Mice that are homozygous for the mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Screening of third generation mice (G3) after more than 5 weeks atherogenic diet identified a 13 week old female (born 9/04/2002) with a 4 hour fasted plasma total cholesterol of 517 mg/dl and HDL of 129 mg/dl, which is approximately 522% and 160% higher, respectively, than controls. One sibling was similarly affected. This mutant mouse strain may be useful in studies of diet-induced hypercholesterolemia.
This phenotypic deviant was identified following multidose ethylnitrosourea (ENU) treatments to induce mutations in male founder C57BL/6J mice (Stock No. 000664), in complex heart, lung, blood, and sleep disorders at the Mouse Heart, Lung, Blood, and Sleep Disorders (HLBS) Center at The Jackson Laboratory.
|Allele Name||heart, lung, and blood, 243|
|Allele Type||Chemically induced (ENU)|
|Gene Symbol and Name||hlb243, heart, lung, and blood, 243|
|Strain of Origin||C57BL/6J|
|Molecular Note||This mutation was identified in an ENU mutagenesis screen.|