojure E; Diaz C; Alvarez FJ; Mentis GZ; Jessell TM. 2016. Spinal Inhibitory Interneuron Diversity Delineates Variant Motor Microcircuits. Cell 165(1):207-19. PubMed: 26949184MGI: J:234419
- Brade T; Kumar S; Cunningham TJ; Chatzi C; Zhao X; Cavallero S; Li P; Sucov HM; Ruiz-Lozano P; Duester G. 2011. Retinoic acid stimulates myocardial expansion by induction of hepatic erythropoietin which activates epicardial Igf2. Development 138(1):139-48. PubMed: 21138976MGI: J:167039
- Brenner S; Drewel D; Steinbart T; Weisel F; Hartel E; Potzsch S; Welzel H; Brandl A; Yu P; Mudde GC; Schweizer A; Nitschke L; Winkler TH. 2011. A hypomorphic IgH-chain allele affects development of B-cell subsets and favours receptor editing. EMBO J 30(13):2705-18. PubMed: 21623346MGI: J:174233
- Cai CL; Zhou W; Yang L; Bu L; Qyang Y; Zhang X; Li X; Rosenfeld MG; Chen J; Evans S. 2005. T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis. Development 132(10):2475-87. PubMed: 15843407MGI: J:98516
- Chaboissier MC; Kobayashi A; Vidal VI; Lutzkendorf S; van de Kant HJ; Wegner M; de Rooij DG; Behringer RR; Schedl A. 2004. Functional analysis of Sox8 and Sox9 during sex determination in the mouse. Development 131(9):1891-901. PubMed: 15056615MGI: J:89368
- Chandra S; Fornai F; Kwon HB; Yazdani U; Atasoy D; Liu X; Hammer RE; Battaglia G; German DC; Castillo PE; Sudhof TC. 2004. Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions. Proc Natl Acad Sci U S A 101(41):14966-71. PubMed: 15465911MGI: J:93544
- Chang YF; Lee-Chang JS; Harris KY; Sinha-Hikim AP; Rao MK. 2011. Role of beta-catenin in post-meiotic male germ cell differentiation. PLoS One 6(11):e28039. PubMed: 22125654MGI: J:180951
- Chang YF; Lee-Chang JS; Imam JS; Buddavarapu KC; Subaran SS; Sinha-Hikim AP; Gorospe M; Rao MK. 2012. Interaction between microRNAs and actin-associated protein Arpc5 regulates translational suppression during male germ cell differentiation. Proc Natl Acad Sci U S A 109(15):5750-5. PubMed: 22447776MGI: J:183553
- Chau BN; Borges HL; Chen TT; Masselli A; Hunton IC; Wang JY. 2002. Signal-dependent protection from apoptosis in mice expressing caspase-resistant Rb. Nat Cell Biol 4(10):757-65. PubMed: 12360286MGI: J:80087
- Chen CY; Chan CH; Chen CM; Tsai YS; Tsai TY; Wu Lee YH; You LR. 2016. Targeted inactivation of murine Ddx3x: essential roles of Ddx3x in placentation and embryogenesis. Hum Mol Genet 25(14):2905-2922. PubMed: 27179789MGI: J:231798
- Chen JW; Zhou B; Yu QC; Shin SJ; Jiao K; Schneider MD; Baldwin HS; Bergelson JM. 2006. Cardiomyocyte-specific deletion of the coxsackievirus and adenovirus receptor results in hyperplasia of the embryonic left ventricle and abnormalities of sinuatrial valves. Circ Res 98(7):923-30. PubMed: 16543498MGI: J:121400
- Cheng A; Arumugam TV; Liu D; Khatri RG; Mustafa K; Kwak S; Ling HP; Gonzales C; Xin O; Jo DG; Guo Z; Mark RJ; Mattson MP. 2007. Pancortin-2 interacts with WAVE1 and Bcl-xL in a mitochondria-associated protein complex that mediates ischemic neuronal death. J Neurosci 27(7):1519-28. PubMed: 17301160MGI: J:118333
- Cheng H; Zheng M; Peter AK; Kimura K; Li X; Ouyang K; Shen T; Cui L; Frank D; Dalton ND; Gu Y; Frey N; Peterson KL; Evans SM; Knowlton KU; Sheikh F; Chen J. 2011. Selective deletion of long but not short Cypher isoforms leads to late-onset dilated cardiomyopathy. Hum Mol Genet 20(9):1751-62. PubMed: 21303826MGI: J:170494
- Clark-Knowles KV; He X; Jardine K; Coulombe J; Dewar-Darch D; Caron AZ; Gray DA; McBurney MW. 2017. Reversible modulation of SIRT1 activity in a mouse strain. PLoS One 12(3):e0173002. PubMed: 28273169MGI: J:241633
- Crone SA; Quinlan KA; Zagoraiou L; Droho S; Restrepo CE; Lundfald L; Endo T; Setlak J; Jessell TM; Kiehn O; Sharma K. 2008. Genetic ablation of V2a ipsilateral interneurons disrupts left-right locomotor coordination in mammalian spinal cord. Neuron 60(1):70-83. PubMed: 18940589MGI: J:145621
- Crone SA; Viemari JC; Droho S; Mrejeru A; Ramirez JM; Sharma K. 2012. Irregular Breathing in Mice following Genetic Ablation of V2a Neurons. J Neurosci 32(23):7895-906. PubMed: 22674265MGI: J:185186
- Debbache J; Zaidi MR; Davis S; Guo T; Bismuth K; Wang X; Skuntz S; Maric D; Pickel J; Meltzer P; Merlino G; Arnheiter H. 2012. In vivo Role of Alternative Splicing and Serine Phosphorylation of the Microphthalmia-associated Transcription Factor MITF. Genetics :. PubMed: 22367038MGI: J:182722
- Debruyne JP; Noton E; Lambert CM; Maywood ES; Weaver DR; Reppert SM. 2006. A clock shock: mouse CLOCK is not required for circadian oscillator function. Neuron 50(3):465-77. PubMed: 16675400MGI: J:109634
- Dendouga N; Gao H; Moechars D; Janicot M; Vialard J; McGowan CH. 2005. Disruption of murine Mus81 increases genomic instability and DNA damage sensitivity but does not promote tumorigenesis. Mol Cell Biol 25(17):7569-79. PubMed: 16107704MGI: J:100407
- Dickendesher TL; Baldwin KT; Mironova YA; Koriyama Y; Raiker SJ; Askew KL; Wood A; Geoffroy CG; Zheng B; Liepmann CD; Katagiri Y; Benowitz LI; Geller HM; Giger RJ. 2012. NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans. Nat Neurosci 15(5):703-12. PubMed: 22406547MGI: J:191258
- Dominguez D; Tournoy J; Hartmann D; Huth T; Cryns K; Deforce S; Serneels L; Camacho IE; Marjaux E; Craessaerts K; Roebroek AJ; Schwake M; D'Hooge R; Bach P; Kalinke U; Moechars D; Alzheimer C; Reiss K; Saftig P; De Strooper B. 2005. Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice. J Biol Chem 280(35):30797-806. PubMed: 15987683MGI: J:100925
- Dorfman MD; Garcia-Rudaz C; Alderman Z; Kerr B; Lomniczi A; Dissen GA; Castellano JM; Garcia-Galiano D; Gaytan F; Xu B; Tena-Sempere M; Ojeda SR. 2014. Loss of Ntrk2/Kiss1r signaling in oocytes causes premature ovarian failure. Endocrinology 155(8):3098-111. PubMed: 24877631MGI: J:214372
- Dubail J; Aramaki-Hattori N; Bader HL; Nelson CM; Katebi N; Matuska B; Olsen BR; Apte SS. 2014. A new Adamts9 conditional mouse allele identifies its non-redundant role in interdigital web regression. Genesis 52(7):702-12. PubMed: 24753090MGI: J:213412
- Dy P; Han Y; Lefebvre V. 2008. Generation of mice harboring a Sox5 conditional null allele. Genesis 46(6):294-9. PubMed: 18543318MGI: J:137217
- Dy P; Smits P; Silvester A; Penzo-Mendez A; Dumitriu B; Han Y; de la Motte CA; Kingsley DM; Lefebvre V. 2010. Synovial joint morphogenesis requires the chondrogenic action of Sox5 and Sox6 in growth plate and articular cartilage. Dev Biol 341(2):346-59. PubMed: 20206616MGI: J:160493
- Fernandes HB; Catches JS; Petralia RS; Copits BA; Xu J; Russell TA; Swanson GT; Contractor A. 2009. High-affinity kainate receptor subunits are necessary for ionotropic but not metabotropic signaling. Neuron 63(6):818-29. PubMed: 19778510MGI: J:155003
- Francis SM; Bergsied J; Isaac CE; Coschi CH; Martens AL; Hojilla CV; Chakrabarti S; Dimattia GE; Khoka R; Wang JY; Dick FA. 2009. A functional connection between pRB and transforming growth factor beta in growth inhibition and mammary gland development. Mol Cell Biol 29(16):4455-66. PubMed: 19506017MGI: J:151417
- Frew IJ; Smole Z; Thoma CR; Krek W. 2013. Genetic deletion of the long isoform of the von Hippel-Lindau tumour suppressor gene product alters microtubule dynamics. Eur J Cancer 49(10):2433-40. PubMed: 23541568MGI: J:198361
- Gao X; Tate P; Hu P; Tjian R; Skarnes WC; Wang Z. 2008. ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a. Proc Natl Acad Sci U S A 105(18):6656-61. PubMed: 18448678MGI: J:134633
- Gao Z; Huang Z; Olivey HE; Gurbuxani S; Crispino JD; Svensson EC. 2010. FOG-1-mediated recruitment of NuRD is required for cell lineage re-enforcement during haematopoiesis. EMBO J 29(2):457-68. PubMed: 20010697MGI: J:156475
- Garcia-Galiano D; van Ingen Schenau D; Leon S; Krajnc-Franken MA; Manfredi-Lozano M; Romero-Ruiz A; Navarro VM; Gaytan F; van Noort PI; Pinilla L; Blomenrohr M; Tena-Sempere M. 2012. Kisspeptin signaling is indispensable for neurokinin B, but not glutamate, stimulation of gonadotropin secretion in mice. Endocrinology 153(1):316-28. PubMed: 22067321MGI: J:181650
- Garnatz AS; Gao Z; Broman M; Martens S; Earley JU; Svensson EC. 2014. FOG-2 mediated recruitment of the NuRD complex regulates cardiomyocyte proliferation during heart development. Dev Biol 395(1):50-61. PubMed: 25196150MGI: J:216295
- Gaytan F; Garcia-Galiano D; Dorfman MD; Manfredi-Lozano M; Castellano JM; Dissen GA; Ojeda SR; Tena-Sempere M. 2014. Kisspeptin receptor haplo-insufficiency causes premature ovarian failure despite preserved gonadotropin secretion. Endocrinology 155(8):3088-97. PubMed: 24885574MGI: J:214363
- Gazit R; Gruda R; Elboim M; Arnon TI; Katz G; Achdout H; Hanna J; Qimron U; Landau G; Greenbaum E; Zakay-Rones Z; Porgador A; Mandelboim O. 2006. Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1. Nat Immunol 7(5):517-23. PubMed: 16565719MGI: J:112394
- Genetic Resource Science at The Jackson Laboratory. 2013. Expression/Specificity Patterns of Cre Alleles, 2013 Direct Data Submission from Genetic Resource Science :. MGI: J:193672
- Gomez TS; Gorman JA; de Narvajas AA; Koenig AO; Billadeau DD. 2012. Trafficking defects in WASH-knockout fibroblasts originate from collapsed endosomal and lysosomal networks. Mol Biol Cell 23(16):3215-28. PubMed: 22718907MGI: J:199703
- Grieves JL; Fye JM; Harvey S; Grayson JM; Hollis T; Perrino FW. 2015. Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease. Proc Natl Acad Sci U S A 112(16):5117-22. PubMed: 25848017MGI: J:220965
- Grisanti L; Clavel C; Cai X; Rezza A; Tsai SY; Sennett R; Mumau M; Cai CL; Rendl M. 2013. Tbx18 targets dermal condensates for labeling, isolation, and gene ablation during embryonic hair follicle formation. J Invest Dermatol 133(2):344-53. PubMed: 22992803MGI: J:196480
- Guan X; Shi X; Li X; Chang B; Wang Y; Li D; Chan L. 2012. GLP-2 receptor in POMC neurons suppresses feeding behavior and gastric motility. Am J Physiol Endocrinol Metab 303(7):E853-64. PubMed: 22829581MGI: J:189593
- Harada K; Truong AB; Cai T; Khavari PA. 2005. The class II phosphoinositide 3-kinase C2beta is not essential for epidermal differentiation. Mol Cell Biol 25(24):11122-30. PubMed: 16314532MGI: J:103754
- Hartman HB; Lai K; Evans MJ. 2009. Loss of small heterodimer partner expression in the liver protects against dyslipidemia. J Lipid Res 50(2):193-203. PubMed: 18820241MGI: J:149005
- Hellsten E; Evans JP; Bernard DJ; Janne PA; Nussbaum RL. 2001. Disrupted sperm function and fertilin beta processing in mice deficient in the inositol polyphosphate 5-phosphatase Inpp5b. Dev Biol 240(2):641-53. PubMed: 11784089MGI: J:73678
- Hirai M; Chen J; Evans SM. 2016. Generation and Characterization of a Tissue-Specific Centrosome Indicator Mouse Line. Genesis 54(5):286-96. PubMed: 26990996MGI: J:234834
- Hodges CA; Cotton CU; Palmert MR; Drumm ML. 2008. Generation of a conditional null allele for Cftr in mice. Genesis 46(10):546-52. PubMed: 18802965MGI: J:142723
- Howng SY; Avila RL; Emery B; Traka M; Lin W; Watkins T; Cook S; Bronson R; Davisson M; Barres BA; Popko B. 2010. ZFP191 is required by oligodendrocytes for CNS myelination. Genes Dev 24(3):301-11. PubMed: 20080941MGI: J:156938
- Hu X; Atzler D; Xu X; Zhang P; Guo H; Lu Z; Fassett J; Schwedhelm E; Boger RH; Bache RJ; Chen Y. 2011. Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine. Arterioscler Thromb Vasc Biol 31(7):1540-6. PubMed: 21493890MGI: J:182373
- Izvolsky KI; Lu J; Martin G; Albrecht KH; Cardoso WV. 2008. Systemic inactivation of Hs6st1 in mice is associated with late postnatal mortality without major defects in organogenesis. Genesis 46(1):8-18. PubMed: 18196599MGI: J:135241
- Jang S; Oh D; Lee Y; Hosy E; Shin H; van Riesen C; Whitcomb D; Warburton JM; Jo J; Kim D; Kim SG; Um SM; Kwon SK; Kim MH; Roh JD; Woo J; Jun H; Lee D; Mah W; Kim H; Kaang BK; Cho K; Rhee JS; Choquet D; Kim E. 2016. Synaptic adhesion molecule IgSF11 regulates synaptic transmission and plasticity. Nat Neurosci 19(1):84-93. PubMed: 26595655MGI: J:234439
- Johansson JU; Ericsson J; Janson J; Beraki S; Stanic D; Mandic SA; Wikstrom MA; Hokfelt T; Ogren SO; Rozell B; Berggren PO; Bark C. 2008. An ancient duplication of exon 5 in the Snap25 gene is required for complex neuronal development/function. PLoS Genet 4(11):e1000278. PubMed: 19043548MGI: J:142096
- Jonassen JA; San Agustin J; Follit JA; Pazour GJ. 2008. Deletion of IFT20 in the mouse kidney causes misorientation of the mitotic spindle and cystic kidney disease. J Cell Biol 183(3):377-84. PubMed: 18981227MGI: J:141071
- Jones-Mason ME; Zhao X; Kappes D; Lasorella A; Iavarone A; Zhuang Y. 2012. E protein transcription factors are required for the development of CD4(+) lineage T cells. Immunity 36(3):348-61. PubMed: 22425249MGI: J:187334
- Kaeser PS; Deng L; Chavez AE; Liu X; Castillo PE; Sudhof TC. 2009. ELKS2alpha/CAST deletion selectively increases neurotransmitter release at inhibitory synapses. Neuron 64(2):227-39. PubMed: 19874790MGI: J:155764
- Kaeser PS; Kwon HB; Chiu CQ; Deng L; Castillo PE; Sudhof TC. 2008. RIM1alpha and RIM1beta are synthesized from distinct promoters of the RIM1 gene to mediate differential but overlapping synaptic functions. J Neurosci 28(50):13435-47. PubMed: 19074017MGI: J:143053
- Karamitros D; Kotantaki P; Lygerou Z; Veiga-Fernandes H; Pachnis V; Kioussis D; Taraviras S. 2010. Differential geminin requirement for proliferation of thymocytes and mature T cells. J Immunol 184(5):2432-41. PubMed: 20107189MGI: J:159657
- Kehrl JM; Sahaya K; Dalton HM; Charbeneau RA; Kohut KT; Gilbert K; Pelz MC; Parent J; Neubig RR. 2014. Gain-of-function mutation in Gnao1: a murine model of epileptiform encephalopathy (EIEE17)? Mamm Genome 25(5-6):202-10. PubMed: 24700286MGI: J:216850
- Kim IS; Lee M; Park KC; Jeon Y; Park JH; Hwang EJ; Jeon TI; Ko S; Lee H; Baek SH; Kim KI. 2012. Roles of Mis18alpha in epigenetic regulation of centromeric chromatin and CENP-A loading. Mol Cell 46(3):260-73. PubMed: 22516971MGI: J:188023
- Kim JD; Kang K; Kim J. 2009. YY1's role in DNA methylation of Peg3 and Xist. Nucleic Acids Res 37(17):5656-64. PubMed: 19628663MGI: J:173022
- Kim Y; Kobayashi A; Sekido R; DiNapoli L; Brennan J; Chaboissier MC; Poulat F; Behringer RR; Lovell-Badge R; Capel B. 2006. Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination. PLoS Biol 4(6):e187. PubMed: 16700629MGI: J:110252
- Kimura H; Kwan KM; Zhang Z; Deng JM; Darnay BG; Behringer RR; Nakamura T; de Crombrugghe B; Akiyama H. 2008. Cthrc1 is a positive regulator of osteoblastic bone formation. PLoS One 3(9):e3174. PubMed: 18779865MGI: J:143940
- Kobuke K; Piccolo F; Garringer KW; Moore SA; Sweezer E; Yang B; Campbell KP. 2008. A Common Disease-Associated Missense Mutation in Alpha-Sarcoglycan Fails to Cause Muscular Dystrophy in Mice. Hum Mol Genet :. PubMed: 18252746MGI: J:130252
- Kokoszka JE; Waymire KG; Flierl A; Sweeney KM; Angelin A; MacGregor GR; Wallace DC. 2016. Deficiency in the mouse mitochondrial adenine nucleotide translocator isoform 2 gene is associated with cardiac noncompaction. Biochim Biophys Acta 1857(8):1203-12. PubMed: 27048932MGI: J:240226
- Kostetskii I; Li J; Xiong Y; Zhou R; Ferrari VA; Patel VV; Molkentin JD; Radice GL. 2005. Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure. Circ Res 96(3):346-54. PubMed: 15662031MGI: J:98828
- Lalancette-Hebert M; Sharma A; Lyashchenko AK; Shneider NA. 2016. Gamma motor neurons survive and exacerbate alpha motor neuron degeneration in ALS. Proc Natl Acad Sci U S A 113(51):E8316-E8325. PubMed: 27930290MGI: J:239077
- Lee S; Lee DK; Dou Y; Lee J; Lee B; Kwak E; Kong YY; Lee SK; Roeder RG; Lee JW. 2006. Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases. Proc Natl Acad Sci U S A 103(42):15392-7. PubMed: 17021013MGI: J:116064
- Leland S; Nagarajan P; Polyzos A; Thomas S; Samaan G; Donnell R; Marchetti F; Venkatachalam S. 2009. Heterozygosity for a Bub1 mutation causes female-specific germ cell aneuploidy in mice. Proc Natl Acad Sci U S A 106(31):12776-81. PubMed: 19617567MGI: J:151880
- Li H; Wang D; Singh LS; Berk M; Tan H; Zhao Z; Steinmetz R; Kirmani K; Wei G; Xu Y. 2009. Abnormalities in osteoclastogenesis and decreased tumorigenesis in mice deficient for ovarian cancer G protein-coupled receptor 1. PLoS One 4(5):e5705. PubMed: 19479052MGI: J:149315
- Li H; Wang Z; Wang B; Guo Q; Dolios G; Tabuchi K; Hammer RE; Sudhof TC; Wang R; Zheng H. 2010. Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis. J Biol Chem 285(40):30598-605. PubMed: 20693289MGI: J:166379
- Li X; Zima AV; Sheikh F; Blatter LA; Chen J. 2005. Endothelin-1-induced arrhythmogenic Ca2+ signaling is abolished in atrial myocytes of inositol-1,4,5-trisphosphate(IP3)-receptor type 2-deficient mice. Circ Res 96(12):1274-81. PubMed: 15933266MGI: J:110271
- Li Z; Cai X; Cai CL; Wang J; Zhang W; Petersen BE; Yang FC; Xu M. 2011. Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies. Blood 118(17):4509-18. PubMed: 21803851MGI: J:178415
- Liang X; Sun Y; Ye M; Scimia MC; Cheng H; Martin J; Wang G; Rearden A; Wu C; Peterson KL; Powell HC; Evans SM; Chen J. 2009. Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethality. Circulation 120(7):568-76. PubMed: 19652092MGI: J:167114
- Liang X; Zhou Q; Li X; Sun Y; Lu M; Dalton N; Ross J Jr; Chen J. 2005. PINCH1 plays an essential role in early murine embryonic development but is dispensable in ventricular cardiomyocytes. Mol Cell Biol 25(8):3056-62. PubMed: 15798193MGI: J:97635
- Lin SH; Cheng YR; Banks RW; Min MY; Bewick GS; Chen CC. 2016. Evidence for the involvement of ASIC3 in sensory mechanotransduction in proprioceptors. Nat Commun 7:11460. PubMed: 27161260MGI: J:239934
- Ling H; Zhang T; Pereira L; Means CK; Cheng H; Gu Y; Dalton ND; Peterson KL; Chen J; Bers D; Heller Brown J. 2009. Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice. J Clin Invest 119(5):1230-40. PubMed: 19381018MGI: J:149675
- Liodis P; Denaxa M; Grigoriou M; Akufo-Addo C; Yanagawa Y; Pachnis V. 2007. Lhx6 activity is required for the normal migration and specification of cortical interneuron subtypes. J Neurosci 27(12):3078-89. PubMed: 17376969MGI: J:119476
- Lou Y; Javed A; Hussain S; Colby J; Frederick D; Pratap J; Xie R; Gaur T; van Wijnen AJ; Jones SN; Stein GS; Lian JB; Stein JL. 2009. A Runx2 threshold for the cleidocranial dysplasia phenotype. Hum Mol Genet 18(3):556-68. PubMed: 19028669MGI: J:143532
- Lozovatsky L; Abayasekara N; Piawah S; Walther Z. 2009. CASK deletion in intestinal epithelia causes mislocalization of LIN7C and the DLG1/Scrib polarity complex without affecting cell polarity. Mol Biol Cell 20(21):4489-99. PubMed: 19726564MGI: J:164479
- Lyu YL; Wang JC. 2003. Aberrant lamination in the cerebral cortex of mouse embryos lacking DNA topoisomerase IIbeta. Proc Natl Acad Sci U S A 100(12):7123-8. PubMed: 12773624MGI: J:94879
- Marchlik E; Thakker P; Carlson T; Jiang Z; Ryan M; Marusic S; Goutagny N; Kuang W; Askew GR; Roberts V; Benoit S; Zhou T; Ling V; Pfeifer R; Stedman N; Fitzgerald KA; Lin LL; Hall JP. 2010. Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues and increased susceptibility to LPS-induced lethality. J Leukoc Biol 88(6):1171-80. PubMed: 20651301MGI: J:166476
- Mark MD; Maejima T; Kuckelsberg D; Yoo JW; Hyde RA; Shah V; Gutierrez D; Moreno RL; Kruse W; Noebels JL; Herlitze S. 2011. Delayed Postnatal Loss of P/Q-Type Calcium Channels Recapitulates the Absence Epilepsy, Dyskinesia, and Ataxia Phenotypes of Genomic Cacna1A Mutations. J Neurosci 31(11):4311-26. PubMed: 21411672MGI: J:170451
- Masubuchi S; Gao T; O'Neill A; Eckel-Mahan K; Newton AC; Sassone-Corsi P. 2010. Protein phosphatase PHLPP1 controls the light-induced resetting of the circadian clock. Proc Natl Acad Sci U S A :. PubMed: 20080691MGI: J:156530
- Morabito MV; Abbas AI; Hood JL; Kesterson RA; Jacobs MM; Kump DS; Hachey DL; Roth BL; Emeson RB. 2010. Mice with altered serotonin 2C receptor RNA editing display characteristics of Prader-Willi syndrome. Neurobiol Dis 39(2):169-80. PubMed: 20394819MGI: J:163043
- Nakamura Y; Lee S; Haddox CL; Weaver EJ; Lemmon VP. 2010. Role of the cytoplasmic domain of the L1 cell adhesion molecule in brain development. J Comp Neurol 518(7):1113-32. PubMed: 20127821MGI: J:197240
- O'Donnell N; Zachara NE; Hart GW; Marth JD. 2004. Ogt-dependent X-chromosome-linked protein glycosylation is a requisite modification in somatic cell function and embryo viability. Mol Cell Biol 24(4):1680-90. PubMed: 14749383MGI: J:93112
- O'Gorman S; Dagenais NA; Qian M; Marchuk Y. 1997. Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells. Proc Natl Acad Sci U S A 94(26):14602-7. PubMed: 9405659MGI: J:67932
- Olive KP; Tuveson DA; Ruhe ZC; Yin B; Willis NA; Bronson RT; Crowley D; Jacks T. 2004. Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell 119(6):847-60. PubMed: 15607980MGI: J:95316
- Paulusma CC; Van der Kruijssen CM; Van den Eijnden-Van Raaij AJ. 1994. Localization of activin subunits in early murine development determined by subunit-specific antibodies. J Immunol Methods 169(2):143-52. PubMed: 8133077MGI: J:17302
- Penzo-Mendez A; Dy P; Pallavi B; Lefebvre V. 2007. Generation of mice harboring a Sox4 conditional null allele. Genesis 45(12):776-80. PubMed: 18064674MGI: J:130461
- Pereira L; Cheng H; Lao DH; Na L; van Oort RJ; Brown JH; Wehrens XH; Chen J; Bers DM. 2013. Epac2 mediates cardiac beta1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia. Circulation 127(8):913-22. PubMed: 23363625MGI: J:210426
- Pershing NL; Lampson BL; Belsky JA; Kaltenbrun E; MacAlpine DM; Counter CM. 2015. Rare codons capacitate Kras-driven de novo tumorigenesis. J Clin Invest 125(1):222-33. PubMed: 25437878MGI: J:220039
- Piotrowski JT; Gomez TS; Schoon RA; Mangalam AK; Billadeau DD. 2013. WASH knockout T cells demonstrate defective receptor trafficking, proliferation, and effector function. Mol Cell Biol 33(5):958-73. PubMed: 23275443MGI: J:217269
- Potter KA; Kern MJ; Fullbright G; Bielawski J; Scherer SS; Yum SW; Li JJ; Cheng H; Han X; Venkata JK; Akbar Ali Khan P; Rohrer B; Hama H. 2011. Central nervous system dysfunction in a mouse model of Fa2h deficiency. Glia 59(7):1009-21. PubMed: 21491498MGI: J:171655
- Puckelwartz MJ; Kessler E; Zhang Y; Hodzic D; Randles KN; Morris G; Earley JU; Hadhazy M; Holaska JM; Mewborn SK; Pytel P; McNally EM. 2009. Disruption of nesprin-1 produces an Emery Dreifuss muscular dystrophy-like phenotype in mice. Hum Mol Genet 18(4):607-20. PubMed: 19008300MGI: J:144757
- Puschendorf M; Terranova R; Boutsma E; Mao X; Isono K; Brykczynska U; Kolb C; Otte AP; Koseki H; Orkin SH; van Lohuizen M; Peters AH. 2008. PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos. Nat Genet 40(4):411-20. PubMed: 18311137MGI: J:134477
- Rajan I; Read R; Small DL; Perrard J; Vogel P. 2011. An alternative splicing variant in Clcn7-/- mice prevents osteopetrosis but not neural and retinal degeneration. Vet Pathol 48(3):663-75. PubMed: 20448277MGI: J:186049
- Reginensi A; Clarkson M; Neirijnck Y; Lu B; Ohyama T; Groves AK; Sock E; Wegner M; Costantini F; Chaboissier MC; Schedl A. 2011. SOX9 controls epithelial branching by activating RET effector genes during kidney development. Hum Mol Genet 20(6):1143-53. PubMed: 21212101MGI: J:168845
- Rice DS; Calandria JM; Gordon WC; Jun B; Zhou Y; Gelfman CM; Li S; Jin M; Knott EJ; Chang B; Abuin A; Issa T; Potter D; Platt KA; Bazan NG. 2015. Adiponectin receptor 1 conserves docosahexaenoic acid and promotes photoreceptor cell survival. Nat Commun 6:6228. PubMed: 25736573MGI: J:229207
- Ricke RM; Jeganathan KB; Malureanu L; Harrison AM; van Deursen JM. 2012. Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression. J Cell Biol 199(6):931-49. PubMed: 23209306MGI: J:195237
- Sati L; Zeiss C; Yekkala K; Demir R; McGrath J. 2015. Expression of the CTCFL Gene during Mouse Embryogenesis Causes Growth Retardation, Postnatal Lethality, and Dysregulation of the Transforming Growth Factor beta Pathway. Mol Cell Biol 35(19):3436-45. PubMed: 26169830MGI: J:228230
- Schaff UY; Shih HH; Lorenz M; Sako D; Kriz R; Milarski K; Bates B; Tchernychev B; Shaw GD; Simon SI. 2008. SLIC-1/sorting nexin 20: A novel sorting nexin that directs subcellular distribution of PSGL-1. Eur J Immunol 38(2):550-64. PubMed: 18196517MGI: J:131282
- Schoch S; Mittelstaedt T; Kaeser PS; Padgett D; Feldmann N; Chevaleyre V; Castillo PE; Hammer RE; Han W; Schmitz F; Lin W; Sudhof TC. 2006. Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release. EMBO J 25(24):5852-63. PubMed: 17124501MGI: J:119934
- Seidler B; Schmidt A; Mayr U; Nakhai H; Schmid RM; Schneider G; Saur D. 2008. A Cre-loxP-based mouse model for conditional somatic gene expression and knockdown in vivo by using avian retroviral vectors. Proc Natl Acad Sci U S A 105(29):10137-42. PubMed: 18621715MGI: J:140423
- Seifert EL; Caron AZ; Morin K; Coulombe J; Hong He X; Jardine K; Dewar-Darch D; Boekelheide K; Harper ME; McBurney MW. 2012. SirT1 catalytic activity is required for male fertility and metabolic homeostasis in mice. FASEB J 26(2):555-66. PubMed: 22006156MGI: J:180628
- Seymour PA; Freude KK; Dubois CL; Shih HP; Patel NA; Sander M. 2008. A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation. Dev Biol 323(1):19-30. PubMed: 18723011MGI: J:141017
- Sharma A; Lyashchenko AK; Lu L; Nasrabady SE; Elmaleh M; Mendelsohn M; Nemes A; Tapia JC; Mentis GZ; Shneider NA. 2016. ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function. Nat Commun 7:10465. PubMed: 26842965MGI: J:232167
- Sharma K; Leonard AE; Lettieri K; Pfaff SL. 2000. Genetic and epigenetic mechanisms contribute to motor neuron pathfinding. Nature 406(6795):515-9. PubMed: 10952312MGI: J:63774
- Shaw AT; Meissner A; Dowdle JA; Crowley D; Magendantz M; Ouyang C; Parisi T; Rajagopal J; Blank LJ; Bronson RT; Stone JR; Tuveson DA; Jaenisch R; Jacks T. 2007. Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis. Genes Dev 21(6):694-707. PubMed: 17369402MGI: J:119477
- St Amand TR; Lu JT; Zamora M; Gu Y; Stricker J; Hoshijima M; Epstein JA; Ross JJ Jr; Ruiz-Lozano P; Chien KR. 2006. Distinct roles of HF-1b/Sp4 in ventricular and neural crest cells lineages affect cardiac conduction system development. Dev Biol 291(2):208-17. PubMed: 16430881MGI: J:107057
- Stark KL; Xu B; Bagchi A; Lai WS; Liu H; Hsu R; Wan X; Pavlidis P; Mills AA; Karayiorgou M; Gogos JA. 2008. Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model. Nat Genet 40(6):751-60. PubMed: 18469815MGI: J:136969
- Starremans PG; Li X; Finnerty PE; Guo L; Takakura A; Neilson EG; Zhou J. 2008. A mouse model for polycystic kidney disease through a somatic in-frame deletion in the 5' end of Pkd1. Kidney Int 73(12):1394-405. PubMed: 18385665MGI: J:140012
- Stewart R; Flechner L; Montminy M; Berdeaux R. 2011. CREB is activated by muscle injury and promotes muscle regeneration. PLoS One 6(9):e24714. PubMed: 21931825MGI: J:177923
- Su X; Paris M; Gi YJ; Tsai KY; Cho MS; Lin YL; Biernaskie JA; Sinha S; Prives C; Pevny LH; Miller FD; Flores ER. 2009. TAp63 prevents premature aging by promoting adult stem cell maintenance. Cell Stem Cell 5(1):64-75. PubMed: 19570515MGI: J:151638
- Sumara G; Formentini I; Collins S; Sumara I; Windak R; Bodenmiller B; Ramracheya R; Caille D; Jiang H; Platt KA; Meda P; Aebersold R; Rorsman P; Ricci R. 2009. Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis. Cell 136(2):235-48. PubMed: 19135240MGI: J:146185
- Tadjali M; Zhou S; Rehg J; Sorrentino BP. 2006. Prospective isolation of murine hematopoietic stem cells by expression of an Abcg2/GFP allele. Stem Cells 24(6):1556-63. PubMed: 16484343MGI: J:128682
- Takagi Y; Mitsui A; Nishiyama A; Nozaki K; Sono H; Gon Y; Hashimoto N; Yodoi J. 1999. Overexpression of thioredoxin in transgenic mice attenuates focal ischemic brain damage. Proc Natl Acad Sci U S A 96(7):4131-6. PubMed: 10097175MGI: J:108918
- Teves ME; Jha KN; Song J; Nagarkatti-Gude DR; Herr JC; Foster JA; Strauss JF 3rd; Zhang Z. 2013. Germ cell-specific disruption of the Meig1 gene causes impaired spermiogenesis in mice. Andrology 1(1):37-46. PubMed: 23258628MGI: J:194944
- Timofeev O; Schlereth K; Wanzel M; Braun A; Nieswandt B; Pagenstecher A; Rosenwald A; Elsasser HP; Stiewe T. 2013. p53 DNA binding cooperativity is essential for apoptosis and tumor suppression in vivo. Cell Rep 3(5):1512-25. PubMed: 23665223MGI: J:198482
- Toka HR; Al-Romaih K; Koshy JM; DiBartolo S 3rd; Kos CH; Quinn SJ; Curhan GC; Mount DB; Brown EM; Pollak MR. 2012. Deficiency of the calcium-sensing receptor in the kidney causes parathyroid hormone-independent hypocalciuria. J Am Soc Nephrol 23(11):1879-90. PubMed: 22997254MGI: J:225084
- Usdin TB; Paciga M; Riordan T; Kuo J; Parmelee A; Petukova G; Camerini-Otero RD; Mezey E. 2008. Tuberoinfundibular Peptide of 39 residues is required for germ cell development. Endocrinology 149(9):4292-300. PubMed: 18483145MGI: J:138142
- Veenstra-Vanderweele J; Jessen TN; Thompson BJ; Carter M; Prasad HC; Steiner JA; Sutcliffe JS; Blakely RD. 2009. Modeling rare gene variation to gain insight into the oldest biomarker in autism: construction of the serotonin transporter Gly56Ala knock-in mouse. J Neurodev Disord 1(2):158-71. PubMed: 19960097MGI: J:202521
- Verhulst PJ; De Smet B; Saels I; Thijs T; Ver Donck L; Moechars D; Peeters TL; Depoortere I. 2008. Role of ghrelin in the relationship between hyperphagia and accelerated gastric emptying in diabetic mice. Gastroenterology 135(4):1267-76. PubMed: 18657539MGI: J:141985
- Vidal VP; Chaboissier MC; Lutzkendorf S; Cotsarelis G; Mill P; Hui CC; Ortonne N; Ortonne JP; Schedl A. 2005. Sox9 is essential for outer root sheath differentiation and the formation of the hair stem cell compartment. Curr Biol 15(15):1340-51. PubMed: 16085486MGI: J:100131
- Vincent SD; Dunn NR; Hayashi S; Norris DP; Robertson EJ. 2003. Cell fate decisions within the mouse organizer are governed by graded Nodal signals. Genes Dev 17(13):1646-62. PubMed: 12842913MGI: J:84300
- Vissel B; Royle GA; Christie BR; Schiffer HH; Ghetti A; Tritto T; Perez-Otano I; Radcliffe RA; Seamans J; Sejnowski T; Wehner JM; Collins AC; O'Gorman S; Heinemann SF. 2001. The role of RNA editing of kainate receptors in synaptic plasticity and seizures. Neuron 29(1):217-27. PubMed: 11182093MGI: J:107698
- Vogel P; Donoviel MS; Read R; Hansen GM; Hazlewood J; Anderson SJ; Sun W; Swaffield J; Oravecz T. 2009. Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions. PLoS One 4(1):e4112. PubMed: 19119317MGI: J:145159
- Von Coelln R; Thomas B; Savitt JM; Lim KL; Sasaki M; Hess EJ; Dawson VL; Dawson TM. 2004. Loss of locus coeruleus neurons and reduced startle in parkin null mice. Proc Natl Acad Sci U S A 101(29):10744-9. PubMed: 15249681MGI: J:91487
- Wang C; Lee JE; Cho YW; Xiao Y; Jin Q; Liu C; Ge K. 2012. UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity. Proc Natl Acad Sci U S A 109(38):15324-9. PubMed: 22949634MGI: J:190157
- Wang CC; Held RG; Chang SC; Yang L; Delpire E; Ghosh A; Hall BJ. 2011. A Critical Role for GluN2B-Containing NMDA Receptors in Cortical Development and Function. Neuron 72(5):789-805. PubMed: 22153375MGI: J:178913
- Wang Y; Lin L; Lai H; Parada LF; Lei L. 2013. Transcription factor Sox11 is essential for both embryonic and adult neurogenesis. Dev Dyn 242(6):638-53. PubMed: 23483698MGI: J:198233
- Weinert S; Bergmann N; Luo X; Erdmann B; Gotthardt M. 2006. M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere. J Cell Biol 173(4):559-70. PubMed: 16702235MGI: J:111284
- Westmuckett AD; Nguyen EB; Herlea-Pana OM; Alvau A; Salicioni AM; Moore KL. 2014. Impaired sperm maturation in RNASE9 knockout mice. Biol Reprod 90(6):120. PubMed: 24719258MGI: J:212760
- Wijshake T; Malureanu LA; Baker DJ; Jeganathan KB; van de Sluis B; van Deursen JM. 2012. Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation. PLoS Genet 8(12):e1003138. PubMed: 23300461MGI: J:194926
- Williams G; Wood A; Williams EJ; Gao Y; Mercado ML; Katz A; Joseph-McCarthy D; Bates B; Ling HP; Aulabaugh A; Zaccardi J; Xie Y; Pangalos MN; Walsh FS; Doherty P. 2008. Ganglioside inhibition of neurite outgrowth requires Nogo receptor function: identification of interaction sites and development of novel antagonists. J Biol Chem 283(24):16641-52. PubMed: 18411262MGI: J:138580
- Wiltgen BJ; Royle GA; Gray EE; Abdipranoto A; Thangthaeng N; Jacobs N; Saab F; Tonegawa S; Heinemann SF; O'Dell TJ; Fanselow MS; Vissel B. 2010. A role for calcium-permeable AMPA receptors in synaptic plasticity and learning. PLoS One 5(9):. PubMed: 20927382MGI: J:223717
- Winden KD; Oldham MC; Mirnics K; Ebert PJ; Swan CH; Levitt P; Rubenstein JL; Horvath S; Geschwind DH. 2009. The organization of the transcriptional network in specific neuronal classes. Mol Syst Biol 5:291. PubMed: 19638972MGI: J:160728
- Xiao G; Cheng H; Cao H; Chen K; Tu Y; Yu S; Jiao H; Yang S; Im HJ; Chen D; Chen J; Wu C. 2012. Critical role of filamin-binding LIM protein 1 (FBLP-1)/migfilin in regulation of bone remodeling. J Biol Chem 287(25):21450-60. PubMed: 22556421MGI: J:186501
- Xu J; Cohen BN; Zhu Y; Dziewczapolski G; Panda S; Lester HA; Heinemann SF; Contractor A. 2011. Altered activity-rest patterns in mice with a human autosomal-dominant nocturnal frontal lobe epilepsy mutation in the beta2 nicotinic receptor. Mol Psychiatry 16(10):1048-61. PubMed: 20603624MGI: J:228269
- Yamamoto K; Wang Y; Jiang W; Liu X; Dubois RL; Lin CS; Ludwig T; Bakkenist CJ; Zha S. 2012. Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice. J Cell Biol 198(3):305-13. PubMed: 22869596MGI: J:191288
- Yan J; Mei FC; Cheng H; Lao DH; Hu Y; Wei J; Patrikeev I; Hao D; Stutz SJ; Dineley KT; Motamedi M; Hommel JD; Cunningham KA; Chen J; Cheng X. 2013. Enhanced leptin sensitivity, reduced adiposity, and improved glucose homeostasis in mice lacking exchange protein directly activated by cyclic AMP isoform 1. Mol Cell Biol 33(5):918-26. PubMed: 23263987MGI: J:207599
- Yang J; Goldstein JL; Hammer RE; Moon YA; Brown MS; Horton JD. 2001. Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene. Proc Natl Acad Sci U S A 98(24):13607-12. PubMed: 11717426MGI: J:72930
- Yang L; Cai CL; Lin L; Qyang Y; Chung C; Monteiro RM; Mummery CL; Fishman GI; Cogen A; Evans S. 2006. Isl1Cre reveals a common Bmp pathway in heart and limb development. Development 133(8):1575-85. PubMed: 16556916MGI: J:107396
- Yao J; Le TC; Kos CH; Henderson JM; Allen PG; Denker BM; Pollak MR. 2004. Alpha-actinin-4-mediated FSGS: an inherited kidney disease caused by an aggregated and rapidly degraded cytoskeletal protein. PLoS Biol 2(6):787-94. PubMed: 15208719MGI: J:90755
- Yin Y; Lin C; Kim ST; Roig I; Chen H; Liu L; Veith GM; Jin RU; Keeney S; Jasin M; Moley K; Zhou P; Ma L. 2011. The E3 ubiquitin ligase Cullin 4A regulates meiotic progression in mouse spermatogenesis. Dev Biol 356(1):51-62. PubMed: 21624359MGI: J:175255
- Yuan Z; Opas EE; Vrikshajanani C; Libutti SK; Levine MA. 2014. Generation of mice encoding a conditional null allele of Gcm2. Transgenic Res 23(4):631-41. PubMed: 24736975MGI: J:213334
- Zhang J; Felder A; Liu Y; Guo LT; Lange S; Dalton ND; Gu Y; Peterson KL; Mizisin AP; Shelton GD; Lieber RL; Chen J. 2010. Nesprin 1 is critical for nuclear positioning and anchorage. Hum Mol Genet 19(2):329-41. PubMed: 19864491MGI: J:155342
- Zhang J; Wang Y; Chi Z; Keuss MJ; Pai YM; Kang HC; Shin JH; Bugayenko A; Wang H; Xiong Y; Pletnikov MV; Mattson MP; Dawson TM; Dawson VL. 2011. The AAA+ ATPase Thorase regulates AMPA receptor-dependent synaptic plasticity and behavior. Cell 145(2):284-99. PubMed: 21496646MGI: J:173768
- Zhang X; Heaney S; Maas RL. 2003. Cre-loxp fate-mapping of Pax6 enhancer active retinal and pancreatic progenitors. Genesis 35(1):22-30. PubMed: 12481295MGI: J:81626
- Zhang Y; Foreman O; Wigle DA; Kosari F; Vasmatzis G; Salisbury JL; van Deursen J; Galardy PJ. 2012. USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis. J Clin Invest 122(12):4362-74. PubMed: 23187126MGI: J:193965
- Zhao F; Edwards R; Dizon D; Afrasiabi K; Mastroianni JR; Geyfman M; Ouellette AJ; Andersen B; Lipkin SM. 2010. Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2-/- mice. Dev Biol 338(2):270-9. PubMed: 20025862MGI: J:156704
- Zheng K; Wang PJ. 2012. Blockade of pachytene piRNA biogenesis reveals a novel requirement for maintaining post-meiotic germline genome integrity. PLoS Genet 8(11):e1003038. PubMed: 23166510MGI: J:194084
- Zhuang T; Hess RA; Kolla V; Higashi M; Raabe TD; Brodeur GM. 2014. CHD5 is required for spermiogenesis and chromatin condensation. Mech Dev 131:35-46. PubMed: 24252660MGI: J:207846