The BXD#/Rww recombinant inbred (RI) strains originate from crosses between C57BL/6J (000664) females and DBA/2J (000671) males and were generated using a strategy of advanced intercrosses (AI). They may be used to study the genetics of behavioral phenotypes (including alcohol and drug addiction, stress, and locomotor activity) and complex or potentially complex physiologic phenotypes (including differences in organ weight and bone mineral density).Read More +
The BXD recombinant inbred (RI) strains are used to study the genetics of behavioral phenotypes including alcohol and drug addiction, stress, and locomotor activity. The BXD set of RI strains also are used in the genetic analysis of numerous complex or potentially complex physiologic phenotypes including differences in organ weight and bone mineral density.
The BXD#/Rww set was generated using a strategy of advanced intercrosses (AI). The AI technique produces recombinant RI strains which incorporate approximately twice as many recombinations as the standard RI strains. The addition of the AI BXD RI lines to the existing BXD set creates the largest of the mouse RI mapping panels. This set is useful in QTL mapping and analysis of gene function.
The strain distribution pattern (SDP) for the BXD RI strains is available through the Mouse Genome Informatics
Contributed Data Sets and Gene Network.
Additional tools and information are presented through the Mouse Phenome Database
Specialized Strain Panel Query Form, and
Gene Network .
Through high density MUGA (Mouse Universal Genotyping Array) analysis performed in 2011 and Affymetrix screening in 2008, it has been determined that some BXD recombinant inbred strains are the same or nearly the same genetically. BXD73/RwwJ (Stock No. 007117), BXD80/RwwJ and BXD103/RwwJ (Stock No. 007146) were found to be highly similar in their overall genomes, but with particular chromosomes differing between them. We have renamed two of these sister strains to reflect the genetic similarity. BXD73/RwwJ is designated the primary strain, and the name will not be changed. BXD80/RwwJ is now designated BXD73a/RwwJ and BXD103/RwwJ is now designated BXD73b/RwwJ. In general, the "sister" strains (the ones with a suffix) should not be used for primary screening/QTL mapping. However, if a QTL is located in a region of difference in a sister recombinant inbred then this strain can serve as a "near congenic" for additional analysis. For additional information see
The BXD#/Rww advanced recombinant inbred (ARI) lines are derived from two independently derived advanced intercrosses between the C57BL/6J and DBA/2J progenitor strains generated at Princeton University and the University of Tennessee. Crosses at Princeton were intiated using B6D2F1/J mice crossed to generate B6D2F2 mice. These mice were randomly mated to generate a G3 population. Subsequent matings were chosen to minimize the number of common parents. AIL from the Tennessee crosses were initiated with reciprocal crosses of the parental strains. As a result, mice from the Tennessee set can have the Y chromosome and mitochondrial genome from either progenitor. Mice from the Princeton set have a Y chromosome from DBA/2J and the mitochondrial genome from C57BL/6J. All ARI lines were intercrossed for 9-14 generations before inbreeding. Like the Princeton crosses, the Tennessee crosses also sought to miminize common ancestors in each cross although fewer breeding cages per generation were used. As of early 2007, most lines were inbred for more than 20 generations.
The lines were donated to The Jackson Laboratory Repository in 2007 by Dr. Robert Williams.
Currently there are no related genes or alleles for this strain.
When using the BXD73a/RwwJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #007124 in your Materials and Methods section.